Product References
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD278 (ICOS) monoclonal antibody (Product # 12-9942-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency.
Nature communications
Abdelbary M,Hobbs SJ,Gibbs JS,Yewdell JW,Nolz JC
12-9942-82 was used in Flow cytometry/Cell sorting to show that access to antigen presentation and strength of TCR-signaling required for Blimp1 expression establishes the chemotactic properties of effector CD8+ T cells to promote residency within non-lymphoid tissues.
Tue Jul 04 00:00:00 EDT 2023
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
12-9942-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Assessing Lupus-Like Disease in Murine Model Systems.
Current protocols
Lee HY,Celhar T,Fairhurst AM
12-9942-82 was used in Flow Cytometry to evaluate the underlying immunological features of the disease, as a more sensitive strategy to understand the disease itself and the mechanisms of potential novel therapeutics.
Mon Nov 01 00:00:00 EDT 2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Nature immunology
Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY
12-9942-82 was used in flow cytometry to show that Treg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis.
Wed Sep 01 00:00:00 EDT 2021
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Cell metabolism
Su W,Chapman NM,Wei J,Zeng H,Dhungana Y,Shi H,Saravia J,Zhou P,Long L,Rankin S,Kc A,Vogel P,Chi H
12-9942-82 was used in Flow Cytometry to identify bidirectional metabolic signaling, specifically between immunoreceptor signaling and metabolism-mediated posttranslational lipid modifications, for the differentiation and maintenance of eTreg cells.
Tue Dec 01 00:00:00 EST 2020
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Immunity
Wei SC,Sharma R,Anang NAS,Levine JH,Zhao Y,Mancuso JJ,Setty M,Sharma P,Wang J,Pe'er D,Allison JP
12-9942 was used in Flow cytometry/Cell sorting to implicate negative co-stimulation as a key regulator and determinant of T cell differentiation and suggest that checkpoint blockade might work in part by altering the limits of T cell phenotypes.
Tue Apr 16 00:00:00 EDT 2019
A Novel Role for Triglyceride Metabolism in Foxp3 Expression.
Frontiers in immunology
Howie D,Ten Bokum A,Cobbold SP,Yu Z,Kessler BM,Waldmann H
12-9942-82 was used in Flow Cytometry to demonstrate Tregs utilize a positive feedback mechanism to promote sustained expression of Foxp3 associated with control of LD formation.
Wed Sep 30 00:00:00 EDT 2020
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using CD278 (ICOS) monoclonal antibody (Product # 12-9942-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.
Nature communications
Chen S,Fang L,Guo W,Zhou Y,Yu G,Li W,Dong K,Liu J,Luo Y,Wang B,Li Z,Zhao C,Sun Z,Shen Y,Leng Q,Zhou D,Han Z,Huang H,Ren H,Xu G,Feng X
Published figure using CD278 (ICOS) monoclonal antibody (Product # 12-9942-82) in Flow Cytometry
Thu Dec 13 00:00:00 EST 2018
Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Nature communications
Essig K,Kronbeck N,Guimaraes JC,Lohs C,Schlundt A,Hoffmann A,Behrens G,Brenner S,Kowalska J,Lopez-Rodriguez C,Jemielity J,Holtmann H,Reiche K,Hackermüller J,Sattler M,Zavolan M,Heissmeyer V
Published figure using CD278 (ICOS) monoclonal antibody (Product # 12-9942-82) in Flow Cytometry
Wed Sep 19 00:00:00 EDT 2018
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD278 (ICOS) monoclonal antibody (Product # 12-9942-82) in Flow Cytometry
Mon May 15 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Tue Oct 17 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Tue Oct 17 00:00:00 EDT 2017
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
12-9942 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory signals and Foxp3 balance mTORC1 signaling and glucose metabolism to control the proliferation and suppressive function of Treg cells.
Thu Dec 01 00:00:00 EST 2016
CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation.
International immunology
Rampuria P,Lang ML
12-9942 was used in Flow cytometry/Cell sorting to demonstrate that α-GC-stimulated, CD1d-dependent increase in peripheral NKT follicular helper cells is a result of cellular proliferation and differentiation.
Fri May 01 00:00:00 EDT 2015
Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.
Oncotarget
Yuan CH,Sun XM,Zhu CL,Liu SP,Wu L,Chen H,Feng MH,Wu K,Wang FB
12-9942 was used in Flow cytometry/Cell sorting to investigate how hepatocellular carcinoma cells alter endogenous anti-tumor immunity and their related signaling pathways.
Tue Oct 13 00:00:00 EDT 2015
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
Nature communications
Polte T,Petzold S,Bertrand J,Schütze N,Hinz D,Simon JC,Lehmann I,Echtermeyer F,Pap T,Averbeck M
12-9942 was used in Flow cytometry/Cell sorting to demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as a possible target for therapeutic intervention in this disease.
Mon Jul 13 00:00:00 EDT 2015
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
The Journal of experimental medicine
Fan X,Quezada SA,Sepulveda MA,Sharma P,Allison JP
12-9942 was used in Flow cytometry/Cell sorting to investigate the role of the ICOS pathway in increasing the efficiency of the CTLA-4 blockade in cancer immunotherapy.
Mon Apr 07 00:00:00 EDT 2014
Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.
Arthritis & rheumatology (Hoboken, N.J.)
Ding Y,Li J,Yang P,Luo B,Wu Q,Zajac AJ,Wildner O,Hsu HC,Mountz JD
12-9942 was used in Flow cytometry/Cell sorting to indicate that high levels of IL-21 selectively enhance Tfh cell differentiation but inhibit Tfr cell commitment and the suppressive function of Tfr cells on Tfh cells and B cells.
Mon Sep 01 00:00:00 EDT 2014
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.
European journal of immunology
Sinai P,Dozmorov IM,Song R,Schwartzberg PL,Wakeland EK,Wülfing C
12-9942 was used in in vitro experiments to analyse primary T and B cells from a mouse model of systemic lupus erythematosus prior to the onset of disease.
Mon Dec 01 00:00:00 EST 2014
Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Scientific reports
Montufar-Solis D,Vigneswaran N,Nakra N,Schaefer JS,Klein JR
12-9942 was used in Flow cytometry/Cell sorting to investigate the intestinal immunopathology caused by insufficient Roquin, showing that hematopoietic, not systematic, impairment of Roquin expression accounts for pathology.
Mon May 12 00:00:00 EDT 2014
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
BMC biology
Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R
12-9942 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.
Fri May 09 00:00:00 EDT 2014
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Immunity
McHedlidze T,Waldner M,Zopf S,Walker J,Rankin AL,Schuchmann M,Voehringer D,McKenzie AN,Neurath MF,Pflanz S,Wirtz S
12-9942 was used in Flow cytometry/Cell sorting to investigate the role of inflammatory networks in liver fibrosis, showing that it is mediated by interleukin-33-dependent innate lymphoid cells.
Thu Aug 22 00:00:00 EDT 2013
IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.
Journal of immunology (Baltimore, Md. : 1950)
Ding Y,Li J,Wu Q,Yang P,Luo B,Xie S,Druey KM,Zajac AJ,Hsu HC,Mountz JD
12-9942 was used in Flow cytometry/Cell sorting to investigate the role of germinal centres in autoimmunity, showing that IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.
Thu Aug 15 00:00:00 EDT 2013
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
12-9942 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
On the role of regulatory T cells during viral-induced inflammatory lesions.
Journal of immunology (Baltimore, Md. : 1950)
Veiga-Parga T,Suryawanshi A,Mulik S,Giménez F,Sharma S,Sparwasser T,Rouse BT
12-9942 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3(+)CD4(+) Tregs during ongoing inflammatory reactions in ocular HSV-1 infection.
Sat Dec 15 00:00:00 EST 2012
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
European journal of microbiology & immunology
Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D
12-9942 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.
Fri Jun 01 00:00:00 EDT 2012
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
12-9942 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.
The Journal of clinical investigation
Publicover J,Goodsell A,Nishimura S,Vilarinho S,Wang ZE,Avanesyan L,Spolski R,Leonard WJ,Cooper S,Baron JL
12-9942 was used in Flow cytometry/Cell sorting to characterise an animal model that mimics important aspects of the age-related dichotomy in human HBV infection outcome.
Tue Mar 01 00:00:00 EST 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
12-9942 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Subleski JJ,Hall VL,Wolfe TB,Scarzello AJ,Weiss JM,Chan T,Hodge DL,Back TC,Ortaldo JR,Wiltrout RH
12-9942 was used in Flow cytometry/Cell sorting to investigate TCR -dependent and -independent activation of NKT cells in the liver.
Sat Jan 15 00:00:00 EST 2011
ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.
Journal of autoimmunity
Hondowicz BD,Batheja AO,Metzgar MH,Caton AJ,Erikson J
12-9942 was used in Flow cytometry/Cell sorting to study the effect of elevated effector T-cell ICOS levels on immunity and immune cells.
Tue Jun 01 00:00:00 EDT 2010
Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Lin E,Kemball CC,Hadley A,Wilson JJ,Hofstetter AR,Pack CD,Lukacher AE
12-9942 was used in Flow cytometry/Cell sorting to investigate the heterogeneity in the viral antigen-specific CD4+ T cell responses to chronic polyomavirus infection.
Sun Aug 01 00:00:00 EDT 2010
Efficient help for autoreactive B-cell activation requires CD4+ T-cell recognition of an agonist peptide at the effector stage.
European journal of immunology
Hondowicz BD,Batheja AO,Metzgar MH,Pagán AJ,Perng OA,Willms S,Caton AJ,Erikson J
12-9942 was used in Flow cytometry/Cell sorting to investigate the effect of stimulation by agonist or partial agonist ligands during initial CD4(+) T-cell priming on antibody production by anti-chromatin B cells.
Tue Sep 01 00:00:00 EDT 2009
In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Ahangarani RR,Janssens W,VanderElst L,Carlier V,VandenDriessche T,Chuah M,Weynand B,Vanoirbeek JA,Jacquemin M,Saint-Remy JM
12-9942 was used in Flow cytometry/Cell sorting to design a method for in vivo induction of Ag-specific Tregs, in BALB/c H-2d, that share characteristics with type 1 Tregs.
Tue Dec 15 00:00:00 EST 2009
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-9942 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.
The Journal of experimental medicine
Witsch EJ,Cao H,Fukuyama H,Weigert M
12-9942 was used in Flow cytometry/Cell sorting to investigate the structure, specificity, and origin of the induced autoantibodies in chronic graft-versus-host disease, showing that light chain editing generates polyreactive antibodies.
Mon Jul 10 00:00:00 EDT 2006
