Product References
Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins.
Cancer communications (London, England)
Qiao Y,Chen J,Wang X,Yan S,Tan J,Xia B,Chen Y,Lin K,Zou F,Liu B,He X,Zhang Y,Zhang X,Zhang H,Wu X,Lu L
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2023
Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model.
Journal for immunotherapy of cancer
Corgnac S,Damei I,Gros G,Caidi A,Terry S,Chouaib S,Deloger M,Mami-Chouaib F
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2022
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.
Nature communications
Piekarska K,Urban-Wójciuk Z,Kurkowiak M,Pelikant-Małecka I,Schumacher A,Sakowska J,Spodnik JH,Arcimowicz Ł,Zielińska H,Tymoniuk B,Renkielska A,Siebert J,Słomińska E,Trzonkowski P,Hupp T,Marek-Trzonkowska NM
12-1529-42 was used in Flow Cytometry to demonstrate that both direct and indirect contact with allogeneic ASCs improves therapeutic potential of Tregs (Regulatory T cells).
Mon Feb 14 00:00:00 EST 2022
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes.
Heliyon
Trovato FM,Mujib S,Jerome E,Cavazza A,Morgan P,Smith J,Depante MT,O'Reilly K,Luxton J,Mare T,Napoli S,McPhail MJ
12-1529-42 was used in Flow cytometry/Cell sorting to support the hypothesis that IFN-γ -PD-L1 axis might be involved in the cytokine release syndrome typical of severe Covid-19 and the phenomenon persisted through multiple pandemic waves despite use of immunomodulation.
Wed Jun 01 00:00:00 EDT 2022
Engineering advanced logic and distributed computing in human CAR immune cells.
Nature communications
Cho JH,Okuma A,Sofjan K,Lee S,Collins JJ,Wong WW
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Thu Feb 04 00:00:00 EST 2021
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis.
Annals of translational medicine
Ye LL,Peng WB,Niu YR,Xiang X,Wei XS,Wang ZH,Wang X,Zhang SY,Chen X,Zhou Q
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Genome medicine
Wierzbinska JA,Toth R,Ishaque N,Rippe K,Mallm JP,Klett LC,Mertens D,Zenz T,Hielscher T,Seifert M,Küppers R,Assenov Y,Lutsik P,Stilgenbauer S,Roessner PM,Seiffert M,Byrd J,Oakes CC,Plass C,Lipka DB
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Wed Mar 18 00:00:00 EDT 2020
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Cell reports. Medicine
Dhariwala MO,Karthikeyan D,Vasquez KS,Farhat S,Weckel A,Taravati K,Leitner EG,Clancy S,Pauli M,Piper ML,Cohen JN,Ashouri JF,Lowe MM,Rosenblum MD,Scharschmidt TC
12-1529 was used in Flow cytometry/Cell sorting to elucidate features of of human prenatal skin lymphocytes by using mass and flow cytometry.
Tue Nov 17 00:00:00 EST 2020
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Cell reports. Medicine
Dhariwala MO,Karthikeyan D,Vasquez KS,Farhat S,Weckel A,Taravati K,Leitner EG,Clancy S,Pauli M,Piper ML,Cohen JN,Ashouri JF,Lowe MM,Rosenblum MD,Scharschmidt TC
12-1529 was used in Flow cytometry/Cell sorting to elucidate features of of human prenatal skin lymphocytes by using mass and flow cytometry.
Tue Nov 17 00:00:00 EST 2020
Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.
Hepatology (Baltimore, Md.)
Cobb DA,Kim OK,Golden-Mason L,Rosen HR,Hahn YS
12-1529 was used in Flow cytometry/Cell sorting to examine the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion.
Mon Jan 01 00:00:00 EST 2018
Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.
International journal of nanomedicine
Tomić S,Ilić N,Kokol V,Gruden-Movsesijan A,Mihajlović D,Bekić M,Sofronić-Milosavljević L,Čolić M,Vučević D
12-1529 was used in Flow cytometry/Cell sorting to investigate how differentially functionalised cellulose nanofibrils affect dendritic cell properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response.
Mon Dec 31 00:00:00 EST 2018
Schistosoma mansoni rSm29 Antigen Induces a Regulatory Phenotype on Dendritic Cells and Lymphocytes From Patients With Cutaneous Leishmaniasis.
Frontiers in immunology
Lopes DM,Oliveira SC,Page B,Carvalho LP,Carvalho EM,Cardoso LS
12-1529 was used in Flow cytometry/Cell sorting to evaluate the potential of the S.mansoni Sm29 antigen to change aspects of profiles of monocyte derived dendritic cells and lymphocytes from subjects with cutaneous leishmaniasis.
Tue Oct 15 00:00:00 EDT 2019
Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2-CH3 IgG spacer domains.
Journal of translational medicine
Proff J,Brey CU,Ensser A,Holter W,Lehner M
12-1529 was used in Flow cytometry/Cell sorting to identify HCMV-encoded FcRs as an attractive additional target for HCMV immunotherapy by CARs and possibly bispecific antibodies.
Thu Feb 08 00:00:00 EST 2018
Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells.
Cancer immunology research
Zahm CD,Colluru VT,McNeel DG
12-1529 was used in Flow cytometry/Cell sorting to investigate whether the dose, MHC affinity, or TCR affinity of an epitope affected the antitumor response via the PD-1/PD-L1 axis in mice.
Tue Aug 01 00:00:00 EDT 2017
Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response.
Journal of immunology (Baltimore, Md. : 1950)
Borken F,Markwart R,Requardt RP,Schubert K,Spacek M,Verner M,Rückriem S,Scherag A,Oehmichen F,Brunkhorst FM,Rubio I
12-1529 was used in Flow cytometry/Cell sorting to reveal that CCI sepsis patients feature signs of immune suppression but that their T cells exhibit a primed, rather than a suppressed, phenotype in their TCR response, arguing against a generalized T cell paralysis as a major cause of protracted immune suppression from sepsis.
Thu Jun 15 00:00:00 EDT 2017
HDAC inhibition potentiates immunotherapy in triple negative breast cancer.
Oncotarget
Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Tue Dec 26 00:00:00 EST 2017
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Oncoimmunology
Ehx G,Fransolet G,de Leval L,D'Hondt S,Lucas S,Hannon M,Delens L,Dubois S,Drion P,Beguin Y,Humblet-Baron S,Baron F
12-1529 was used in Flow cytometry/Cell sorting to investigate the impact of 5-azacytidine on xenogeneic graft-vs.-host disease and graft-vs.-leukaemia effects in a humanised murine model of transplantation.
Tue Jan 12 00:00:00 EST 2021
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
JCI insight
Siska PJ,Beckermann KE,Mason FM,Andrejeva G,Greenplate AR,Sendor AB,Chiang YJ,Corona AL,Gemta LF,Vincent BG,Wang RC,Kim B,Hong J,Chen CL,Bullock TN,Irish JM,Rathmell WK,Rathmell JC
12-1529 was used in Flow cytometry/Cell sorting to show that improving metabolic function of clear cell renal cell carcinoma CD8 tumor infiltrating lymphocytes may promote the immune response.
Thu Jun 15 00:00:00 EDT 2017
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
JCI insight
Siska PJ,Beckermann KE,Mason FM,Andrejeva G,Greenplate AR,Sendor AB,Chiang YJ,Corona AL,Gemta LF,Vincent BG,Wang RC,Kim B,Hong J,Chen CL,Bullock TN,Irish JM,Rathmell WK,Rathmell JC
12-1529 was used in Flow cytometry/Cell sorting to show that improving metabolic function of clear cell renal cell carcinoma CD8 tumor infiltrating lymphocytes may promote the immune response.
Thu Jun 15 00:00:00 EDT 2017
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.
PloS one
Geißler K,Markwart R,Requardt RP,Weigel C,Schubert K,Scherag A,Rubio I,Guntinas-Lichius O
12-1529 was used in Flow cytometry/Cell sorting to analyse and characterise the response of tonsillar T-cells from chronic tonsillitis to antigenic stimulation.
Mon Oct 16 00:00:00 EDT 2017
Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.
Scientific reports
Raijmakers RPH,Sprenkeler EGG,Aleva FE,Jacobs CWM,Kanneganti TD,Joosten LAB,van de Veerdonk FL,Gresnigt MS
12-1529 was used in Flow cytometry/Cell sorting to suggest a role for regulatory T-cells with a pro-inflammatory TH17-like phenotype in Aspergillus-associated immunopathology, and identifies key players, i.e. TLR2 and CTLA4, involved in this mechanism.
Wed Sep 13 00:00:00 EDT 2017
Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells.
Haematologica
Scottà C,Fanelli G,Hoong SJ,Romano M,Lamperti EN,Sukthankar M,Guggino G,Fazekasova H,Ratnasothy K,Becker PD,Afzali B,Lechler RI,Lombardi G
12-1529 was used in Flow cytometry/Cell sorting to study the effect of immunosuppressive drugs on Treg cells.
Fri Jan 01 00:00:00 EST 2016
Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors.
Cancer immunology research
Thommen DS,Schreiner J,Müller P,Herzig P,Roller A,Belousov A,Umana P,Pisa P,Klein C,Bacac M,Fischer OS,Moersig W,Savic Prince S,Levitsky V,Karanikas V,Lardinois D,Zippelius A
12-1529 was used in Flow cytometry/Cell sorting to characterise the diversity and expression patterns of inhibitory receptors on tumour-infiltrating T cells from patients with non-small cell lung cancer.
Tue Dec 01 00:00:00 EST 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
12-1529 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.
Mon Jun 01 00:00:00 EDT 2015
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Giannakopoulou E,Lom H,Wedderburn LR
12-1529 was used in Flow cytometry/Cell sorting to identify a unique population of Treg cells which arise from separate lineages to conventional T cells in response to chronic inflammatory conditions.
Tue Dec 15 00:00:00 EST 2015
Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals.
Journal of immunology research
Rodríguez-Perea AL,Montoya CJ,Olek S,Chougnet CA,Velilla PA
12-1529 was used in Flow cytometry/Cell sorting to investigate the effect of statins on Tregs in the absence of inflammation, showing that they increase the frequency of CD4(+)FOXP3(+) Tregs.
Tue Dec 01 00:00:00 EST 2015
Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.
Human immunology
Rueda CM,Wells CB,Gisslen T,Jobe AH,Kallapur SG,Chougnet CA
12-1529 was used in Flow cytometry/Cell sorting to show that relative to term, prematurity and chorioamnionitis decrease Treg cell functionality without affecting their frequency or phenotype.
Thu Jan 01 00:00:00 EST 2015
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1529-42) in Flow Cytometry
Tue Oct 20 00:00:00 EDT 2015
Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Pesenacker AM,Ursu S,Wu Q,Lom H,Thirugnanabalan B,Wedderburn LR
12-1529 was used in Flow cytometry/Cell sorting to study dissociation of CD25 and FOXP3 in CD4+ T cells at the site of inflammation in patients with juvenile arthritis..
Mon Sep 15 00:00:00 EDT 2014
Circulating T regulatory cells migration and phenotype in glioblastoma patients: an in vitro study.
Journal of neuro-oncology
Vasco C,Canazza A,Rizzo A,Mossa A,Corsini E,Silvani A,Fariselli L,Salmaggi A,Ciusani E
12-1529-42 was used in Sample Preparation to provide evidence that CCL2 is implicated in Treg migration, other factors are needed as well to provide such effect.
Sun Dec 01 00:00:00 EST 2013
Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner.
The Journal of allergy and clinical immunology
Schmetterer KG,Haiderer D,Leb-Reichl VM,Neunkirchner A,Jahn-Schmid B,Küng HJ,Schuch K,Steinberger P,Bohle B,Pickl WF
12-1529 was used in Flow cytometry/Cell sorting to demonstrate a transgenic approach to engineer customised, allergen-specific, human Treg cells, with potential implications for the treatment of allergic diseases.
Sat Jan 01 00:00:00 EST 2011
The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer.
British journal of cancer
Horlock C,Stott B,Dyson PJ,Morishita M,Coombes RC,Savage P,Stebbing J
12-1529 was used in Immunocytochemistry to investigate the therapeutic role of trastuzumab in modulating the activity of the cellular immune system in patients with breast cancer.
Tue Apr 07 00:00:00 EDT 2009
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.
The Journal of clinical investigation
Bashuda H,Kimikawa M,Seino K,Kato Y,Ono F,Shimizu A,Yagita H,Teraoka S,Okumura K
12-1529 was used in Flow cytometry/Cell sorting to test whether anergic T cells generated ex vivo are immunosuppressive in nonhuman primates, showing that renal allograft rejection is prevented by adoptive transfer of these cells.
Fri Jul 01 00:00:00 EDT 2005
