AbboMax

Bak Polyclonal Antibody

View all (19) BAK antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

500-3324

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corrsponding to the internal segment of human Bak

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Positive control: Human pancreatic carcinoma

Cellular location: Mitochondrion membrane.

Target Information

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apoptosis regulator BAK; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; Bcl-2-likeous antagonist/killer; Bcl2 homologous antagonist/killer; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2-like 7protein; MGC117255; MGC3887; pro-apoptotic protein BAK

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Gene Aliases: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1; N-Bak; N-BAK1

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UniProt ID: (Human) Q16611, (Mouse) O08734

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Entrez Gene ID: (Human) 578, (Mouse) 12018, (Chinese hamster) 100689368

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Function(s)
protein binding heat shock protein binding identical protein binding protein homodimerization activity ion channel binding metal ion binding protein heterodimerization activity chaperone binding BH domain binding
Process(es)
leukocyte homeostasis B cell homeostasis B cell apoptotic process release of cytochrome c from mitochondria blood vessel remodeling myeloid cell homeostasis B cell negative selection apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial fusion cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c response to fungus response to mycotoxin establishment or maintenance of transmembrane electrochemical gradient response to gamma radiation positive regulation of calcium ion transport into cytosol negative regulation of gene expression cytolysis negative regulation of endoplasmic reticulum calcium ion concentration negative regulation of peptidyl-serine phosphorylation cellular response to UV limb morphogenesis regulation of apoptotic process positive regulation of apoptotic process regulation of protein homodimerization activity regulation of protein heterodimerization activity fibroblast apoptotic process positive regulation of proteolysis regulation of mitochondrial membrane permeability post-embryonic camera-type eye morphogenesis homeostasis of number of cells regulation of cell cycle regulation of mitochondrial membrane potential vagina development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress thymocyte apoptotic process positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity positive regulation of endoplasmic reticulum unfolded protein response apoptotic process involved in patterning of blood vessels activation of signaling protein activity involved in unfolded protein response brain development aging response to UV-C response to organic cyclic compound endocrine pancreas development organ regeneration endoplasmic reticulum calcium ion homeostasis response to drug response to hydrogen peroxide response to ethanol cellular response to mechanical stimulus positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response
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