Product References
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
11-1278-42 was used in Flow Cytometry to pave the way for LSC-directed disease monitoring and therapy in this disease.
Mon Feb 01 00:00:00 EST 2021
CD73-Mediated Immunosuppression Is Linked to a Specific Fibroblast Population That Paves the Way for New Therapy in Breast Cancer.
Cancers
Magagna I,Gourdin N,Kieffer Y,Licaj M,Mhaidly R,Andre P,Morel A,Vincent-Salomon A,Paturel C,Mechta-Grigoriou F
11-1278-42 was used in Functional assays to support the potential clinical benefit of using both anti-CD73 and immune-checkpoint inhibitors in breast cancer patients for inhibiting CAF-S1-mediated immunosuppression and enhancing anti-tumor immune response.
Tue Nov 23 00:00:00 EST 2021
Distinct microbial and immune niches of the human colon.
Nature immunology
James KR,Gomes T,Elmentaite R,Kumar N,Gulliver EL,King HW,Stares MD,Bareham BR,Ferdinand JR,Petrova VN,Polański K,Forster SC,Jarvis LB,Suchanek O,Howlett S,James LK,Jones JL,Meyer KB,Clatworthy MR,Saeb-Parsy K,Lawley TD,Teichmann SA
11-1278 was used in Flow cytometry/Cell sorting to assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate colonic immune niches at steady state.
Sun Mar 01 00:00:00 EST 2020
Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients.
Frontiers in immunology
Casas R,Dietrich F,Barcenilla H,Tavira B,Wahlberg J,Achenbach P,Ludvigsson J
11-1278-42 was used in Flow Cytometry to improve efficacy of GAD-alum treatment using lymph-node administration in combination with oral vitamin D.
Mon May 03 00:00:00 EDT 2021
TARGET-Seq: A Protocol for High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.
STAR protocols
Rodriguez-Meira A,O'Sullivan J,Rahman H,Mead AJ
11-1278 was used in Flow cytometry/Cell sorting to present a detailed step-by-step protocol for TARGET-seq, including troubleshooting tips, approaches for automation, and methods for high-throughput multiplexing of libraries.
Fri Dec 18 00:00:00 EST 2020
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
11-1278 was used in Flow cytometry/Cell sorting to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 EDT 2019
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.
Molecular cell
Rodriguez-Meira A,Buck G,Clark SA,Povinelli BJ,Alcolea V,Louka E,McGowan S,Hamblin A,Sousos N,Barkas N,Giustacchini A,Psaila B,Jacobsen SEW,Thongjuea S,Mead AJ
11-1278-42 was used in Flow Cytometry to develop a method for the high-sensitivity detection of multiple mutations within single cells from both genomic and coding DNA, in parallel with unbiased whole-transcriptome analysis.
Thu Mar 21 00:00:00 EDT 2019
Regulatory roles of IL-10-producing human follicular T cells.
The Journal of experimental medicine
Cañete PF,Sweet RA,Gonzalez-Figueroa P,Papa I,Ohkura N,Bolton H,Roco JA,Cuenca M,Bassett KJ,Sayin I,Barry E,Lopez A,Canaday DH,Meyer-Hermann M,Doglioni C,Fazekas de St Groth B,Sakaguchi S,Cook MC,Vinuesa CG
11-1278 was used in Flow cytometry/Cell sorting to describe a subset of human tonsillar follicular T cells identified by expression of TFH markers and CD25 that are the main source of follicular T (TF) cell-derived IL-10.
Mon Aug 05 00:00:00 EDT 2019
A probiotic modulates the microbiome and immunity in multiple sclerosis.
Annals of neurology
Tankou SK,Regev K,Healy BC,Tjon E,Laghi L,Cox LM,Kivisäkk P,Pierre IV,Hrishikesh L,Gandhi R,Cook S,Glanz B,Stankiewicz J,Weiner HL
11-1278-42 was used in Flow Cytometry to suggest that probiotics could have a synergistic effect with current MS therapies.
Fri Jun 01 00:00:00 EDT 2018
According to Hepatitis C Virus (HCV) Infection Stage, Interleukin-7 Plus 4-1BB Triggering Alone or Combined with PD-1 Blockade Increases TRAF1low HCV-Specific CD8+ Cell Reactivity.
Journal of virology
Moreno-Cubero E,Subirá D,Sanz-de-Villalobos E,Parra-Cid T,Madejón A,Miquel J,Olveira A,González-Praetorius A,García-Samaniego J,Larrubia JR
11-1278 was used in Flow cytometry/Cell sorting to support novel ways of restoring the specific CD8+ T cell response, shedding light on the importance of TRAF1 signaling as a promising target for future immunotherapy during HCV infection.
Mon Jan 15 00:00:00 EST 2018
Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes.
Journal of diabetes research
Tavira B,Barcenilla H,Wahlberg J,Achenbach P,Ludvigsson J,Casas R
11-1278 was used in Flow cytometry/Cell sorting to compare the immunomodulatory effect of giving GAD-alum directly into lymph nodes versus that induced by subcutaneous administration.
Tue Dec 11 00:00:00 EST 2018
TFH-derived dopamine accelerates productive synapses in germinal centres.
Nature
Papa I,Saliba D,Ponzoni M,Bustamante S,Canete PF,Gonzalez-Figueroa P,McNamara HA,Valvo S,Grimbaldeston M,Sweet RA,Vohra H,Cockburn IA,Meyer-Hermann M,Dustin ML,Doglioni C,Vinuesa CG
11-1278 was used in Flow cytometry/Cell sorting to demonstrate that a proportion of human follicular helper T cells contain dense-core granules marked by chromogranin B.
Thu Jul 20 00:00:00 EDT 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
11-1278 was used in Flow cytometry/Cell sorting to establish the potential of interleukin-2 to enhance regulatory T cell therapy in autoimmune liver disease.
Thu Jun 01 00:00:00 EDT 2017
A human immunodeficiency syndrome caused by mutations in CARMIL2.
Nature communications
Schober T,Magg T,Laschinger M,Rohlfs M,Linhares ND,Puchalka J,Weisser T,Fehlner K,Mautner J,Walz C,Hussein K,Jaeger G,Kammer B,Schmid I,Bahia M,Pena SD,Behrends U,Belohradsky BH,Klein C,Hauck F
11-1278 was used in Flow cytometry/Cell sorting to show that human CARMIL2-deficiency is associated with defective CD28-mediated TCR co-signalling and impaired cytoskeletal dynamics.
Mon Jan 23 00:00:00 EST 2017
Eomesodermin and T-bet mark developmentally distinct human natural killer cells.
JCI insight
Collins A,Rothman N,Liu K,Reiner SL
11-1278 was used in Flow cytometry/Cell sorting to demonstrate the expression pattern of signature NK cell transcription factors during developmental maturation.
Thu Mar 09 00:00:00 EST 2017
Polymorphism in TGFB1 is associated with worse non-relapse mortality and overall survival after stem cell transplantation with unrelated donors.
Haematologica
Arrieta-Bolaños E,Mayor NP,Marsh SG,Madrigal JA,Apperley JF,Kirkland K,Mackinnon S,Marks DI,McQuaker G,Perry J,Potter MN,Russell NH,Thomson K,Shaw BE
11-1278 was used in Flow cytometry/Cell sorting to analyse the role of genetic variation in the regulatory region and exon 1 of TGFB1 on the outcome of unrelated donor hematopoietic stem cell transplantation.
Tue Mar 01 00:00:00 EST 2016
Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells.
Journal of cellular physiology
Bai H,Liu Y,Xie Y,Hoyle DL,Brodsky RA,Cheng L,Cheng T,Wang ZZ
11-1278 was used in Flow cytometry/Cell sorting to demonstrate that CD34+CD31+CD144+ HEPs give rise to hematopoietic MPP cells via hemogenic endothelial cells that exist transiently.
Sun May 01 00:00:00 EDT 2016
Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin.
Medicine
Legorreta-Haquet MV,Chávez-Rueda K,Chávez-Sánchez L,Cervera-Castillo H,Zenteno-Galindo E,Barile-Fabris L,Burgos-Vargas R,Álvarez-Hernández E,Blanco-Favela F
11-1278 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in Treg-mediated immune response, showing that it decreased Treg function in patients with systemic Lupus Erythematosus.
Mon Feb 01 00:00:00 EST 2016
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Giannakopoulou E,Lom H,Wedderburn LR
11-1278 was used in Flow cytometry/Cell sorting to identify a unique population of Treg cells which arise from separate lineages to conventional T cells in response to chronic inflammatory conditions.
Tue Dec 15 00:00:00 EST 2015
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.
Cancer biology & therapy
Wyluda EJ,Cheng J,Schell TD,Haley JS,Mallon C,Neves RI,Robertson G,Sivik J,Mackley H,Talamo G,Drabick JJ
11-1278 was used in Flow cytometry/Cell sorting to study the effectiveness of different therapy regimes on treating melanoma after failure of immunotherapy.
Tue Mar 01 00:00:00 EST 2016
Pre-Vaccination Frequencies of Th17 Cells Correlate with Vaccine-Induced T-Cell Responses to Survivin-Derived Peptide Epitopes.
PloS one
Køllgaard T,Ugurel-Becker S,Idorn M,Andersen MH,Becker JC,Straten PT
11-1278 was used in Flow cytometry/Cell sorting to investigate correlations between Th17 cells, MDSCs and Tregs and vaccine-induced T-cell responses, showing that pre-vaccination frequencies of Tregs correlate with responses to survivin-derived peptide epitopes.
Fri Apr 29 00:00:00 EDT 2016
Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Pesenacker AM,Ursu S,Wu Q,Lom H,Thirugnanabalan B,Wedderburn LR
11-1278 was used in Flow cytometry/Cell sorting to study dissociation of CD25 and FOXP3 in CD4+ T cells at the site of inflammation in patients with juvenile arthritis..
Mon Sep 15 00:00:00 EDT 2014
Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.
Nature communications
Hartmann FJ,Khademi M,Aram J,Ammann S,Kockum I,Constantinescu C,Gran B,Piehl F,Olsson T,Codarri L,Becher B
11-1278 was used in Flow cytometry/Cell sorting to study the link between granulocyte-macrophage colony-stimulating factor release TH cells and interleukin 2 signalling in the context of multiple sclerosi.
Fri Oct 03 00:00:00 EDT 2014
Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR+ NK cell levels correlate with disease outcome.
Oncoimmunology
Chaput N,Flament C,Locher C,Desbois M,Rey A,Rusakiewicz S,Poirier-Colame V,Pautier P,Le Cesne A,Soria JC,Paci A,Rosenzwajg M,Klatzmann D,Eggermont A,Robert C,Zitvogel L
11-1278 was used in Flow cytometry/Cell sorting to show that the combination of IM and IL-2 promoted rapid expansion of HLA-DR+NK cells and increased the CD4+:CD8+T-cell ratio.
Fri Feb 01 00:00:00 EST 2013
Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
PloS one
Xu X,Tan C,Li P,Zhang S,Pang X,Liu H,Li L,Sun X,Zhang Y,Wu H,Chen X,Ge Q
11-1278 was used in Flow cytometry/Cell sorting to investigate the alterations in human immune cell distributions and their functions in response to various stimuli during head-down bed rest.
Tue Jun 17 00:00:00 EDT 2014
Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy.
Haematologica
Touil S,Rosenzwajg M,Landau DA,Le Corvoisier P,Frédéric C,Klatzmann D,Maury S,Cohen JL
11-1278 was used in Flow cytometry/Cell sorting to show that a strategy of CD127 positive selection is an efficient way of eliminating Treg cells from donor lymphocyte infusions and improves alloreactivity.
Thu Nov 01 00:00:00 EDT 2012
Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion.
The Journal of infectious diseases
Raghuraman S,Park H,Osburn WO,Winkelstein E,Edlin BR,Rehermann B
11-1278 was used in Flow cytometry/Cell sorting to analyse multiple immune variables in a patient throughout their recovery from the hepatitis C virus.
Thu Mar 01 00:00:00 EST 2012
Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans.
Journal of molecular endocrinology
Legorreta-Haquet MV,Chávez-Rueda K,Montoya-Díaz E,Arriaga-Pizano L,Silva-García R,Chávez-Sánchez L,Moreno-Lafont M,Zenteno-Galindo E,Blanco-Favela F
11-1278 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which prolactin regulates Tregs, showing that it down-regulates CD4+CD25hiCD127low/- regulatory T cell function.
Wed Feb 01 00:00:00 EST 2012
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
PLoS pathogens
Pido-Lopez J,Kwok WW,Mitchell TJ,Heyderman RS,Williams NA
11-1278 was used in Flow cytometry/Cell sorting to elucidate the balance between mucosal effector and regulatory CD4 T cell immunity that's critical to pneuomococcal commensalism and the prevention of unwanted pathology associated with Streptococcus pneumoniae carriage.
Thu Dec 01 00:00:00 EST 2011
A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer.
Cytotherapy
Geller MA,Cooley S,Judson PL,Ghebre R,Carson LF,Argenta PA,Jonson AL,Panoskaltsis-Mortari A,Curtsinger J,McKenna D,Dusenbery K,Bliss R,Downs LS,Miller JS
11-1278 was used in an ELISA assay to study how adoptive transfer of haplo-identical NK cells after lymphodepleting chemotherapy is associated with transient donor chimerism and may be limited by reconstituting recipient Treg cells.
Sat Jan 01 00:00:00 EST 2011
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.
Journal of immunology (Baltimore, Md. : 1950)
Monteiro P,Gosselin A,Wacleche VS,El-Far M,Said EA,Kared H,Grandvaux N,Boulassel MR,Routy JP,Ancuta P
11-1278 was used in Flow cytometry/Cell sorting to show that, regardless of their integrin expression, productive HIV type 1 infection preferentially targets memory CCR6+CD4+ T cells.
Fri Apr 15 00:00:00 EDT 2011
Frequency of CD4(+)CD25(hi)FOXP3(+) regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Magenau JM,Qin X,Tawara I,Rogers CE,Kitko C,Schlough M,Bickley D,Braun TM,Jang PS,Lowler KP,Jones DM,Choi SW,Reddy P,Mineishi S,Levine JE,Ferrara JL,Paczesny S
11-1278 was used in Flow cytometry/Cell sorting to conduct a prospective analysis of peripheral blood Tregs as determined by the frequency of CD4(+)CD25(hi)FOXP3(+) lymphocytes in 215 BMT patients.
Thu Jul 01 00:00:00 EDT 2010
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.
PloS one
Narayanan S,Silva R,Peruzzi G,Alvarez Y,Simhadri VR,Debell K,Coligan JE,Borrego F
11-1278 was used in Flow cytometry/Cell sorting to investigate a subset within the CD4 T cell population defined by expression of the immunomodulatory receptor CD300a.
Thu May 13 00:00:00 EDT 2010
Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
PloS one
Smolders J,Peelen E,Thewissen M,Cohen Tervaert JW,Menheere P,Hupperts R,Damoiseaux J
11-1278 was used in Flow cytometry/Cell sorting to asses the effects of high dose vitamin D3 supplementation on safety and T cell parameters in relapsing remitting multiple sclerosis patients.
Mon Dec 13 00:00:00 EST 2010
Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction.
Blood
Brémond A,Meynet O,Mahiddine K,Coito S,Tichet M,Scotlandi K,Breittmayer JP,Gounon P,Gleeson PA,Bernard A,Bernard G
11-1278 was used in Flow cytometry/Cell sorting to examine the mechanisms used by CD99 to mediate human leukocyte antigen class I modulation.
Thu Jan 08 00:00:00 EST 2009
NKp80 defines and stimulates a reactive subset of CD8 T cells.
Blood
Kuttruff S,Koch S,Kelp A,Pawelec G,Rammensee HG,Steinle A
11-1278 was used in Flow cytometry/Cell sorting to investigate the role of NKp80 in T cells, showing that it defines and stimulates a reactive subset of CD8 T cells.
Thu Jan 08 00:00:00 EST 2009
Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Kim CH
Sat Dec 01 00:00:00 EST 2007
Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Kim CH
Sat Dec 01 00:00:00 EST 2007
