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Product Details
68294-1-IG
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: QVTAGRHGDD LRNTKQEIAE INRMIQRLRS EIDHVKKQCA NLQAAIADAE QRGEMALKDA KNKLEGLEDA LQKAKQDLAR LLKEYQELMN VKLALDVEIA TYRKLLEGEE CRLNGEGVGQ VNISVVQSTV SSGYGGASGV GSGLGLGGGS SYSYGSGLGV GGGFSSSSGR AIGGGLSSVG GGSSTIKYTT TSSSSRKSYK H
Target Information
Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 60-kDa keratin; CK-6A; CK-6B; CK-6C; CK-6D; CK-6E; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; K6A; K6a keratin; K6B; K6C; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 6A, , type II; keratin 6A, type II; keratin 6B, type II; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; keratin K6; Keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; Keratin-6-alpha; keratin-6-beta; Keratin-6A; Keratin-6B; Keratin-6C; keratin-like 1 (a type II keratin sequence); mK6-alpha; mK6-beta; Type-II keratin Kb10; Type-II keratin Kb12; Type-II keratin Kb6
Gene Aliases: 2310016L08Rik; BB144589; CK-6A; CK-6B; CK-6C; CK-6E; CK6A; CK6B; CK6C; CK6D; K6A; K6B; K6C; K6D; K6E; Ker2; Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; KRTL1; mK6[a]; mK6[b]; MK6a; PC2; PC3; PC4; PPKNEFD
UniProt ID: (Human) P02538, (Human) P04259, (Human) P48668, (Mouse) P50446, (Rat) Q4FZU2
Entrez Gene ID: (Human) 3853, (Human) 3854, (Human) 286887, (Mouse) 16687, (Mouse) 16688, (Rat) 683313
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