Bioss

Aromatase Polyclonal Antibody

View all (23) Aromatase antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-0114M

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Sheep, Rat

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Aromatase, amino acids 51-150.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aromatase; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450 family 19 subfamily a; Cytochrome P450, 19, aromatase; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily 19; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM

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Gene Aliases: Ar; ArKO; ARO; ARO1; Arom; Aromatase; CPV1; CYAR; CYP19; Cyp19a; CYP19A1; CYPXIX; Int-5; Int5; P-450AROM; p450arom

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UniProt ID: (Human) P11511, (Mouse) P28649

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Entrez Gene ID: (Human) 1588, (Mouse) 13075, (Rat) 25147

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Function(s)
iron ion binding steroid hydroxylase activity electron carrier activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding oxygenase
Process(es)
negative regulation of chronic inflammatory response steroid biosynthetic process estrogen biosynthetic process androgen metabolic process negative regulation of macrophage chemotaxis sterol metabolic process oxidation-reduction process prostate gland growth C21-steroid hormone metabolic process negative regulation of bone resorption regulation of synapse structure or activity luteinization bile acid metabolic process male gonad development response to herbicide response to metal ion response to cesium ion response to ionizing radiation response to organic cyclic compound biphenyl metabolic process dibenzo-p-dioxin metabolic process phthalate metabolic process hippocampus development hypothalamus development melatonin metabolic process adrenal gland development granulocyte differentiation response to estradiol response to testosterone progesterone metabolic process response to drug response to morphine response to estrogen cellular response to fibroblast growth factor stimulus bone development cellular response to glucose stimulus cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to hydrostatic pressure
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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