Product References
Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins.
The Journal of membrane biology
Brunner N,Stein L,Amasheh S
35-2500 was used in Western Blotting to reveal endogenous tjp1 expression in protein and mRNA analyses of unfertilized Xenopus laevis oocytes expressing human claudin 1 (CLDN1) to claudin 5 (CLDN5).
Wed Feb 01 00:00:00 EST 2023
Coxsackievirus B3 infects and disrupts human induced-pluripotent stem cell derived brain-like endothelial cells.
Frontiers in cellular and infection microbiology
Mamana J,Humber GM,Espinal ER,Seo S,Vollmuth N,Sin J,Kim BJ
35-2500 was used in Immunocytochemistry to elucidate the unique effects of CVB3 infection on the BBB and shed light on potential mechanisms by which the virus can initiate infections in the brain.
Fri May 05 00:00:00 EDT 2023
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution.
eLife
Wang J,Rattner A,Nathans J
35-2500 was used in Immunohistochemistry-immunofluorescence to imply that EC responses to infection are largely driven by the intrinsic EC response to LPS.
Thu Jun 15 00:00:00 EDT 2023
Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age.
Fluids and barriers of the CNS
Archie SR,Sifat AE,Zhang Y,Villalba H,Sharma S,Nozohouri S,Abbruscato TJ
35-2500 was used in Western Blotting to suggest that prenatal e-cig exposure induces long-term neurovascular changes of neonates by disrupting postnatal BBB integrity and worsening behavioral outcomes.
Fri Mar 10 00:00:00 EST 2023
Endothelial Arid1a deletion disrupts the balance among angiogenesis, neurogenesis and gliogenesis in the developing brain.
Cell proliferation
Wang Y,Su L,Wang W,Zhao J,Wang Y,Li S,Liu Y,Chai R,Li X,Teng Z,Liu C,Hu B,Ji F,Jiao J
35-2500 was used in Western Blotting to suggest that endothelial Arid1a tightly controls fate determination of NPCs by regulating the AKT-SMAD signalling pathway.
Mon May 01 00:00:00 EDT 2023
Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries.
Fluids and barriers of the CNS
Hamada Y,Ogata S,Masuda T,Ito S,Ohtsuki S
35-2500 was used in Western Blotting to develop a method to isolate brain capillaries from a single frozen neonatal mouse brain and elucidate the enrichment of brain capillaries by quantitative proteomic analysis, and compare the expression profile of proteins between neonatal and adult brain capillary fractions.
Fri Jun 23 00:00:00 EDT 2023
NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain.
Immune network
Byun DJ,Lee J,Yu JW,Hyun YM
35-2500 was used in Immunohistochemistry to provide a clue that NLRP3 would be a potential therapeutic target to alleviate neuroinflammation.
Thu Jun 01 00:00:00 EDT 2023
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Nature neuroscience
van Lengerich B,Zhan L,Xia D,Chan D,Joy D,Park JI,Tatarakis D,Calvert M,Hummel S,Lianoglou S,Pizzo ME,Prorok R,Thomsen E,Bartos LM,Beumers P,Capell A,Davis SS,de Weerd L,Dugas JC,Duque J,Earr T,Gadkar K,Giese T,Gill A,Gnörich J,Ha C,Kannuswamy M,Kim DJ,Kunte ST,Kunze LH,Lac D,Lechtenberg K,Leung AW,Liang CC,Lopez I,McQuade P,Modi A,Torres VO,Nguyen HN,Pesämaa I,Propson N,Reich M,Robles-Colmenares Y,Schlepckow K,Slemann L,Solanoy H,Suh JH,Thorne RG,Vieira C,Wind-Mark K,Xiong K,Zuchero YJY,Diaz D,Dennis MS,Huang F,Scearce-Levie K,Watts RJ,Haass C,Lewcock JW,Di Paolo G,Brendel M,Sanchez PE,Monroe KM
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that in an AD mouse model, ATV:TREM2 boosted brain microglial activity and glucose metabolism and that ATV:TREM2 represents a promising approach to improve microglial function and treat brain hypometabolism found in patients with AD.
Wed Mar 01 00:00:00 EST 2023
Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats.
Clinical and experimental pharmacology & physiology
Rodriguez-Ortiz CJ,Thorwald MA,Rodriguez R,Mejias-Ortega M,Kieu Z,Maitra N,Hawkins C,Valenzuela J,Peng M,Nishiyama A,Ortiz RM,Kitazawa M
35-2500 was used in Western Blotting to demonstrate that the progression of MetS in OLETF rats is associated with deterioration of various aspects of neuronal integrity that may manifest neurodegenerative conditions and that overactivation of angiotensin receptor directly or indirectly contributes to these detriments.
Wed Mar 01 00:00:00 EST 2023
rTMS treatment for abrogating intracerebral hemorrhage-induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage.
Brain and behavior
Liu Y,Liu X,Sun P,Li J,Nie M,Gong J,He A,Zhao M,Yang C,Wang Z
35-2500 was used in Western Blotting to indicate that rTMS can abrogate ICH-induced brain parenchymal metabolite clearance dysfunction by regulating intracranial lymphatic drainage.
Sat Jul 01 00:00:00 EDT 2023
Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.
Journal of neuroinflammation
Villalba N,Ma Y,Gahan SA,Joly-Amado A,Spence S,Yang X,Nash KR,Yuan SY
35-2500 was used in Immunocytochemistry to examine the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment.
Sat May 27 00:00:00 EDT 2023
Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells.
International journal of molecular sciences
Matsumoto T,Matsumoto J,Matsushita Y,Arimura M,Aono K,Aoki M,Terada K,Mori M,Haramaki Y,Imatoh T,Yamauchi A,Migita K
35-2500 was used in Western Blotting to suggest that BTZ increases the vascular permeability of the pulmonary microvascular endothelium by downregulating cell-cell junction molecules, particularly claudin-5, occludin, and VE-cadherin.
Thu Jun 29 00:00:00 EDT 2023
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells.
Fluids and barriers of the CNS
Luo Y,Yao F,Shi Y,Zhu Z,Xiao Z,You X,Liu Y,Yu S,Tian D,Cheng L,Zheng M,Jing J
35-2500 was used in Immunohistochemistry to demonstrate that at 14 and 28 dpi, the expression of claudin-5 (CLDN5) and zonula occludens-1 (ZO-1) between vascular endothelial cells was significantly increased and the leakage of BSCB was significantly reduced in the injured core after daily intrathecal injection of Tocilizumab.
Mon Jan 09 00:00:00 EST 2023
A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells.
PloS one
Yang J,Li Y,Bhalla A,Maienschein-Cline M,Fukuchi KI
35-2500 was used in Western Blotting to indicate that the co-culture of bEnd.3 cells with LPS-activated Raw 264.7 cells is a better model than the common mono-culture of LPS-activated bEnd.3 cells to investigate the molecular mechanism in endothelial cells, by which systemic inflammation induces neuroinflammation.
Mon Jul 17 00:00:00 EDT 2023
Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood-Brain Barriers.
Cells
Li Y,Sun Z,Zhu H,Sun Y,Shteyman DB,Markx S,Leong KW,Xu B,Fu BM
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate that the 22q11.2DS iBBB is at least partially caused by the haploinsufficiency of CRKL, which can be rescued by imatinib via its effects on the Abl/CRKL signaling pathway.
Fri Jan 27 00:00:00 EST 2023
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Molecular therapy : the journal of the American Society of Gene Therapy
Yang Z,Huang C,Wen X,Liu W,Huang X,Li Y,Zang J,Weng Z,Lu D,Tsang CK,Li K,Xu A
35-2500 was used in Western Blot, Immunohistochemistry to demonstrate that the circular RNA of FoxO3 promotes autophagy via mTORC1 inhibition to attenuate BBB collapse under ischemia/reperfusion injury.
Wed Mar 02 00:00:00 EST 2022
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Molecular therapy : the journal of the American Society of Gene Therapy
Yang Z,Huang C,Wen X,Liu W,Huang X,Li Y,Zang J,Weng Z,Lu D,Tsang CK,Li K,Xu A
35-2500 was used in Western Blot, Immunohistochemistry to demonstrate that the circular RNA of FoxO3 promotes autophagy via mTORC1 inhibition to attenuate BBB collapse under ischemia/reperfusion injury.
Wed Mar 02 00:00:00 EST 2022
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Aging and disease
Zhang Q,Liu C,Shi R,Zhou S,Shan H,Deng L,Chen T,Guo Y,Zhang Z,Yang GY,Wang Y,Tang Y
35-2500 was used in Immunohistochemistry-immunofluorescence to conclude that astrocytes undergo a phenotypic shift over time after ischemic stroke.
Wed Jun 01 00:00:00 EDT 2022
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Translational stroke research
Yu R,Kim NS,Li Y,Jeong JY,Park SJ,Zhou B,Oh WJ
35-2500 was used in Immunohistochemistry to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury.
Tue Feb 01 00:00:00 EST 2022
miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells.
Breast cancer (Dove Medical Press)
Hammash D,Mahfood M,Khoder G,Ahmed M,Tlili A,Hamoudi R,Harati R
35-2500 was used in Western Blotting to investigate the role of miR-623 in Matrix metalloproteinase-1 regulation and its impact on the extravasation of triple-negative breast cancer cells through the brain metastasis in vitro.
Tue Aug 09 00:00:00 EDT 2022
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Biochemical and biophysical research communications
Choi JY,Park JH,Jo C,Kim KC,Koh YH
35-2500 was used in Western Blotting to demonstrate that BACE1-mediated endothelial cell damage and senescence may be linked to CVD after COVID-19 infection.
Thu Oct 20 00:00:00 EDT 2022
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury.
Journal of neuroinflammation
Navarrete C,García-Martín A,Correa-Sáez A,Prados ME,Fernández F,Pineda R,Mazzone M,Álvarez-Benito M,Calzado MA,Muñoz E
35-2500 was used in Immunohistochemistry-immunofluorescence to investigate the mechanism of action of VCE-004.8 in the hypoxia inducible factor pathway and explored its efficacy in a preclinical model of Traumatic brain injury.
Sat Jul 09 00:00:00 EDT 2022
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination.
Molecular neurodegeneration
Wang N,Wang M,Jeevaratnam S,Rosenberg C,Ikezu TC,Shue F,Doss SV,Alnobani A,Martens YA,Wren M,Asmann YW,Zhang B,Bu G,Liu CC
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to provide critical mechanistic insights into how apolipoprotein E isoforms differentially regulate microglial function and the maintenance of myelin dynamics.
Wed Nov 23 00:00:00 EST 2022
Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hansen L,Lohfink N,Vutukuri R,Kestner RI,Trautmann S,Hecht M,Wagner PV,Spitzer D,Khel MI,Macas J,Ferreirós N,Gurke R,Günther S,Pfeilschifter W,Devraj K
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to demonstrate the expression and novel barrier-protective function of S1P4 in brain endothelial cells and pinpoint its localization to abluminal membranes.
Wed Mar 09 00:00:00 EST 2022
Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.
Developmental cell
Xu J,Xu L,Sui P,Chen J,Moya EA,Hume P,Janssen WJ,Duran JM,Thistlethwaite P,Carlin A,Gulleman P,Banaschewski B,Goldy MK,Yuan JX,Malhotra A,Pryhuber G,Crotty-Alexander L,Deutsch G,Young LR,Sun X
35-2500 was used in Immunohistochemistry-immunofluorescence to suggest that restricting neuropeptide function may limit fluid and improve gas exchange in these conditions.
Mon Apr 11 00:00:00 EDT 2022
Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier.
Cell reports. Medicine
Chang JH,Greene C,Frudd K,Araujo Dos Santos L,Futter C,Nichols BJ,Campbell M,Turowski P
35-2500 was used in Immunohistochemistry to indicate that caveolar transport at the adult BBB is agonist inducible and that METH can enhance drug delivery to the CNS.
Tue Jan 18 00:00:00 EST 2022
"Endothelial Antibody Factory" at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases.
Pharmaceutics
Thinard R,Farkas AE,Halasa M,Chevalier M,Brodaczewska K,Majewska A,Zdanowski R,Paprocka M,Rossowska J,Duc LT,Greferath R,Krizbai I,Van Leuven F,Kieda C,Nicolau C
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show the formation of tight junctions between the injected engineered EPCs and the unlabeled resident endothelial cells.
Wed Jul 06 00:00:00 EDT 2022
Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease.
Brain : a journal of neurology
Wang Q,Huang X,Su Y,Yin G,Wang S,Yu B,Li H,Qi J,Chen H,Zeng W,Zhang K,Verkhratsky A,Niu J,Yi C
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show dysfunctional blood-brain barrier in patients with Alzheimer's disease reflected by perivascular accumulation of blood-derived fibrinogen in the hippocampus and cortex, accompanied by decreased tight junction proteins Claudin-5 and glucose transporter Glut-1 in the brain endothelial cells.
Mon Dec 19 00:00:00 EST 2022
Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease.
Brain : a journal of neurology
Wang Q,Huang X,Su Y,Yin G,Wang S,Yu B,Li H,Qi J,Chen H,Zeng W,Zhang K,Verkhratsky A,Niu J,Yi C
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show dysfunctional blood-brain barrier in patients with Alzheimer's disease reflected by perivascular accumulation of blood-derived fibrinogen in the hippocampus and cortex, accompanied by decreased tight junction proteins Claudin-5 and glucose transporter Glut-1 in the brain endothelial cells.
Mon Dec 19 00:00:00 EST 2022
Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells.
Pharmaceutical research
Nagano H,Ito S,Masuda T,Ohtsuki S
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest that INSR-mediated signaling is involved in the regulation of functional protein expression at the BBB and contributes to the maintenance of BBB function.
Fri Jul 01 00:00:00 EDT 2022
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice.
Neural regeneration research
Deng LD,Qi L,Suo Q,Wu SJ,Mamtilahun M,Shi RB,Liu Z,Sun JF,Tang YH,Zhang ZJ,Yang GY,Wang JX
35-2500 was used in Western Blotting to show that low-intensity ultrasound stimulation attenuated BBB disruption and edema formation, which suggests it may have therapeutic use in ischemic brain disease as a protector of BBB integrity.
Thu Sep 01 00:00:00 EDT 2022
TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
Cell reports
Meena AS,Shukla PK,Bell B,Giorgianni F,Caires R,Fernández-Peña C,Beranova S,Aihara E,Montrose MH,Chaib M,Makowski L,Neeli I,Radic MZ,Vásquez V,Jaggar JH,Cordero-Morales JF,Rao R
35-2500 was used in Immunohistochemistry-immunofluorescence to identify TRPV6, a Ca2+-permeable channel, as responsible for alcohol-induced elevation of intracellular Ca2+, intestinal barrier dysfunction, and systemic inflammation.
Tue Jun 14 00:00:00 EDT 2022
A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress.
Methods in molecular biology (Clifton, N.J.)
Molins Gutiérrez G,Martorell J,Salazar-Martin AG,Balcells M
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to design and synthesize a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes.
Fri Jun 24 00:00:00 EDT 2022
Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells.
Antioxidants (Basel, Switzerland)
van Leeuwen E,Hampton MB,Smyth LCD
35-2500 was used in Immunocytochemistry to indicate that BECs are sensitive to HOSCN, resulting in the eventual loss of barrier function.
Tue Mar 22 00:00:00 EDT 2022
High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats.
Pharmaceutics
Yang J,Betterton RD,Williams EI,Stanton JA,Reddell ES,Ogbonnaya CE,Dorn E,Davis TP,Lochhead JJ,Ronaldson PT
35-2500 was used in Immunohistochemistry-immunofluorescence to show that BBB integrity is altered following a single high APAP dose, results that are relevant to patients abusing or misusing APAP and/or APAP/opioid combination products.
Wed Apr 27 00:00:00 EDT 2022
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Acta neuropathologica communications
Miedema A,Gerrits E,Brouwer N,Jiang Q,Kracht L,Meijer M,Nutma E,Peferoen-Baert R,Pijnacker ATE,Wesseling EM,Wijering MHC,Gabius HJ,Amor S,Eggen BJL,Kooistra SM
35-2500 was used in Immunohistochemistry to characterize early changes in multiple sclerosis brain tissue, identifying specific microglia and macrophage subsets at different stages of demyelinating lesions.
Fri Jan 28 00:00:00 EST 2022
Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema.
Cell communication and signaling : CCS
Xue Y,Wang X,Wan B,Wang D,Li M,Cheng K,Luo Q,Wang D,Lu Y,Zhu L
35-2500 was used in Immunocytochemistry to show that Hypoxia upregulated CAV-1 transcription via the activation of NRF1 in endothelial cells, thus inducing the internalization and autophagic degradation of claudin-5.
Mon Oct 17 00:00:00 EDT 2022
Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema.
Cell communication and signaling : CCS
Xue Y,Wang X,Wan B,Wang D,Li M,Cheng K,Luo Q,Wang D,Lu Y,Zhu L
35-2500 was used in Immunocytochemistry to show that Hypoxia upregulated CAV-1 transcription via the activation of NRF1 in endothelial cells, thus inducing the internalization and autophagic degradation of claudin-5.
Mon Oct 17 00:00:00 EDT 2022
Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema.
Cell communication and signaling : CCS
Xue Y,Wang X,Wan B,Wang D,Li M,Cheng K,Luo Q,Wang D,Lu Y,Zhu L
35-2500 was used in Immunocytochemistry to show that Hypoxia upregulated CAV-1 transcription via the activation of NRF1 in endothelial cells, thus inducing the internalization and autophagic degradation of claudin-5.
Mon Oct 17 00:00:00 EDT 2022
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
eLife
Richards M,Nwadozi E,Pal S,Martinsson P,Kaakinen M,Gloger M,Sjöberg E,Koltowska K,Betsholtz C,Eklund L,Nordling S,Claesson-Welsh L
35-2500 was used in Western Blotting to identify structural and functional in vivo characteristics of the endothelial cell barrier.
Thu Jul 21 00:00:00 EDT 2022
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment.
International journal of biological sciences
Rajeev V,Fann DY,Dinh QN,Kim HA,De Silva TM,Jo DG,Drummond GR,Sobey CG,Lai MKP,Chen CL,Arumugam TV
35-2500 was used in Western Blotting to assess the effect of intermittent fasting (IF) against chronic cerebral hypoperfusion-associated neurovascular pathologies and investigated its underlying mechanisms.
Tue Nov 29 00:00:00 EST 2022
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Fluids and barriers of the CNS
Williams LM,Fujimoto T,Weaver RR,Logsdon AF,Evitts KM,Young JE,Banks WA,Erickson MA
35-2500 was used in Western Blot to study responses to disease-relevant stimuli in proliferating vs. more quiescent endothelial cell states.
Sat Feb 05 00:00:00 EST 2022
Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood-spinal cord barrier breakdown during acute spinal cord injury in rats.
Journal of neuroinflammation
Zhao C,Zhou T,Zhao X,Pang Y,Li W,Fan B,Li M,Liu X,Ma L,Zhang J,Sun C,Shen W,Kong X,Yao X,Feng S
35-2500 was used in Immunohistochemistry-immunofluorescence to reveal that nafamostat functions through inhibiting the thrombin-mediated BSCB breakdown and subsequent peripheral immune cells infiltration.
Sat Jul 16 00:00:00 EDT 2022
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice.
Cell reports
Kiani Shabestari S,Morabito S,Danhash EP,McQuade A,Sanchez JR,Miyoshi E,Chadarevian JP,Claes C,Coburn MA,Hasselmann J,Hidalgo J,Tran KN,Martini AC,Chang Rothermich W,Pascual J,Head E,Hume DA,Pridans C,Davtyan H,Swarup V,Blurton-Jones M
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification.
Tue Jun 14 00:00:00 EDT 2022
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice.
Cell reports
Kiani Shabestari S,Morabito S,Danhash EP,McQuade A,Sanchez JR,Miyoshi E,Chadarevian JP,Claes C,Coburn MA,Hasselmann J,Hidalgo J,Tran KN,Martini AC,Chang Rothermich W,Pascual J,Head E,Hume DA,Pridans C,Davtyan H,Swarup V,Blurton-Jones M
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification.
Tue Jun 14 00:00:00 EDT 2022
Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells.
American journal of physiology. Regulatory, integrative and comparative physiology
Garvin J,Semenikhina M,Liu Q,Rarick K,Isaeva E,Levchenko V,Staruschenko A,Palygin O,Harder D,Cohen S
35-2500 was used in Western Blotting to provide insight into gliovascular adaptations to increased glucose levels resulting in impaired cellular cross talk between astrocytes and CMEC, which could be one explanation for cerebral BBB disruption in diabetic conditions.
Wed Jun 01 00:00:00 EDT 2022
Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy.
Brain communications
Faulhaber LD,Phuong AQ,Hartsuyker KJ,Cho Y,Mand KK,Harper SD,Olson AK,Garden GA,Shih AY,Gust J
35-2500 was used in Immunohistochemistry to reveal that brain capillary obstruction may cause sufficient microvascular compromise to explain the clinical phenotype of chimeric antigen receptor T-cell neurotoxicity.
Thu Aug 31 00:00:00 EDT 2023
Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor-mediated transcytosis.
Materials today. Bio
Piantino M,Louis F,Shigemoto-Mogami Y,Kitamura K,Sato K,Yamaguchi T,Kawabata K,Yamamoto S,Iwasaki S,Hirabayashi H,Matsusaki M
35-2500 was used in Immunocytochemistry to evaluate the effectiveness of receptor-mediated transcytosis for drug delivery across the blood-brain barrier.
Tue Mar 01 00:00:00 EST 2022
Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats.
Brain sciences
Nonoguchi HA,Kouo TWS,Kortagere S,Hillman J,Boyle DL,Mandyam CD
35-2500 was used in Western Blotting to examine whether inflammatory response to Lipopolysaccharide and the associated blood-brain barrier disruption differed in male and female adult rats.
Sun Jul 24 00:00:00 EDT 2022
Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity after Cortical Spreading Depression.
Pharmaceutics
Palomino SM,Levine AA,Wahl J,Liktor-Busa E,Streicher JM,Largent-Milnes TM
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to support HSP90 inhibition mitigates KCl-induced BBB permeability and suggests the development of new therapeutic approaches targeting HSP90 in headache disorders.
Wed Aug 10 00:00:00 EDT 2022
Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.
Brain : a journal of neurology
Mishra A,Duplaà C,Vojinovic D,Suzuki H,Sargurupremraj M,Zilhão NR,Li S,Bartz TM,Jian X,Zhao W,Hofer E,Wittfeld K,Harris SE,van der Auwera-Palitschka S,Luciano M,Bis JC,Adams HHH,Satizabal CL,Gottesman RF,Gampawar PG,Bülow R,Weiss S,Yu M,Bastin ME,Lopez OL,Vernooij MW,Beiser AS,Völker U,Kacprowski T,Soumare A,Smith JA,Knopman DS,Morris Z,Zhu Y,Rotter JI,Dufouil C,Valdés Hernández M,Muñoz Maniega S,Lathrop M,Boerwinkle E,Schmidt R,Ihara M,Mazoyer B,Yang Q,Joutel A,Tournier-Lasserve E,Launer LJ,Deary IJ,Mosley TH,Amouyel P,DeCarli CS,Psaty BM,Tzourio C,Kardia SLR,Grabe HJ,Teumer A,van Duijn CM,Schmidt H,Wardlaw JM,Ikram MA,Fornage M,Gudnason V,Seshadri S,Matthews PM,Longstreth WT,Couffinhal T,Debette S
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, In Vitro Assay to present a comprehensive gene-mapping study and preliminary functional evaluation suggesting a putative role of TRIM47 in the pathophysiology of cerebral small vessel disease, making it an important candidate for extensive in vivo explorations and future translational work.
Thu Jun 30 00:00:00 EDT 2022
Development of a three-dimensional blood-brain barrier network with opening capillary structures for drug transport screening assays.
Materials today. Bio
Piantino M,Kang DH,Furihata T,Nakatani N,Kitamura K,Shigemoto-Mogami Y,Sato K,Matsusaki M
35-2500 was used in Immunocytochemistry to develop a 3D self-assembled microvascular network formed by BMEC covered by pericytes and astrocyte end feet.
Wed Jun 01 00:00:00 EDT 2022
Endothelial Unc5B controls blood-brain barrier integrity.
Nature communications
Boyé K,Geraldo LH,Furtado J,Pibouin-Fragner L,Poulet M,Kim D,Nelson B,Xu Y,Jacob L,Maissa N,Agalliu D,Claesson-Welsh L,Ackerman SL,Eichmann A
35-2500 was used in Western Blot to identify Netrin-1-Unc5B signaling as a ligand-receptor pathway that regulates BBB integrity.
Fri Mar 04 00:00:00 EST 2022
Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.
Pharmaceutics
Wahl JR,Vivek A,Palomino SM,Almuslim M,Cottier KE,Langlais PR,Streicher JM,Vanderah TW,Liktor-Busa E,Largent-Milnes TM
35-2500 was used in Immunocytochemistry-immunoflourescence to demonstrate relocalization and functional alteration to proteins associated with the actin cytoskeleton and endothelial tight junctions.
Fri Jul 15 00:00:00 EDT 2022
Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang W,Su L,Wang Y,Li C,Ji F,Jiao J
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to provide mechanistic insights into how endothelial UCP2 regulates the neurogenic-to-gliogenic fate switch in the developing neocortex.
Wed Jun 01 00:00:00 EDT 2022
Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang W,Su L,Wang Y,Li C,Ji F,Jiao J
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to provide mechanistic insights into how endothelial UCP2 regulates the neurogenic-to-gliogenic fate switch in the developing neocortex.
Wed Jun 01 00:00:00 EDT 2022
Autophagic degradation of claudin-5 mediated by its binding to a Clostridium perfringens enterotoxin fragment modulates endothelial barrier permeability.
FEBS letters
Lin P,Tan R,Yu P,Li Y,Mo Y,Li W,Zhang J
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to explore the mechanisms regulating the dynamics of membranous claudin-5 and BBB permeability.
Fri Apr 01 00:00:00 EDT 2022
ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Khan A,Ni W,Baltazar T,Lopez-Giraldez F,Pober JS,Pierce RW
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to conclude that in TJ-forming HDMECs, ArhGEF12 selectively activates Rap1A to limit capillary barrier disruption in a mechanism independent of cAMP-mediated Epac1 activation.
Fri Apr 01 00:00:00 EDT 2022
Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism.
Cells
Jhun H,Lee WY,Park JK,Hwang SG,Park HJ
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to indicate that testicular hyperthermia caused by cryptorchidism affects claudin expression, regulated germ cell death, and the proliferation of Sertoli cells.
Wed Aug 10 00:00:00 EDT 2022
Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2.
Cell reports
Xu L,Nirwane A,Xu T,Kang M,Devasani K,Yao Y
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest that Col1α1+ fibroblasts repair BBB damage in ICH via the paracellular pathway in a TIMP2-dependent manner.
Tue Nov 22 00:00:00 EST 2022
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease.
Journal of neuroinflammation
Qian XH,Liu XL,Chen G,Chen SD,Tang HD
35-2500 was used in Western Blotting to suggest that Aβ in the CNS can induce gut microbiota dysbiosis, alter intestinal structure and accelerate the amyloidogenic pathways, which were related to inhibiting cholinergic anti-inflammatory pathways.
Wed Sep 28 00:00:00 EDT 2022
Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis.
Nutritional neuroscience
Yanckello LM,Hoffman JD,Chang YH,Lin P,Nehra G,Chlipala G,McCulloch SD,Hammond TC,Yackzan AT,Lane AN,Green SJ,Hartz AMS,Lin AL
35-2500 was used in Western Blotting to identify the potential nutrigenetic effects to inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants.
Mon Aug 01 00:00:00 EDT 2022
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Signal transduction and targeted therapy
Zhang L,Zhou L,Bao L,Liu J,Zhu H,Lv Q,Liu R,Chen W,Tong W,Wei Q,Xu Y,Deng W,Gao H,Xue J,Song Z,Yu P,Han Y,Zhang Y,Sun X,Yu X,Qin C
35-2500 was used in Immunohistochemistry to elucidate whether and how SARS-CoV-2 crosses the blood-brain barrier.
Mon Sep 06 00:00:00 EDT 2021
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Cell metabolism
Gruber T,Pan C,Contreras RE,Wiedemann T,Morgan DA,Skowronski AA,Lefort S,De Bernardis Murat C,Le Thuc O,Legutko B,Ruiz-Ojeda FJ,Fuente-Fernández M,García-Villalón AL,González-Hedström D,Huber M,Szigeti-Buck K,Müller TD,Ussar S,Pfluger P,Woods SC,Ertürk A,LeDuc CA,Rahmouni K,Granado M,Horvath TL,Tschöp MH,García-Cáceres C
35-2500 was used in Immunohistochemistry (Frozen) to report that an obesity-associated increase in serum leptin triggers the select expansion of the micro-angioarchitecture in pre-autonomic brain centers that regulate hemodynamic homeostasis.
Tue Jun 01 00:00:00 EDT 2021
Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.
Cardiovascular research
Hollier PL,Chapouly C,Diop A,Guimbal S,Cornuault L,Gadeau AP,Renault MA
35-2500 was used in Immunocytochemistry to demonstrate that ectopically administered N-terminal Sonic Hedgehog (N-Shh) and endogenous endothelial-derived Desert Hedgehog (Dhh) induce opposite effects in endothelial cells (ECs).
Mon Nov 01 00:00:00 EDT 2021
Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.
Cardiovascular research
Yu Z,Zeng J,Wang J,Cui Y,Song X,Zhang Y,Cheng X,Hou N,Teng Y,Lan Y,Chen Y,Yang X
35-2500 was used in Western Blotting to generate brain endothelial cell (EC) specific Hgs knockout mice to uncover the function of Hgs in EC polarity and cerebrovascular stability.
Thu Jan 21 00:00:00 EST 2021
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Molecular therapy. Nucleic acids
Wang C,Dong J,Sun J,Huang S,Wu F,Zhang X,Pang D,Fu Y,Li L
35-2500 was used in Immunohistochemistry to evaluate the impact of long non-coding RNA X-inactive-specific transcript in acute cerebral ischemic stroke patients, middle cerebral artery occlusion mice, and oxygen-glucose deprivation and restoration brain endothelial cells.
Fri Dec 03 00:00:00 EST 2021
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Ogata S,Ito S,Masuda T,Ohtsuki S
35-2500 was used in Western Blot to establish a brain capillary isolation method from a single mouse brain for protein expression analysis.
Sat May 01 00:00:00 EDT 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 EDT 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 EDT 2021
Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components.
Frontiers in aging neuroscience
González-Molina LA,Villar-Vesga J,Henao-Restrepo J,Villegas A,Lopera F,Cardona-Gómez GP,Posada-Duque R
35-2500 was used in Immunocytochemistry to evaluate the effects of adult PS1-KI and 3xTg-AD astrocyte conditioned media (CM) and EVs on NVU components (neuroglia and endothelium) in vitro.
Wed Mar 10 00:00:00 EST 2021
Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study.
Journal of cellular and molecular medicine
Sivandzade F,Alqahtani F,Cucullo L
35-2500 was used in Western Blot to show that chronic TS exposure exacerbates traumatic endothelial injury and abrogates the protective antioxidative cell responses.
Sun Aug 01 00:00:00 EDT 2021
Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood-Brain Barrier after Traumatic Brain Injury.
Journal of neurotrauma
Bennett M,Chin A,Lee HJ,Morales Cestero E,Strazielle N,Ghersi-Egea JF,Threlkeld SW,Schmidt TA,Richendrfer HA,Szmydynger-Chodobska J,Jay GD,Chodobski A
35-2500 was used in Western Blotting to investigate the effect of targeting TLRs with proteoglycan 4 on post-traumatic neuroinflammation and blood-brain barrier function.
Mon Feb 15 00:00:00 EST 2021
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.
Pediatric research
Nguyen V,Chavali M,Larpthaveesarp A,Kodali S,Gonzalez G,Franklin RJM,Rowitch DH,Gonzalez F
35-2500 was used in Immunohistochemistry to show that sonic hedgehog agonist is one of the most promising therapies in treating neonatal stroke thanks to its safety profile and low dosage.
Wed Dec 01 00:00:00 EST 2021
Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain.
eLife
Parab S,Quick RE,Matsuoka RL
35-2500 was used in Immunohistochemistry to show that specific combinations of vascular endothelial growth factors are required to selectively drive fenestrated vessel formation in the zebrafish myelencephalic choroid plexus.
Mon Jan 18 00:00:00 EST 2021
Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation.
American journal of physiology. Cell physiology
Herrera M,Molina P,Souza-Smith FM
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to hypothesize that ethanol induces lymphatic endothelial cell (LEC) permeability via disruption of LEC TJ through MAPK activation.
Thu Jul 01 00:00:00 EDT 2021
Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death.
Antioxidants (Basel, Switzerland)
Shin HJ,Jeong EA,Lee JY,An HS,Jang HM,Ahn YJ,Lee J,Kim KE,Roh GS
35-2500 was used in Western Blotting to examine the effect of blocking LCN2 genetically on neuroinflammation and oxidative stress in KA-induced neuronal death.
Tue Jan 12 00:00:00 EST 2021
Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome.
PloS one
Ivashkin V,Poluektov Y,Kogan E,Shifrin O,Sheptulin A,Kovaleva A,Kurbatova A,Krasnov G,Poluektova E
35-2500 was used in Immunohistochemistry to assess the changes of gut microbiome composition, tight junction proteins, and cytokines expression of intestinal mucosa from the duodenum to the distal part of the colon in irritable bowel syndrome patients and healthy volunteers.
Tue Nov 16 00:00:00 EST 2021
Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier.
ACS nano
Bony BA,Tarudji AW,Miller HA,Gowrikumar S,Roy S,Curtis ET,Gee CC,Vecchio A,Dhawan P,Kievit FM
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to report on the development of a nanoparticle (C1C2-NP) that targets regions of increased claudin-1 expression that reduces BBB integrity.
Tue Nov 23 00:00:00 EST 2021
QiShenYiQi Inhibits Tissue Plasminogen Activator-Induced Brain Edema and Hemorrhage after Ischemic Stroke in Mice.
Frontiers in pharmacology
Ye Y,Li Q,Pan CS,Yan L,Sun K,Wang XY,Yao SQ,Fan JY,Han JY
35-2500 was used in Western Blotting to support QiShenYiQi as an effective adjunctive therapy to increase the safety of delayed tPA thrombolysis for ischemic stroke.
Tue Feb 01 00:00:00 EST 2022
Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.
STAR protocols
Nishihara H,Gastfriend BD,Kasap P,Palecek SP,Shusta EV,Engelhardt B
35-2500 was used in Immunocytochemistry to demonstrate a method for differentiating human pluripotent stem cells into brain microvascular endothelial cell-like cells.
Fri Jun 18 00:00:00 EDT 2021
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Cell reports
Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G
35-2500 was used in Immunohistochemistry to investigate in vivo the role of Tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase (MAP3K) member with pleiotropic effects in inflammation and cancer.
Tue May 25 00:00:00 EDT 2021
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
Theranostics
Dong X,Lei Y,Yu Z,Wang T,Liu Y,Han G,Zhang X,Li Y,Song Y,Xu H,Du M,Yin H,Wang X,Yan H
35-2500 was used in Immunohistochemistry to show that KV11 itself has an anti-angiogenic effect through retro-orbital injection, but that this effect was greatly enhanced when delivered with EXOs.
Wed Jul 28 00:00:00 EDT 2021
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife
Sasson E,Anzi S,Bell B,Yakovian O,Zorsky M,Deutsch U,Engelhardt B,Sherman E,Vatine G,Dzikowski R,Ben-Zvi A
35-2500 was used in Immunohistochemistry to provide a unique perspective of BBB TJs and open new directions for understanding TJ functionality in biological barriers, ultimately enabling restoration in disease or modulation for drug delivery.
Fri Dec 24 00:00:00 EST 2021
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
Nature communications
Pediaditakis I,Kodella KR,Manatakis DV,Le CY,Hinojosa CD,Tien-Street W,Manolakos ES,Vekrellis K,Hamilton GA,Ewart L,Rubin LL,Karalis K
35-2500 was used in Immunohistochemistry to enable research into the dynamics of cell-cell interactions in human synucleinopathies and serve as a testing platform for target identification and validation of novel therapeutics.
Fri Oct 08 00:00:00 EDT 2021
Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.
Molecular neurobiology
Ismael S,Nasoohi S,Yoo A,Mirzahosseini G,Ahmed HA,Ishrat T
35-2500 was used in Western Blotting to investigate whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption.
Sun Aug 01 00:00:00 EDT 2021
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
International journal of molecular sciences
Kozma M,Mészáros Á,Nyúl-Tóth Á,Molnár K,Costea L,Hernádi Z,Fazakas C,Farkas AE,Wilhelm I,Krizbai IA
35-2500 was used in Western Blotting to demonstrate that the noncanonical inflammasome pathway can be induced in cerebral endothelial cells as well, leading to a further increase in the secretion of active interleukin-1β over that observed in response to activation of the canonical pathway.
Sun Jun 06 00:00:00 EDT 2021
Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy.
Pharmaceuticals (Basel, Switzerland)
Salman M,Ismael S,Li L,Ahmed HA,Puchowicz MA,Ishrat T
35-2500 was used in Western Blot to test the hypothesis that endothelial-specific thioredoxin-interacting protein knock-out mice will be more resistant to the neurovascular damage associated with hyperglycemia in embolic stroke.
Mon Sep 27 00:00:00 EDT 2021
Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.
eLife
Gastfriend BD,Nishihara H,Canfield SG,Foreman KL,Engelhardt B,Palecek SP,Shusta EV
35-2500 was used in Western Blot, Immunocytochemistry to define effects of Wnt activation in naïve ECs and establish an improved hPSC-based model for interrogation of CNS barriergenesis.
Wed Nov 10 00:00:00 EST 2021
Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.
eLife
Gastfriend BD,Nishihara H,Canfield SG,Foreman KL,Engelhardt B,Palecek SP,Shusta EV
35-2500 was used in Western Blot, Immunocytochemistry to define effects of Wnt activation in naïve ECs and establish an improved hPSC-based model for interrogation of CNS barriergenesis.
Wed Nov 10 00:00:00 EST 2021
Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.
Frontiers in cellular neuroscience
Heyburn L,Abutarboush R,Goodrich S,Urioste R,Batuure A,Wheel J,Wilder DM,Arun P,Ahlers ST,Long JB,Sajja VS
35-2500 was used in Western Blotting to show that cumulative effects of repeated low-level BOP may increase the vulnerability to injury of the brain by disrupting neurovascular architecture, which may lead to downstream deleterious effects on behavior and cognition.
Wed Mar 10 00:00:00 EST 2021
Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages.
Journal of inflammation research
Wang R,Song W,Xie C,Zhong W,Xu H,Zhou Q,Deng Y,Hong Y,Li X,Fang M
35-2500 was used in Western Blot to detect zonula occludens-1 (ZO-1), occludin and claudin-5 expression in PMVECs, as well as TNF-α, TGF-β, iNOS, CD86 and CD206 expression in lungs.
Sat Apr 23 00:00:00 EDT 2022
Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages.
Journal of inflammation research
Wang R,Song W,Xie C,Zhong W,Xu H,Zhou Q,Deng Y,Hong Y,Li X,Fang M
35-2500 was used in Western Blot to detect zonula occludens-1 (ZO-1), occludin and claudin-5 expression in PMVECs, as well as TNF-α, TGF-β, iNOS, CD86 and CD206 expression in lungs.
Sat Apr 23 00:00:00 EDT 2022
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
Neuron
Chavali M,Ulloa-Navas MJ,Pérez-Borredá P,Garcia-Verdugo JM,McQuillen PS,Huang EJ,Rowitch DH
35-2500 was used in Immunohistochemistry to report that oligodendrocyte precursor cells (OPCs) contact sprouting endothelial tip cells in mouse, ferret, and human neonatal white matter.
Wed Dec 23 00:00:00 EST 2020
Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Liu CC,Yamazaki Y,Heckman MG,Martens YA,Jia L,Yamazaki A,Diehl NN,Zhao J,Zhao N,DeTure M,Davis MD,Felton LM,Qiao W,Li Y,Li H,Fu Y,Wang N,Wren M,Aikawa T,Holm ML,Oue H,Linares C,Allen M,Carrasquillo MM,Murray ME,Petersen RC,Ertekin-Taner N,Dickson DW,Kanekiyo T,Bu G
35-2500 was used in ELISA to assess how the amounts of two major tight junction proteins, CLDN5 and OCLN, are correlated with cerebral amyloid angiopathy severity and the levels of several Alzheimer's disease related molecules.
Thu Oct 01 00:00:00 EDT 2020
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Acta neuropathologica
Devraj G,Guérit S,Seele J,Spitzer D,Macas J,Khel MI,Heidemann R,Braczynski AK,Ballhorn W,Günther S,Ogunshola OO,Mittelbronn M,Ködel U,Monoranu CM,Plate KH,Hammerschmidt S,Nau R,Devraj K,Kempf VAJ
35-2500 was used in Immunohistochemistry to demonstrate paracellular migration of bacteria across BBB and a critical role for HIF-1α/VEGF therein and hence propose targeting this pathway to prevent BBB dysfunction and ensuing brain damage in infections.
Sat Aug 01 00:00:00 EDT 2020
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Acta neuropathologica
Devraj G,Guérit S,Seele J,Spitzer D,Macas J,Khel MI,Heidemann R,Braczynski AK,Ballhorn W,Günther S,Ogunshola OO,Mittelbronn M,Ködel U,Monoranu CM,Plate KH,Hammerschmidt S,Nau R,Devraj K,Kempf VAJ
35-2500 was used in Immunohistochemistry to demonstrate paracellular migration of bacteria across BBB and a critical role for HIF-1α/VEGF therein and hence propose targeting this pathway to prevent BBB dysfunction and ensuing brain damage in infections.
Sat Aug 01 00:00:00 EDT 2020
TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin 1 complex and regulating downstream FAK/RhoA signaling.
Acta pharmaceutica Sinica. B
Tang J,Kang Y,Huang L,Wu L,Peng Y
35-2500 was used in Western Blotting to explore the neuroprotective role of TIMP1 in mice with experimental brain injury.
Mon Jun 01 00:00:00 EDT 2020
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Proceedings of the National Academy of Sciences of the United States of America
Vázquez-Rosa E,Shin MK,Dhar M,Chaubey K,Cintrón-Pérez CJ,Tang X,Liao X,Miller E,Koh Y,Barker S,Franke K,Crosby DR,Schroeder R,Emery J,Yin TC,Fujioka H,Reynolds JD,Harper MM,Jain MK,Pieper AA
35-2500 was used in Western Blotting to report that pharmacologic restoration of the blood-brain barrier (BBB), 12 mo after murine TBI, is associated with arrested axonal neurodegeneration and cognitive recovery, benefits that persisted for months after treatment cessation.
Tue Nov 03 00:00:00 EST 2020
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke.
Science signaling
Ma F,Sun P,Zhang X,Hamblin MH,Yin KJ
35-2500 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of miR-15a/16-1 cluster deletion in blood brain barrier dysregulation following ischaemic stroke.
Tue Apr 07 00:00:00 EDT 2020
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke.
Science signaling
Ma F,Sun P,Zhang X,Hamblin MH,Yin KJ
35-2500 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of miR-15a/16-1 cluster deletion in blood brain barrier dysregulation following ischaemic stroke.
Tue Apr 07 00:00:00 EDT 2020
Downregulation of circulating miR 802-5p and miR 194-5p and upregulation of brain MEF2C along breast cancer brain metastasization.
Molecular oncology
Sereno M,Haskó J,Molnár K,Medina SJ,Reisz Z,Malhó R,Videira M,Tiszlavicz L,Booth SA,Wilhelm I,Krizbai IA,Brito MA
35-2500 was used in Immunohistochemistry to establish the alterations in circulating miRNAs during brain metastasis formation and development.
Sun Mar 01 00:00:00 EST 2020
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.
Journal of cellular physiology
Semina EV,Rubina KA,Shmakova AA,Rysenkova KD,Klimovich PS,Aleksanrushkina NA,Sysoeva VY,Karagyaur MN,Tkachuk VA
35-2500 was used in Western Blotting to show that urokinase-type plasminogen activator receptor (uPAR) expression is essential for maintaining the epithelial phenotype in Neuro2a cells and that uPAR silencing promotes epithelial-mesenchymal transition (EMT) and increased cell migration.
Tue Sep 01 00:00:00 EDT 2020
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Molecular therapy oncolytics
Shen S,Yang C,Liu X,Zheng J,Liu Y,Liu L,Ma J,Ma T,An P,Lin Y,Cai H,Wang D,Li Z,Zhao L,Xue Y
35-2500 was used in Western Blotting to demonstrate that overexpression of RNA-binding Fox-1 homolog 1 (RBFOX1) increases blood-tumour barrier permeability through the LINC00673/MAFF pathway, potentially providing a future target to enhance blood-tumour barrier permeability.
Fri Jun 26 00:00:00 EDT 2020
Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.
Frontiers in bioengineering and biotechnology
Salman MM,Marsh G,Kusters I,Delincé M,Di Caprio G,Upadhyayula S,de Nola G,Hunt R,Ohashi KG,Gray T,Shimizu F,Sano Y,Kanda T,Obermeier B,Kirchhausen T
35-2500 was used in Immunocytochemistry-immunoflourescence to validate barrier function of our brain microvessel-on-a-chip by measuring permeability of fluorescent dextran and a human monoclonal antibody.
Fri Oct 30 00:00:00 EDT 2020
Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro.
Frontiers in cardiovascular medicine
Ittner C,Burek M,Störk S,Nagai M,Förster CY
35-2500 was used in Western Blotting to demonstrate that the proteins forming the blood brain barrier (BBB) and the cell count are clearly influenced by catecholamine (CAT) and INF applied under oxygen glucose deprivation (OGD) conditions.
Mon Sep 28 00:00:00 EDT 2020
Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis.
The American journal of pathology
D'Agnillo F,Zhang X,Williams MC
35-2500 was used in Immunohistochemistry to provide evidence that lethal toxin plays a determinative role in bacterial dissemination and alveolar-capillary barrier dysfunction, and edema toxin may significantly exacerbate pulmonary pathologies in a systemic infection.
Thu Oct 01 00:00:00 EDT 2020
Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer's Disease Leads to Neuroglial and Endothelial Cell Degeneration.
Frontiers in aging neuroscience
Villar-Vesga J,Henao-Restrepo J,Voshart DC,Aguillon D,Villegas A,Castaño D,Arias-Londoño JD,Zuhorn IS,Ribovski L,Barazzuol L,Cardona-Gómez GP,Posada-Duque R
35-2500 was used in Immunohistochemistry-immunofluorescence to indicate that the phenotype of systemic AD-EVs is differentially defined by the etiopathology of the disease (SAD or FAD), which results in a differential alteration of the NVU cells implied in neurodegeneration.
Tue Dec 08 00:00:00 EST 2020
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Journal of neurochemistry
Wu J,He J,Tian X,Luo Y,Zhong J,Zhang H,Li H,Cen B,Jiang T,Sun X
35-2500 was used in Western Blot, Immunocytochemistry to investigate the effects of miRNA-9-5p on brain function in traumatic brain injury using rat models.
Mon Jun 01 00:00:00 EDT 2020
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Journal of neurochemistry
Wu J,He J,Tian X,Luo Y,Zhong J,Zhang H,Li H,Cen B,Jiang T,Sun X
35-2500 was used in Western Blot, Immunocytochemistry to investigate the effects of miRNA-9-5p on brain function in traumatic brain injury using rat models.
Mon Jun 01 00:00:00 EDT 2020
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Inflammation
Huang Y,Wang C,Tian X,Mao Y,Hou B,Sun Y,Gu X,Ma Z
35-2500 was used in Western Blotting to investigate biological roles of pioglitazone in relieving colitis-associated pain hypersensitivity by a PPARγ tight junction protein-dependent mechanism during the course of dextran sodium sulfate (DSS)-induced intestinal inflammation.
Wed Apr 01 00:00:00 EDT 2020
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Experimental and therapeutic medicine
Zhang H,Liu J,Liu Y,Su C,Fan G,Lu W,Feng L
35-2500 was used in Western Blotting to investigate the therapeutic mechanism of hypertonic saline (HS) in brain edema in terms of aquaporins and inflammatory factors.
Sun Nov 01 00:00:00 EDT 2020
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
PloS one
Cobo-Calvo A,Ruiz A,Richard C,Blondel S,Cavagna S,Strazielle N,Ghersi-Egea JF,Giraudon P,Marignier R
35-2500 was used in Immunohistochemistry-immunofluorescence to evaluate the effect of human immunoglobulins from neuromyelitis optica spectrum disorders (NMOSD) patients (NMO-IgG) on blood-brain barrier (BBB) properties.
Thu Oct 22 00:00:00 EDT 2020
Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction.
Frontiers in physiology
Brunner N,Stein L,Cornelius V,Knittel R,Fallier-Becker P,Amasheh S
35-2500 was used in Western Blotting to test a new screening approach for barrier effectors, exemplarily, this 2-cell model of oocytes was used to analyze the effect of the absorption enhancer sodium caprate on the oocyte pairs.
Mon Sep 28 00:00:00 EDT 2020
A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.
Frontiers in cellular neuroscience
Jinnai M,Koning G,Singh-Mallah G,Jonsdotter A,Leverin AL,Svedin P,Nair S,Takeda S,Wang X,Mallard C,Ek CJ,Rocha-Ferreira E,Hagberg H
35-2500 was used in Immunohistochemistry (Paraffin) to develop and characterize a grade III and IV GMH model in postnatal day 5 (P5) rats, the equivalent of preterm human brain maturation.
Tue Dec 22 00:00:00 EST 2020
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury.
Glia
Lefevere E,Salinas-Navarro M,Andries L,Noterdaeme L,Etienne I,Van Wonterghem E,Vinckier S,Davis BM,Van Bergen T,Van Hove I,Movahedi K,Vandenbroucke RE,Moons L,De Groef L
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to investigate the structure and function of the glia limitans, and reveal that the blood-retina barrier and glia limitans function as a coordinated double barrier to limit infiltration of leukocytes and immune molecules.
Tue Dec 01 00:00:00 EST 2020
Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.
Cell reports
Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM
35-2500 was used in Immunohistochemistry to demonstrate brain-region-specific differences in myeloid responses induced by chronic peripheral inflammation.
Tue Mar 24 00:00:00 EDT 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
35-2500 was used in Immunocytochemistry to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 EST 2020
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Fluids and barriers of the CNS
Aoki H,Yamashita M,Hashita T,Iwao T,Matsunaga T
35-2500 was used in Immunocytochemistry-immunoflourescence to show that the LN221F-iBMELCs had more robust barrier function for a longer period than Matrigel-iBMELCs with characteristics of BMECs.
Mon Mar 30 00:00:00 EDT 2020
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Fluids and barriers of the CNS
Aoki H,Yamashita M,Hashita T,Iwao T,Matsunaga T
35-2500 was used in Immunocytochemistry-immunoflourescence to show that the LN221F-iBMELCs had more robust barrier function for a longer period than Matrigel-iBMELCs with characteristics of BMECs.
Mon Mar 30 00:00:00 EDT 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
35-2500 was used in Immunohistochemistry and Western Blotting to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 EDT 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
35-2500 was used in Immunohistochemistry and Western Blotting to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 EDT 2020
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Cells
Ristori E,Cicaloni V,Salvini L,Tinti L,Tinti C,Simons M,Corti F,Donnini S,Ziche M
35-2500 was used in Immunocytochemistry to identify and investigate major cellular targets of APP down-regulation in endothelial cells.
Thu Nov 19 00:00:00 EST 2020
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Frontiers in neuroscience
Zhang S,Gong P,Zhang J,Mao X,Zhao Y,Wang H,Gan L,Lin X
35-2500 was used in Western Blot, Immunohistochemistry to propose that specific frequency EA can transiently open the BBB and may be related to the change of tight junctions (TJ).
Sat Oct 31 00:00:00 EDT 2020
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Frontiers in neuroscience
Zhang S,Gong P,Zhang J,Mao X,Zhao Y,Wang H,Gan L,Lin X
35-2500 was used in Western Blot, Immunohistochemistry to propose that specific frequency EA can transiently open the BBB and may be related to the change of tight junctions (TJ).
Sat Oct 31 00:00:00 EDT 2020
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Scientific reports
Lu J,Lu L,Yu Y,Baranowski J,Claud EC
35-2500 was used in Immunohistochemistry to demonstrate the efficacy of maternal LB supplementation in modulating systemic and central nervous system inflammation as well as promoting neural/oligodendrocyte progenitor development in the offspring.
Mon May 18 00:00:00 EDT 2020
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Fluids and barriers of the CNS
Curtaz CJ,Schmitt C,Herbert SL,Feldheim J,Schlegel N,Gosselet F,Hagemann C,Roewer N,Meybohm P,Wöckel A,Burek M
35-2500 was used in Western Blotting to demonstrate that the CD34+ cell-derived human in vitro blood-brain barrier model can be used as a tool to study the molecular mechanisms underlying cerebrovascular pathologies.
Wed Apr 22 00:00:00 EDT 2020
Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
International journal of molecular sciences
Chen CM,Wu ML,Ho YC,Gung PY,Tsai MH,Orekhov AN,Sobenin IA,Lin P,Yet SF
35-2500 was used in Immunohistochemistry to investigate the effects of zinc oxide nanoparticle exposure on vascular functions, particularly on endothelial barriers, using in vitro and in vivo models.
Wed May 13 00:00:00 EDT 2020
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Journal of neuroinflammation
Zhang X,Wang L,Han Z,Dong J,Pang D,Fu Y,Li L
35-2500 was used in Immunohistochemistry-immunofluorescence to examine the correlation between serum levels of CAMs/KLF4 and infarct volume in acute CIS patients.
Tue Apr 07 00:00:00 EDT 2020
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Pharmaceutics
Chaves C,Do TM,Cegarra C,Roudières V,Tolou S,Thill G,Rocher C,Didier M,Lesuisse D
35-2500 was used in Immunocytochemistry to compare the blood-brain barrier features of NHP transciptome of isolated brain microcapillaries and in vitro-selected brain endothelial cells.
Wed Oct 14 00:00:00 EDT 2020
Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier.
Science advances
Wang Z,Zheng Y,Wang F,Zhong J,Zhao T,Xie Q,Zhu T,Ma F,Tang Q,Zhou B,Zhu J
35-2500 was used in Immunocytochemistry-Immunofluorescence to help unravel the mechanism by which S1P regulates BBB and also provide previously unidentified insights into the delivery of neurological drugs in the CNS.
Fri May 01 00:00:00 EDT 2020
Alanyl-Glutamine Restores Tight Junction Organization after Disruption by a Conventional Peritoneal Dialysis Fluid.
Biomolecules
Bartosova M,Herzog R,Ridinger D,Levai E,Jenei H,Zhang C,González Mateo GT,Marinovic I,Hackert T,Bestvater F,Hausmann M,López Cabrera M,Kratochwill K,Zarogiannis SG,Schmitt CP
35-2500 was used in Western Blot to show that arteriolar endothelial claudin-5 was reduced in CPDF, but restored with AlaGln, while mesothelial claudin-5 abundance was unchanged.
Thu Aug 13 00:00:00 EDT 2020
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components.
Arteriosclerosis, thrombosis, and vascular biology
Yamazaki Y,Shinohara M,Yamazaki A,Ren Y,Asmann YW,Kanekiyo T,Bu G
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that brain pericytes, the mural cells of the capillary walls, differentially modulate endothelial cell phenotype in an apoE isoform-dependent manner.
Wed Jan 01 00:00:00 EST 2020
MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes.
Scientific reports
Hu H,Hone EA,Provencher EAP,Sprowls SA,Farooqi I,Corbin DR,Sarkar SN,Hollander JM,Lockman PR,Simpkins JW,Ren X
35-2500 was used in Immunohistochemistry to provide the first description of miR-34a affecting stroke outcomes and may lead to discovery of new mechanisms and treatments for cerebrovascular and neurodegenerative diseases such as stroke.
Mon Feb 24 00:00:00 EST 2020
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
Scientific reports
Rom S,Heldt NA,Gajghate S,Seliga A,Reichenbach NL,Persidsky Y
35-2500 was used in Immunocytochemistry to demonstrate that exposure of brain microvessels to hyperglycemic conditions or advanced glycation end products (AGEs) ex vivo results in significant abnormalities in membranous distribution of TJ proteins.
Wed Apr 29 00:00:00 EDT 2020
Site-specific opening of the blood-brain barrier by extracellular histones.
Journal of neuroinflammation
Villalba N,Baby S,Cha BJ,Yuan SY
35-2500 was used in Immunocytochemistry-immunoflourescence to suggest that circulating histones may contribute to cerebrovascular injury or brain dysfunction by altering BBB structure and function.
Tue Sep 22 00:00:00 EDT 2020
Site-specific opening of the blood-brain barrier by extracellular histones.
Journal of neuroinflammation
Villalba N,Baby S,Cha BJ,Yuan SY
35-2500 was used in Immunocytochemistry-immunoflourescence to suggest that circulating histones may contribute to cerebrovascular injury or brain dysfunction by altering BBB structure and function.
Tue Sep 22 00:00:00 EDT 2020
The Contractile Apparatus Is Essential for the Integrity of the Blood-Brain Barrier After Experimental Subarachnoid Hemorrhage.
Translational stroke research
Luh C,Feiler S,Frauenknecht K,Meyer S,Lubomirov LT,Neulen A,Thal SC
35-2500 was used in Western Blotting to identify that myosin light chain kinases contribute to blood-brain barrier dysfunction after subarachnoid hemorrhage through activation of the contractile apparatus of the endothelial cell skeleton.
Tue Oct 01 00:00:00 EDT 2019
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
Chinese medical journal
Ye ZY,Xing HY,Wang B,Liu M,Lv PY
35-2500 was used in Immunohistochemistry to investigate the potential effect of DL-3-n-butylphthalide on the tight junction proteins claudin-5, zonula occludens-1, and occludin during brain ischemia.
Wed Jun 05 00:00:00 EDT 2019
Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4.
Molecular neurobiology
Abdul Y,Abdelsaid M,Li W,Webb RC,Sullivan JC,Dong G,Ergul A
35-2500 was used in Western Blotting to explore whether inhibition of TLR-4 signaling prevents endothelial cell death and improves outcomes after stroke.
Fri Mar 01 00:00:00 EST 2019
In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves.
Journal of the peripheral nervous system : JPNS
Ouyang X,Dong C,Ubogu EE
35-2500 was used in Immunocytochemistry-immunoflourescence to investigate proteins specifically expressed by restrictive endoneurial microvascular endothelium in four adult sural nerves.
Sat Jun 01 00:00:00 EDT 2019
Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.
Genetics
Korecki AJ,Hickmott JW,Lam SL,Dreolini L,Mathelier A,Baker O,Kuehne C,Bonaguro RJ,Smith J,Tan CV,Zhou M,Goldowitz D,Deussing JM,Stewart AF,Wasserman WW,Holt RA,Simpson EM
35-2500 was used in Immunohistochemistry-immunofluorescence to investigate the suitability of using knock-ins at the docking site 5' of Hprt for rapid development of numerous cre-driver strains focused on expression in adulthood.
Mon Apr 01 00:00:00 EDT 2019
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.
Cell and tissue research
Domke LM,Franke WW
35-2500 was used in Immunocytochemistry-immunoflourescence to show the LSMCs of the peritubular wall monolayers are SMCs sensu stricto which are laterally connected by a novel architectonic system of arrays of vertical AJs located in overlapping cell protrusions.
Fri Feb 01 00:00:00 EST 2019
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Cell stem cell
Vatine GD,Barrile R,Workman MJ,Sances S,Barriga BK,Rahnama M,Barthakur S,Kasendra M,Lucchesi C,Kerns J,Wen N,Spivia WR,Chen Z,Van Eyk J,Svendsen CN
35-2500 was used in Immunocytochemistry-immunoflourescence to create a neurovascular unit that recapitulates complex BBB functions.
Thu Jun 06 00:00:00 EDT 2019
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Frontiers in physiology
Yang Z,Huang C,Wu Y,Chen B,Zhang W,Zhang J
35-2500 was used in Immunohistochemistry to study the essential role of autophagy in maintaining the integrity of endothelial barrier by regulating the localisation of Claudin-5 under starvation.
Thu Oct 01 00:00:00 EDT 2020
Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke.
Frontiers in neuroscience
Durán-Laforet V,Fernández-López D,García-Culebras A,González-Hijón J,Moraga A,Palma-Tortosa S,García-Yébenes I,Vega-Pérez A,Lizasoain I,Moro MÁ
35-2500 was used in Western Blotting to describe the impact of early, non-thrombolytic reperfusion on the vascular brain component and its potential contribution to tissue remodelling and long-term functional recovery beyond the acute phase after stroke in 3-month-old male C57bl/6 mice.
Thu Oct 01 00:00:00 EDT 2020
Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
BioResearch open access
Ohshima M,Kamei S,Fushimi H,Mima S,Yamada T,Yamamoto T
35-2500 was used in Immunocytochemistry-immunoflourescence to conclude that iPSC-BBB models make it possible to predict BBB permeability, and employing coculturing can improve iPSC-BBB function.
Thu Oct 01 00:00:00 EDT 2020
Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.
Acta neuropathologica communications
Nirwane A,Johnson J,Nguyen B,Miner JH,Yao Y
35-2500 was used in Immunocytochemistry-immunoflourescence to investigate whether mural cell-derived laminin-α5 is involved in vascular integrity regulation.
Mon Feb 18 00:00:00 EST 2019
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Cell stem cell
Wang J,Cui Y,Yu Z,Wang W,Cheng X,Ji W,Guo S,Zhou Q,Wu N,Chen Y,Chen Y,Song X,Jiang H,Wang Y,Lan Y,Zhou B,Mao L,Li J,Yang H,Guo W,Yang X
35-2500 was used in Western Blotting to delineate how the brain endothelium maintains lactate homeostasis and contributes to adult hippocampal neurogenesis and cognitive functions.
Thu Dec 05 00:00:00 EST 2019
Response of the neurovascular unit to brain metastatic breast cancer cells.
Acta neuropathologica communications
Haskó J,Fazakas C,Molnár K,Mészáros Á,Patai R,Szabó G,Erdélyi F,Nyúl-Tóth Á,Győri F,Kozma M,Farkas AE,Krizbai IA,Wilhelm I
35-2500 was used in Immunohistochemistry to explore new mechanisms related to the neurovascular unit during extravasation and proliferation of triple negative breast cancer cells in the brain.
Mon Aug 19 00:00:00 EDT 2019
The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.
Fluids and barriers of the CNS
Katt ME,Mayo LN,Ellis SE,Mahairaki V,Rothstein JD,Cheng L,Searson PC
35-2500 was used in Western Blotting to suggest that the accumulation of defects in brain microvascular endothelial cells may ultimately lead to impairment of the BBB and that accumulated defects that result in positive feedback may lead to unrelated central nervous system diseases.
Mon Jul 15 00:00:00 EDT 2019
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Nature communications
Haruwaka K,Ikegami A,Tachibana Y,Ohno N,Konishi H,Hashimoto A,Matsumoto M,Kato D,Ono R,Kiyama H,Moorhouse AJ,Nabekura J,Wake H
35-2500 was used in Flow Cytometry to show microglia play a dual role in maintaining BBB integrity with implications for elucidating how systemic immune-activation impacts neural functions.
Fri Dec 20 00:00:00 EST 2019
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Nature communications
Haruwaka K,Ikegami A,Tachibana Y,Ohno N,Konishi H,Hashimoto A,Matsumoto M,Kato D,Ono R,Kiyama H,Moorhouse AJ,Nabekura J,Wake H
35-2500 was used in Flow Cytometry to show microglia play a dual role in maintaining BBB integrity with implications for elucidating how systemic immune-activation impacts neural functions.
Fri Dec 20 00:00:00 EST 2019
Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability.
PloS one
Rivera J,Isidro RA,Loucil-Alicea RY,Cruz ML,Appleyard CB,Isidro AA,Chompre G,Colon-Rivera K,Noel RJ
35-2500 was used in Immunohistochemistry-immunofluorescence to suggest that Nef contributes to the chronic inflammation seen in HIV patients, even in those whose viremia is controlled by cART.
Wed Mar 25 00:00:00 EDT 2020
The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats.
PloS one
Nierwińska K,Nowacka-Chmielewska M,Bernacki J,Jagsz S,Chalimoniuk M,Langfort J,Małecki A
35-2500 was used in Western Blotting to study the effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats.
Mon Nov 04 00:00:00 EST 2019
Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats.
International journal of molecular sciences
Schuhmann MK,Stoll G,Papp L,Bohr A,Volkmann J,Fluri F
35-2500 was used in Immunohistochemistry to conclude that, in a rat model, high frequency stimulation of the mesencephalic locomotor region not alleviate blood-brain barrier after dysfunction after ischemic stroke.
Mon Aug 19 00:00:00 EDT 2019
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.
Brain, behavior, and immunity
Cheng Y,Desse S,Martinez A,Worthen RJ,Jope RS,Beurel E
35-2500 was used in Western Blotting to study factors that regulate recovery from major depressive disorder.
Thu Mar 01 00:00:00 EST 2018
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Neuron
Park MH,Lee JY,Park KH,Jung IK,Kim KT,Lee YS,Ryu HH,Jeong Y,Kang M,Schwaninger M,Gulbins E,Reichel M,Kornhuber J,Yamaguchi T,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
35-2500 was used in Western Blot, Immunohistochemistry to reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging.
Wed Oct 10 00:00:00 EDT 2018
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Neuron
Park MH,Lee JY,Park KH,Jung IK,Kim KT,Lee YS,Ryu HH,Jeong Y,Kang M,Schwaninger M,Gulbins E,Reichel M,Kornhuber J,Yamaguchi T,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
35-2500 was used in Western Blot, Immunohistochemistry to reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging.
Wed Oct 10 00:00:00 EDT 2018
Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rempe RG,Hartz AMS,Soldner ELB,Sokola BS,Alluri SR,Abner EL,Kryscio RJ,Pekcec A,Schlichtiger J,Bauer B
35-2500 was used in Western Blotting to determine the role of glutamate release in matrix metalloproteinase mediated blood brain barrier dysfunction in epilepsy.
Wed May 02 00:00:00 EDT 2018
Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.
Journal of inflammation (London, England)
Lin R,Chen F,Wen S,Teng T,Pan Y,Huang H
35-2500 was used in Western Blotting to study the mechanisms by which IL-10 protects the blood-brain barrier in severe acute pancreatitis.
Wed Mar 16 00:00:00 EDT 2022
Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Biotechnology journal
Stebbins MJ,Lippmann ES,Faubion MG,Daneman R,Palecek SP,Shusta EV
35-2500 was used in Flow cytometry/Cell sorting to elucidate the roles of RA signaling in iPSC-derived BMEC differentiation, and identifies directed agonist approaches that can improve BMEC fidelity for drug screening studies while also distinguishing potential nuclear receptor targets to explore in BBB dysfunction and therapy.
Thu Feb 01 00:00:00 EST 2018
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
American journal of physiology. Heart and circulatory physiology
Van Skike CE,Jahrling JB,Olson AB,Sayre NL,Hussong SA,Ungvari Z,Lechleiter JD,Galvan V
35-2500 was used in Western Blotting to study the role of mammalian/mechanistic target of rapamycin as a critical mediator of blood-brain barrier breakdown in models of Alzheimer's disease and vascular cognitive impairment.
Sun Apr 01 00:00:00 EDT 2018
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.
Journal of neurotrauma
Zhao J,Hylin MJ,Kobori N,Hood KN,Moore AN,Dash PK
35-2500 was used in Immunohistochemistry to investigate whether acute administration of galantamine can reduce traumatic brain injury pathology and improve cognitive function tested days after the termination of the drug treatment.
Mon Jan 15 00:00:00 EST 2018
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.
Journal of neurotrauma
Zhao J,Hylin MJ,Kobori N,Hood KN,Moore AN,Dash PK
35-2500 was used in Immunohistochemistry to investigate whether acute administration of galantamine can reduce traumatic brain injury pathology and improve cognitive function tested days after the termination of the drug treatment.
Mon Jan 15 00:00:00 EST 2018
Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Pierce RW,Zahr RA,Kandil S,Faustino EVS,Pober JS
35-2500 was used in Immunocytochemistry-immunoflourescence to analyze the effects of 10% patient sera on the "function, structure, and gene expression" of cultured human dermal and pulmonary microvascular endothelial cells.
Sun Jul 01 00:00:00 EDT 2018
Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Neuroscience
Boussadia B,Lakhal L,Payrastre L,Ghosh C,Pascussi JM,Gangarossa G,Marchi N
35-2500 was used in Western Blotting to link modulation of nuclear receptors in the physiology and pathophysiology of the brain and central nervous system.
Thu Feb 01 00:00:00 EST 2018
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Journal of the American Heart Association
Pena-Philippides JC,Gardiner AS,Caballero-Garrido E,Pan R,Zhu Y,Roitbak T
35-2500 was used in Western Blotting and ICC/IF to investigate the influence of microRNA-155 on the barrier characteristics of human primary brain microvascular endothelial cells.
Tue Jun 26 00:00:00 EDT 2018
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Journal of the American Heart Association
Pena-Philippides JC,Gardiner AS,Caballero-Garrido E,Pan R,Zhu Y,Roitbak T
35-2500 was used in Western Blotting and ICC/IF to investigate the influence of microRNA-155 on the barrier characteristics of human primary brain microvascular endothelial cells.
Tue Jun 26 00:00:00 EDT 2018
Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2.
Journal of neuroinflammation
Zhou Q,Wang YW,Ni PF,Chen YN,Dong HQ,Qian YN
35-2500 was used in Western Blotting to investigate the effects of tryptase on mouse brain microvascular endothelial cell line bEnd3 and its potential mechanisms of action.
Fri Aug 31 00:00:00 EDT 2018
Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways.
Frontiers in pharmacology
Fang M,Zhong WH,Song WL,Deng YY,Yang DM,Xiong B,Zeng HK,Wang HD
35-2500 was used in Immunocytochemistry-immunoflourescence to investigate the effect of urinary trypsin inhibitor on expression of junctional proteins in pulmonary microvascular endothelial cells during sepsis.
Tue Sep 29 00:00:00 EDT 2020
Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.
eNeuro
Cottier KE,Galloway EA,Calabrese EC,Tome ME,Liktor-Busa E,Kim J,Davis TP,Vanderah TW,Largent-Milnes TM
35-2500 was used in Western Blotting to demonstrate the ability of cortical spreading depression (CSD) events to produce transient, time-dependent changes in blood-brain barrier (BBB) permeability when allodynia is present and to mediate access of clinically relevant therapeutics (i.e., sumatriptan) to the CNS.
Wed Feb 27 00:00:00 EST 2019
Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury.
Molecular neurodegeneration
Main BS,Villapol S,Sloley SS,Barton DJ,Parsadanian M,Agbaegbu C,Stefos K,McCann MS,Washington PM,Rodriguez OC,Burns MP
35-2500 was used in Immunohistochemistry to confirm apolipoprotein-E as an important modulator of spontaneous Blood Brain Barrier stabilisation following Traumatic Brain Injury.
Wed Apr 04 00:00:00 EDT 2018
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Frontiers in cellular neuroscience
Shigemoto-Mogami Y,Hoshikawa K,Sato K
35-2500 was used in Immunocytochemistry to investigate the interaction of microglia with blood-brain barrier cells.
Thu Oct 01 00:00:00 EDT 2020
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Frontiers in cellular neuroscience
Shigemoto-Mogami Y,Hoshikawa K,Sato K
35-2500 was used in Immunocytochemistry to investigate the interaction of microglia with blood-brain barrier cells.
Thu Oct 01 00:00:00 EDT 2020
Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
Journal of cellular biochemistry
Takata F,Dohgu S,Matsumoto J,Machida T,Sakaguchi S,Kimura I,Yamauchi A,Kataoka Y
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest that OSM-induced sustained increases in STAT3 phosphorylation levels largely contribute to BBB impairment.
Thu Nov 01 00:00:00 EDT 2018
GDNF enhances human blood-nerve barrier function in vitro via MAPK signaling pathways.
Tissue barriers
Dong C,Ubogu EE
35-2500 was used in Immunocytochemistry to determine the molecular changes that may occur at human BNB intercellular junctions under the influence of glial-derived neurotrophic factor (GDNF).
Mon Apr 01 00:00:00 EDT 2019
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
The Journal of clinical investigation
Horng S,Therattil A,Moyon S,Gordon A,Kim K,Argaw AT,Hara Y,Mariani JN,Sawai S,Flodby P,Crandall ED,Borok Z,Sofroniew MV,Chapouly C,John GR
35-2500 was used in Immunofluorescence to identify a inducible barrier to CNS entry at the glia limitans, which may be therapeutically targetable in inflammatory CNS disease.
Tue Aug 01 00:00:00 EDT 2017
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
The Journal of clinical investigation
Horng S,Therattil A,Moyon S,Gordon A,Kim K,Argaw AT,Hara Y,Mariani JN,Sawai S,Flodby P,Crandall ED,Borok Z,Sofroniew MV,Chapouly C,John GR
35-2500 was used in Immunofluorescence to identify a inducible barrier to CNS entry at the glia limitans, which may be therapeutically targetable in inflammatory CNS disease.
Tue Aug 01 00:00:00 EDT 2017
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
Neuron
Mazzoni J,Smith JR,Shahriar S,Cutforth T,Ceja B,Agalliu D
35-2500 was used in Immunohistochemistry-immunofluorescence to study how the canonical Norrin/Fz4/Lrp5/6 pathway coordinates angiogenesis, vascular remodelling, and barrier maturation.
Wed Dec 06 00:00:00 EST 2017
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Proceedings of the National Academy of Sciences of the United States of America
Yanagida K,Liu CH,Faraco G,Galvani S,Smith HK,Burg N,Anrather J,Sanchez T,Iadecola C,Hla T
352500 was used in western blot to describe a role for sphingosine 1-phosphate receptor-1 in regulating blood brain barrier permeability
Tue Apr 25 00:00:00 EDT 2017
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Gross S,Devraj K,Feng Y,Macas J,Liebner S,Wieland T
352500 was used in immunocytochemistry to ask if nucleoside diphosphate kinase B interacting with caveolin-1 in endothelial cells is required for the regulation of angiogenesis and adherens junction integrity
Sat Jul 01 00:00:00 EDT 2017
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
Annals of the New York Academy of Sciences
Cornely RM,Schlingmann B,Shepherd WS,Chandler JD,Neujahr DC,Koval M
35-2500 was used in Western Blotting to compare the differences between two common CLDN5 alleles with different open reading frames.
Thu Jun 01 00:00:00 EDT 2017
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome.
Molecular human reproduction
Di Pietro M,Pascuali N,Scotti L,Irusta G,Bas D,May M,Tesone M,Abramovich D,Parborell F
35-2500 was used in Western Blotting to show that in vivo administration of S1P may prevent the early onset of ovarian hyperstimulation syndrome (OHSS) and decrease its severity.
Thu Jun 01 00:00:00 EDT 2017
Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib.
Diabetes & vascular disease research
Acharya NK,Qi X,Goldwaser EL,Godsey GA,Wu H,Kosciuk MC,Freeman TA,Macphee CH,Wilensky RL,Venkataraman V,Nagele RG
35-2500 was used in Immunohistochemistry to suggest that drugs with vascular anti-inflammatory properties, such as Darapladib, may have beneficial effects on eye diseases strongly linked to vascular abnormalities such as diabetic retinopathy and age-related macular degeneration.
Mon May 01 00:00:00 EDT 2017
The Human Blood-Nerve Barrier Transcriptome.
Scientific reports
Palladino SP,Helton ES,Jain P,Dong C,Crowley MR,Crossman DK,Ubogu EE
35-2500 was used in Immunohistochemistry to sequence the human blood-nerve barrier transcriptome using confluent P3 and P8 pHEndEC monolayers and normal adult laser-capture microdissected endoneurial microvessels.
Tue Dec 12 00:00:00 EST 2017
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Translational research : the journal of laboratory and clinical medicine
Chehaibi K,le Maire L,Bradoni S,Escola JC,Blanco-Vaca F,Slimane MN
352500 was used in western blot to report the effects of peroxisome proliferator-activated receptor beta/delta agonist on the acute phase response after brain injury
Sat Apr 01 00:00:00 EDT 2017
Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
mSphere
Kim BJ,Bee OB,McDonagh MA,Stebbins MJ,Palecek SP,Doran KS,Shusta EV
35-2500 was used in Western Blotting to evaluate whether induced pluripotent stem cell-derived brain microvascular endothelial cells are appropriate for modelling bacterial interaction with the blood-brain barrier.
Wed Nov 20 00:00:00 EST 2019
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.
PloS one
Kim JG,Bae SJ,Lee HS,Park JH,Kim KW
35-2500 was used in Immunohistochemistry-immunofluorescence to investigate the role of claudin5a in the Zebrafish Kupffer's vesicle lumen.
Fri Oct 06 00:00:00 EDT 2017
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Arteriosclerosis, thrombosis, and vascular biology
Schossleitner K,Rauscher S,Gröger M,Friedl HP,Finsterwalder R,Habertheuer A,Sibilia M,Brostjan C,Födinger D,Citi S,Petzelbauer P
35-2500 was used in Immunohistochemistry-immunofluorescence to investigate the role of cingulin in the barrier function of endothelial cells.
Fri Apr 01 00:00:00 EDT 2016
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.
PLoS pathogens
Swanson PA,Hart GT,Russo MV,Nayak D,Yazew T,Peña M,Khan SM,Janse CJ,Pierce SK,McGavern DB
352500 was used in immunohistochemistry - frozen section to show that parasite-specific CD8 positive T cell-induced fatal vascular breakdown and subsequent neuronal death in an animal model of cerebral malaria
Thu Dec 01 00:00:00 EST 2016
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Experimental neurology
Boussadia B,Gangarossa G,Mselli-Lakhal L,Rousset MC,de Bock F,Lassere F,Ghosh C,Pascussi JM,Janigro D,Marchi N
35-2500 was used in Western Blotting to investigate whether the impact of constitutive androstane nuclear receptors on neurophysiology and behaviour is underlined by cerebrovascular-neuronal modifications.
Thu Sep 01 00:00:00 EDT 2016
PEGylation of Reduced Graphene Oxide Induces Toxicity in Cells of the Blood-Brain Barrier: An in Vitro and in Vivo Study.
Molecular pharmaceutics
Mendonça MC,Soares ES,de Jesus MB,Ceragioli HJ,Batista ÂG,Nyúl-Tóth Á,Molnár J,Wilhelm I,Maróstica MR,Krizbai I,da Cruz-Höfling MA
352500 was used in immunocytochemistry to assess the effects of PEGylation on the toxicity of nanoparticles in rat brains
Mon Nov 07 00:00:00 EST 2016
Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
Molecular pharmaceutics
Clark PA,Al-Ahmad AJ,Qian T,Zhang RR,Wilson HK,Weichert JP,Palecek SP,Kuo JS,Shusta EV
35-2500 was used in immunocytochemistry to examine trafficking of cancer-targeting alkylphosphocholine analogues across the blood brain barrier
Tue Sep 06 00:00:00 EDT 2016
Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.
Methods (San Diego, Calif.)
Stebbins MJ,Wilson HK,Canfield SG,Qian T,Palecek SP,Shusta EV
35-2500 was used in immunocytochemistry to describe methods to differentiate and characterize hPSC-derived brain microvascular endothelial cells
Sun May 15 00:00:00 EDT 2016
miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis.
Brain research
Ge X,Huang S,Gao H,Han Z,Chen F,Zhang S,Wang Z,Kang C,Jiang R,Yue S,Lei P,Zhang J
352500 was used in immunohistochemistry and western blot to elucidate how miR-21-5p alleviates traumatic brain injury in rats
Tue Nov 01 00:00:00 EDT 2016
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Molecular medicine reports
Ahn C,Shin DH,Lee D,Kang SM,Seok JH,Kang HY,Jeung EB
352500 was used in immunohistochemistry - paraffin section and western blot to measure tight junction protein expression in canine duodenum, lung, liver, and kidney
Sat Oct 01 00:00:00 EDT 2016
Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS).
Reproduction, fertility, and development
Scotti L,Abramovich D,Pascuali N,Durand LH,Irusta G,de Zúñiga I,Tesone M,Parborell F
35-2500 was used in Western Blot to investigate the effect of angiopoietins 1 inhibition on ovarian angiogenesis in follicular fluid (FF) from women at risk of Ovarian hyperstimulation syndrome, using the chorioallantoic membrane (CAM) of quail embryos as an experimental model.
Fri Apr 01 00:00:00 EDT 2016
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
PloS one
Huang LY,Stuart C,Takeda K,D'Agnillo F,Golding B
35-2500 was used in Western Blotting to provide new insight on how dsRNA-activated signaling pathways may disrupt vascular endothelial function and contribute to vascular leakage pathologies.
Fri Aug 04 00:00:00 EDT 2017
Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes.
BMC neuroscience
Huang L,Cao W,Deng Y,Zhu G,Han Y,Zeng H
352500 was used in western blot to elucidate the mechanisms by which hypertonic saline attenuates cerebral oedema
Thu Oct 13 00:00:00 EDT 2016
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.
Molecular autism
Fiorentino M,Sapone A,Senger S,Camhi SS,Kadzielski SM,Buie TM,Kelly DL,Cascella N,Fasano A
35-2500 was used in Western Blotting to investigate whether an altered blood-brain barrier and gut permeability is part of the pathophysiology of autism spectrum disorders.
Mon Oct 23 00:00:00 EDT 2017
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Neurobiology of disease
Pienaar IS,Lee CH,Elson JL,McGuinness L,Gentleman SM,Kalaria RN,Dexter DT
35-2500 was used in immunohistochemistry to investigate the efficacy of deep-brain stimulation on microvascular integrity in the subthalamic nucleus in Parkinson disease.
Sun Feb 01 00:00:00 EST 2015
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Brkic M,Balusu S,Van Wonterghem E,Gorlé N,Benilova I,Kremer A,Van Hove I,Moons L,De Strooper B,Kanazir S,Libert C,Vandenbroucke RE
35-2500 was used in immunohistochemistry to study the effects of Aβ on the functionality of the blood-CSF barrier.
Wed Sep 16 00:00:00 EDT 2015
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Journal of neuroscience research
Zhao YY,Zhao LN,Wang P,Miao YS,Liu YH,Wang ZH,Ma J,Li Z,Li ZQ,Xue YX
35-2500 was used in immunocytochemistry and western blot to elucidate the effects and mechanism of miR-18a on the permeability of the blood-tumor barrier.
Tue Dec 01 00:00:00 EST 2015
Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Swager SA,Delfín DA,Rastogi N,Wang H,Canan BD,Fedorov VV,Mohler PJ,Kilic A,Higgins RSD,Ziolo MT,Janssen PML,Rafael-Fortney JA
35-2500 was used in immunohistochemistry and western blot to show that the loss of claudin-5 in cardiomyocytes and endothelial cells is prevalent in human heart failure.
Wed Mar 16 00:00:00 EDT 2016
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Casselbrant A,Elias E,Fändriks L,Wallenius V
35-2500 was used in western blot to study tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery
Fri Jan 15 00:00:00 EST 2016
Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion.
Experimental and therapeutic medicine
Tan F,Fu W,Cheng N,Meng DI,Gu Y
35-2500 was used in western blot to test if 2,3,5,6-tetramethylpyrazine protects the blood brain barries integrity in ischemia/reperfusion injury.
Fri May 01 00:00:00 EDT 2015
Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.
The Journal of biological chemistry
Muramatsu R,Kuroda M,Matoba K,Lin H,Takahashi C,Koyama Y,Yamashita T
35-2500 was used in western blot to investigate the effect of prostacyclin on pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system
Fri May 01 00:00:00 EDT 2015
The human urothelial tight junction: claudin 3 and the ZO-1α+ switch.
Bladder (San Francisco, Calif.)
Smith NJ,Hinley J,Varley CL,Eardley I,Trejdosiewicz LK,Southgate J
35-2500 was used in western blot to test if claudin 3 plays an instigating and/or a functional role in the urothelial tight junctions.
Fri Mar 18 00:00:00 EDT 2022
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
F1000Research
Sreekanthreddy P,Gromnicova R,Davies H,Phillips J,Romero IA,Male D
35-2500 was used in immunocytochemistry to study a model of the human blood-brain barrier in 3D to analyze astrocyte/endothelial interactions and transport of nanoparticles
Mon Feb 15 00:00:00 EST 2016
Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line.
Fluids and barriers of the CNS
Sajja RK,Prasad S,Cucullo L
35-2500 was used in immunocytochemistry and western blot to test the effect of hypo and hyperglycemic conditions on blood brain barrier integrity and endothelial function in vitro.
Sat Apr 05 00:00:00 EDT 2014
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Journal of neurochemistry
Hawkins KE,DeMars KM,Singh J,Yang C,Cho HS,Frankowski JC,Doré S,Candelario-Jalil E
35-2500 was used in western blot to evaluate the neuroprotective effect of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke
Tue Apr 01 00:00:00 EDT 2014
Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
The Journal of steroid biochemistry and molecular biology
Scotti L,Abramovich D,Pascuali N,Irusta G,Meresman G,Tesone M,Parborell F
35-2500 was used in western blot to study the role of vascular endothelial growth factor A in ovarian hyperstimulation syndrome
Wed Oct 01 00:00:00 EDT 2014
Claudins as prognostic factors for renal cell cancer.
Anticancer research
Virman J,Soini Y,Kujala P,Luukkaala T,Salminen T,Sunela K,Kellokumpu-Lehtinen PL
35-2500 was used in immunohistochemistry - paraffin section to correlate claudin 1-5 and 7 expression with the survival, grade, and stage of patients with renal cell cancer
Fri Aug 01 00:00:00 EDT 2014
C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.
Frontiers in cellular neuroscience
Albert-Weissenberger C,Mencl S,Schuhmann MK,Salur I,Göb E,Langhauser F,Hopp S,Hennig N,Meuth SG,Nolte MW,Sirén AL,Kleinschnitz C
35-2500 was used in Western Blotting to investigate the therapeutic potential of C-1 inhibitors in traumatic brain injury.
Wed Sep 24 00:00:00 EDT 2014
A neurovascular blood-brain barrier in vitro model.
Methods in molecular biology (Clifton, N.J.)
Zehendner CM,White R,Hedrich J,Luhmann HJ
35-2500 was used in immunocytochemistry to describe a murine blood-brain barrier coculture model that includes neurons, astrocytes, and brain endothelial cells.
Mon Sep 29 00:00:00 EDT 2014
Analysis of angiogenesis in the developing mouse central nervous system.
Methods in molecular biology (Clifton, N.J.)
Ziegler N,Plate KH,Liebner S
35-2500 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to describe how to fix, dissect, stain, and analyze the developing hindbrain vasculature.
Mon Sep 29 00:00:00 EDT 2014
Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.
Molecular pharmaceutics
Strazielle N,Ghersi-Egea JF
35-2500 was used in immunohistochemistry - paraffin section to discuss factors that regulate the blood brain barrier.
Mon May 06 00:00:00 EDT 2013
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Neurotoxicology and teratology
Szczepkowska A,Lagaraine C,Robert V,Dufourny L,Thiéry JC,Skipor J
35-2500 was used in western blot to examine the photoperiodically different concentration of polychlorinated biphenyls in the cerebrospinal fluid in sheep.
Mon Dec 30 00:00:00 EST 2013
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Human pathology
Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL
35-2500 was used in immunohistochemistry (paraffin) to examine tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis.
Wed May 01 00:00:00 EDT 2013
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption.
PloS one
Zehendner CM,Librizzi L,Hedrich J,Bauer NM,Angamo EA,de Curtis M,Luhmann HJ
35-2500 was used in immunocytochemistry to analyze why the blood-brain barrier breakdown occurs via oxidative stress-dependent tight junction protein disruption following moderate hypoxia and reoxygenation
Thu Jul 31 00:00:00 EDT 2014
12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.
The Journal of biological chemistry
Kundumani-Sridharan V,Dyukova E,Hansen DE,Rao GN
35-2500 was used in Immunocytochemistry to understand the mechanisms by which 12/15-LO mediates endothelial dysfunction.
Fri May 31 00:00:00 EDT 2013
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
International journal of clinical and experimental pathology
Hintsala HR,Siponen M,Haapasaari KM,Karihtala P,Soini Y
Mon Aug 04 00:00:00 EDT 2014
CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support.
Journal of immunology (Baltimore, Md. : 1950)
Johnson HL,Chen Y,Jin F,Hanson LM,Gamez JD,Pirko I,Johnson AJ
35-2500 was used in immunocytochemistry to determine the contribution of neutrophils to central nervous system vascular permeability.
Wed Aug 15 00:00:00 EDT 2012
Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier.
Neurochemical research
Rapôso C,Odorissi PA,Oliveira AL,Aoyama H,Ferreira CV,Verinaud L,Fontana K,Ruela-de-Sousa RR,da Cruz-Höfling MA
Sat Sep 01 00:00:00 EDT 2012
Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier.
Neurochemical research
Rapôso C,Odorissi PA,Oliveira AL,Aoyama H,Ferreira CV,Verinaud L,Fontana K,Ruela-de-Sousa RR,da Cruz-Höfling MA
Sat Sep 01 00:00:00 EDT 2012
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Infection and immunity
Lécuyer H,Nassif X,Coureuil M
Sun Jan 01 00:00:00 EST 2012
Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.
Histochemistry and cell biology
Kratzer I,Vasiljevic A,Rey C,Fevre-Montange M,Saunders N,Strazielle N,Ghersi-Egea JF
Sat Dec 01 00:00:00 EST 2012
Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.
Histochemistry and cell biology
Kratzer I,Vasiljevic A,Rey C,Fevre-Montange M,Saunders N,Strazielle N,Ghersi-Egea JF
Sat Dec 01 00:00:00 EST 2012
Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.
Journal of translational medicine
Ghulé VV,Gray C,Galimberti A,Anumba DO
35-2500 was used in western blot to assess the role of tight junctions and gap proteins in cervical remodeling.
Wed Mar 07 00:00:00 EST 2012
Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Riski M,Santala M,Soini Y,Talvensaari-Mattila A
35-2500 was used in immunohistochemistry - paraffin section to ascertain the expression of claudin 1, 3M, 3S, 4, 5, and 7 in vulvar epithelial neoplasia and compare their expression in samples with invasive vulvar squamous cell carcinoma
Sun Apr 01 00:00:00 EDT 2012
Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas.
The American journal of surgical pathology
Miettinen M,Sarlomo-Rikala M,Wang ZF
35-2500 was used in immunohistochemistry to assess claudin-5 expression in human mesenchymal tumors.
Thu Dec 01 00:00:00 EST 2011
Novel expression of claudin-5 in glomerular podocytes.
Cell and tissue research
Koda R,Zhao L,Yaoita E,Yoshida Y,Tsukita S,Tamura A,Nameta M,Zhang Y,Fujinaka H,Magdeldin S,Xu B,Narita I,Yamamoto T
35-2500 was used in immunohistochemistry and western blot to identify and characterize claudin-5 expression in podocytes.
Tue Mar 01 00:00:00 EST 2011
Novel expression of claudin-5 in glomerular podocytes.
Cell and tissue research
Koda R,Zhao L,Yaoita E,Yoshida Y,Tsukita S,Tamura A,Nameta M,Zhang Y,Fujinaka H,Magdeldin S,Xu B,Narita I,Yamamoto T
35-2500 was used in immunohistochemistry and western blot to identify and characterize claudin-5 expression in podocytes.
Tue Mar 01 00:00:00 EST 2011
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Brain research
Lagaraine C,Skipor J,Szczepkowska A,Dufourny L,Thiery JC
35-2500 was used in western blot to compare the tight junction proteins in the choroid plexus of ewes exposed to short or long days.
Wed Jun 01 00:00:00 EDT 2011
Detection of multiple proteins in intracerebral vessels by confocal microscopy.
Methods in molecular biology (Clifton, N.J.)
Manias JL,Kapadia A,Nag S
35-2500 was used in immunohistochemistry - paraffin section to discuss methods to assess blood brain barrier integrity
Wed Jun 01 00:00:00 EDT 2011
MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.
Methods in molecular biology (Clifton, N.J.)
Yang Y,Rosenberg GA
35-2500 was used in Western Blotting to study the activation of matrix metalloproteinases in the brain following stroke, and the effects that they have on the blood-brain barrier.
Fri Nov 04 00:00:00 EDT 2011
MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.
Methods in molecular biology (Clifton, N.J.)
Yang Y,Rosenberg GA
35-2500 was used in Western Blotting to study the activation of matrix metalloproteinases in the brain following stroke, and the effects that they have on the blood-brain barrier.
Fri Nov 04 00:00:00 EDT 2011
Perifoveal müller cell depletion in a case of macular telangiectasia type 2.
Ophthalmology
Powner MB,Gillies MC,Tretiach M,Scott A,Guymer RH,Hageman GS,Fruttiger M
35-2500 was used in immunohistochemistry to report a clinical case of macular telangiectasia type 2 with perifoveal m
Wed Dec 01 00:00:00 EST 2010
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Diabetes
Leal EC,Martins J,Voabil P,Liberal J,Chiavaroli C,Bauer J,Cunha-Vaz J,Ambrósio AF
Fri Oct 01 00:00:00 EDT 2010
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Diabetes
Leal EC,Martins J,Voabil P,Liberal J,Chiavaroli C,Bauer J,Cunha-Vaz J,Ambrósio AF
Fri Oct 01 00:00:00 EDT 2010
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Bauer AT,Bürgers HF,Rabie T,Marti HH
35-2500 was used in immunohistochemistry and western blot to examine the effect of prolonged hypoxia on blood-brain barrier integrity in vivo
Thu Apr 01 00:00:00 EDT 2010
Retinal vascular changes after glial disruption in rats.
Journal of neuroscience research
Shen W,Li S,Chung SH,Gillies MC
35-2500 was used in immunohistochemistry to test if glial dysfunction is a major contributor to the blood-retinal barrier
Sat May 15 00:00:00 EDT 2010
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
The Journal of biological chemistry
Su SC,Maxwell SA,Bayless KJ
35-2500 was used in western blot to identify annexin 2 as a regulator of endothelial morphogenesis
Fri Dec 24 00:00:00 EST 2010
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.
Nature medicine
Yemisci M,Gursoy-Ozdemir Y,Vural A,Can A,Topalkara K,Dalkara T
35-2500 was used in immunohistochemistry to study the role of ischemia in inducing sustained contraction of pericytes on microvessels in the intact mouse brain
Tue Sep 01 00:00:00 EDT 2009
Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.
Journal of virology
Gralinski LE,Ashley SL,Dixon SD,Spindler KR
Tue Sep 01 00:00:00 EDT 2009
Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma.
Anticancer research
Turunen M,Talvensaari-Mattila A,Soini Y,Santala M
35-2500 was used in immunohistochemistry - paraffin section to correlate expression of claudin-5 to ovarian cancer behavior
Tue Dec 01 00:00:00 EST 2009
Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide.
The Journal of surgical research
Waldow T,Witt W,Janke A,Ulmer A,Buzin A,Matschke K
35-2500 was used in western blot to test if pre-treatment with nitric oxide before ischemia and reperfusion injury affects cell junction proteins and vascular endothelial growth factor
Sun Nov 01 00:00:00 EDT 2009
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Hepatology (Baltimore, Md.)
Reynolds GM,Harris HJ,Jennings A,Hu K,Grove J,Lalor PF,Adams DH,Balfe P,Hübscher SG,McKeating JA
35-2500 was used in immunohistochemistry - paraffin section to define the localization of CD81, scavenger receptor class B member I, and Claudin-1 in HCV entry of hepatocytes
Fri Feb 01 00:00:00 EST 2008
Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.
American journal of physiology. Cell physiology
Su SC,Mendoza EA,Kwak HI,Bayless KJ
35-2500 was used in western blot to elucidate the mechanisms that direct the transformation of adherent endothelial cells to multicellular invading sprouts
Sat Nov 01 00:00:00 EDT 2008
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
Cell and tissue research
Akat K,Bleck CK,Lee YM,Haselmann-Weiss U,Kartenbeck J
35-2500 was used in immunoprecipitation identify and characterize a new type of adherens junction in human meningiomas
Fri Feb 01 00:00:00 EST 2008
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Neuroscience letters
Neuhaus W,Wirth M,Plattner VE,Germann B,Gabor F,Noe CR
35-2500 was used in immunocytochemistry to study tight junction proteins in ECV304 cells
Wed Dec 03 00:00:00 EST 2008
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus.
Journal of chemical neuroanatomy
Norsted E,Gömüç B,Meister B
35-2500 was used in immunohistochemistry - frozen section to characterize the blood brain barrier in the median eminence-arcuate nucleus complex
Wed Oct 01 00:00:00 EDT 2008
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Histochemistry and cell biology
Uehara K,Uehara A
35-2500 was used in immunohistochemistry - frozen section to study the spatial and functional relationships between tight and adherens junctions in the sinus endothelial cells of rat spleen
Tue Jan 01 00:00:00 EST 2008
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Paschoud S,Bongiovanni M,Pache JC,Citi S
35-2500 was used in immunohistochemistry to measure the expression of tight junction proteins in human lung squamous cell carcinomas and adenocarcinomas
Sat Sep 01 00:00:00 EDT 2007
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.
Neuroscience
Morgan L,Shah B,Rivers LE,Barden L,Groom AJ,Chung R,Higazi D,Desmond H,Smith T,Staddon JM
35-2500 was used in western blot to analyze lumbar spinal cord proteins present in naive and experimental autoimmune encephalomyelitis rats
Fri Jul 13 00:00:00 EDT 2007
Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas.
Human pathology
Sheehan GM,Kallakury BV,Sheehan CE,Fisher HA,Kaufman RP,Ross JS
Sun Apr 01 00:00:00 EDT 2007
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
American journal of physiology. Gastrointestinal and liver physiology
Musch MW,Walsh-Reitz MM,Chang EB
Wed Feb 01 00:00:00 EST 2006
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
American journal of physiology. Gastrointestinal and liver physiology
Musch MW,Walsh-Reitz MM,Chang EB
Wed Feb 01 00:00:00 EST 2006
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Journal of clinical pathology
Soini Y,Kinnula V,Kahlos K,Pääkkö P
35-2500 was used in immunohistochemistry - paraffin section to observe the expression of claudins in mesothelioma and metastatic pleural adenocarcinoma
Wed Mar 01 00:00:00 EST 2006
Tight junction proteins and perineurial cells in neurofibromas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Pummi KP,Aho HJ,Laato MK,Peltonen JT,Peltonen SA
35-2500 was used in immunohistochemistry - frozen section to determine the distribution and role of perineurial cells in neurofibromas
Sun Jan 01 00:00:00 EST 2006
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
American journal of physiology. Gastrointestinal and liver physiology
Weng XH,Beyenbach KW,Quaroni A
Fri Apr 01 00:00:00 EST 2005
The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development.
Journal of cell science
Rahner C,Fukuhara M,Peng S,Kojima S,Rizzolo LJ
Thu Jul 01 00:00:00 EDT 2004
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Pummi KP,Heape AM,Grénman RA,Peltonen JT,Peltonen SA
35-2500 was used in Immunofluorescence to show that the perineurial diffusion barrier matures relatively late during human peripheral nerve development.
Sun Aug 01 00:00:00 EDT 2004
Heterogeneity of claudin expression by alveolar epithelial cells.
American journal of respiratory cell and molecular biology
Wang F,Daugherty B,Keise LL,Wei Z,Foley JP,Savani RC,Koval M
35-2500 was used in western blot to study claudins in the lung.
Tue Jul 01 00:00:00 EDT 2003
Expression and localization of tight junction-associated proteins in human hair follicles.
Archives of dermatological research
Brandner JM,McIntyre M,Kief S,Wladykowski E,Moll I
35-2500 was used in immunohistochemistry to discuss the role of tight junctions in hair cells.
Mon Sep 01 00:00:00 EDT 2003
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
The Journal of cell biology
Poliak S,Matlis S,Ullmer C,Scherer SS,Peles E
Mon Oct 28 00:00:00 EST 2002
