Product References
The Sympathetic Nervous System Regulates Sodium Glucose Co-Transporter 1 Expression in the Kidney.
Biomedicines
Matthews J,Hibbs M,Herat L,Schlaich M,Matthews V
Published figure using CDK4 monoclonal antibody (Product # AHZ0202) in Western Blot
Tue Mar 07 00:00:00 EST 2023
Specific Forms of Graphene Quantum Dots Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells.
International journal of molecular sciences
Ku TH,Shen WT,Hsieh CT,Chen GS,Shia WC
AHZ0202 was used in Western Blotting to indicate that these GQDs induce apoptosis and G2/M cell cycle arrest in specific breast cancer subtypes and could potentially be used for treating breast cancers.
Fri Feb 17 00:00:00 EST 2023
Prophylactic oophorectomy and aromatase inhibitors for premenopausal deep angiomyxoma: A case report and literature review.
Experimental and therapeutic medicine
Tonai N,Nasu K,Yano M,Sato M,Kai K,Nishida M,Kawano Y
AHZ0202 was used in Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to study the role of prophylactic oophorectomy in premenopausal women.
Sun Jan 01 00:00:00 EST 2023
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
IUBMB life
Zhu J,Han S
AHZ0202 was used in Western Blotting to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened-out miRNA target.
Thu Apr 01 00:00:00 EDT 2021
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
IUBMB life
Zhu J,Han S
AHZ0202 was used in Western Blotting to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened-out miRNA target.
Thu Apr 01 00:00:00 EDT 2021
CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.
British journal of cancer
Skowron MA,Vermeulen M,Winkelhausen A,Becker TK,Bremmer F,Petzsch P,Schönberger S,Calaminus G,Köhrer K,Albers P,Nettersheim D
AHZ0202 was used in Immunohistochemistry to analyse the potential of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors palbociclib and ribociclib (PaRi) as molecular drugs to treat cisplatin-resistant and -sensitive paediatric and adult germ cell tumours(GCTs).
Sat Aug 01 00:00:00 EDT 2020
CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.
British journal of cancer
Skowron MA,Vermeulen M,Winkelhausen A,Becker TK,Bremmer F,Petzsch P,Schönberger S,Calaminus G,Köhrer K,Albers P,Nettersheim D
AHZ0202 was used in Immunohistochemistry to analyse the potential of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors palbociclib and ribociclib (PaRi) as molecular drugs to treat cisplatin-resistant and -sensitive paediatric and adult germ cell tumours(GCTs).
Sat Aug 01 00:00:00 EDT 2020
FAIM-S functions as a negative regulator of NF-κB pathway and blocks cell cycle progression in NSCLC cells.
Cell cycle (Georgetown, Tex.)
Wang P,Xun W,Han T,Cheng Z
AHZ0202 was used in Western Blot to demonstrate that FAIM-S functioned as a negative regulator of the NF-κB pathway and played a tumor-suppressing role through blocking cell cycle progression in NSCLC cells.
Tue Dec 01 00:00:00 EST 2020
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
NPJ systems biology and applications
Mastrogamvraki N,Zaravinos A
AHZ0202 was used in Immunohistochemistry to analyse 19 GEO gene expression profiles to identify and annotate CRC versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
Fri Jul 31 00:00:00 EDT 2020
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
NPJ systems biology and applications
Mastrogamvraki N,Zaravinos A
AHZ0202 was used in Immunohistochemistry to analyse 19 GEO gene expression profiles to identify and annotate CRC versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
Fri Jul 31 00:00:00 EDT 2020
Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis - A systematic analysis of 204 cases.
Scientific reports
Trautmann M,Rehkämper J,Gevensleben H,Becker J,Wardelmann E,Hartmann W,Grünewald I,Huss S
AHZ0202 was used in Immunohistochemistry to show that DTF may harbor a broader mutational spectrum beyond CTNNB1 mutations, comprising targetable alterations including the herewith first reported imatinib-sensitive KIT V559D mutation in DTF.
Tue Feb 25 00:00:00 EST 2020
Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology.
Laboratory investigation; a journal of technical methods and pathology
Kim YJ,Kim M,Park HK,Yu DB,Jung K,Song K,Choi YL
AHZ0202 was used in Immunocytochemistry-immunoflourescence to examine whether MDM2 and/or CDK4 cause well-differentiated liposarcoma (WDLPS)/dedifferentiated liposarcoma (DDLPS).
Sun Sep 01 00:00:00 EDT 2019
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
International journal of clinical and experimental pathology
Matsuda I,Nakamura J,Ohkouchi M,Torii Y,Futani H,Tsukamoto Y,Hirota S
AHZ0202 was used in Immunohistochemistry to examine whether myofibroblastic cells in NF express p16 protein, a gene product of CDKN2A gene and an inhibitor of cyclin-dependent kinase 4 (CDK4) as well as one of the hallmarks of cellular senescence.
Wed Mar 25 00:00:00 EDT 2020
The molecular mechanism of treating osteoarthritis with dipsacus saponins by inhibiting chondrocyte apoptosis.
Experimental and therapeutic medicine
Li XR,Li J,Ren Q,Sun S
AHZ0202 was used in Western Blotting to demonstrate that dipsacus saponins inhibits the apoptosis of chondrocytes by up-regulating Bcl-2 and down-regulating caspase-9, caspase-3 and Bax expression.
Wed Nov 01 00:00:00 EDT 2017
Expression of cell cycle proteins in cortical neurons-Correlation with glutamate-induced neurotoxicity.
BioFactors (Oxford, England)
Negis Y,Karabay A
AHZ0202 was used in western blot to study the correlation between glutamate-induced neurotoxicity and expression of cell cycle proteins in cortical neurons
Fri Jul 08 00:00:00 EDT 2016
MDM2 and CDK4 Immunohistochemistry: Should It Be Used in Problematic Differentiated Lipomatous Tumors?: A New Perspective.
The American journal of surgical pathology
Clay MR,Martinez AP,Weiss SW,Edgar MA
AHZ0202 was used in immunohistochemistry - paraffin section to determine the concordance between two methods to detect cases of atypical lipomatous tumor/well-differentiated liposarcoma
Thu Dec 01 00:00:00 EST 2016
MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas.
Oncotarget
Grünewald I,Trautmann M,Busch A,Bauer L,Huss S,Schweinshaupt P,Vollbrecht C,Odenthal M,Quaas A,Büttner R,Meyer MF,Beutner D,Hüttenbrink KB,Wardelmann E,Stenner M,Hartmann W
AHZ0202 was used in Immunohistochemistry to analyse the mutational status, genomic amplification and protein expression in a range of oncogenes in adenoma salivary duct carcinoma.
Tue Nov 15 00:00:00 EST 2016
Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma.
Diagnostic pathology
Sugita S,Asanuma H,Hasegawa T
AHZ0202 was used in Immunohistochemistry-immunofluorescence to study the use of fluorescence in situ hybridisation in expert review in a phase 2 study of trabectedin monotherapy for patients with advanced translocation-related sarcoma.
Tue Apr 12 00:00:00 EDT 2016
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Nature genetics
Shain AH,Garrido M,Botton T,Talevich E,Yeh I,Sanborn JZ,Chung J,Wang NJ,Kakavand H,Mann GJ,Thompson JF,Wiesner T,Roy R,Olshen AB,Gagnon A,Gray JW,Huh N,Hur JS,Busam KJ,Scolyer RA,Cho RJ,Murali R,Bastian BC
AHZ0202 was used in immunohistochemistry to identify mutations in desmoplastic melanoma samples
Thu Oct 01 00:00:00 EDT 2015
CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Olanich ME,Sun W,Hewitt SM,Abdullaev Z,Pack SD,Barr FG
AHZ0202 was used in Immunohistochemistry to examine the biologic consequences of CDK4 knockdown, CDK4 overexpression, and pharmacologic CDK4/6 inhibition by LEE011 in fusion-positive rhabdomyosarcoma cell lines and xenografts.
Sun Nov 01 00:00:00 EDT 2015
Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Saâda-Bouzid E,Burel-Vandenbos F,Ranchère-Vince D,Birtwisle-Peyrottes I,Chetaille B,Bouvier C,Château MC,Peoc'h M,Battistella M,Bazin A,Gal J,Michiels JF,Coindre JM,Pedeutour F,Bianchini L
AHZ0202 was used in immunohistochemistry to investigate the frequency and contribution of HMGA2, CDK4, and JUN to dedifferentiated liposarcomas and atypical lipomatous tumors/well-differentiated liposarcomas.
Sun Nov 01 00:00:00 EDT 2015
Myxoid liposarcoma with heterologous components: dedifferentiation or metaplasia? A FISH-documented and CGH-documented case report.
Applied immunohistochemistry & molecular morphology : AIMM
Weingertner N,Neuville A,Chibon F,Ray-Coquard I,Marcellin L,Ghnassia JP
AHZ0202 was used in immunohistochemistry - paraffin section to characterize a primary myxoid liposarcoma with chondroid and osseous components
Sun Mar 01 00:00:00 EST 2015
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.
Oncotarget
Kennedy AL,Vallurupalli M,Chen L,Crompton B,Cowley G,Vazquez F,Weir BA,Tsherniak A,Parasuraman S,Kim S,Alexe G,Stegmaier K
AHZ0202 was used in western blot to analyze sensitivity to the cyclin D1/CDK4 pathway inhibition in Ewing sarcoma by a chemical genomic, functional, and super-enhancer screening
Tue Oct 06 00:00:00 EDT 2015
Plexiform fibromyxoma (plexiform angiomyxoid myofibroblastic tumor) of stomach: an unusual presentation as a fistulating abscess.
International journal of surgical pathology
Lee PW,Yau DT,Lau PP,Chan JK
AHZ0202 was used in immunohistochemistry to report on a case of plexiform fibromyxoma of the stomach.
Thu May 01 00:00:00 EDT 2014
Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases.
Histopathology
Sioletic S,Dal Cin P,Fletcher CD,Hornick JL
AHZ0202 was used in immunohistochemistry to study the clinicopathological and genetic features of well-differentiated/dedifferentiated liposarcoma with prominent myxoid stroma.
Tue Jan 01 00:00:00 EST 2013
Incidental lipoma-like hibernoma arising from the adrenal gland: a well-differentiated liposarcoma mimicker.
Pathology, research and practice
Val-Bernal JF,Azueta A,Ortiz-Rivas LA,Fuentes J,Ballestero R
AHZ0202 was used in immunohistochemistry to describe a woman showing an incidental hibernoma associated with a cortical adenoma producing primary hyperaldosteronism.
Sun Dec 01 00:00:00 EST 2013
Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Kashima T,Halai D,Ye H,Hing SN,Delaney D,Pollock R,O'Donnell P,Tirabosco R,Flanagan AM
AHZ0202 was used in immunohistochemistry to assess if MDM2 copy number distinguishes lipomas from atypical lipomatous tumors.
Mon Oct 01 00:00:00 EDT 2012
MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype.
The American journal of surgical pathology
Yoshida A,Ushiku T,Motoi T,Beppu Y,Fukayama M,Tsuda H,Shibata T
Thu Mar 01 00:00:00 EST 2012
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Dujardin F,Binh MB,Bouvier C,Gomez-Brouchet A,Larousserie F,Muret Ad,Louis-Brennetot C,Aurias A,Coindre JM,Guillou L,Pedeutour F,Duval H,Collin C,de Pinieux G
AHZ0202 was used in immunohistochemistry to examine expression of MDM2-CDK4 in low-grade osteosarcomas and fibrous or fibro-osseous lesions of the bone or paraosseous soft tissue.
Sun May 01 00:00:00 EDT 2011
Malignant fat-forming solitary fibrous tumor (so-called "lipomatous hemangiopericytoma"): clinicopathologic analysis of 14 cases.
The American journal of surgical pathology
Lee JC,Fletcher CD
AHZ0202 was used in immunocytochemistry to characterize malignant fat-forming solitary fibrous tumor.
Mon Aug 01 00:00:00 EDT 2011
Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Yoshida A,Ushiku T,Motoi T,Shibata T,Beppu Y,Fukayama M,Tsuda H
AHZ0202 was used in immunohistochemistry - paraffin section to explore the use of MDM2 and CDK4 for the histological diagnosis of low-grade osteosarcoma
Wed Sep 01 00:00:00 EDT 2010
Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.
The American journal of surgical pathology
Mariño-Enríquez A,Fletcher CD,Dal Cin P,Hornick JL
AHZ0202 was used in immunohistochemistry - paraffin section to characterize 12 unusual liposarcomas
Sun Aug 01 00:00:00 EDT 2010
Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant.
The American journal of surgical pathology
Yoshida A,Ushiku T,Motoi T,Shibata T,Fukayama M,Tsuda H
AHZ0202 was used in immunohistochemistry - paraffin section to use 9 cases of well-differentiated/dedifferentiated liposarcoma to characterize unappreciated features
Wed Sep 01 00:00:00 EDT 2010
Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Italiano A,Bianchini L,Gjernes E,Keslair F,Ranchere-Vince D,Dumollard JM,Haudebourg J,Leroux A,Mainguené C,Terrier P,Chibon F,Coindre JM,Pedeutour F
AHZ0202 was used in immunohistochemistry to study the significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
Tue Sep 15 00:00:00 EDT 2009
Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Horvai AE,DeVries S,Roy R,O'Donnell RJ,Waldman F
AHZ0202 was used in immunohistochemistry - paraffin section to report genetic changes in dedifferentiated liposarcomas
Sun Nov 01 00:00:00 EDT 2009
Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases.
The American journal of pathology
Neuwirt H,Puhr M,Santer FR,Susani M,Doppler W,Marcias G,Rauch V,Brugger M,Hobisch A,Kenner L,Culig Z
Fri May 01 00:00:00 EDT 2009
Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases.
The American journal of pathology
Neuwirt H,Puhr M,Santer FR,Susani M,Doppler W,Marcias G,Rauch V,Brugger M,Hobisch A,Kenner L,Culig Z
Fri May 01 00:00:00 EDT 2009
Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases.
The American journal of pathology
Neuwirt H,Puhr M,Santer FR,Susani M,Doppler W,Marcias G,Rauch V,Brugger M,Hobisch A,Kenner L,Culig Z
Fri May 01 00:00:00 EDT 2009
Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases.
The American journal of pathology
Neuwirt H,Puhr M,Santer FR,Susani M,Doppler W,Marcias G,Rauch V,Brugger M,Hobisch A,Kenner L,Culig Z
Fri May 01 00:00:00 EDT 2009
Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma.
American journal of clinical oncology
Nahal A,Meterissian S
AHZ0202 was used in immunohistochemistry to discuss a rare presentation of a lipoleiomyosarcoma and review the method of pathologic diagnosis
Sat Aug 01 00:00:00 EDT 2009
Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Horvai AE,Schaefer JT,Nakakura EK,O'Donnell RJ
AHZ0202 was used in immunohistochemistry - paraffin section to assess if immunostaining for PPAR-gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas
Thu May 01 00:00:00 EDT 2008
Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
JOP : Journal of the pancreas
Amiot A,Dokmak S,Sauvanet A,Vilgrain V,Bringuier PP,Scoazec JY,Sastre X,Ruszniewski P,Bedossa P,Couvelard A
AHZ0202 was used in immunohistochemistry to discuss the properties of desmoid tumors
Thu May 08 00:00:00 EDT 2008
Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status.
Molecular carcinogenesis
Al-Ayyoubi S,Gali-Muhtasib H
AHZ0202 was used in western blot to elucidate how treatment with gallotannin prevents cancer
Thu Mar 01 00:00:00 EST 2007
Reproducibility of MDM2 and CDK4 staining in soft tissue tumors.
American journal of clinical pathology
Binh MB,Garau XS,Guillou L,Aurias A,Coindre JM
Mon May 01 00:00:00 EDT 2006
alpha-fetoprotein expression in a dedifferentiated liposarcoma.
Virchows Archiv : an international journal of pathology
Bosco M,Allia E,Coindre JM,Odasso C,Pagani A,Pacchioni D
AHZ0202 was used in immunohistochemistry - paraffin section to present a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with alpha-fetoprotein ectopic production
Sat Apr 01 00:00:00 EST 2006
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.
The American journal of surgical pathology
Binh MB,Sastre-Garau X,Guillou L,de Pinieux G,Terrier P,Lagacé R,Aurias A,Hostein I,Coindre JM
Sat Oct 01 00:00:00 EDT 2005
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
Virchows Archiv : an international journal of pathology
Mentzel T,Toennissen J,Rütten A,Schaller J
AHZ0202 was used in immunohistochemistry - paraffin section to present the case of a patient with a rare atypical lipomatous tumor with spindle cell features
Tue Mar 01 00:00:00 EST 2005
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity.
The Journal of pathology
Coindre JM,Hostein I,Maire G,Derré J,Guillou L,Leroux A,Ghnassia JP,Collin F,Pedeutour F,Aurias A
AHZ0202 was used in immunohistochemistry (frozen) to characterize dedifferentiated liposarcomas with an inflammatory malignant fibrous histiocytoma component.
Thu Jul 01 00:00:00 EDT 2004
Antimitogenesis linked to regulation of Skp2 gene expression.
The Journal of biological chemistry
Stewart SA,Kothapalli D,Yung Y,Assoian RK
AHZ0202 was used in western blot to report that cicaprost regulates the expression of Skp2
Fri Jul 09 00:00:00 EDT 2004
Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Coindre JM,Mariani O,Chibon F,Mairal A,De Saint Aubain Somerhausen N,Favre-Guillevin E,Bui NB,Stoeckle E,Hostein I,Aurias A
AHZ0202 was used in immunohistochemistry (paraffin) to report that most so-called malignant fibrous histiocytomas from the retroperitoneum are dedifferentiated liposarcoma.
Sat Mar 01 00:00:00 EST 2003
