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Product Details
PA5-95991
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: ANDITQSLTG KGNDSEEEMR FQEVFMEHMS NMEKRIQHIL DMEANLMDTE HFQNFSMTTD QRFNDILLQL STLFSSVQGH GNAIDEISKS LISLNTTLLD LQLNIENLNG KIQENTFKQQ EEISKLEERV YNVSAEIMAM KEEQVHLEQE IKGEVKVLNN ITNDLRLKDW EHSQTLRNIT LIQGP
Positive Samples: PC-3, HUVEC, U-937, 293T, Mouse liver, Mouse testis; Cellular Location: Membrane, Single-pass type II membrane protein
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; Scavenger receptor type A; SR-A; SR-AI/II
Gene Aliases: CD204; MRS-A; MSR; MSR-A; MSR1; phSR1; phSR2; RGD1564316; SCARA1; Scvr; SR-A; SR-AI; SR-AII; SRA
UniProt ID: (Human) P21757, (Mouse) P30204
Entrez Gene ID: (Human) 4481, (Rat) 498638, (Mouse) 20288
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