Invitrogen

CD44 Monoclonal Antibody (IM7), Alexa Fluor™ 700, eBioscience™

FIGURE: 1 / 98

CD44 Antibody (56-0441-82) in Flow

Staining of BALB/c splenocytes with 0.03 µg of Rat IgG2b K Isotype Control Alexa Fluor® 700 (Product # 56-4031-80) (open histogram) or 0.03 µg of Anti-Human/Mouse CD44 Alexa Fluor® 700 (filled histogram). Cells in the lymphocyte gate were used for analysis.

CD44 Antibody in Immunocytochemistry (ICC/IF)

CD44 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD44 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

CD44 Antibody in Immunohistochemistry (IHC)

CD44 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

Product Details

56-0441-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 16 publications 16 publications

Immunocytochemistry (ICC/IF)

View 15 publications 15 publications

Flow Cytometry (Flow)

0.06 µg/test

View 210 publications 210 publications

Neutralization (Neu)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fruit fly, Human, Mouse, Non-human primate

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), Alexa Fluor™ 700, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

IM7

Conjugate

Alexa Fluor™ 700 Alexa Fluor™ 700 Alexa Fluor™ 700

Excitation/Emission Max

696/719 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_494011

Product Specific Information

Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.

Applications Reported: This IM7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocyte suspensions. This can be used at less than or equal to 0.06 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Alexa Fluor® 700 emits at 723 nm and can be excited with the red laser (633 nm). Most instruments will require a 685 LP mirror and 710/20 filter. Please make sure that your instrument is capable of detecting this fluorochrome.

Excitation: 633-647 nm; Emission: 723 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Frontiers in immunology

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PloS one

Baldwin SL,Reese VA,Larsen SE,Beebe E,Guderian J,Orr MT,Fox CB,Reed SG,Coler RN

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Babaei A,Bannazadeh Baghi H,Nezhadi A,Jamalpoor Z

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Breuls N,Giarratana N,Yedigaryan L,Garrido GM,Carai P,Heymans S,Ranga A,Deroose C,Sampaolesi M

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Cancer cell international

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Immuno-Electron and Confocal Laser Scanning Microscopy of the Glycocalyx.

Biology

Twamley SG,Stach A,Heilmann H,Söhl-Kielczynski B,Stangl V,Ludwig A,Münster-Wandowski A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

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Cell reports

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Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

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Cancers

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Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

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Attenuation of apoptotic cell detection triggers thymic regeneration after damage.

Cell reports

Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA

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STAR protocols

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EBioMedicine

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c-FOS drives reversible basal to squamous cell carcinoma transition.

Cell reports

Kuonen F,Li NY,Haensel D,Patel T,Gaddam S,Yerly L,Rieger K,Aasi S,Oro AE

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

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CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.

iScience

Qadir AS,Guégan JP,Ginestier C,Chaibi A,Bessede A,Charafe-Jauffret E,Macario M,Lavoué V,Rouge TM,Law C,Vilker J,Wang H,Stroup E,Schipma MJ,Bridgeman B,Murmann AE,Ji Z,Legembre P,Peter ME

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Fri Nov 19 00:00:00 EST 2021

3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness.

Cell death discovery

Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

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A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.

Cell death & disease

Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Dec 16 00:00:00 EST 2021

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Jan 11 00:00:00 EST 2022

Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.

International journal of molecular sciences

Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Feb 04 00:00:00 EST 2021

Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.

Cell death & disease

He Y,Cheng D,Lian C,Liu Y,Luo W,Wang Y,Ma C,Wu Q,Tian P,He D,Jia Z,Lv X,Zhang X,Pan Z,Lu J,Xiao Y,Zhang P,Liang Y,Yang Q,Hu G

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Neutralization

Thu Sep 23 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.

Cell

Sadik A,Somarribas Patterson LF,Öztürk S,Mohapatra SR,Panitz V,Secker PF,Pfänder P,Loth S,Salem H,Prentzell MT,Berdel B,Iskar M,Faessler E,Reuter F,Kirst I,Kalter V,Foerster KI,Jäger E,Guevara CR,Sobeh M,Hielscher T,Poschet G,Reinhardt A,Hassel JC,Zapatka M,Hahn U,von Deimling A,Hopf C,Schlichting R,Escher BI,Burhenne J,Haefeli WE,Ishaque N,Böhme A,Schäuble S,Thedieck K,Trump S,Seiffert M,Opitz CA

56-0441 was used in Flow cytometry/Cell sorting to show that IL4I1 blockade opens new avenues for cancer therapy.

Thu Sep 03 00:00:00 EDT 2020

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Immunity

Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R

56-0441-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.

Tue Dec 15 00:00:00 EST 2020

An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Immunity

Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R

56-0441-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.

Tue Dec 15 00:00:00 EST 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.

Clinical and translational medicine

Tang D,Xu X,Ying J,Xie T,Cao G

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Cancer cells educate natural killer cells to a metastasis-promoting cell state.

The Journal of cell biology

Chan IS,Knútsdóttir H,Ramakrishnan G,Padmanaban V,Warrier M,Ramirez JC,Dunworth M,Zhang H,Jaffee EM,Bader JS,Ewald AJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Mon Sep 07 00:00:00 EDT 2020

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.

Molecular oncology

Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Frontiers in cell and developmental biology

Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.

International journal of oncology

Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Therapeutic advances in chronic disease

Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

Explant culture: A relevant tool for the study of telocytes.

Cell biology international

Sanches BDA,Maldarine JDS,Tamarindo GH,Da Silva ADT,Lima MLD,Rahal P,Góes RM,Taboga SR,Carvalho HF

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Tue Dec 01 00:00:00 EST 2020

Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.

Veterinary research

Sisteré-Oró M,Pedersen GK,Córdoba L,López-Serrano S,Christensen D,Darji A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Apr 20 00:00:00 EDT 2020

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.

Molecular medicine reports

Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation.

Nature communications

Azazmeh N,Assouline B,Winter E,Ruppo S,Nevo Y,Maly A,Meir K,Witkiewicz AK,Cohen J,Rizou SV,Pikarsky E,Luxenburg C,Gorgoulis VG,Ben-Porath I

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Wed Dec 09 00:00:00 EST 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Wed Dec 09 00:00:00 EST 2020

Diacerein treatment prevents colitis-associated cancer in mice.

World journal of clinical oncology

Paulino DSM,Mendes MCS,Camargo JA,Brambilla SR,Wood Dos Santos T,Ribeiro ML,Carvalheira JBC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Thu Sep 24 00:00:00 EDT 2020

Graphene-based 2D constructs for enhanced fibroblast support.

PloS one

Safina I,Bourdo SE,Algazali KM,Kannarpady G,Watanabe F,Vang KB,Biris AS

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Tue Aug 04 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.

eLife

Lee J,Zhang J,Chung YJ,Kim JH,Kook CM,González-Navajas JM,Herdman DS,Nürnberg B,Insel PA,Corr M,Mo JH,Tao A,Yasuda K,Rifkin IR,Broide DH,Sciammas R,Webster NJ,Raz E

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat May 23 00:00:00 EDT 2020

Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.

International journal of molecular sciences

Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Jan 08 00:00:00 EST 2020

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells.

Cell reports

Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Mar 10 00:00:00 EDT 2020

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.

Cancers

Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro.

Frontiers in microbiology

Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.

International journal of molecular sciences

Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.

Cell reports

Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Jan 14 00:00:00 EST 2020

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.

Frontiers in immunology

Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jun 14 00:00:00 EDT 2021

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Cell death & disease

Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2020

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.

Cells

Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Dec 11 00:00:00 EST 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Cell

Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y

56-0441-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.

Thu Aug 22 00:00:00 EDT 2019

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Immunity

Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R

56-0441-82 was used in Flow Cytometry to identify a transcriptional program that links the CD4+ lineage with Tfh differentiation, a limiting factor for efficient B cell responses.

Tue Sep 17 00:00:00 EDT 2019

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circulation research

Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Dec 06 00:00:00 EST 2019

A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4⁺ T and Natural Killer Cells.

Cancer research

Barsoumian HB,Batra L,Shrestha P,Bowen WS,Zhao H,Egilmez NK,Gomez-Gutierrez JG,Yolcu ES,Shirwan H

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.

PLoS pathogens

Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

In vitro Characteristics of Heterogeneous Equine Hoof Progenitor Cell Isolates.

Frontiers in bioengineering and biotechnology

Yang Q,Pinto VMR,Duan W,Paxton EE,Dessauer JH,Ryan W,Lopez MJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Wed Sep 30 00:00:00 EDT 2020

In vitro Characteristics of Heterogeneous Equine Hoof Progenitor Cell Isolates.

Frontiers in bioengineering and biotechnology

Yang Q,Pinto VMR,Duan W,Paxton EE,Dessauer JH,Ryan W,Lopez MJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Wed Sep 30 00:00:00 EDT 2020

Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes.

Frontiers in endocrinology

Palhinha L,Liechocki S,Hottz ED,Pereira JADS,de Almeida CJ,Moraes-Vieira PMM,Bozza PT,Maya-Monteiro CM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jan 13 00:00:00 EST 2020

Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.

International journal of oncology

Ye W,Ni Z,Yicheng S,Pan H,Huang Y,Xiong Y,Liu T

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

Journal of immunology (Baltimore, Md. : 1950)

Kotov DI,Mitchell JS,Pengo T,Ruedl C,Way SS,Langlois RA,Fife BT,Jenkins MK

56-0441-82 was used in Flow Cytometry to study TCR affinity and influence on regulation of genes in naive T cells that control the differentiation process in cells.

Wed May 01 00:00:00 EDT 2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Journal of cellular and molecular medicine

Xu W,Xu R,Li Z,Wang Y,Hu R

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.

Cancer management and research

Gu J,Xu T,Huang QH,Zhang CM,Chen HY

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2020

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.

Molecular medicine reports

Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.

Experimental and therapeutic medicine

Lee H,Min SK,Park JB

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment.

Biology open

Sun Y,Ren Y,Yang F,He Y,Liang S,Guan L,Cheng F,Liu Y,Lin J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu May 02 00:00:00 EDT 2019

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.

EBioMedicine

Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regenerative medicine

Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.

Scientific reports

Hung JJ,Kao YS,Huang CH,Hsu WH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Feb 28 00:00:00 EST 2019

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.

Cell reports

Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM

56-0441-82 was used in Flow Cytometry to show that miR-15/16 restrict T cell cycle, survival, and memory T cell differentiation.

Tue Aug 20 00:00:00 EDT 2019

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.

Cancer cell international

Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

56-0441 was used in Flow cytometry/Cell sorting to investigate the underlying sex differences that may contribute to differential footpad delayed-type hypersensitivity responses using wildtype and four core genotypes mice and popliteal lymphnode cellularity and gene expression.

Wed Jan 30 00:00:00 EST 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Wed Jan 30 00:00:00 EST 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.

Cell reports

Colunga T,Hayworth M,Kreß S,Reynolds DM,Chen L,Nazor KL,Baur J,Singh AM,Loring JF,Metzger M,Dalton S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

IL-17 inhibits CXCL9/10-mediated recruitment of CD8⁺ cytotoxic T cells and regulatory T cells to colorectal tumors.

Journal for immunotherapy of cancer

Chen J,Ye X,Pitmon E,Lu M,Wan J,Jellison ER,Adler AJ,Vella AT,Wang K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Nov 27 00:00:00 EST 2019

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.

Scientific reports

Kim H,Lin Q,Yun Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4⁺ T Cells.

Current protocols in immunology

Kotov DI,Jenkins MK

56-0441 was used in Flow cytometry/Cell sorting to study polyclonal epitope-specific CD4+ T cells under physiological conditions.

Sat Jun 01 00:00:00 EDT 2019

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

International journal of molecular sciences

Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Conserved regulation of RNA processing in somatic cell reprogramming.

BMC genomics

Kanitz A,Syed AP,Kaji K,Zavolan M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jan 31 00:00:00 EST 2019

Non-conventional Inhibitory CD4⁺Foxp3^-PD-1^hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.

Cancer cell

Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD

56-0441-82 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.

Mon Jun 11 00:00:00 EDT 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Oncogene

Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Mar 06 00:00:00 EST 2018

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

The Journal of cell biology

Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

CCR7 on CD4⁺ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Belikan P,Bühler U,Wolf C,Pramanik GK,Gollan R,Zipp F,Siffrin V

56-0441 was used in Flow cytometry/Cell sorting to indicate a crucial role of CCR7 in neuroinflammation during the priming of autoimmune CD4+ T cells but not in the CNS.

Sun Apr 15 00:00:00 EDT 2018

Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer.

Nutrition and cancer

Silva I,Estrada MF,V Pereira C,da Silva AB,Bronze MR,Alves PM,Duarte CMM,Brito C,Serra AT

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunocytochemistry

Wed Apr 03 00:00:00 EDT 2019

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.

Experimental and therapeutic medicine

Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients.

Journal of experimental & clinical cancer research : CR

Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Wed Sep 12 00:00:00 EDT 2018

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.

Open life sciences

Wang H,Xiao Y,Su L,Cui N,Liu D

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Isolation and characterization of mesenchymal stem/stromal cells from Ctenomys minutus.

Genetics and molecular biology

Pereira MRJ,Pinhatti VR,Silveira MDD,Matzenbacher CA,Freitas TRO,Silva JD,Camassola M,Nardi NB

56-0441-82 was used in Flow cytometry/Cell sorting to show that the collection of biological information for biobanks represents an important contribution to the creation of strategies for prevention of loss of genetic diversity.

Thu Oct 01 00:00:00 EDT 2020

Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.

Oncotarget

Huang W,Bei L,Eklund EA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 25 00:00:00 EDT 2018

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.

eLife

Li J,Choi PS,Chaffer CL,Labella K,Hwang JH,Giacomelli AO,Kim JW,Ilic N,Doench JG,Ly SH,Dai C,Hagel K,Hong AL,Gjoerup O,Goel S,Ge JY,Root DE,Zhao JJ,Brooks AN,Weinberg RA,Hahn WC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jul 30 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.

Cell reports

Chiou NT,Kageyama R,Ansel KM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Dec 18 00:00:00 EST 2018

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction.

Immunity

Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

56-0441-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.

Tue Dec 19 00:00:00 EST 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Dec 11 00:00:00 EST 2017

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Cell stem cell

Ruetz T,Pfisterer U,Di Stefano B,Ashmore J,Beniazza M,Tian TV,Kaemena DF,Tosti L,Tan W,Manning JR,Chantzoura E,Ottosson DR,Collombet S,Johnsson A,Cohen E,Yusa K,Linnarsson S,Graf T,Parmar M,Kaji K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Dec 07 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Bierie B,Pierce SE,Kroeger C,Stover DG,Pattabiraman DR,Thiru P,Liu Donaher J,Reinhardt F,Chaffer CL,Keckesova Z,Weinberg RA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8⁺ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.

Chinese medical journal

Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.

Journal of immunology (Baltimore, Md. : 1950)

Zaid A,Hor JL,Christo SN,Groom JR,Heath WR,Mackay LK,Mueller SN

56-0441 was used in Flow cytometry/Cell sorting to examine the signals required for the migration of tissue-resident memory T cells within the constrained epidermal environment.

Sun Oct 01 00:00:00 EDT 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).

Stem cell reviews and reports

Suchorska WM,Augustyniak E,Richter M,Trzeciak T

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Nature communications

Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Theranostics

Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Apr 30 00:00:00 EDT 2018

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.

Oncotarget

Gao Z,Jin YQ,Wu W

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

PLoS biology

Kim BR,Van de Laar E,Cabanero M,Tarumi S,Hasenoeder S,Wang D,Virtanen C,Suzuki T,Bandarchi B,Sakashita S,Pham NA,Lee S,Keshavjee S,Waddell TK,Tsao MS,Moghal N

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.

Stem cells (Dayton, Ohio)

Park JW,Park JM,Park DM,Kim DY,Kim HK

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Song Y,Kumar V,Wei HX,Qiu J,Stanley P

56-0441 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.

Fri Jan 01 00:00:00 EST 2016

Helios Controls a Limited Subset of Regulatory T Cell Functions.

Journal of immunology (Baltimore, Md. : 1950)

Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM

56-0441 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.

Fri Jan 01 00:00:00 EST 2016

Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.

Molecular medicine reports

Shao J,Fan W,Ma B,Wu Y

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Thu Dec 01 00:00:00 EST 2016

Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.

Molecular medicine reports

Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.

Oncology letters

Hiraga T,Nakamura H

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.

Oncology letters

Zhang Y,Cabarcas SM,Zheng JI,Sun L,Mathews LA,Zhang X,Lin H,Farrar WL

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.

Stem cell reports

Quattrocelli M,Giacomazzi G,Broeckx SY,Ceelen L,Bolca S,Spaas JH,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Tue Jan 12 00:00:00 EST 2016

Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.

Stem cell reports

Quattrocelli M,Giacomazzi G,Broeckx SY,Ceelen L,Bolca S,Spaas JH,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Tue Jan 12 00:00:00 EST 2016

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

Nature communications

Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Dec 21 00:00:00 EST 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Nature communications

Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL

56-0441 was used in Flow cytometry/Cell sorting to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Thu Mar 03 00:00:00 EST 2016

The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.

BMC biology

Toneff MJ,Sreekumar A,Tinnirello A,Hollander PD,Habib S,Li S,Ellis MJ,Xin L,Mani SA,Rosen JM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jun 17 00:00:00 EDT 2016

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

Stem cell research & therapy

Camilleri ET,Gustafson MP,Dudakovic A,Riester SM,Garces CG,Paradise CR,Takai H,Karperien M,Cool S,Sampen HJ,Larson AN,Qu W,Smith J,Dietz AB,van Wijnen AJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Aug 11 00:00:00 EDT 2016

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget

Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Sep 20 00:00:00 EDT 2016

Anisotropic stress orients remodelling of mammalian limb bud ectoderm.

Nature cell biology

Lau K,Tao H,Liu H,Wen J,Sturgeon K,Sorfazlian N,Lazic S,Burrows JT,Wong MD,Li D,Deimling S,Ciruna B,Scott I,Simmons C,Henkelman RM,Williams T,Hadjantonakis AK,Fernandez-Gonzalez R,Sun Y,Hopyan S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Fri May 01 00:00:00 EDT 2015

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

The Journal of clinical investigation

Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

Cancer research

Zhang S,Chung WC,Wu G,Egan SE,Miele L,Xu K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Leptin receptor signaling in T cells is required for Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D

56-0441 was used in Flow cytometry/Cell sorting to show that leptin receptor signalling in T cells is required for Th17 differentiation.

Mon Jun 01 00:00:00 EDT 2015

Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.

Stem cells and development

Bauderlique-Le Roy H,Vennin C,Brocqueville G,Spruyt N,Adriaenssens E,Bourette RP

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.

Stem cells and development

Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses.

Toxicological sciences : an official journal of the Society of Toxicology

Marshall NB,Lukomska E,Long CM,Kashon ML,Sharpnack DD,Nayak AP,Anderson KL,Jean Meade B,Anderson SE

56-0441 was used in Flow cytometry/Cell sorting to examine the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses.

Tue Sep 01 00:00:00 EDT 2015

Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.

Molecular medicine reports

Sun Z,Zhang C,Zou X,Jiang G,Xu Z,Li W,Xie H

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.

PloS one

Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.

PloS one

Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

Reprogramming Roadblocks Are System Dependent.

Stem cell reports

Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.

Stem cell research & therapy

Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat May 09 00:00:00 EDT 2015

Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.

Journal of virology

Boyoglu-Barnum S,Chirkova T,Todd SO,Barnum TR,Gaston KA,Jorquera P,Haynes LM,Tripp RA,Moore ML,Anderson LJ

56-0441 was used in Flow cytometry/Cell sorting to suggest that the RSV G protein not only contributes to disease, but also dampens the host immune response to infection.

Mon Sep 01 00:00:00 EDT 2014

Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice.

Journal of immunology (Baltimore, Md. : 1950)

Lucca LE,Desbois S,Ramadan A,Ben-Nun A,Eisenstein M,Carrié N,Guéry JC,Sette A,Nguyen P,Geiger TL,Mars LT,Liblau RS

56-0441 was used in Flow cytometry/Cell sorting to assess whether cross-reactivity is a common feature of the myelin oligodendrocyte glycoprotein epitope 35-55-specific T cell response.

Wed Oct 01 00:00:00 EDT 2014

An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G

56-0441 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.

Sat Mar 15 00:00:00 EDT 2014

Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.

Journal of immunology (Baltimore, Md. : 1950)

Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

56-0441 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.

Fri Aug 01 00:00:00 EDT 2014

Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.

Tissue engineering. Part A

Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2014

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.

Neoplasia (New York, N.Y.)

Zhang S,Chung WC,Wu G,Egan SE,Xu K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2014

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Oncotarget

Wei HJ,Nickoloff JA,Chen WH,Liu HY,Lo WC,Chang YT,Yang PC,Wu CW,Williams DF,Gelovani JG,Deng WP

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Wed Oct 15 00:00:00 EDT 2014

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.

Cancer cell international

Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Mar 03 00:00:00 EST 2014

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.

Nature

O'Malley J,Skylaki S,Iwabuchi KA,Chantzoura E,Ruetz T,Johnsson A,Tomlinson SR,Linnarsson S,Kaji K

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2013

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.

Nature immunology

Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D

56-0441 was used in Flow cytometry/Cell sorting to demonstrate plasticity in the CD4(+) T cell lineage that allows chronic exposure to luminal antigens without pathological inflammation.

Fri Mar 01 00:00:00 EST 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.

The Journal of experimental medicine

Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

56-0441 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.

Mon Apr 08 00:00:00 EDT 2013

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.

Cancer research

Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast cancer research : BCR

Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Dec 08 00:00:00 EST 2014

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sosunov AA,Guilfoyle E,Wu X,McKhann GM,Goldman JE

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Wed Apr 24 00:00:00 EDT 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Mon Apr 01 00:00:00 EDT 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Mon Apr 01 00:00:00 EDT 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Mon Apr 01 00:00:00 EDT 2013

Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Stem cells (Dayton, Ohio)

Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Stem cells (Dayton, Ohio)

Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.

Cancer cell international

Yan W,Chen Y,Yao Y,Zhang H,Wang T

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Mon Jun 24 00:00:00 EDT 2013

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

PloS one

Wu S,Ju GQ,Du T,Zhu YJ,Liu GH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue Oct 22 00:00:00 EDT 2013

Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.

Journal of virology

Seedhom MO,Mathurin KS,Kim SK,Welsh RM

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2012

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Thu Nov 01 00:00:00 EDT 2012

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Thu Nov 01 00:00:00 EDT 2012

Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ

56-0441 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.

Tue May 01 00:00:00 EDT 2012

Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL

56-0441 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.

Sun Jan 01 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Fluorescence Resonance Energy Transfer (FRET)

Fri Dec 14 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Fluorescence Resonance Energy Transfer (FRET)

Fri Dec 14 00:00:00 EST 2012

Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.

PLoS biology

Younes SA,Punkosdy G,Caucheteux S,Chen T,Grossman Z,Paul WE

56-0441 was used in Flow cytometry/Cell sorting to identify and characterise two sub-populations of memory T cells.

Sat Oct 01 00:00:00 EDT 2011

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice.

European journal of immunology

Smithey MJ,Renkema KR,Rudd BD,Nikolich-Žugich J

56-0441 was used in Flow cytometry/Cell sorting to show that C57BL/6 (B6) mice exhibit an age-dependent reduction in survival, with delayed bacterial clearance in old animals.

Sun May 01 00:00:00 EDT 2011

GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.

PloS one

Nadendla SK,Hazan A,Ward M,Harper LJ,Moutasim K,Bianchi LS,Naase M,Ghali L,Thomas GJ,Prowse DM,Philpott MP,Neill GW

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2011

PTEN loss accelerates KrasG12D-induced pancreatic cancer development.

Cancer research

Hill R,Calvopina JH,Kim C,Wang Y,Dawson DW,Donahue TR,Dry S,Wu H

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunohistochemistry

Wed Sep 15 00:00:00 EDT 2010

CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury.

Differentiation; research in biological diversity

Desai VD,Wang Y,Simirskii VN,Duncan MK

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Immunofluorescence

Mon Feb 01 00:00:00 EST 2010

iNKT cell development is orchestrated by different branches of TGF-beta signaling.

The Journal of experimental medicine

Doisne JM,Bartholin L,Yan KP,Garcia CN,Duarte N,Le Luduec JB,Vincent D,Cyprian F,Horvat B,Martel S,Rimokh R,Losson R,Benlagha K,Marie JC

56-0441 was used in Flow cytometry/Cell sorting to show that TGF-beta controls the differentiation program of iNKT cells.

Mon Jun 08 00:00:00 EDT 2009

Tracking epitope-specific T cells.

Nature protocols

Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK

56-0441 was used in Flow cytometry/Cell sorting to track epitope-specific T cells.

Tue Jun 30 00:00:00 EDT 2009

Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.

PloS one

Meunier MC,Baron C,Perreault C

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Fri Feb 13 00:00:00 EST 2009

Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.

The open stem cell journal

Maddox JR,Liao X,Li F,Niyibizi C

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.

Infection and immunity

Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH

Published figure using CD44 monoclonal antibody (Product # 56-0441-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

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Gene Aliases: AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1

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UniProt ID: (Human) Q16064, (Mouse) P15379

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Entrez Gene ID: (Human) 960, (Mouse) 12505

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Function(s)

cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signal receptor

Process(es)

cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis

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CD44 Monoclonal Antibody (IM7), Alexa Fluor™ 700, eBioscience™

CD44 Antibody (56-0441-82) in Flow

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56-0441-82

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