Product References
Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats.
Journal of biochemical and molecular toxicology
Peng H,Lv Y,Li C,Cheng Z,He S,Wang C,Liu J
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Fri Sep 01 00:00:00 EDT 2023
Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.
JCI insight
Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Feb 08 00:00:00 EST 2023
Single-cell RNA sequencing reveals the molecular features of peripheral blood immune cells in children, adults and centenarians.
Frontiers in immunology
Zhong J,Ding R,Jiang H,Li L,Wan J,Feng X,Chen M,Peng L,Li X,Lin J,Yang H,Wang M,Li Q,Chen Q
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Jan 30 00:00:00 EST 2023
Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.
Nature communications
McEvoy CM,Murphy JM,Zhang L,Clotet-Freixas S,Mathews JA,An J,Karimzadeh M,Pouyabahar D,Su S,Zaslaver O,Röst H,Arambewela R,Liu LY,Zhang S,Lawson KA,Finelli A,Wang B,MacParland SA,Bader GD,Konvalinka A,Crome SQ
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sat Dec 10 00:00:00 EST 2022
Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.
Cell discovery
Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue May 10 00:00:00 EDT 2022
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
Nature communications
Ramirez NP,Lee J,Zheng Y,Li L,Dennis B,Chen D,Challa A,Planelles V,Westover KD,Alto NM,D'Orso I
45-0049-42 was used in Flow Cytometry to define ADAP1 as an unexpected tuner of T cell programs facilitating HIV-1 latency escape.
Tue Mar 01 00:00:00 EST 2022
Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells.
Biomolecules & therapeutics
Yoon H,Sung JH,Song MJ
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation.
Cancers
Prat M,Salon M,Allain T,Dubreuil O,Noël G,Preisser L,Jean B,Cassard L,Lemée F,Tabah-Fish I,Pipy B,Jeannin P,Prost JF,Barret JM,Coste A
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Molecular therapy. Methods & clinical development
Kierkels GJJ,van Diest E,Hernández-López P,Scheper W,de Bruin ACM,Frijlink E,Aarts-Riemens T,van Dooremalen SFJ,Beringer DX,Oostvogels R,Kramer L,Straetemans T,Uckert W,Sebestyén Z,Kuball J
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Fri Sep 10 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Oct 21 00:00:00 EDT 2021
Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV.
Journal of neurochemistry
Gorska AM,Donoso M,Valdebenito S,Prideaux B,Queen S,Scemes E,Clements J,Eugenin E
45-0049-42 was used in Flow cytometry/Cell sorting to determine the contribution of Panx-1 to HIV and NeuroHIV.
Thu Jul 01 00:00:00 EDT 2021
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Immunity
Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA
45-0049-42 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.
Tue Dec 15 00:00:00 EST 2020
Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Thomas R,Shaath H,Naik A,Toor SM,Elkord E,Decock J
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.
The Journal of international medical research
He J,Xu Y,Yi M,Gu C,Zhu Y,Hu G
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
JCI insight
Imura Y,Ando M,Kondo T,Ito M,Yoshimura A
45-0049 was used in Flow cytometry/Cell sorting to suggest that CD19-CAR regulatory T cells can treat autoantibody-mediated autoimmune diseases by suppressing B cell pathology.
Thu Jul 23 00:00:00 EDT 2020
Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells.
Journal of biological methods
Manuszak C,Brainard M,Thrash E,Hodi FS,Severgnini M
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo.
Molecular medicine reports
Lv M,Li Z,Liu J,Lin F,Zhang Q,Li Z,Wang Y,Wang K,Xu Y
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Cell
Bradley T,Peppa D,Pedroza-Pacheco I,Li D,Cain DW,Henao R,Venkat V,Hora B,Chen Y,Vandergrift NA,Overman RG,Edwards RW,Woods CW,Tomaras GD,Ferrari G,Ginsburg GS,Connors M,Cohen MS,Moody MA,Borrow P,Haynes BF
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Oct 04 00:00:00 EDT 2018
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Evaluation of a combination "lymphocyte apoptosis model" to predict survival of sepsis patients in an intensive care unit.
BMC anesthesiology
Jiang W,Zhong W,Deng Y,Chen C,Wang Q,Zhou M,Li X,Sun C,Zeng H
45-0049 was used in Flow cytometry/Cell sorting to postulate that a panel of biomarkers of lymphocyte apoptosis and immune function, termed the "lymphocyte apoptosis model," would be an effective tool for predicting 28-day survival for sepsis patients.
Wed Jul 18 00:00:00 EDT 2018
Survival, Retention, and Selective Proliferation of Lymphocytes Is Mediated by Gingival Fibroblasts.
Frontiers in immunology
Moonen CGJ,Alders ST,Bontkes HJ,Schoenmaker T,Nicu EA,Loos BG,de Vries TJ
45-0049 was used in Flow cytometry/Cell sorting to study the cellular interactions of gingival fibroblasts with immune cells and their role in lymphocyte proliferation.
Mon Sep 16 00:00:00 EDT 2019
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
Cell
Horwitz JA,Bar-On Y,Lu CL,Fera D,Lockhart AAK,Lorenzi JCC,Nogueira L,Golijanin J,Scheid JF,Seaman MS,Gazumyan A,Zolla-Pazner S,Nussenzweig MC
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Aug 10 00:00:00 EDT 2017
Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
Cell
Van Dyken SJ,Liang HE,Naikawadi RP,Woodruff PG,Wolters PJ,Erle DJ,Locksley RM
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Apr 20 00:00:00 EDT 2017
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis.
Frontiers in immunology
Hou TY,Chen MR,Chou YC,Kan PC,Tsai YT,Cha TL
45-0049 was used in Flow cytometry/Cell sorting to investigate the function of enhancer of zeste homolog 2 in human Th1 and Th2 cell differentiation, and its association with allergic rhinitis.
Wed Nov 20 00:00:00 EST 2019
Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.
Journal of leukocyte biology
de Bourayne M,Gallais Y,El Ali Z,Rousseau P,Damiens MH,Cochet C,Filhol O,Chollet-Martin S,Pallardy M,Kerdine-Römer S
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
45-0049 was used in Flow cytometry/Cell sorting to establish the potential of interleukin-2 to enhance regulatory T cell therapy in autoimmune liver disease.
Thu Jun 01 00:00:00 EDT 2017
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Zanin-Zhorov A,Weiss JM,Trzeciak A,Chen W,Zhang J,Nyuydzefe MS,Arencibia C,Polimera S,Schueller O,Fuentes-Duculan J,Bonifacio KM,Kunjravia N,Cueto I,Soung J,Fleischmann RM,Kivitz A,Lebwohl M,Nunez M,Woodson J,Smith SL,West RF,Berger M,Krueger JG,Ryan JL,Waksal SD
45004942 was used in flow cytometry to find that oral administration of a selective Rho-associated kinase 2 inhibitor, KD025, reduces psoriasis area in 46% of patients with psoriasis vulgaris
Mon May 15 00:00:00 EDT 2017
CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer.
JCI insight
Gu-Trantien C,Migliori E,Buisseret L,de Wind A,Brohée S,Garaud S,Noël G,Dang Chi VL,Lodewyckx JN,Naveaux C,Duvillier H,Goriely S,Larsimont D,Willard-Gallo K
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Fri Jun 02 00:00:00 EDT 2017
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions.
JCI insight
Gunnarsen KS,Høydahl LS,Risnes LF,Dahal-Koirala S,Neumann RS,Bergseng E,Frigstad T,Frick R,du Pré MF,Dalhus B,Lundin KE,Qiao SW,Sollid LM,Sandlie I,Løset GÅ
45-0049 was used in Flow cytometry/Cell sorting to study the molecular basis underlying the selection of T cell receptor repertoires.
Thu Sep 07 00:00:00 EDT 2017
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Proceedings of the National Academy of Sciences of the United States of America
Jönsson P,Southcombe JH,Santos AM,Huo J,Fernandes RA,McColl J,Lever M,Evans EJ,Hudson A,Chang VT,Hanke T,Godkin A,Dunne PD,Horrocks MH,Palayret M,Screaton GR,Petersen J,Rossjohn J,Fugger L,Dushek O,Xu XN,Davis SJ,Klenerman D
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium.
PLoS pathogens
Pachnio A,Ciaurriz M,Begum J,Lal N,Zuo J,Beggs A,Moss P
45-0049 was used in Flow cytometry/Cell sorting to reveal the marked accumulation and unique phenotype of CMV-specific CD4+ T cells.
Thu Sep 01 00:00:00 EDT 2016
Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion.
Arthritis research & therapy
Noack M,Ndongo-Thiam N,Miossec P
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Jun 23 00:00:00 EDT 2016
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.
Molecular medicine reports
Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Experimental and therapeutic medicine
Zhao J,Ma J,Zhang X,Li Q,Yang X
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Scientific reports
Kumar A,Abbas W,Colin L,Khan KA,Bouchat S,Varin A,Larbi A,Gatot JS,Kabeya K,Vanhulle C,Delacourt N,Pasquereau S,Coquard L,Borch A,König R,Clumeck N,De Wit S,Rohr O,Rouzioux C,Fulop T,Van Lint C,Herbein G
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2016
Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.
Stem cell reports
Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Oct 11 00:00:00 EDT 2016
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.
Oncoimmunology
Hirayama M,Tomita Y,Yuno A,Tsukamoto H,Senju S,Imamura Y,Sayem MA,Irie A,Yoshitake Y,Fukuma D,Shinohara M,Hamada A,Jono H,Yuba E,Kono K,Yoshida K,Tsunoda T,Nakayama H,Nishimura Y
45-0049 was used in Flow cytometry/Cell sorting to investigate the potential usefulness of IMP-3-LPs in propagating both Th cells and CTLs.
Wed Jun 01 00:00:00 EDT 2016
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Oncotarget
Abd Al Samid M,Chaudhary B,Khaled YS,Ammori BJ,Elkord E
45-0049 was used in Flow cytometry/Cell sorting to demonstrate that studying a combination of Treg-specific markers could be used to more accurately determine expanded Treg subsets and to understand their contribution in cancer settings.
Tue Mar 22 00:00:00 EDT 2016
B cells from African American lupus patients exhibit an activated phenotype.
JCI insight
Menard LC,Habte S,Gonsiorek W,Lee D,Banas D,Holloway DA,Manjarrez-Orduno N,Cunningham M,Stetsko D,Casano F,Kansal S,Davis PM,Carman J,Zhang CK,Abidi F,Furie R,Nadler SG,Suchard SJ
45-0049 was used in Flow cytometry/Cell sorting to investigate immunological differences between African American and European American patients with systemic lupus erythematosus, showing that B cells from African American patients exhibit an activated phenotype.
Thu Jun 16 00:00:00 EDT 2016
DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.
Human molecular genetics
Volk T,Pannicke U,Reisli I,Bulashevska A,Ritter J,Björkman A,Schäffer AA,Fliegauf M,Sayar EH,Salzer U,Fisch P,Pfeifer D,Di Virgilio M,Cao H,Yang F,Zimmermann K,Keles S,Caliskaner Z,Güner SÜ,Schindler D,Hammarström L,Rizzi M,Hummel M,Pan-Hammarström Q,Schwarz K,Grimbacher B
45-0049 was used in Flow cytometry/Cell sorting to investigate the range of phenotypes associated with DCLRE1C (ARTEMIS) mutations in humans.
Sun Dec 20 00:00:00 EST 2015
Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Ly J,Lagman M,Saing T,Singh MK,Tudela EV,Morris D,Anderson J,Daliva J,Ochoa C,Patel N,Pearce D,Venketaraman V
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2015
Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease.
Autoimmunity
Burns JC,Touma R,Song Y,Padilla RL,Tremoulet AH,Sidney J,Sette A,Franco A
45-0049 was used in Flow cytometry/Cell sorting to demonstrate an approach to expand the fragment crystallisable region-specific nTreg population to prevent the development of coronary artery abnormalities.
Fri May 01 00:00:00 EDT 2015
Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma.
Oncoimmunology
Partlová S,Bouček J,Kloudová K,Lukešová E,Zábrodský M,Grega M,Fučíková J,Truxová I,Tachezy R,Špíšek R,Fialová A
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
Investigating the causes for decreased levels of glutathione in individuals with type II diabetes.
PloS one
Lagman M,Ly J,Saing T,Kaur Singh M,Vera Tudela E,Morris D,Chi PT,Ochoa C,Sathananthan A,Venketaraman V
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Dec 30 00:00:00 EST 2015
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.
PloS one
Klarenbeek PL,Doorenspleet ME,Esveldt RE,van Schaik BD,Lardy N,van Kampen AH,Tak PP,Plenge RM,Baas F,de Bakker PI,de Vries N
45-0049 was used in Flow cytometry/Cell sorting to investigate how a single T cell commits to become either CD4+ or CD8+.
Wed Jun 08 00:00:00 EDT 2016
Immune cell subsets and their gene expression profiles from human PBMC isolated by Vacutainer Cell Preparation Tube (CPT™) and standard density gradient.
BMC immunology
Corkum CP,Ings DP,Burgess C,Karwowska S,Kroll W,Michalak TI
45-0049 was used in Flow cytometry/Cell sorting to assess and compare the ability of two isolation protocols to purify high quality immune cell subpopulations.
Wed Aug 26 00:00:00 EDT 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
45-0049 was used in Flow cytometry/Cell sorting to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
45-0049 was used in Flow cytometry/Cell sorting to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
Immune response to JC virus T antigen in patients with and without colorectal neoplasia.
Gut microbes
Butcher LD,Garcia M,Arnold M,Ueno H,Goel A,Boland CR
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.
Cancer immunology, immunotherapy : CII
Panni RZ,Sanford DE,Belt BA,Mitchem JB,Worley LA,Goetz BD,Mukherjee P,Wang-Gillam A,Link DC,Denardo DG,Goedegebuure SP,Linehan DC
45-0049 was used in Flow cytometry/Cell sorting to suggest that targeting STAT3 activation may be an effective therapeutic strategy in targeting cancer stem cells in PC.
Thu May 01 00:00:00 EDT 2014
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
mAbs
Thaventhiran T,Alhumeed N,Yeang HX,Sethu S,Downey JS,Alghanem AF,Olayanju A,Smith EL,Cross MJ,Webb SD,Williams DP,Bristow A,Ball C,Stebbings R,Sathish JG
45-0049 was used in Flow cytometry/Cell sorting to understand the underlying molecular mechanisms of T-cell activation in response to TGN1412-like CD28 superagonist, showing that failure to upregulate the inhibitory PD-1 cell surface receptor is part of this mechanism.
Mon Aug 24 00:00:00 EDT 2015
OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Graves AJ,Padilla MG,Hokey DA
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Nature communications
Willmann KL,Klaver S,Doğu F,Santos-Valente E,Garncarz W,Bilic I,Mace E,Salzer E,Conde CD,Sic H,Májek P,Banerjee PP,Vladimer GI,Haskoloğlu S,Bolkent MG,Küpesiz A,Condino-Neto A,Colinge J,Superti-Furga G,Pickl WF,van Zelm MC,Eibel H,Orange JS,Ikincioğulları A,Boztuğ K
45-0049 was used in Flow cytometry/Cell sorting to study the effect of a biallelic mutation in the gene encoding NF-κB-inducing kinase on immune cell populations.
Wed Nov 19 00:00:00 EST 2014
Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Tezgel AÖ,Gonzalez-Perez G,Telfer JC,Osborne BA,Minter LM,Tew GN
45-0049 was used in Flow cytometry/Cell sorting to develop a novel system for intracellular delivery of siRNA molecules.
Tue Jan 01 00:00:00 EST 2013
Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.
Cancer immunology research
Choi BD,Gedeon PC,Herndon JE,Archer GE,Reap EA,Sanchez-Perez L,Mitchell DA,Bigner DD,Sampson JH
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2013
Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.
The Journal of infectious diseases
Dutra MS,Béla SR,Peixoto-Rangel AL,Fakiola M,Cruz AG,Gazzinelli A,Quites HF,Bahia-Oliveira LM,Peixe RG,Campos WR,Higino-Rocha AC,Miller NE,Blackwell JM,Antonelli LR,Gazzinelli RT
45-0049 was used in Flow cytometry/Cell sorting to suggest that NOD2 influences the production of IL-17A by CD4 T lymphocytes and might contribute to the development of ocular toxoplasmosis.
Tue Jan 01 00:00:00 EST 2013
Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy.
PloS one
Fernandes C,Gonçalves HS,Cabral PB,Pinto HC,Pinto MI,Câmara LM
45-0049 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in leprosy in individuals under 15 years old.
Mon Aug 18 00:00:00 EDT 2014
Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome.
PloS one
Zhang L,Wang T,Wang XQ,Du RZ,Zhang KN,Liu XG,Ma DX,Yu S,Su GH,Li ZH,Guan YQ,Du NL
45-0049 was used in Flow cytometry/Cell sorting to investigate the roles and profiles of T helper cells in the pathogenesis of inflammatory heart diseases.
Mon Aug 18 00:00:00 EDT 2014
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
45-0049 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease.
The Journal of pediatrics
Tremoulet AH,Pancoast P,Franco A,Bujold M,Shimizu C,Onouchi Y,Tamamoto A,Erdem G,Dodd D,Burns JC
45-0049 was used in Flow cytometry/Cell sorting to investigate treatment of refractory KD with a calcineurin inhibitor.
Sat Sep 01 00:00:00 EDT 2012
Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis.
Journal of immunological methods
Vicetti Miguel RD,Maryak SA,Cherpes TL
45-0049 was used in Flow cytometry/Cell sorting to compare the ability of brefeldin A and monensin to concurrently trap 4 cytokines within peripheral blood mononuclear cells.
Wed Oct 31 00:00:00 EDT 2012
Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis.
PloS one
Zhang L,Li YG,Li YH,Qi L,Liu XG,Yuan CZ,Hu NW,Ma DX,Li ZF,Yang Q,Li W,Li JM
45-0049 was used in Immunohistochemistry to suggest that Th22 cells and Th17 cells may be implicated in the pathogenesis of ankylosing spondylitis and rheumatoid arthritis.
Fri Jul 27 00:00:00 EDT 2012
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.
Critical care (London, England)
Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Wed Dec 07 00:00:00 EST 2011
Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.
Molecular pharmaceutics
Park J,Gao W,Whiston R,Strom TB,Metcalfe S,Fahmy TM
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Feb 07 00:00:00 EST 2011
Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease.
Autoimmunity
Franco A,Shimizu C,Tremoulet AH,Burns JC
45-0049 was used in Flow cytometry/Cell sorting to provide insight into the nature and kinetics of the adaptive immune response in Kawasaki disease.
Tue Jun 01 00:00:00 EDT 2010
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Journal of leukocyte biology
Unsinger J,McDonough JS,Shultz LD,Ferguson TA,Hotchkiss RS
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2009
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.
Retrovirology
Brudek T,Christensen T,Aagaard L,Petersen T,Hansen HJ,Møller-Larsen A
Published figure using CD4 monoclonal antibody (Product # 45-0049-42) in Flow Cytometry
Mon Nov 16 00:00:00 EST 2009
