Invitrogen

CD4 Monoclonal Antibody (RM4-5), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

96 Published Figures

318 References

View all (606) CD4 antibodies

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CD4 Antibody (11-0042-82) in Flow

Staining of C57BL/6 splenocytes with Anti-Mouse CD3e PE (Product # 12-0031-82) and 0.125 µg of Rat IgG2a K Isotype Control FITC (Product # 11-4321-42) (left) or 0.125 µg of Anti-Mouse CD4 FITC (right). Cells in the lymphocyte gate were used for analysis.

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes and bone marrow cells. Right: As expected based on known relative expression patterns, CD4 clone RM4-5 stains a subset of splenocytes and does not stain any bone marrow cells. Details: Balb/c bone marrow cells (left) and splenocytes (middle) were surface stained with CD4 (clone RM4-5) followed by staining with 7-AAD. Viable bone marrow cells in the lymphoid (blue histogram) and myeloid (purple histogram) gates and viable splenocytes (orange histogram) were used for analysis. {RE}

Product Details

11-0042-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 2 publications 2 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Flow Cytometry (Flow)

0.25 µg/test

View 292 publications 292 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

RM4-5

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_464896

Product Specific Information

Description: The RM4-5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of RM4-5 is blocked by GK1.5.

Applications Reported: The RM4-5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The RM4-5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Product References

Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.

Brain, behavior, & immunity - health

Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2023

Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.

EMBO molecular medicine

Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2023

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.

Cell death & disease

Zhuang W,Zhou J,Zhong L,Lv J,Zhong X,Liu G,Xie L,Wang C,Saimaier K,Han S,Shi C,Hua Q,Zhang R,Xie X,Du C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Sep 14 00:00:00 EDT 2023

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.

Investigative ophthalmology & visual science

Galletti JG,Scholand KK,Trujillo-Vargas CM,Haap W,Santos-Ferreira T,Ullmer C,Yu Z,de Paiva CS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Platelet factors attenuate inflammation and rescue cognition in ageing.

Nature

Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Feb 23 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis.

Pharmaceutical biology

Zhao W,Yu HH,Meng WW,Liu AM,Zhang BX,Wang Y,Li J,Wang L,Fang YF

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2023

Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.

Cell metabolism

Becker M,Joseph SS,Garcia-Carrizo F,Tom RZ,Opaleva D,Serr I,Tschöp MH,Schulz TJ,Hofmann SM,Daniel C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Oct 03 00:00:00 EDT 2023

Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.

British journal of pharmacology

Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Palmitoyl transferases act as novel drug targets for pancreatic cancer.

Journal of translational medicine

Lin Z,Lv Z,Liu X,Huang K

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Apr 10 00:00:00 EDT 2023

NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.

iScience

Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME

11-0042-82 was used in Flow Cytometry to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.

Fri Mar 17 00:00:00 EDT 2023

SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.

Cell communication and signaling : CCS

Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Mar 02 00:00:00 EST 2023

Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner.

iScience

Pan N,Xiu L,Xu Y,Bao X,Liang Y,Zhang H,Liu B,Feng Y,Guo H,Wu J,Li H,Ma C,Sheng S,Wang T,Wang X

11-0042-82 was used in Flow Cytometry to find that neutrophil recruitment via IL-17A-mediated signaling was required for host defense against S. aureus-induced mastitis in a mouse model.

Fri Dec 15 00:00:00 EST 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2023

Complete Freund's Adjuvant Induces a Fibroblast-like Synoviocytes (FLS) Metabolic and Migratory Phenotype in Resident Fibroblasts of the Inoculated Footpad at the Earliest Stage of Adjuvant-Induced Arthritis.

Cells

González-Chávez SA,Chaparro-Barrera E,Alvarado-Jáquez MF,Cuevas-Martínez R,Ochoa-Albíztegui RE,Pacheco-Tena C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Wed Mar 08 00:00:00 EST 2023

Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice.

Current microbiology

Tang T,Wang F,Liu J,Ye W,Zhao T,Li Z

11-0042-82 was used in Flow Cytometry to show that rhubarb promoted Alistipes, Clostridium, and Lactobacillus proliferation, increased the HDAC6 concentration, restored the Th17/Treg cell balance, and protected against acute lung injury.

Sat Feb 26 00:00:00 EST 2022

Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.

Cell & bioscience

Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Apr 23 00:00:00 EDT 2022

IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.

Nature communications

Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Nov 12 00:00:00 EST 2022

Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.

The Journal of biological chemistry

Matsumoto K,Kumar V,Varshney S,Nairn AV,Ito A,Pennarubia F,Moremen KW,Stanley P,Haltiwanger RS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2022

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling.

Nature communications

Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling.

Nature communications

Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis.

Theranostics

Yao RQ,Li ZX,Wang LX,Li YX,Zheng LY,Dong N,Wu Y,Xia ZF,Billiar TR,Ren C,Yao YM

11-0042-82 was used in Flow cytometry/Cell sorting to find a conserved and potentially targetable immunoregulatory program within DCs that associates with hyperinflammation and organ dysfunction early following sepsis induction.

Fri Jul 15 00:00:00 EDT 2022

BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.

Blood

Zaiken MC,Flynn R,Paz KG,Rhee SY,Jin S,Mohamed FA,Saha A,Thangavelu G,Park PMC,Hemming ML,Sage PT,Sharpe AH,DuPage M,Bluestone JA,Panoskaltsis-Mortari A,Cutler CS,Koreth J,Antin JH,Soiffer RJ,Ritz J,Luznik L,Maillard I,Hill GR,MacDonald KPA,Munn DH,Serody JS,Murphy WJ,Kean LS,Zhang Y,Bradner JE,Qi J,Blazar BR

11-0042-82 was used in Immunohistochemistry (Frozen) to demonstrate that EZH2 is obligatory for the initiation of cGVHD/BO.

Thu May 12 00:00:00 EDT 2022

Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention.

Frontiers in immunology

Ryan NM,Lamenza FF,Upadhaya P,Pracha H,Springer A,Swingler M,Siddiqui A,Oghumu S

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry (Paraffin)

Mon Aug 29 00:00:00 EDT 2022

SYK coordinates neuroprotective microglial responses in neurodegenerative disease.

Cell

Ennerfelt H,Frost EL,Shapiro DA,Holliday C,Zengeler KE,Voithofer G,Bolte AC,Lammert CR,Kulas JA,Ulland TK,Lukens JR

11-0042-82 was used in flow cytometry to study the critical intracellular molecules that orchestrate neuroprotective functions of microglia.

Thu Oct 27 00:00:00 EDT 2022

Galectin-9 Mediates the Therapeutic Effect of Mesenchymal Stem Cells on Experimental Endotoxemia.

Frontiers in cell and developmental biology

Zhao Y,Yu D,Wang H,Jin W,Li X,Hu Y,Qin Y,Kong D,Li G,Ellen A,Wang H

11-0042-82 was used in Flow cytometry/Cell sorting to reveal that the optimized immunoregulatory effect of MSCs is strongly correlated with Gal-9 high expression, which provides a novel idea for the investigation of MSC immunomodulatory mechanisms and offers a potential strategy for the treatment of endotoxemia in clinical settings.

Wed Mar 09 00:00:00 EST 2022

A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.

Cancer discovery

Wei SC,Meijers WC,Axelrod ML,Anang NAS,Screever EM,Wescott EC,Johnson DB,Whitley E,Lehmann L,Courand PY,Mancuso JJ,Himmel LE,Lebrun-Vignes B,Wleklinski MJ,Knollmann BC,Srinivasan J,Li Y,Atolagbe OT,Rao X,Zhao Y,Wang J,Ehrlich LIR,Sharma P,Salem JE,Balko JM,Moslehi JJ,Allison JP

11-0042 was used in Flow cytometry/Cell sorting to report a robust preclinical mouse model ofiImmune checkpoint inhibitors-associated myocarditis in which mono-allelic loss of Ctla4 in the context of complete genetic absence of Pdcd1 leads to premature death in approximately half of mice.

Mon Mar 01 00:00:00 EST 2021

Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.

The Journal of experimental medicine

Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Apr 05 00:00:00 EDT 2021

Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.

The Journal of experimental medicine

Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Apr 05 00:00:00 EDT 2021

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.

Journal of autoimmunity

Bogie JFJ,Vanmierlo T,Vanmol J,Timmermans S,Mailleux J,Nelissen K,Wijnands E,Wouters K,Stinissen P,Gustafsson JÅ,Steffensen KR,Mulder M,Zelcer N,Hendriks JJA

11-0042-82 was used in Flow cytometry/Cell sorting to show that LXRα and LXRβ have an opposite impact on immune cell function and disease severity in the experimental autoimmune encephalomyelitis model, an experimental multiple sclerosis model.

Mon Nov 01 00:00:00 EDT 2021

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.

Cancer immunology, immunotherapy : CII

Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice.

Mediators of inflammation

Chen J,Yang F,Shi S,Liu X,Qin F,Wei X,Huang Y,Liang W,Miao L

11-0042-82 was used in Flow Cytometry to demonstrate a key role of the NLRP3 inflammasome and its close relationship with Th17 in the pathological progression of coxsackievirus B3-induced viral myocarditis.

Wed Dec 22 00:00:00 EST 2021

Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios⁺Foxp3⁺ Tregs in clinical and experimental acute respiratory distress syndrome.

Molecular immunology

Wang C,Xie K,Li K,Lin S,Xu F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System.

BioMed research international

Choi JH,Kim JY,Yi MH,Kim M,Yong TS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jan 12 00:00:00 EST 2022

Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.

Journal of veterinary science

Park SG,An JH,Li Q,Chae HK,Park SM,Lee JH,Ahn JO,Song WJ,Youn HY

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.

Theranostics

Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Aug 04 00:00:00 EDT 2021

Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.

Oncoimmunology

Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.

Vaccines

Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Apr 02 00:00:00 EDT 2021

Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.

Frontiers in microbiology

Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed May 26 00:00:00 EDT 2021

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine

Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept.

Frontiers in immunology

Santopaolo M,Sullivan N,Thomas AC,Alvino VV,Nicholson LB,Gu Y,Spinetti G,Kallikourdis M,Blom A,Madeddu P

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jul 02 00:00:00 EDT 2021

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.

Nature communications

Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model.

Drug development research

Gao J,Wang S,Liu S

11-0042-82 was used in Flow cytometry/Cell sorting to indicate that the coronary endothelial inflammation triggered TNFSF18 expression, which promoted p-STAT1 phosphorylation to activate the proteins VCAM1, ICAM1, ITGAD and ITGB3, thus exacerbating coronary microcirculation disorder in atherosclerotic mouse model.

Mon Feb 01 00:00:00 EST 2021

Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L infantum infection.

Parasite immunology

Carvalho LM,de Brito RCF,Gusmão MR,de Oliveira Aguiar-Soares RD,Reis AB,Roatt BM

11-0042-82 was used in flow cytometry to propose the validation of some important commercially anti-mouse mAbs (CD4, TNF-α, IFN-γ and IL-10) and how this could be useful to evaluate a specific cellular immune response in Leishmania-infected hamster using flow cytometry experiments.

Thu Apr 01 00:00:00 EDT 2021

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.

Journal of neuroinflammation

Hélie P,Camacho-Toledano C,Lesec L,Seillier C,Miralles AJ,Ortega MC,Guérit S,Lebas H,Bardou I,Vila-Del Sol V,Vivien D,Le Mauff B,Clemente D,Docagne F,Toutirais O

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Sat Feb 20 00:00:00 EST 2021

Ddb1 Is Essential for the Expansion of CD4⁺ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.

Frontiers in immunology

Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Dec 20 00:00:00 EST 2021

Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.

Biology

Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry (Frozen)

Thu May 27 00:00:00 EDT 2021

Anti-aging effects of a functional food via the action of gut microbiota and metabolites in aging mice.

Aging

Zhang J,Chen Z,Yu H,Lu Y,Yu W,Miao M,Shi H

11-0042-82 was used in Flow cytometry/Cell sorting to reveal the preventive effect of wushen on aging mice via a combined analysis of gut microbiome and metabolome.

Tue Apr 20 00:00:00 EDT 2021

Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models.

Cancers

Wang J,Hu Y,Escamilla-Rivera V,Gonzalez CL,Tang L,Wang B,El-Naggar AK,Myers JN,Caulin C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Tue Mar 23 00:00:00 EDT 2021

Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.

Vaccines

Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon May 10 00:00:00 EDT 2021

Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.

STAR protocols

Viant C,Escolano A,Chen ST,Nussenzweig MC

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jun 18 00:00:00 EDT 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

11-0042-82 was used in Flow Cytometry to present a stringent hypoxia-sensing CAR T cell system that achieves selective expression of a pan-ErbB-targeted CAR within a solid tumor.

Tue Apr 20 00:00:00 EDT 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.

Journal for immunotherapy of cancer

Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

PloS one

Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Oct 15 00:00:00 EDT 2021

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.

eLife

Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC

11-0042 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.

Tue May 18 00:00:00 EDT 2021

A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae.

iScience

Macbeth JC,Liu R,Alavi S,Hsiao A

11-0042-82 was used in Flow cytometry/Cell sorting to suggest that gut microbiome composition at time of infection or vaccination may be pivotal for providing robust mucosal immunity, and suggest a target for improved prophylactic and therapeutic strategies for cholera.

Fri Dec 17 00:00:00 EST 2021

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.

Cell

Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunocytochemistry

Thu Jan 09 00:00:00 EST 2020

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.

Immunity

Tummers B,Mari L,Guy CS,Heckmann BL,Rodriguez DA,Rühl S,Moretti J,Crawford JC,Fitzgerald P,Kanneganti TD,Janke LJ,Pelletier S,Blander JM,Green DR

11-0042-82 was used in Flow Cytometry to suggest an in vivo role of the inflammatory RIPK1-caspase-8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role of caspase-8 that involves activation of an inflammasome.

Tue Jun 16 00:00:00 EDT 2020

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

The Journal of clinical investigation

Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.

British journal of pharmacology

Wang W,Yao J,Chen Z,Sun Y,Shi Y,Wei Y,Zhou H,Yu Y,Li S,Duan L

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP

11-0042 was used in Flow cytometry/Cell sorting to support a direct role of IgE in abdominal aortic aneurysm by promoting lesion chemokine expression, inflammatory cell accumulation, MAPK signalling and cytokine expression in mice.

Sat Feb 01 00:00:00 EST 2020

MOSPD2 is a therapeutic target for the treatment of CNS inflammation.

Clinical and experimental immunology

Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I

11-0042 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.

Sat Aug 01 00:00:00 EDT 2020

Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4⁺ CD25⁺ regulatory T cells.

Journal of cellular and molecular medicine

Ge Y,Huang M,Wu Y,Dong N,Yao YM

11-0042-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.

Wed Jan 01 00:00:00 EST 2020

Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.

Journal of cell science

Salz A,Gurniak C,Jönsson F,Witke W

11-0042 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.

Fri Mar 06 00:00:00 EST 2020

Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.

Journal of Cancer

Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.

Experimental and therapeutic medicine

Kang J,Feng D,Yang F,Tian X,Han W,Jia H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.

Experimental and therapeutic medicine

Kang J,Feng D,Yang F,Tian X,Han W,Jia H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Effects of CD4⁺ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.

Experimental and therapeutic medicine

Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.

Journal for immunotherapy of cancer

Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.

Antibody therapeutics

Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.

NPJ vaccines

Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Oct 29 00:00:00 EDT 2020

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

Frontiers in immunology

Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed May 26 00:00:00 EDT 2021

Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.

Microbiome

van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon May 18 00:00:00 EDT 2020

Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.

Microbiome

van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon May 18 00:00:00 EDT 2020

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Loss of testosterone impairs anti-tumor neutrophil function.

Nature communications

Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Mar 31 00:00:00 EDT 2020

STING couples with PI3K to regulate actin reorganization during BCR activation.

Science advances

Jing Y,Dai X,Yang L,Kang D,Jiang P,Li N,Cheng J,Li J,Miller H,Ren B,Gong Q,Yin W,Liu Z,Mattila PK,Ning Q,Sun J,Yu B,Liu C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Wed Apr 01 00:00:00 EDT 2020

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.

NPJ vaccines

Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT

11-0042 was used in Flow cytometry/Cell sorting to provide a framework for effective vaccination against cancer-associated herpesviruses through the elimination of latency and key immune evasion mechanisms from the pathogen.

Thu Nov 05 00:00:00 EST 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C

11-0042-82 was used in Immunocytochemistry to examine immunomodulatory properties of potential probiotic strains in Crohn's disease and colitis.

Tue Mar 24 00:00:00 EDT 2020

A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.

Cells

Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Apr 07 00:00:00 EDT 2020

Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation.

Oncoimmunology

Lee GJ,Jun Y,Yoo HY,Jeon YK,Lee D,Lee S,Kim J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Wed May 13 00:00:00 EDT 2020

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.

Cell reports

Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K

11-0042 was used in Flow cytometry/Cell sorting to show that inactivating mutations in the epigenetic regulator TET2, which lead to clonal hematopoiesis, aggravate age- and obesity-related insulin resistance in mice.

Tue Oct 27 00:00:00 EDT 2020

Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury.

Frontiers in immunology

Wojciechowski S,Virenque A,Vihma M,Galbardi B,Rooney EJ,Keuters MH,Antila S,Koistinaho J,Noe FM

11-0042-82 was used in Flow Cytometry to explore the role of meningeal lymphatic vessels in modulating the neuro-immune response following a traumatic brain injury.

Wed May 19 00:00:00 EDT 2021

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

11-0042 was used in Flow cytometry/Cell sorting to investigate the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis.

Wed Apr 29 00:00:00 EDT 2020

Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice.

Cancers

Liu YM,Wu TH,Chiu YH,Wang H,Li TL,Hsia S,Chan YL,Wu CJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Fri Aug 28 00:00:00 EDT 2020

Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.

Cell reports

Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY

11-0042-82 was used in Flow Cytometry to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.

Tue Mar 17 00:00:00 EDT 2020

Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts.

Frontiers in immunology

Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

11-0042-82 was used in Flow Cytometry to compare targeting Malt1 versus using calcineurin inhibitors as immunosuppression in a stringent experimental transplantation model.

Fri Jun 18 00:00:00 EDT 2021

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

Immunity

Burzynski LC,Humphry M,Pyrillou K,Wiggins KA,Chan JNE,Figg N,Kitt LL,Summers C,Tatham KC,Martin PB,Bennett MR,Clarke MCH

11-0042-82 was used in Immunocytochemistry to show that thrombin-cleaved IL-1α was detected in humans during sepsis, pointing to the relevance of this pathway for normal physiology and the pathogenesis of inflammatory and thrombotic diseases.

Tue Apr 16 00:00:00 EDT 2019

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.

Immunity

Fu YY,Egorova A,Sobieski C,Kuttiyara J,Calafiore M,Takashima S,Clevers H,Hanash AM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunocytochemistry

Tue Jul 16 00:00:00 EDT 2019

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.

Immunity

Fu YY,Egorova A,Sobieski C,Kuttiyara J,Calafiore M,Takashima S,Clevers H,Hanash AM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunocytochemistry

Tue Jul 16 00:00:00 EDT 2019

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.

Immunity

Fu YY,Egorova A,Sobieski C,Kuttiyara J,Calafiore M,Takashima S,Clevers H,Hanash AM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunocytochemistry

Tue Jul 16 00:00:00 EDT 2019

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Cell host & microbe

Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL

11-0042 was used in Flow cytometry/Cell sorting to indicate that bacteriophages can alter mucosal immunity to impact mammalian health.

Wed Feb 13 00:00:00 EST 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Memory CD4⁺ T cells enhance B-cell responses to drifting influenza immunization.

European journal of immunology

Gage E,Van Hoeven N,Dubois Cauwelaert N,Larsen SE,Erasmus J,Orr MT,Coler RN

11-0042-82 was used in Flow Cytometry to show that MHC Class II haplotype and T-cell reactivity influences subsequent hemagglutination inhibitory antibody responses.

Fri Feb 01 00:00:00 EST 2019

Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland.

Investigative ophthalmology & visual science

Lee HK,Kim KW,Ryu JS,Jeong HJ,Lee SM,Kim MK

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that a unilateral cut of the corneal nerve results in activation of immune cells on the ocular surface and dysregulation of lacrimal secretion bilaterally through the bidirectional neuronal signals.

Wed Jan 02 00:00:00 EST 2019

A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.

JCI insight

Yin M,Baslan T,Walker RL,Zhu YJ,Freeland A,Matsukawa T,Sridharan S,Nussenzweig A,Pruitt SC,Lowe SW,Meltzer PS,Aplan PD

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Dec 05 00:00:00 EST 2019

Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.

Frontiers in immunology

Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Oct 29 00:00:00 EDT 2020

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.

Scientific reports

Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.

Scientific reports

Park TY,Jang Y,Kim W,Shin J,Toh HT,Kim CH,Yoon HS,Leblanc P,Kim KS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Oct 29 00:00:00 EDT 2019

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.

Nature communications

Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Mar 06 00:00:00 EST 2019

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models.

Journal of visualized experiments : JoVE

Sano S,Wang Y,Evans MA,Yura Y,Sano M,Ogawa H,Horitani K,Doviak H,Walsh K

11-0042-82 was used in Flow Cytometry to describe a protocol that provides a high-throughput evaluation of hematopoiesis-regulatory genes using lentivirus-mediated transgene delivery systems.

Thu Oct 03 00:00:00 EDT 2019

ImmGen report: sexual dimorphism in the immune system transcriptome.

Nature communications

Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T

11-0042 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.

Fri Sep 20 00:00:00 EDT 2019

Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4⁺ T Cells in the Regulation of T Cell Differentiation.

Frontiers in immunology

Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

11-0042 was used in Flow cytometry/Cell sorting to investigate the specific function α7 nAChRs on T cells and antigen presenting cells (APCs) in mice.

Fri Aug 21 00:00:00 EDT 2020

Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model.

International journal of molecular sciences

Wai CYY,Leung NYH,Leung PSC,Chu KH

11-0042-82 was used in Flow Cytometry to demonstrate the potency of hypoallergen-encoding DNA vaccines as a therapeutic strategy for human shellfish allergy via the vigorous induction of functional Treg cells.

Thu Sep 19 00:00:00 EDT 2019

The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria.

Frontiers in immunology

Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K

11-0042 was used in Flow cytometry/Cell sorting to reveal the essential role of early host interactions in the liver that may dampen the subsequent pro-inflammatory immune responses and influence the occurrence of ECM, highlighting a novel checkpoint in this fatal pathology.

Mon Nov 16 00:00:00 EST 2020

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8⁺ T cell tumor-infiltration impairing anti-PD1 therapy.

Nature communications

Pascual-García M,Bonfill-Teixidor E,Planas-Rigol E,Rubio-Perez C,Iurlaro R,Arias A,Cuartas I,Sala-Hojman A,Escudero L,Martínez-Ricarte F,Huber-Ruano I,Nuciforo P,Pedrosa L,Marques C,Braña I,Garralda E,Vieito M,Squatrito M,Pineda E,Graus F,Espejo C,Sahuquillo J,Tabernero J,Seoane J

11-0042-82 was used in Flow Cytometry to study the effect of the combination of LIF neutralising antibodies with the inhibition of the PD1 immune checkpoint on tumour progression.

Tue Jun 11 00:00:00 EDT 2019

Protective immunity by an engineered DNA vaccine for Mayaro virus.

PLoS neglected tropical diseases

Choi H,Kudchodkar SB,Reuschel EL,Asija K,Borole P,Ho M,Wojtak K,Reed C,Ramos S,Bopp NE,Aguilar PV,Weaver SC,Kim JJ,Humeau L,Tebas P,Weiner DB,Muthumani K

11-0042 was used in Flow cytometry/Cell sorting to develop and test a novel DNA vaccine for Mayaro virus which encodes a synthetically designed consesus Mayaro envelope sequence.

Fri Feb 01 00:00:00 EST 2019

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.

Immunity

Shimada K,Porritt RA,Markman JL,O'Rourke JG,Wakita D,Noval Rivas M,Ogawa C,Kozhaya L,Martins GA,Unutmaz D,Baloh RH,Crother TR,Chen S,Arditi M

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4⁺CD8⁺ thymocytes.

Nature immunology

Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4⁺CD8⁺ thymocytes.

Nature immunology

Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.

The Journal of experimental medicine

Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Nov 05 00:00:00 EST 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.

Frontiers in immunology

Li Z,Gothard E,Coles MC,Ambler CA

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Mar 27 00:00:00 EDT 2019

Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.

American journal of physiology. Lung cellular and molecular physiology

Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.

Journal of enzyme inhibition and medicinal chemistry

Xu G,Wang T,Li Y,Huang Z,Wang X,Zheng J,Yang S,Fan Y,Xiang R

Sat Dec 01 00:00:00 EST 2018

PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.

Journal of Cancer

Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z

11-0042 was used in Flow cytometry/Cell sorting to investigate whether PD-L1 mediated adaptive resistance could occur in treatment with Anchored-GM-CSF vaccine and whether PD-1 blockade combined with Anchored-GM-CSF vaccine could induce a greater anti-tumour immune response than either immunotherapy alone.

Thu Oct 01 00:00:00 EDT 2020

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.

Oncology letters

Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2018

Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.

Experimental and therapeutic medicine

Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Effect of immune tolerance induced by immature dendritic cells and CTLA4-Ig on systemic lupus erythematosus: An in vivo study.

Experimental and therapeutic medicine

Huang C,Zhang L,Ling F,Wen S,Luo Y,Liu H,Liu J,Zheng W,Liang M,Sun J,Lin YK

11-0042-82 was used in Flow Cytometry to suggest that combined treatment with IL-10-DCs and CTLA4-Ig may be a promising novel therapeutic strategy for the treatment of SLE.

Thu Mar 01 00:00:00 EST 2018

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.

Nature communications

Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Sep 05 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.

Cell death & disease

Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Mar 07 00:00:00 EST 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Mon Sep 10 00:00:00 EDT 2018

Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.

Frontiers in immunology

Cheng Y,Zhu X,Wang X,Zhuang Q,Huyan X,Sun X,Huang J,Zhan B,Zhu X

Mon Jan 28 00:00:00 EST 2019

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

JCI insight

Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.

Thu Mar 22 00:00:00 EDT 2018

Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.

Cell death & disease

Lai D,Tang J,Chen L,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Fang X,Shu Q,Fan J

Tue Mar 06 00:00:00 EST 2018

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses.

Oncoimmunology

Rekers NH,Olivo Pimentel V,Yaromina A,Lieuwes NG,Biemans R,Zegers CML,Germeraad WTV,Van Limbergen EJ,Neri D,Dubois LJ,Lambin P

11-0042 was used in Flow cytometry/Cell sorting to show that radiotherapy and L19-IL2 can activate a curative abscopal effect, with a long-lasting immunological memory.

Tue Jan 12 00:00:00 EST 2021

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Nature communications

Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB

11-0042 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.

Mon Dec 17 00:00:00 EST 2018

Targeting CD40 enhances antibody- and CD8-mediated protection against respiratory syncytial virus infection.

Scientific reports

Muralidharan A,Russell M,Larocque L,Gravel C,Li C,Chen W,Cyr T,Lavoie JR,Farnsworth A,Rosu-Myles M,Wang L,Li X

11-0042 was used in Flow cytometry/Cell sorting to study a method for controlling the axon and dendrite morphology of single primary-cultured neurons and assembling a neural circuit using mobile microplates.

Fri Nov 09 00:00:00 EST 2018

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.

Oncoimmunology

Hung AL,Maxwell R,Theodros D,Belcaid Z,Mathios D,Luksik AS,Kim E,Wu A,Xia Y,Garzon-Muvdi T,Jackson C,Ye X,Tyler B,Selby M,Korman A,Barnhart B,Park SM,Youn JI,Chowdhury T,Park CK,Brem H,Pardoll DM,Lim M

11-0042 was used in Flow cytometry/Cell sorting to determine the effect of anti-PD-1 and anti-TIGIT combination therapy on survival in a murine glioblastoma model, and to elucidate the underlying immune mechanisms.

Wed Nov 03 00:00:00 EDT 2021

Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice.

Scientific reports

Lee JTC,Shanina I,Chu YN,Horwitz MS,Johnson JD

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that carbamazepine reduces the development of type 1 diabetes in non-obese diabetic mice by maintaining functional beta-cell mass.

Thu Mar 15 00:00:00 EDT 2018

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

Immunity

Coelho MA,de Carné Trécesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J

11-0042-82 was used in Flow Cytometry to demonstrate that RAS can drive cell-intrinsic PD-L1 expression, thus presenting therapeutic opportunities to reverse the innately immunoresistant phenotype of RAS mutant cancers.

Tue Dec 19 00:00:00 EST 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

11-0042 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.

Mon Dec 11 00:00:00 EST 2017

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.

The Journal of clinical investigation

Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.

Journal of the American Society of Nephrology : JASN

Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Jul 01 00:00:00 EDT 2017

Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3⁺CD49b^-Foxp3^- regulatory T cells.

The Journal of allergy and clinical immunology

Dawicki W,Li C,Town J,Zhang X,Gordon JR

11-0042-82 was used in Flow cytometry separation to indicate that regulatory DC immunotherapy can be an effective strategy for reversing food allergies.

Mon May 01 00:00:00 EDT 2017

Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.

Frontiers in immunology

Hammer A,Waschbisch A,Knippertz I,Zinser E,Berg J,Jörg S,Kuhbandner K,David C,Pi J,Bayas A,Lee DH,Haghikia A,Gold R,Steinkasserer A,Linker RA

11-0042 was used in Flow cytometry/Cell sorting to reveal, using treatment with fumaric acid esters as a model, the effects of Nrf2 activation and signalling on dendritic cells.

Wed Nov 20 00:00:00 EST 2019

Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.

Mucosal immunology

Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL

11-0042 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.

Mon May 01 00:00:00 EDT 2017

Rediscovering peritoneal macrophages in a murine endometriosis model.

Human reproduction (Oxford, England)

Yuan M,Li D,An M,Li Q,Zhang L,Wang G

11-0042 was used in Flow Cytometry to study the role of large and small peritoneal macrophages in endometriosis.

Sun Jan 01 00:00:00 EST 2017

Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.

Journal of immunology (Baltimore, Md. : 1950)

Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH

11-0042 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.

Wed Mar 15 00:00:00 EDT 2017

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation.

Gene therapy

Sun Y,Peng S,Yang A,Farmer E,Wu TC,Hung CF

11-0042 was used in Flow cytometry/Cell sorting to assess the therapeutic efficacy of intravaginal immunisation with human papillomavirus pcDNA3-CRT/E7 followed by electroporation.

Sat Jul 01 00:00:00 EDT 2017

Changes in CD4⁺CD25⁺ Tregs in the pathogenesis of atherosclerosis in ApoE^-/- mice.

Experimental biology and medicine (Maywood, N.J.)

Xue-Mei L,Jie C,Xuan D,Xiao-Xing L,Chun-Lin H,Yu-Jie L

11-0042 was used in Flow cytometry/Cell sorting to observe the pathological characteristics of atherosclerotic plaques in the aortic walls of ApoE-/-and C57BL/6J mice and the changes of CD4+CD25+regulatory T cells in atherosclerotic mice.

Mon May 01 00:00:00 EDT 2017

IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.

Frontiers in neurology

Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.

Molecular medicine reports

Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice.

Molecular medicine reports

Tang A,Li C,Chen Z,Li T

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.

Cancer prevention research (Philadelphia, Pa.)

Wang J,Xie T,Wang B,William WN,Heymach JV,El-Naggar AK,Myers JN,Caulin C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunohistochemistry

Fri Dec 01 00:00:00 EST 2017

Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.

Oncology letters

Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.

Oncology letters

Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Effect of follicular helper T cells on the pathogenesis of asthma.

Experimental and therapeutic medicine

Ma X,Sun Z,Zhai P,Yu W,Wang T,Li F,Ding J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.

Oncotarget

Zamanian-Daryoush M,Lindner DJ,DiDonato JA,Wagner M,Buffa J,Rayman P,Parks JS,Westerterp M,Tall AR,Hazen SL

11-0042 was used in Flow cytometry/Cell sorting to study the tumour protective and immune regulatory role of circulating cholesterol homeostasis in murine bladder cancer and melanoma.

Fri Sep 22 00:00:00 EDT 2017

The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.

Endocrinology

Fenske RJ,Cadena MT,Harenda QE,Wienkes HN,Carbajal K,Schaid MD,Laundre E,Brill AL,Truchan NA,Brar H,Wisinski J,Cai J,Graham TE,Engin F,Kimple ME

11-0042-82 was used in Flow cytometry/Cell sorting to study Gαz protein preserving functional β-cell mass in the nonobese diabetic (NOD) model, protecting from overt diabetes.

Thu Jun 01 00:00:00 EDT 2017

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Nature communications

Ratsimandresy RA,Chu LH,Khare S,de Almeida L,Gangopadhyay A,Indramohan M,Misharin AV,Greaves DR,Perlman H,Dorfleutner A,Stehlik C

11-0042 was used in Flow cytometry/Cell sorting to investigate the complex interactions governing inflammasome assembly and function.

Mon Jun 05 00:00:00 EDT 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.

Clinical and translational allergy

Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J

11-0042 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.

Fri Apr 08 00:00:00 EDT 2022

Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4⁺T cells Immune Responses.

Scientific reports

Hu X,Li X,Hu C,Qin L,He R,Luo L,Tang W,Feng J

11-0042 was used in Flow cytometry/Cell sorting to indicate that respiratory syncytial virus infection can increase C5a and C5aR expression in the pathogenesis of infected, asthmatic mice.

Thu Nov 09 00:00:00 EST 2017

Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob^tm2Sgy/Ldlr^tm1Her/J mice.

Scientific reports

Thota LN,Ponnusamy T,Philip S,Lu X,Mundkur L

11-0042 was used in Flow cytometry/Cell sorting to evaluate the effect of multi-antigenic construct expressing three peptides AHC in stabilising advanced atherosclerosis in Apobtm2Sgy/Ldlrtm1Her/J mice.

Wed Jun 21 00:00:00 EDT 2017

Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma.

Oncotarget

Movassagh H,Shan L,Duke-Cohan JS,Chakir J,Halayko AJ,Koussih L,Gounni AS

11-0042 was used in Flow cytometry/Cell sorting to determine the role of semaphorin 3E in the chronic course of allergic asthma.

Fri Nov 17 00:00:00 EST 2017

Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation.

Journal of neuroinflammation

Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that sodium chloride and lauric acid have an additive effect on T helper cell polarisation and responses in autoimmune neuroinflammation.

Tue Sep 12 00:00:00 EDT 2017

CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.

Nature immunology

Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.

The Journal of experimental medicine

Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD

11-0042 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.

Mon Nov 14 00:00:00 EST 2016

STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.

Clinical cancer research : an official journal of the American Association for Cancer Research

Vieyra-Garcia PA,Wei T,Naym DG,Fredholm S,Fink-Puches R,Cerroni L,Odum N,O'Malley JT,Gniadecki R,Wolf P

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection.

Frontiers in immunology

Neyt K,GeurtsvanKessel CH,Deswarte K,Hammad H,Lambrecht BN

11-0042 was used in Immunohistochemistry to demonstrate that innate IL-1α-IL-1R signalling is necessary for influenza A virus clearance and induction of CXCL13 early after infection.

Wed Aug 31 00:00:00 EDT 2016

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Madsen PM,Motti D,Karmally S,Szymkowski DE,Lambertsen KL,Bethea JR,Brambilla R

11-0042 was used in Flow cytometry/Cell sorting to provide evidence that TNFR2 in oligodendrocytes is important for oligodendrocyte differentiation, thereby sustaining tmTNF-dependent repair in neuroimmune disease.

Wed May 04 00:00:00 EDT 2016

IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.

European journal of immunology

Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L

11-0042 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.

Wed Jun 01 00:00:00 EDT 2016

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Song Y,Kumar V,Wei HX,Qiu J,Stanley P

11-0042 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.

Fri Jan 01 00:00:00 EST 2016

Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes.

Infection and immunity

Maaz D,Rausch S,Richter D,Krücken J,Kühl AA,Demeler J,Blümke J,Matuschka FR,von Samson-Himmelstjerna G,Hartmann S

11-0042 was used in Flow cytometry/Cell sorting to analyse the immunological impact of the nematode/tick coinfection, showing that susceptibility to ticks and Lyme disease is not affected by coinfection.

Sun May 01 00:00:00 EDT 2016

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

Molecular medicine reports

Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model.

Experimental and therapeutic medicine

Ruan G,Tao B,Wang D,Li Y,Wu J,Yin G

11-0042 was used in Flow cytometry/Cell sorting to determine the protective effects and underlying mechanisms of Gu-Ben-Fang-Xiao-Tang on ovalbumin-induced allergic inflammation.

Thu Sep 01 00:00:00 EDT 2016

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Nature communications

Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Jul 18 00:00:00 EDT 2016

Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.

The Journal of biological chemistry

Maganti AV,Tersey SA,Syed F,Nelson JB,Colvin SC,Maier B,Mirmira RG

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that PPAR-γ activation directly improves Β cell function and survival in non-obese diabetic mice.

Fri Oct 21 00:00:00 EDT 2016

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

eLife

Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Jul 04 00:00:00 EDT 2016

PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.

PloS one

Jones K,Ballesteros A,Mentink-Kane M,Warren J,Rattila S,Malech H,Kang E,Dveksler G

11-0042 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-specific glycoprotein 9, a potential predictive biomarker of pre-eclampsia, plays an immunoregulatory role during pregnancy.

Wed Jul 26 00:00:00 EDT 2017

Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment.

Oncoimmunology

Saxon JA,Sherrill TP,Polosukhin VV,Sai J,Zaynagetdinov R,McLoed AG,Gulleman PM,Barham W,Cheng DS,Hunt RP,Gleaves LA,Richmond A,Young LR,Yull FE,Blackwell TS

11-0042 was used in Flow cytometry/Cell sorting to investigate the function of NF-κB signalling in epidermal growth factor receptor-mutant lung tumours using a transgenic mouse model.

Wed Jun 01 00:00:00 EDT 2016

A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.

JCI insight

Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG

11-0042 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.

Thu Jul 21 00:00:00 EDT 2016

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.

Nature communications

Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Apr 13 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Scientific reports

Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Jul 11 00:00:00 EDT 2016

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

Journal of hepatology

Liu Y,Ji H,Zhang Y,Shen X,Gao F,He X,Li GA,Busuttil RW,Kuchroo VK,Kupiec-Weglinski JW

11-0042 was used in Immunofluorescence to investigate whether negative T cell-dependent TIM-3 co-stimulation rescues orthotopic liver transplants stressed by ischaemia-reperfusion from innate immunity-driven inflammation.

Sun Mar 01 00:00:00 EST 2015

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates.

Science translational medicine

Muthumani K,Falzarano D,Reuschel EL,Tingey C,Flingai S,Villarreal DO,Wise M,Patel A,Izmirly A,Aljuaid A,Seliga AM,Soule G,Morrow M,Kraynyak KA,Khan AS,Scott DP,Feldmann F,LaCasse R,Meade-White K,Okumura A,Ugen KE,Sardesai NY,Kim JJ,Kobinger G,Feldmann H,Weiner DB

11-0042 was used in Flow cytometry/Cell sorting to report on the development of a synthetic DNA vaccine against a novel member of the lineage C betacoronaviruses.

Wed Aug 19 00:00:00 EDT 2015

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.

Science translational medicine

Hu-Lieskovan S,Mok S,Homet Moreno B,Tsoi J,Robert L,Goedert L,Pinheiro EM,Koya RC,Graeber TG,Comin-Anduix B,Ribas A

11-0042 was used in Flow cytometry/Cell sorting to investigate the use of BRAF and MEK inhibitors with immunotherapy in patients with BRAF(V600E) melanoma.

Wed Mar 18 00:00:00 EDT 2015

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research

Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.

Proceedings of the National Academy of Sciences of the United States of America

Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y

11-0042 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.

Tue May 19 00:00:00 EDT 2015

The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo.

PLoS biology

Turqueti-Neves A,Otte M,Schwartz C,Schmitt ME,Lindner C,Pabst O,Yu P,Voehringer D

11-0042 was used in Flow cytometry/Cell sorting to explore the relationship between repertoires of IgE and IgG1 in vivo.

Tue May 24 00:00:00 EDT 2016

Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Liu Y,Ji H,Zhang Y,Shen XD,Gao F,Nguyen TT,Shang X,Lee N,Busuttil RW,Kupiec-Weglinski JW

11-0042 was used in Flow cytometry/Cell sorting to explore TIM-3-Gal-9 function in a clinically relevant murine model of hepatic cold storage and orthotopic liver transplantation.

Wed Apr 01 00:00:00 EDT 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

Regulatory T Cells Modulate DNA Vaccine Immunogenicity at Early Time via Functional CD4(+) T Cells and Antigen Duration.

Frontiers in immunology

Qin L,Jiang G,Han J,Letvin NL

11-0042 was used in Flow cytometry/Cell sorting to suggest that Treg cells control early DNA vaccine immunogenicity via antigen duration and functional CD4(+) T-cell responses.

Tue Oct 20 00:00:00 EDT 2015

Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells.

Journal of immunology (Baltimore, Md. : 1950)

Xu T,Zhou Y,Qiu L,Do DC,Zhao Y,Cui Z,Wang H,Liu X,Saradna A,Cao X,Wan M,Gao P

11-0042 was used in Flow cytometry/Cell sorting to investigate whether AhR can sense cockroach allergens and modulate allergen-induced lung inflammation, showing that it protects from inflammation by modulating MSCs.

Tue Dec 15 00:00:00 EST 2015

IκBNS regulates murine Th17 differentiation during gut inflammation and infection.

Journal of immunology (Baltimore, Md. : 1950)

Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I

11-0042 was used in Flow cytometry/Cell sorting to study the role of nuclear IκBNS in murine Th17 cell generation upon inflammation and infection.

Sun Mar 15 00:00:00 EDT 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.

Human vaccines & immunotherapeutics

Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Mar 11 00:00:00 EST 2016

iPSC-MSCs Combined with Low-Dose Rapamycin Induced Islet Allograft Tolerance Through Suppressing Th1 and Enhancing Regulatory T-Cell Differentiation.

Stem cells and development

Cheng PP,Liu XC,Ma PF,Gao C,Li JL,Lin YY,Shao W,Han S,Zhao B,Wang LM,Fu JZ,Meng LX,Li Q,Lian QZ,Xia JJ,Qi ZQ

11-0042 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of iPSC-mesechymal stem cells on diabetic mice.

Sat Aug 01 00:00:00 EDT 2015

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Gene therapy

Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2015

Mucosal immunization with the live attenuated vaccine SPY1 induces humoral and Th2-Th17-regulatory T cell cellular immunity and protects against pneumococcal infection.

Infection and immunity

Xu X,Wang H,Liu Y,Wang Y,Zeng L,Wu K,Wang J,Ma F,Xu W,Yin Y,Zhang X

11-0042 was used in Flow cytometry/Cell sorting to determine the immune cell subsets that contribute to the protection conferred by the live attenuated SPY1 vaccine.

Thu Jan 01 00:00:00 EST 2015

Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.

PLoS neglected tropical diseases

Tsou YL,Lin YW,Shao HY,Yu SL,Wu SR,Lin HY,Liu CC,Huang C,Chong P,Chow YH

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.

Journal of translational medicine

Ghonim MA,Pyakurel K,Ibba SV,Al-Khami AA,Wang J,Rodriguez P,Rady HF,El-Bahrawy AH,Lammi MR,Mansy MS,Al-Ghareeb K,Ramsay A,Ochoa A,Naura AS,Boulares AH

11-0042 was used in Flow cytometry/Cell sorting to examine the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in human asthma in animal models of the disease.

Tue Jul 14 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunofluorescence

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunofluorescence

Tue Sep 15 00:00:00 EDT 2015

In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide.

PloS one

van Herwijnen MJ,van der Zee R,van Eden W,Broere F

11-0042 was used in Flow cytometry/Cell sorting to determine whether natural nTregs or induced iTregs were targeted after Hsp70-peptide immunisation.

Mon Mar 28 00:00:00 EDT 2016

Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.

eLife

He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Dec 08 00:00:00 EST 2015

Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model.

Oncotarget

Wu L,Wu MO,De la Maza L,Yun Z,Yu J,Zhao Y,Cho J,de Perrot M

11-0042 was used in Flow cytometry/Cell sorting to investigate the local and abscopal effects of targeting the CTLA-4 T cell inhibitory receptor in a murine mesothelioma model.

Wed May 20 00:00:00 EDT 2015

PD-L1hi B cells are critical regulators of humoral immunity.

Nature communications

Khan AR,Hams E,Floudas A,Sparwasser T,Weaver CT,Fallon PG

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that elevated PD-L1 expression on B cells is an important regulator of T follicular helper-cell activity, downstream antibody responses and autoimmune disease.

Thu Jan 22 00:00:00 EST 2015

Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.

Oncoimmunology

Domingos-Pereira S,Hojeij R,Reggi E,Derré L,Chevalier MF,Romero P,Jichlinski P,Nardelli-Haefliger D

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that combining vaccination with local immunostimulation may be an effective treatment strategy for different types of cancer.

Wed Jul 01 00:00:00 EDT 2015

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

11-0042 was used in Flow cytometry/Cell sorting to show that the addition of antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Tue Sep 29 00:00:00 EDT 2015

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.

Scientific reports

Singh K,Hjort M,Thorvaldson L,Sandler S

11-0042 was used in Flow cytometry/Cell sorting to investigate the use of Helios and Nrp1 as markers for thymic-derived Tregs, showing that Helios may be a more reliable marker than Nrp1.

Wed Jan 14 00:00:00 EST 2015

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.

Scientific reports

Van den Bossche J,Laoui D,Naessens T,Smits HH,Hokke CH,Stijlemans B,Grooten J,De Baetselier P,Van Ginderachter JA

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of overexpression of E-cadherin in macrophages, showing that it dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies.

Fri Jul 31 00:00:00 EDT 2015

LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.

The Journal of clinical investigation

Nakamura T,Hamuro J,Takaishi M,Simmons S,Maruyama K,Zaffalon A,Bentley AJ,Kawasaki S,Nagata-Takaoka M,Fullwood NJ,Itami S,Sano S,Ishii M,Barrandon Y,Kinoshita S

11-0042 was used in Flow cytometry/Cell sorting to investigate the role of corneal stem cells in cornea homeostasis, showing that LRIG1 inhibits STAT3-dependent inflammation to maintain homeostasis.

Wed Jan 01 00:00:00 EST 2014

Immunosuppressive effect of compound K on islet transplantation in an STZ-induced diabetic mouse model.

Diabetes

Ma PF,Jiang J,Gao C,Cheng PP,Li JL,Huang X,Lin YY,Li Q,Peng YZ,Cai MC,Shao W,Zhu Q,Han S,Qin Q,Xia JJ,Qi ZQ

11-0042 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of Cpd K in diabetic mice.

Wed Oct 01 00:00:00 EDT 2014

Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms.

British journal of cancer

Gujar SA,Clements D,Dielschneider R,Helson E,Marcato P,Lee PW

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that reovirus and gemcitabine combination treatment postpones peritoneal carcinomatosis development and prolongs the survival of cancer-bearing hosts.

Tue Jan 07 00:00:00 EST 2014

TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.

European journal of immunology

Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M

11-0042 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.

Mon Sep 01 00:00:00 EDT 2014

Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Sasaki K,Bean A,Shah S,Schutten E,Huseby PG,Peters B,Shen ZT,Vanguri V,Liggitt D,Huseby ES

11-0042 was used in Immunohistochemistry to investigate the mechanism by which CD8 T cells mediate relapsing-remitting inflammatory CNS autoimmunity.

Tue Apr 01 00:00:00 EDT 2014

Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.

Journal of immunology (Baltimore, Md. : 1950)

Gao P,Zhou Y,Xian L,Li C,Xu T,Plunkett B,Huang SK,Wan M,Cao X

11-0042 was used in Flow cytometry/Cell sorting to investigate the role of TGF-β1 in mesenchymal stem cell migration in allergic asthma.

Thu May 15 00:00:00 EDT 2014

B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.

Journal of immunology (Baltimore, Md. : 1950)

Weinstein JS,Bertino SA,Hernandez SG,Poholek AC,Teplitzky TB,Nowyhed HN,Craft J

11-0042 was used in Flow cytometry/Cell sorting to study the role of B cells in the development of Tfh cells and germinal centres.

Tue Apr 01 00:00:00 EDT 2014

Protein-bound polysaccharide-K reduces the proportion of regulatory T cells in vitro and in vivo.

Oncology reports

Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K

11-0042 was used in Flow cytometry/Cell sorting to investigate the potential of PSK to augment antitumour immunity.

Wed Jan 01 00:00:00 EST 2014

Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A.

Infection and immunity

Montgomery CP,Daniels M,Zhao F,Alegre ML,Chong AS,Daum RS

11-0042 was used in Flow cytometry/Cell sorting to develop an antibody and interlukin-17 combined vaccine which provides protective immunity against Staphylococcus aureus infections.

Thu May 01 00:00:00 EDT 2014

Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells.

PloS one

Wang X,Qin J,Zhao RC,Zenke M

11-0042 was used in Flow cytometry/Cell sorting to compare immunogenicity of fibroblast- and sertoli cell-derived iPS cells, showing that sertoli cell-derived iPS cells have lower immunogenicity.

Tue Nov 17 00:00:00 EST 2015

Modified extracorporeal photopheresis with cells from a healthy donor for acute graft-versus-host disease in a mouse model.

PloS one

Budde H,Kolb S,Salinas Tejedor L,Wulf G,Reichardt HM,Riggert J,Legler TJ

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that conventional human extracorporeal photopheresis setup is effective in the mouse model of severe acute graft-versus-host disease.

Thu Mar 17 00:00:00 EDT 2016

Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.

PloS one

Funda DP,Fundova P,Hansen AK,Buschard K

11-0042 was used in Flow cytometry/Cell sorting to investigate whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process, showing that i.n. administration of gliadin prevents type 1 diabetes in NOD mice.

Tue Jan 13 00:00:00 EST 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

11-0042 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.

Mon Jul 06 00:00:00 EDT 2015

Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.

PloS one

Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.

Thu Dec 17 00:00:00 EST 2015

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.

BMC cancer

Khong A,Cleaver AL,Fahmi Alatas M,Wylie BC,Connor T,Fisher SA,Broomfield S,Lesterhuis WJ,Currie AJ,Lake RA,Robinson BW

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Wed Dec 17 00:00:00 EST 2014

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.

PloS one

Maneva-Radicheva L,Amatya C,Parker C,Ellefson J,Radichev I,Raghavan A,Charles ML,Williams MS,Robbins MS,Savinov AY

11-0042 was used in Flow cytometry/Cell sorting to reveal that the protein, DM199, may benefit type 1 diabetics by attenuating autoimmunity and improving beta cell health.

Wed Jun 10 00:00:00 EDT 2015

Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.

PloS one

Maneva-Radicheva L,Amatya C,Parker C,Ellefson J,Radichev I,Raghavan A,Charles ML,Williams MS,Robbins MS,Savinov AY

11-0042 was used in Flow cytometry/Cell sorting to reveal that the protein, DM199, may benefit type 1 diabetics by attenuating autoimmunity and improving beta cell health.

Wed Jun 10 00:00:00 EDT 2015

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.

Nature medicine

Zouggari Y,Ait-Oufella H,Bonnin P,Simon T,Sage AP,Guérin C,Vilar J,Caligiuri G,Tsiantoulas D,Laurans L,Dumeau E,Kotti S,Bruneval P,Charo IF,Binder CJ,Danchin N,Tedgui A,Tedder TF,Silvestre JS,Mallat Z

11-0042 was used in Flow cytometry/Cell sorting to identify the interaction between mature B lymphocytes and monocytes as a potential therapeutic target after a heart attack.

Tue Oct 01 00:00:00 EDT 2013

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Nature immunology

Strainic MG,Shevach EM,An F,Lin F,Medof ME

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that a lack of signalling can convert CD4(+) cells to Foxp3(+) iT(reg) cells, amongst other effects.

Fri Feb 01 00:00:00 EST 2013

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.

The EMBO journal

Reichardt P,Patzak I,Jones K,Etemire E,Gunzer M,Hogg N

11-0042 was used in Flow cytometry/Cell sorting to study the role of the leukocyte function-associated antigen-1 (LFA-1) during T cell migration within and away from the lymph nodes.

Wed Mar 20 00:00:00 EDT 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

Molecular therapy : the journal of the American Society of Gene Therapy

Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW

11-0042 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.

Fri Feb 01 00:00:00 EST 2013

Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.

Arteriosclerosis, thrombosis, and vascular biology

Ait-Oufella H,Herbin O,Lahoute C,Coatrieux C,Loyer X,Joffre J,Laurans L,Ramkhelawon B,Blanc-Brude O,Karabina S,Girard CA,Payré C,Yamamoto K,Binder CJ,Murakami M,Tedgui A,Lambeau G,Mallat Z

11-0042 was used in Flow cytometry/Cell sorting to study the proatherogenic properties of PLA2G10, a type of several secreted phospholipase A2.

Fri Mar 01 00:00:00 EST 2013

Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen.

British journal of cancer

Reginato E,Mroz P,Chung H,Kawakubo M,Wolf P,Hamblin MR

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that photodynamic therapy with cyclophosphamide can foster immunity against wild-type tumours expressing self-antigen.

Tue Oct 15 00:00:00 EDT 2013

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine.

Cancer immunology, immunotherapy : CII

Peng S,Lyford-Pike S,Akpeng B,Wu A,Hung CF,Hannaman D,Saunders JR,Wu TC,Pai SI

11-0042 was used in Flow cytometry/Cell sorting to demonstrate a decreased vaccine-induced CD8(+) T-cell frequency after administration of CTX.

Tue Jan 01 00:00:00 EST 2013

Detection of Foreign Antigen-specific CD4(+)Foxp3(+) Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining.

Immune network

Choi JY,Eo SK

11-0042 was used in Flow cytometry/Cell sorting to evaluate the use of intracellular CD154 staining to detect and characterize foreign Ag-specific CD4+Foxp3+ regulatory T-cells in various models.

Sun Dec 01 00:00:00 EST 2013

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kipari T,Hadoke PW,Iqbal J,Man TY,Miller E,Coutinho AE,Zhang Z,Sullivan KM,Mitic T,Livingstone DE,Schrecker C,Samuel K,White CI,Bouhlel MA,Chinetti-Gbaguidi G,Staels B,Andrew R,Walker BR,Savill JS,Chapman KE,Seckl JR

11-0042 was used in Flow cytometry/Cell sorting to determine the effects of 11Β-Hydroxysteroid dehydrogenase type-1 deficiency on atherosclerosis and its inflammation.

Mon Apr 01 00:00:00 EDT 2013

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Suzukawa M,Miller M,Rosenthal P,Cho JY,Doherty TA,Varki A,Broide D

11-0042 was used in Flow cytometry/Cell sorting to study the regulated murine expression of Siglec-F ligand in immune and lung airway epithelial cells.

Sat Jun 15 00:00:00 EDT 2013

Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.

Journal of immunology (Baltimore, Md. : 1950)

Tsuboi K,Hirakawa J,Seki E,Imai Y,Yamaguchi Y,Fukuda M,Kawashima H

11-0042 was used in Flow cytometry/Cell sorting to suggest that chemokine presentation by heparan sulfate on the surface of high endothelial venules facilitates lymphocyte homing.

Mon Jul 01 00:00:00 EDT 2013

Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice.

World journal of gastroenterology

Zhao HM,Huang XY,Zuo ZQ,Pan QH,Ao MY,Zhou F,Liu HN,Liu ZY,Liu DY

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that probiotics treat experimental colitis by increasing regulatory T-cell number and regulating Th1 and Th2 cytokine ratios.

Thu Feb 07 00:00:00 EST 2013

Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.

American journal of physiology. Gastrointestinal and liver physiology

Takigawa T,Miyazaki H,Kinoshita M,Kawarabayashi N,Nishiyama K,Hatsuse K,Ono S,Saitoh D,Seki S,Yamamoto J

11-0042 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effect of ursodeoxycholic acid on experimental hepatitis, endotoxin shock, and bacterial infection in mice.

Sun Sep 15 00:00:00 EDT 2013

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.

Carcinogenesis

Chopra M,Riedel SS,Biehl M,Krieger S,von Krosigk V,Bäuerlein CA,Brede C,Jordan Garrote AL,Kraus S,Schäfer V,Ritz M,Mattenheimer K,Degla A,Mottok A,Einsele H,Wajant H,Beilhack A

11-0042 was used in Flow cytometry/Cell sorting to reveal a novel role for TNF and its receptor, TNFR2, in the progression of metastasis in a melanoma mouse model of lung metastasis.

Sat Jun 01 00:00:00 EDT 2013

Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Dighe AS,Yang S,Madhu V,Balian G,Cui Q

11-0042 was used in Flow cytometry/Cell sorting to investigate whether MSCs can be used for bone repair, showing that interferon gamma and T cells inhibit osteogenesis induced by allogeneic MSCs.

Fri Feb 01 00:00:00 EST 2013

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.

PloS one

Selemidis S,Seow HJ,Broughton BR,Vinh A,Bozinovski S,Sobey CG,Drummond GR,Vlahos R

11-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms that regulate lung inflammation in influenza A infection.

Tue Oct 22 00:00:00 EDT 2013

Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.

PloS one

Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunofluorescence

Mon Feb 23 00:00:00 EST 2015

Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.

PloS one

Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Immunofluorescence

Mon Feb 23 00:00:00 EST 2015

Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.

PloS one

Chopra M,Lang I,Salzmann S,Pachel C,Kraus S,Bäuerlein CA,Brede C,Garrote AL,Mattenheimer K,Ritz M,Schwinn S,Graf C,Schäfer V,Frantz S,Einsele H,Wajant H,Beilhack A

11-0042 was used in Flow cytometry/Cell sorting to assess the mechanisms underlying the contribution of tumour necrosis factor to carcinogenesis.

Mon May 12 00:00:00 EDT 2014

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.

Journal of hematology & oncology

Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW

11-0042 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.

Tue Oct 01 00:00:00 EDT 2013

Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.

Immunity

Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

11-0042 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.

Fri Apr 20 00:00:00 EDT 2012

Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.

Cellular & molecular immunology

Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.

Sun Jan 01 00:00:00 EST 2012

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

The Journal of experimental medicine

Yokosuka T,Takamatsu M,Kobayashi-Imanishi W,Hashimoto-Tane A,Azuma M,Saito T

11-0042 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of PD-1-mediated suppression of T cell activation, showing that it inhibits T cell receptor signalling via SHP2.

Mon Jun 04 00:00:00 EDT 2012

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.

Proceedings of the National Academy of Sciences of the United States of America

van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F

11-0042 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.

Tue Aug 28 00:00:00 EDT 2012

Regulatory T-cell response to apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.

Arteriosclerosis, thrombosis, and vascular biology

Herbin O,Ait-Oufella H,Yu W,Fredrikson GN,Aubier B,Perez N,Barateau V,Nilsson J,Tedgui A,Mallat Z

11-0042 was used in Flow cytometry/Cell sorting to investigate how the induction of a specific Treg cell response to Apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.

Thu Mar 01 00:00:00 EST 2012

Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes.

Oncogene

Zaynagetdinov R,Stathopoulos GT,Sherrill TP,Cheng DS,McLoed AG,Ausborn JA,Polosukhin VV,Connelly L,Zhou W,Fingleton B,Peebles RS,Prince LS,Yull FE,Blackwell TS

11-0042 was used in Flow cytometry/Cell sorting to study whether nuclear factor kP provides an interface between persistent lung inflammation and carcinogenesis.

Thu Jun 28 00:00:00 EDT 2012

Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.

Breast cancer research : BCR

Wang B,Zaidi N,He LZ,Zhang L,Kuroiwa JM,Keler T,Steinman RM

11-0042 was used in Flow cytometry/Cell sorting to demonstrate how the immunisation of mice with HER2 vaccine confers high levels of T- and B-cell immunity, providing long-term survival benefit.

Wed Mar 07 00:00:00 EST 2012

IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.

PLoS pathogens

Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.

Tue Jan 29 00:00:00 EST 2013

Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.

Cancer immunology, immunotherapy : CII

Alb M,Sie C,Adam C,Chen S,Becker JC,Schrama D

11-0042 was used in Flow cytometry/Cell sorting to investigate the cellular and cytokine-dependent immunosuppressive mechanisms in tumour-bearing grm1-transgenic mice.

Sat Dec 01 00:00:00 EST 2012

Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.

Immunology and cell biology

Walker KM,Rytelewski M,Mazzuca DM,Meilleur SA,Mannik LA,Yue D,Brintnell WC,Welch I,Cairns E,Haeryfar SM

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that treatment with a Th2-skewing iNKT cell agonist prevents citrulline-induced autoimmune arthritis.

Sun Jul 01 00:00:00 EDT 2012

Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice.

Arthritis research & therapy

Xiao ZY,Chen SH,Cheng JP,Zhou WX,Zhang YX,Yang RF,Yun LH

11-0042 was used in Flow cytometry/Cell sorting to demonstrate the protective effects of Y27 against autoimmune nephritis.

Thu Nov 01 00:00:00 EDT 2012

Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.

The Journal of nutrition

Monk JM,Jia Q,Callaway E,Weeks B,Alaniz RC,McMurray DN,Chapkin RS

11-0042 was used in Flow cytometry/Cell sorting to test the hypothesis that (n-3) PUFA is protective against colonic inflammation during colitis.

Sun Jan 01 00:00:00 EST 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.

The Journal of biological chemistry

Hartmann J,Tran TV,Kaudeer J,Oberle K,Herrmann J,Quagliano I,Abel T,Cohnen A,Gatterdam V,Jacobs A,Wollscheid B,Tampé R,Watzl C,Diefenbach A,Koch J

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Sep 07 00:00:00 EDT 2012

Impact of dietary gluten on regulatory T cells and Th17 cells in BALB/c mice.

PloS one

Antvorskov JC,Fundova P,Buschard K,Funda DP

11-0042 was used in Flow cytometry/Cell sorting to study the effect of a gluten-free diet compared to a gluten-containing standard diet on selected T cell subsets in mice.

Mon Aug 20 00:00:00 EDT 2012

SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.

PloS one

Berge T,Grønningsæter IH,Lorvik KB,Abrahamsen G,Granum S,Sundvold-Gjerstad V,Corthay A,Bogen B,Spurkland A

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Tue Aug 26 00:00:00 EDT 2014

Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.

BMC gastroenterology

Majowicz A,van der Marel S,te Velde AA,Meijer SL,Petry H,van Deventer SJ,Ferreira V

11-0042 was used in Flow cytometry/Cell sorting to identify a new method to generate in vitro iTreg cells (TregPMA cells) with demonstrated functionality in vivo.

Mon Dec 03 00:00:00 EST 2012

Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model.

Cancer gene therapy

Chaves KC,Peron JP,Chammas R,Turaça LT,Pesquero JB,Braga MS,Foguer K,Schor N,Bellini MH

11-0042-82 was used in Flow cytometry/Cell sorting to demonstrate an antitumor inflammatory effect of Endostatin (ES) in an mRCC model, and this effect is mediated by an increase in ICAM-1 and VCAM-1 expression in tumor-associated endothelial cells.

Wed Aug 01 00:00:00 EDT 2012

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.

Immunity

Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S

Published figure using CD4 monoclonal antibody (Product # 11-0042-82) in Flow Cytometry

Fri Feb 25 00:00:00 EST 2011

Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.

Gastroenterology

Aoki N,Kido M,Iwamoto S,Nishiura H,Maruoka R,Tanaka J,Watanabe T,Tanaka Y,Okazaki T,Chiba T,Watanabe N

11-0042 was used in Immunohistochemistry to identify induction sites, responsible T-cell subsets, and key molecules for induction of autoimmune hepatitis.

Fri Apr 01 00:00:00 EDT 2011

Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.

The Journal of experimental medicine

Ohmichi Y,Hirakawa J,Imai Y,Fukuda M,Kawashima H

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that PNAd is essential for lymphocyte homing to NALT and nasal allergic responses.

Mon May 09 00:00:00 EDT 2011

Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells.

Diabetes

Muller YD,Golshayan D,Ehirchiou D,Wyss JC,Giovannoni L,Meier R,Serre-Beinier V,Puga Yung G,Morel P,Bühler LH,Seebach JD

11-0042 was used in Flow cytometry/Cell sorting to evaluate how STZ-induced diabetes affects adaptive immunity and the consequences thereof on allograft rejection.

Thu Sep 01 00:00:00 EDT 2011

Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.

Cancer gene therapy

Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.

Wed Jun 01 00:00:00 EDT 2011

Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.

Cancer gene therapy

Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.

Wed Jun 01 00:00:00 EDT 2011

Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis.

The American journal of pathology

Piehler D,Stenzel W,Grahnert A,Held J,Richter L,Köhler G,Richter T,Eschke M,Alber G,Müller U

11-0042 was used in Flow cytometry/Cell sorting to investigate the time course of IL-4 production and its innate cellular source in mice infected intranasally with Cryptococcus neoformans.

Mon Aug 01 00:00:00 EDT 2011

TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Subleski JJ,Hall VL,Wolfe TB,Scarzello AJ,Weiss JM,Chan T,Hodge DL,Back TC,Ortaldo JR,Wiltrout RH

11-0042 was used in Flow cytometry/Cell sorting to investigate TCR -dependent and -independent activation of NKT cells in the liver.

Sat Jan 15 00:00:00 EST 2011

Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.

Infection and immunity

Hsieh SH,Lin JS,Huang JH,Wu SY,Chu CL,Kung JT,Wu-Hsieh BA

11-0042 was used in Flow cytometry/Cell sorting to investigate the effect of immunisation with apoptotic phagocytes containing heat-killed Histoplasma, showing that it activates functional CD8(+) T cells to protect against histoplasmosis.

Tue Nov 01 00:00:00 EDT 2011

Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.

PloS one

Efimova O,Szankasi P,Kelley TW

11-0042 was used in Flow cytometry/Cell sorting to investigate whether oxidants mediate the direct suppression of T effector cells by Tregs.

Thu Jan 06 00:00:00 EST 2011

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.

Blood

Huber S,Hoffmann R,Muskens F,Voehringer D

11-0042 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.

Thu Oct 28 00:00:00 EDT 2010

B cell depletion reduces the development of atherosclerosis in mice.

The Journal of experimental medicine

Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z

11-0042 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.

Mon Aug 02 00:00:00 EDT 2010

B cell depletion reduces the development of atherosclerosis in mice.

The Journal of experimental medicine

Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z

Mon Aug 02 00:00:00 EDT 2010

MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus.

Proceedings of the National Academy of Sciences of the United States of America

Xie X,Stadnisky MD,Coats ER,Ahmed Rahim MM,Lundgren A,Xu W,Makrigiannis AP,Brown MG

11-0042 was used in Flow cytometry/Cell sorting to reveal a role for NK cell interaction with D(k)-bearing haematopoietic and nonhaematopoietic cells to shape NK-mediated virus immunity.

Tue May 11 00:00:00 EDT 2010

VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model.

Immunology and cell biology

Chen L,Lin SX,Amin S,Overbergh L,Maggiolino G,Chan LS

11-0042 was used in Flow cytometry/Cell sorting to investigate the functions of ICAM-1 and VCAM-1 in a keratin-14 IL-4-Tg mouse model of atopic dermatitis.

Fri Jun 11 00:00:00 EDT 2010

The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW

11-0042 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.

Sun Aug 01 00:00:00 EDT 2010

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.

Journal of molecular medicine (Berlin, Germany)

Polansky JK,Schreiber L,Thelemann C,Ludwig L,Krüger M,Baumgrass R,Cording S,Floess S,Hamann A,Huehn J

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network.

Fri Oct 01 00:00:00 EDT 2010

8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.

Journal of immunology (Baltimore, Md. : 1950)

Singh TP,Schön MP,Wallbrecht K,Michaelis K,Rinner B,Mayer G,Schmidbauer U,Strohmaier H,Wang XJ,Wolf P

11-0042 was used in Flow cytometry/Cell sorting to elucidate the mechanism of PUVA for treatment of psoriasis, showing that inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involves CTLA4 signalling.

Tue Jun 15 00:00:00 EDT 2010

Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.

Journal of immunology (Baltimore, Md. : 1950)

Ito H,Hoshi M,Ohtaki H,Taguchi A,Ando K,Ishikawa T,Osawa Y,Hara A,Moriwaki H,Saito K,Seishima M

11-0042 was used in Flow cytometry/Cell sorting to study the immunological effects of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis.

Fri Oct 15 00:00:00 EDT 2010

Resistance to dengue virus infection in mice is potentiated by CXCL10 and is independent of CXCL10-mediated leukocyte recruitment.

Journal of immunology (Baltimore, Md. : 1950)

Ip PP,Liao F

11-0042 was used in Flow cytometry/Cell sorting to study how CXCL10(-/-) mice are more susceptible than wild-type mice to dengue virus infection.

Sat May 15 00:00:00 EDT 2010

Antigen aggregation decides the fate of the allergic immune response.

Journal of immunology (Baltimore, Md. : 1950)

Zaborsky N,Brunner M,Wallner M,Himly M,Karl T,Schwarzenbacher R,Ferreira F,Achatz G

11-0042 was used in Flow cytometry/Cell sorting to elucidate the molecular background of hypoallergenicity using Betula verrucosa.

Fri Jan 15 00:00:00 EST 2010

CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors.

Journal of immunology (Baltimore, Md. : 1950)

Haynes NM,Hawkins ED,Li M,McLaughlin NM,Hämmerling GJ,Schwendener R,Winoto A,Wensky A,Yagita H,Takeda K,Kershaw MH,Darcy PK,Smyth MJ

11-0042 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms contributing to the antitumour activity of selective antagonism of death receptors 4 and 5, showing that CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy.

Thu Jul 01 00:00:00 EDT 2010

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B

11-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.

Mon Feb 15 00:00:00 EST 2010

Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor.

Investigative ophthalmology & visual science

Zhang L,Ma J,Takeuchi M,Usui Y,Hattori T,Okunuki Y,Yamakawa N,Kezuka T,Kuroda M,Goto H

11-0042 was used in Flow cytometry/Cell sorting to examine whether the aryl hydrocarbon receptor-mediated effect of TCDD suppresses mouse experimental autoimmune uveitis, showing that it induces differentiation of Tregs.

Thu Apr 01 00:00:00 EDT 2010

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that dystrophin gene transfer induces anti-dystrophin immunity that are diminished by temporal removal of host immune cells.

Wed Sep 01 00:00:00 EDT 2010

Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.

Microbiology and immunology

Kumabe S,Itsumi M,Yamada H,Yajima T,Matsuguchi T,Yoshikai Y

11-0042 was used in Flow cytometry/Cell sorting to elucidate the roles of DUSP16 in T cells.

Mon Feb 01 00:00:00 EST 2010

Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.

PloS one

Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH

11-0042 was used in Immunohistochemistry on paraffin embedded tissues to investigate the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival, showing that it induces T regulatory cell mediated tolerance.

Mon Apr 26 00:00:00 EDT 2010

Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.

PloS one

Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH

Mon Apr 26 00:00:00 EDT 2010

Regulatory T cells modulate postischemic neovascularization.

Circulation

Zouggari Y,Ait-Oufella H,Waeckel L,Vilar J,Loinard C,Cochain C,Récalde A,Duriez M,Levy BI,Lutgens E,Mallat Z,Silvestre JS

11-0042 was used in Flow cytometry/Cell sorting to study the role of Treg cell activation in postischemic response and vessel growth.

Tue Oct 06 00:00:00 EDT 2009

Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease.

Blood

Pillai AB,George TI,Dutt S,Strober S

11-0042 was used in Flow cytometry/Cell sorting to investigate the interactions between Tregs and NKTs following allogenic bone transplant, showing that NKTs induce IL-4-dependent expansion of Tregs that protects against graft-versus-host disease.

Thu Apr 30 00:00:00 EDT 2009

Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.

Brain, behavior, and immunity

Steelman AJ,Dean DD,Young CR,Smith R,Prentice TW,Meagher MW,Welsh CJ

11-0042 was used in Flow cytometry/Cell sorting to examine how stress during acute TMEV infection alters virus-specific cell mediated responses, showing that stress-induced immunosuppression enhances viral persistence.

Sat Aug 01 00:00:00 EDT 2009

IL-15 is critical for the maintenance and innate functions of self-specific CD8(+) T cells.

European journal of immunology

Itsumi M,Yoshikai Y,Yamada H

11-0042 was used in Flow cytometry/Cell sorting to study the role of memory phenotype CD8+ cells in host defence mechanisms and their origin and antigen specificity.

Wed Jul 01 00:00:00 EDT 2009

The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.

Annals of the New York Academy of Sciences

Wang B,Kuroiwa JM,He LZ,Charalambous A,Keler T,Steinman RM

11-0042 was used in Flow cytometry/Cell sorting to show that targeting of mesothelin to DEC-205 improves the induction of CD4(+) and CD8(+) T-cell immunity accompanied by an antibody response.

Tue Sep 01 00:00:00 EDT 2009

In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsiveness.

Journal of immunology (Baltimore, Md. : 1950)

Ahangarani RR,Janssens W,VanderElst L,Carlier V,VandenDriessche T,Chuah M,Weynand B,Vanoirbeek JA,Jacquemin M,Saint-Remy JM

11-0042 was used in Flow cytometry/Cell sorting to design a method for in vivo induction of Ag-specific Tregs, in BALB/c H-2d, that share characteristics with type 1 Tregs.

Tue Dec 15 00:00:00 EST 2009

Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)

Broomfield SA,van der Most RG,Prosser AC,Mahendran S,Tovey MG,Smyth MJ,Robinson BW,Currie AJ

11-0042 was used in Flow cytometry/Cell sorting to show that locally delivered TLR7 agonist imiquimod in conjuction with systemic anti-CD40 immunotherapy significantly enhances the local antitumor response and retards growth of distal tumors.

Fri May 01 00:00:00 EDT 2009

Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.

Journal of immunology (Baltimore, Md. : 1950)

Akilov OE,Ustyugova IV,Zhi L,Hasan T,Wu MX

11-0042 was used in Flow cytometry/Cell sorting to explore a potential role for immediate early response gene X-1 in control of the susceptibility to Leishmania major infection.

Tue Dec 15 00:00:00 EST 2009

Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.

Reproduction (Cambridge, England)

Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP

11-0042 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.

Thu Oct 01 00:00:00 EDT 2009

Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.

Infection and immunity

Zhou X,Chen Q,Moore J,Kolls JK,Halperin S,Wang J

11-0042 was used in Flow cytometry/Cell sorting to demonstrate that Chlamydia stimulates IL-17/IL-17R-associated responses in Chlamydia-resistant and Chlamydia-susceptible mice.

Sun Nov 01 00:00:00 EDT 2009

Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells.

International journal of clinical and experimental medicine

Fan H,Wang J,Zhou X,Liu Z,Zheng SG

11-0042 was used in Flow cytometry/Cell sorting to investigate the use of TGF-beta-induced Treg cells to protect MHC-mismatched organ grafts from rejection in a clinical setting.

Tue Aug 25 00:00:00 EDT 2009

Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.

Journal of medical microbiology

Chaitra MG,Shaila MS,Nayak R

11-0042 was used in Flow cytometry/Cell sorting to demonstrate the immunogenicity of two PE/PPE proteins in BALB/c mice.

Mon Sep 01 00:00:00 EDT 2008

IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.

Journal of immunology (Baltimore, Md. : 1950)

Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA

Fri Jun 15 00:00:00 EDT 2007

A key role of dendritic cells in probiotic functionality.

PloS one

Foligne B,Zoumpopoulou G,Dewulf J,Ben Younes A,Chareyre F,Sirard JC,Pot B,Grangette C

11-0042 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in the anti-inflammatory potential of probiotic lactic acid bacteria.

Wed Mar 21 00:00:00 EDT 2007

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.

Proceedings of the National Academy of Sciences of the United States of America

Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J

Tue Jun 13 00:00:00 EDT 2006

Constitutive expression of AID leads to tumorigenesis.

The Journal of experimental medicine

Okazaki IM,Hiai H,Kakazu N,Yamada S,Muramatsu M,Kinoshita K,Honjo T

11-0042 was used in Flow cytometry/Cell sorting to indicate that AID can mutate non-Ig genes including oncogenes, potentially leading to tumorigenesis.

Mon May 05 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (RM4-5), FITC, eBioscience™

CD4 Antibody (11-0042-82) in Flow

Product Details

11-0042-82

Immunohistochemistry (IHC)

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