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BTLA Antibody (PA5-120216) in WB
Product Details
PA5-120216
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
Storage buffer
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RRID
Product Specific Information
Positive test controls include: Jurkat, Mouse spleen, Mouse thymus. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.
Immunogen sequence: KESCDVQLYI KRQSEHSILA GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTGKQNEL SDTAGREINL VDAHLKSEQT EASTRQNSQV LLSETGIYDN DPDLCFRMQE GSEVYSNPCL EENKPGIVYA SLNHSVIGPN SRLARNVKEA PTEYASICVR S
Target Information
BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: B and T lymphocyte associated protein; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA_HUMAN; CD272; CD272 antigen; FLJ16065; MGC129743
Gene Aliases: A630002H24; BTLA; BTLA1; CD272
UniProt ID: (Human) Q7Z6A9, (Mouse) Q7TSA3
Entrez Gene ID: (Human) 151888, (Mouse) 208154
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