Invitrogen

CD25 Monoclonal Antibody (PC61.5), FITC, eBioscience™

FIGURE: 1 / 38

CD25 Antibody (11-0251-82) in Flow

C57BL/6 mouse splenocytes were stained with CD4 Monoclonal Antibody, PE (Product # 12-0041-82) and 0.125 µg of Rat IgG1 lambda Isotype Control, FITC (Product # 11-4301-85) (left) or 0.125 µg of CD25 Monoclonal Antibody, FITC (right). Cells in the lymphocyte gate were used for analysis.

CD25 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

11-0251-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.25 µg/test

View 41 publications 41 publications

Neutralization (Neu)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG1, lambda

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

PC61.5

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802177

Product Specific Information

Description: The PC61.5 antibody reacts with mouse CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2R alpha). CD25 is expressed by early progenitors of the T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. Binding of IL-2 to both the high and low affinity classes of IL-2 receptor is inhibited by the PC61.5 antibody. CD25 plays a role in lymphocyte differentiation and activation/proliferation.

Applications Reported: This PC61.5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This PC61.5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

Target Information

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

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Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.

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Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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SCGN deficiency results in colitis susceptibility.

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Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.

Scientific reports

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Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

Immunity

Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.

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Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y

Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.

Nature communications

Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M

Published figure using CD25 monoclonal antibody (Product # 11-0251-82) in Flow Cytometry

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Hepatic stroma-educated regulatory DCs suppress CD8⁺ T cell proliferation in mice.

Oncotarget

Wang Q,He H,Chen D,Wang C,Xu Y,Song W

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Tue Nov 07 00:00:00 EST 2017

Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.

European journal of immunology

Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H

11-0251-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.

Sat Aug 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: CD25; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; il-2 receptor alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; IL2 receptor subunit alpha; IL2-RA; IL2R subunit alpha; Il2ra antibody; interleukin-2 receptor alpha; Interleukin-2 receptor subunit alpha; Interleukin2 receptor subunit alpha; p55; p55 chain; sIL 2R; soluble IL 2 receptor

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Gene Aliases: CD25; Il2r; Il2ra; Ly-43

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UniProt ID: (Mouse) P01590

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Entrez Gene ID: (Mouse) 16184

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Function(s)

interleukin-2 receptor activity protein binding drug binding interleukin-2 binding transmembrane signal receptor

Process(es)

inflammatory response to antigenic stimulus activation-induced cell death of T cells inflammatory response immune response Notch signaling pathway interleukin-2-mediated signaling pathway positive regulation of T cell proliferation positive regulation of activated T cell proliferation negative regulation of T cell proliferation T cell homeostasis positive regulation of T cell differentiation regulation of T cell homeostatic proliferation negative regulation of lymphocyte proliferation negative regulation of defense response to virus negative regulation of inflammatory response negative regulation of immune response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD25 Monoclonal Antibody (PC61.5), FITC, eBioscience™

CD25 Antibody (11-0251-82) in Flow

Product Details

11-0251-82

Western Blot (WB)

Immunohistochemistry (IHC)

Flow Cytometry (Flow)

Neutralization (Neu)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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