Product References
Cognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type.
Life science alliance
Carús-Cadavieco M,Berenguer López I,Montoro Canelo A,Serrano-Lope MA,González-de la Fuente S,Aguado B,Fernández-Rodrigo A,Saido TC,Frank García A,Venero C,Esteban JA,Guix F,Dotti CG
AHB0042 was used in Western Blotting to show that T2DM produces more severe behavioral, electrophysiological, and structural alterations in these mice compared with wild-type mice.
Thu Jun 01 00:00:00 EDT 2023
Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease.
Brain sciences
Hernandez CM,Barkey RE,Craven KM,Pedemonte KA,Alisantosa B,Sanchez JO,Flinn JM
AHB0042 was used in Western Blot to find that Tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and CA1 region of the hippocampus and smaller tau tangles in the cortex, when compared to Tau mice injected with saline.
Tue May 23 00:00:00 EDT 2023
Uncovering tau in wasteosomes (corpora amylacea) of Alzheimer's disease patients.
Frontiers in aging neuroscience
Riba M,Del Valle J,Romera C,Alsina R,Molina-Porcel L,Pelegrí C,Vilaplana J
AHB0042 was used in Immunohistochemistry-immunofluorescence to reanalyze the presence of tau protein in wasteosomes and point out a methodological problem when immunolabeling.
Tue Apr 18 00:00:00 EDT 2023
High salt induces cognitive impairment via the interaction of the angiotensin II-AT1 and prostaglandin E2-EP1 systems.
British journal of pharmacology
Kubota H,Kunisawa K,Wulaer B,Hasegawa M,Kurahashi H,Sakata T,Tezuka H,Kugita M,Nagao S,Nagai T,Furuyashiki T,Narumiya S,Saito K,Nabeshima T,Mouri A
AHB0042 was used in Western Blotting to suggest that the interaction of Ang II-AT1 receptor and PGE2-EP1 receptor systems could be novel therapeutic targets for hypertension-induced cognitive impairment.
Fri Sep 01 00:00:00 EDT 2023
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation.
Scientific reports
Williams D,Yan BQ,Wang H,Negm L,Sackmann C,Verkuyl C,Rezai-Stevens V,Eid S,Vediya N,Sato C,Watts JC,Wille H,Schmitt-Ulms G
AHB0042 was used in Western Blotting to find that Sst had no influence on whole brain neprilysin transcript, protein or activity levels, an observation that cannot be accounted for by a compensatory upregulation of the Sst paralog, cortistatin (Cort), that we observed in 15-month-old Sst-deficient mice.
Thu Feb 09 00:00:00 EST 2023
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
de Oliveira P,Cella C,Locker N,Ravindran KKG,Mendis A,Wafford K,Gilmour G,Dijk DJ,Winsky-Sommerer R
AHB0042 was used in Western Blot to investigate whether trazodone, a licensed antidepressant with hypnotic efficacy in dementia, can reduce disease-related cellular pathways and improve memory and sleep in male rTg4510 mice with a tauopathy-like phenotype.
Wed Apr 20 00:00:00 EDT 2022
DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes.
Molecular neurobiology
Mai M,Guo X,Huang Y,Zhang W,Xu Y,Zhang Y,Bai X,Wu J,Zu H
AHB0042 was used in Western Blotting to find that DHCR24 knockdown can lead to tau hyperphosphorylation in the astrocyte itself by activating lipid raft-dependent Ras/MEK/ERK signaling, which might contribute to the pathogenesis of AD and other degenerative tauopathies.
Thu Sep 01 00:00:00 EDT 2022
Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy.
Experimental neurobiology
Choi M,Kim TK,Ahn J,Lee JS,Jung BC,An S,Kim D,Lee MJ,Mook-Jung I,Lee SH,Lee SJ
AHB0042 was used in Dot blot to suggest that conformation-specific antibodies targeting α-synuclein aggregates are promising therapeutic agents for PD and related synucleinopathies.
Mon Feb 28 00:00:00 EST 2022
cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus.
Neuroscience bulletin
Zheng J,Wang Y,Liu Y,Han S,Zhang Y,Luo Y,Yan Y,Li J,Zhao L
AHB0042 was used in Western Blot to indicate that cPKCγ promotes autophagy through the AMPK/mTOR signaling pathway, thus reducing the level of phosphorylated Tau at Ser214 and neurofibrillary tangles.
Sat Oct 01 00:00:00 EDT 2022
Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.
The European journal of neuroscience
Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A
AHB0042 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.
Sun May 01 00:00:00 EDT 2022
Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.
The European journal of neuroscience
Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A
AHB0042 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.
Sun May 01 00:00:00 EDT 2022
Extracellular Vesicles Derived from Young Neural Cultures Attenuate Astrocytic Reactivity In Vitro.
International journal of molecular sciences
Almansa D,Peinado H,García-Rodríguez R,Casadomé-Perales Á,Dotti CG,Guix FX
AHB0042 was used in Western Blot to pave the way to evaluate whether similar results occur in vivo and through what mechanisms.
Tue Jan 25 00:00:00 EST 2022
Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures.
Biomolecules
Korde DS,Humpel C
AHB0042 was used in Western Blotting and Immunohistochemistry to examine the spreading of P301S aggregated tau, a mutation that is implicated in tauopathies, using organotypic slice cultures.
Tue Aug 23 00:00:00 EDT 2022
Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures.
Biomolecules
Korde DS,Humpel C
AHB0042 was used in Western Blotting and Immunohistochemistry to examine the spreading of P301S aggregated tau, a mutation that is implicated in tauopathies, using organotypic slice cultures.
Tue Aug 23 00:00:00 EDT 2022
Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Saroja SR,Sharma A,Hof PR,Pereira AC
AHB0042 was used in Western Blotting to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.
Thu Sep 01 00:00:00 EDT 2022
Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.
The Journal of biological chemistry
Tabassum Z,Tseng JH,Isemann C,Tian X,Chen Y,Herring LE,Cohen TJ
AHB0042 was used in Immunoelectrophoresis to suggest that PTM profiles occur through the post-translational control of the master PTM remodeling enzymes themselves.
Wed Jun 01 00:00:00 EDT 2022
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Acta pharmacologica Sinica
Wang XJ,Qi L,Cheng YF,Ji XF,Chi TY,Liu P,Zou LB
AHB0042 was used in Western Blotting to support a critical role of PINK1-mediated mitophagy in controlling mitochondrial quality, tau hyperphosphorylation, and oxidative stress in a rat model of Alzheimer's disease.
Mon Aug 01 00:00:00 EDT 2022
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Cell death and differentiation
Zhao D,Zhou Y,Huo Y,Meng J,Xiao X,Han L,Zhang X,Luo H,Can D,Sun H,Huang TY,Wang X,Zhang J,Liu FR,Xu H,Zhang YW
AHB0042 was used in Western Blot to observe retarded axon outgrowth, elevated p35 and p25 protein levels, and increased tau phosphorylation at major Cdk5 phosphorylation sites in Rps23rg1 knockout (KO) mice.
Fri Jan 01 00:00:00 EST 2021
Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease.
Molecular neurobiology
Hashem J,Hu M,Zhang J,Gao F,Chen C
AHB0042 was used in Western Blotting to show that JZL184, a potent monoacylglycerol lipase inhibitor, significantly reduced proinflammatory cytokines, astrogliosis, phosphorylated GSK3β and tau, cleaved caspase-3, and phosphorylated NF-kB while it elevated PPARγ in P301S/PS19 mice, a tau mouse model of Alzheimer's disease.
Sun Aug 01 00:00:00 EDT 2021
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.
Communications biology
Ye T,Duan Y,Tsang HWS,Xu H,Chen Y,Cao H,Chen Y,Fu AKY,Ip NY
AHB0042 was used in Western Blot to demonstrate a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases.
Fri Feb 12 00:00:00 EST 2021
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau.
The Journal of biological chemistry
Caroux E,Redeker V,Madiona K,Melki R
AHB0042 was used in Western Blot to open new perspectives for the design of highly specific ligands with diagnostic and therapeutic potential.
Mon Nov 01 00:00:00 EDT 2021
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
Nature communications
Choi GE,Lee HJ,Chae CW,Cho JH,Jung YH,Kim JS,Kim SY,Lim JR,Han HJ
AHB0042 was used in Western Blotting to investigate the role of glucocorticoids in mitophagy inhibition and subsequent synaptic defects in hippocampal neurons, SH-SY5Y cells, and ICR mice.
Wed Jan 20 00:00:00 EST 2021
Tau Reduction Prevents Key Features of Autism in Mouse Models.
Neuron
Tai C,Chang CW,Yu GQ,Lopez I,Yu X,Wang X,Guo W,Mucke L
AHB0042 was used in Proximity Ligation Assay (PLA) to suggest an enabling role of tau in the pathogenesis of autism and identify tau reduction as a potential therapeutic strategy for some of the disorders that cause this condition.
Wed May 06 00:00:00 EDT 2020
Tau Reduction Prevents Key Features of Autism in Mouse Models.
Neuron
Tai C,Chang CW,Yu GQ,Lopez I,Yu X,Wang X,Guo W,Mucke L
AHB0042 was used in Proximity Ligation Assay (PLA) to suggest an enabling role of tau in the pathogenesis of autism and identify tau reduction as a potential therapeutic strategy for some of the disorders that cause this condition.
Wed May 06 00:00:00 EDT 2020
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Journal of neurochemistry
Hou TY,Zhou Y,Zhu LS,Wang X,Pang P,Wang DQ,Liuyang ZY,Man H,Lu Y,Zhu LQ,Liu D
AHB0042 was used in Western Blot to investigate the potential role of miR-124/PTPN1 in the tau pathology of AD.
Sat Aug 01 00:00:00 EDT 2020
Dystrophic Dmdmdx rats show early neuronal changes (increased S100β and Tau5) at 8 months, supporting severe dystropathology in this rodent model of Duchenne muscular dystrophy.
Molecular and cellular neurosciences
Krishnan VS,Thanigaiarasu LP,White R,Crew R,Larcher T,Le Guiner C,Grounds MD
AHB0042 was used in Western Blotting to support increased neuronal proteins in dystrophic nerves as a novel pre-clinical readout of ongoing myonecrosis for DMD research.
Thu Oct 01 00:00:00 EDT 2020
Fyn Kinase Controls Tau Aggregation In Vivo.
Cell reports
Briner A,Götz J,Polanco JC
AHB0042 was used in Western Blot to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.
Tue Aug 18 00:00:00 EDT 2020
Acetylation of Aβ42 at Lysine 16 Disrupts Amyloid Formation.
ACS chemical neuroscience
Adhikari R,Yang M,Saikia N,Dutta C,Alharbi WFA,Shan Z,Pandey R,Tiwari A
AHB0042 was used in Immunohistochemistry to show that the hydrophobic patches of aggregates from acetylated peptides were different when compared to wild-type (WT) peptide.
Wed Apr 15 00:00:00 EDT 2020
Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion.
International journal of molecular sciences
Mankhong S,Kim S,Moon S,Lee KH,Jeon HE,Hwang BH,Beak JW,Joa KL,Kang JH
AHB0042 was used in Western Blotting to evaluate the effects of aerobic exercise on the phosphorylation and acetylation of tau and the expressions of tau-related proteins, after middle cerebral artery occlusion (MCAO) stroke.
Fri Aug 14 00:00:00 EDT 2020
Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration.
Annals of neurology
Landa J,Gaig C,Plagumà J,Saiz A,Antonell A,Sanchez-Valle R,Dalmau J,Graus F,Sabater L
AHB0042 was used in Immunohistochemistry-immunofluorescence to suggest that IgLON5 IgG, unlike other cell-surface antibodies, disrupts neuronal cytoskeleton maintenance, providing a link between autoimmunity and neurodegeneration.
Sun Nov 01 00:00:00 EDT 2020
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.
Cell
Martorell AJ,Paulson AL,Suk HJ,Abdurrob F,Drummond GT,Guan W,Young JZ,Kim DN,Kritskiy O,Barker SJ,Mangena V,Prince SM,Brown EN,Chung K,Boyden ES,Singer AC,Tsai LH
AHB0042 was used in Western Blotting to show that GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function.
Thu Apr 04 00:00:00 EDT 2019
Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Lo CH,Lim CK,Ding Z,Wickramasinghe SP,Braun AR,Ashe KH,Rhoades E,Thomas DD,Sachs JN
AHB0042 was used in Western Blotting to discover whether tau biosensors capable of monitoring tau oligomer conformation are able to identify tool compounds that modulate the structure and conformation of these tau assemblies, providing key insight into the unique structural fingerprints of toxic tau oligomers.
Fri Nov 01 00:00:00 EDT 2019
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Cell reports
Meyer K,Feldman HM,Lu T,Drake D,Lim ET,Ling KH,Bishop NA,Pan Y,Seo J,Lin YT,Su SC,Church GM,Tsai LH,Yankner BA
AHB0042 was used in Western Blotting to propose that dysregulation of neural gene networks may set in motion the pathologic cascade that leads to AD.
Tue Jan 29 00:00:00 EST 2019
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
eLife
Silva MC,Ferguson FM,Cai Q,Donovan KA,Nandi G,Patnaik D,Zhang T,Huang HT,Lucente DE,Dickerson BC,Mitchison TJ,Fischer ES,Gray NS,Haggarty SJ
AHB0042 was used in Western Blotting to demonstrate that aberrant tau in FTD patient-derived neurons is amenable to targeted degradation, representing an important advance for therapeutics.
Mon Mar 25 00:00:00 EDT 2019
Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.
Frontiers in aging neuroscience
Foidl BM,Humpel C
AHB0042 was used in Immunohistochemistry to develop a model of organotypic brain slices in which the interactions between amyloid-beta and tau in both plaque and tau pathology can be examined.
Wed Sep 30 00:00:00 EDT 2020
Ovarian Function Modulates the Effects of Long-Chain Polyunsaturated Fatty Acids on the Mouse Cerebral Cortex.
Frontiers in cellular neuroscience
Herrera JL,Ordoñez-Gutierrez L,Fabrias G,Casas J,Morales A,Hernandez G,Acosta NG,Rodriguez C,Prieto-Valiente L,Garcia-Segura LM,Alonso R,Wandosell FG
AHB0042 was used in Western Blotting to determine whether ovarian hormones influence the effect of diet on the brain.
Wed Sep 30 00:00:00 EDT 2020
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Acta neuropathologica communications
Borin M,Saraceno C,Catania M,Lorenzetto E,Pontelli V,Paterlini A,Fostinelli S,Avesani A,Di Fede G,Zanusso G,Benussi L,Binetti G,Zorzan S,Ghidoni R,Buffelli M,Bolognin S
AHB0042 was used in Immunoprecipitation to show that Rac1 levels decreased in the frontal cortex of Alzheimer's disease patients compared to non-demented controls.
Fri Jul 13 00:00:00 EDT 2018
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Acta neuropathologica communications
Borin M,Saraceno C,Catania M,Lorenzetto E,Pontelli V,Paterlini A,Fostinelli S,Avesani A,Di Fede G,Zanusso G,Benussi L,Binetti G,Zorzan S,Ghidoni R,Buffelli M,Bolognin S
AHB0042 was used in Immunoprecipitation to show that Rac1 levels decreased in the frontal cortex of Alzheimer's disease patients compared to non-demented controls.
Fri Jul 13 00:00:00 EDT 2018
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.
The Journal of biological chemistry
Hashimoto S,Ishii A,Kamano N,Watamura N,Saito T,Ohshima T,Yokosuka M,Saido TC
AHB0042 was used in Western Blotting to conclude that the role of ER stress in AD pathogenesis needs to be carefully addressed in future studies.
Fri Mar 02 00:00:00 EST 2018
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
AHB0042 was used in western blot to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels
Mon May 01 00:00:00 EDT 2017
Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4- and 3-repeat tau.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Fujii H,Takahashi T,Mukai T,Tanaka S,Hosomi N,Maruyama H,Sakai N,Matsumoto M
AHB0042 was used in Immunohistochemistry to study the pathological association of tau dynamics in both cerebral ischemia and Alzheimer's disease.
Sat Jul 01 00:00:00 EDT 2017
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
Frontiers in molecular neuroscience
Maphis NM,Jiang S,Binder J,Wright C,Gopalan B,Lamb BT,Bhaskar K
AHB0042 was used in Western Blotting to suggest that MECP2 is a potential novel regulator of tau pathology relevant to AD and tauopathies.
Mon Sep 28 00:00:00 EDT 2020
Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice.
Neurochemical research
Chen S,Sun J,Zhao G,Guo A,Chen Y,Fu R,Deng Y
AHB0042 was used in western blot to elucidate how liraglutide affects disease and cognitive function in a mouse model of Alzheimer disease
Tue Aug 01 00:00:00 EDT 2017
Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases.
Journal of Alzheimer's disease : JAD
Li Y,Li ZX,Jin T,Wang ZY,Zhao P
AHB0042 was used in immunohistochemistry - frozen section to investigate the expression patterns of HA synthases in the murine central nervous system
Mon Feb 26 00:00:00 EST 2018
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
BMC neuroscience
O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M
AHB0042 was used in Immunohistochemistry to determine how flux through specific ion channels contributes to the various pathologies, using partial optic nerve transection in adult female rats to model secondary degeneration following neurotrauma.
Mon Aug 14 00:00:00 EDT 2017
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry
Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D
AHB0042 was used in Western Blotting to identify a potent USP14 inhibitor that retains specificity for USP14.
Fri Nov 24 00:00:00 EST 2017
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry
Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D
AHB0042 was used in Western Blotting to identify a potent USP14 inhibitor that retains specificity for USP14.
Fri Nov 24 00:00:00 EST 2017
Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Nature
Iaccarino HF,Singer AC,Martorell AJ,Rudenko A,Gao F,Gillingham TZ,Mathys H,Seo J,Kritskiy O,Abdurrob F,Adaikkan C,Canter RG,Rueda R,Brown EN,Boyden ES,Tsai LH
AHB0042 was used in Western Blotting to show reduced, behaviourally driven, gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease.
Wed Dec 07 00:00:00 EST 2016
Pulsed electromagnetic fields promote survival and neuronal differentiation of human BM-MSCs.
Life sciences
Urnukhsaikhan E,Cho H,Mishig-Ochir T,Seo YK,Park JK
AHB0042 was used in western blot to investigate survival and neuronal differentiation of human BM-MSCs by pulsed electromagnetic fields
Fri Apr 15 00:00:00 EDT 2016
The Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects.
Molecular medicine (Cambridge, Mass.)
Vintilescu CR,Afreen S,Rubino AE,Ferreira A
AHB0042 was used in Western Blotting to investigate to what extent tau cleavage and the generation of the neurotoxic tau45-230 fragment is associated with amyotrophic lateral sclerosis.
Sat Oct 01 00:00:00 EDT 2016
The Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects.
Molecular medicine (Cambridge, Mass.)
Vintilescu CR,Afreen S,Rubino AE,Ferreira A
AHB0042 was used in Western Blotting to investigate to what extent tau cleavage and the generation of the neurotoxic tau45-230 fragment is associated with amyotrophic lateral sclerosis.
Sat Oct 01 00:00:00 EDT 2016
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Journal of cell science
Yan X,Nykänen NP,Brunello CA,Haapasalo A,Hiltunen M,Uronen RL,Huttunen HJ
AHB0042 was used in immunocytochemistry and western blot to determine modulation of cellular release of tau by FRMD4A-cytohesin signaling
Sun May 15 00:00:00 EDT 2016
The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells.
Cellular and molecular neurobiology
de Paula CA,Santiago FE,de Oliveira AS,Oliveira FA,Almeida MC,Carrettiero DC
AHB0042 was used in western blot to test if BAG2 mediates the cold-induced accumulation of phosphorylated tau protein.
Sun May 01 00:00:00 EDT 2016
A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice.
Journal of neuropathology and experimental neurology
Krishnan VS,White Z,McMahon CD,Hodgetts SI,Fitzgerald M,Shavlakadze T,Harvey AR,Grounds MD
AHB0042 was used in immunohistochemistry - frozen section and western blot to utilize a time course study of sciatic nerves from aging mice to gain a neurogenic perspective of sarcopenia
Sun May 01 00:00:00 EDT 2016
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation.
Nature communications
Choi WH,de Poot SA,Lee JH,Kim JH,Han DH,Kim YK,Finley D,Lee MJ
AHB0042 was used in western blot to investigate the role of channel gating in mammalian proteasomes
Wed Mar 09 00:00:00 EST 2016
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Molecular neurodegeneration
Sohn PD,Tracy TE,Son HI,Zhou Y,Leite RE,Miller BL,Seeley WW,Grinberg LT,Gan L
AHB0042 was used in western blot to investigate the axon initial segment in neurological disorders
Wed Jun 29 00:00:00 EDT 2016
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Brain : a journal of neurology
Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D
AHB0042 was used in Western Blotting to study whether HS3ST2 and its 3-O-sulphated heparan sulphate products are involved in the mechanisms leading to the abnormal phosphorylation of tau in Alzheimer's disease and related tauopathies.
Fri May 01 00:00:00 EDT 2015
Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth.
Cellular and molecular life sciences : CMLS
De Zio D,Molinari F,Rizza S,Gatta L,Ciotti MT,Salvatore AM,Mathiassen SG,Cwetsch AW,Filomeni G,Rosano G,Ferraro E
AHB0042 was used in western blot to investigate the role of Apaf1 in axonogenesis
Sun Nov 01 00:00:00 EDT 2015
High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents.
Biochimica et biophysica acta
Petrov D,Pedrós I,Artiach G,Sureda FX,Barroso E,Pallàs M,Casadesús G,Beas-Zarate C,Carro E,Ferrer I,Vazquez-Carrera M,Folch J,Camins A
AHB0042 was used in western blot to test the effects of high fat diet using a mouse model of familial Alzheimer disease.
Tue Sep 01 00:00:00 EDT 2015
The domestic cat as a natural animal model of Alzheimer's disease.
Acta neuropathologica communications
Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H
AHB0042 was used in western blot to study Alzheimer's disease by use of a domestic cat animal model
Thu Dec 10 00:00:00 EST 2015
Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury.
Journal of neuroinflammation
Gyoneva S,Kim D,Katsumoto A,Kokiko-Cochran ON,Lamb BT,Ransohoff RM
AHB0042 was used in western blot to assess the deletion of Ccr2 and cavity size and tau pathology after mild traumatic brain injury
Thu Dec 03 00:00:00 EST 2015
Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity.
Scientific reports
Lee JH,Shin SK,Jiang Y,Choi WH,Hong C,Kim DE,Lee MJ
AHB0042 was used in Western Blotting to study UPS14 aptamers for degrading proteotoxic proteins to protect cells from neurodegenerative stressors.
Thu Jun 04 00:00:00 EDT 2015
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Frontiers in cellular neuroscience
Piedrahita D,Castro-Alvarez JF,Boudreau RL,Villegas-Lanau A,Kosik KS,Gallego-Gomez JC,Cardona-Gómez GP
AHB0042 was used in western blot to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice
Mon Jan 18 00:00:00 EST 2016
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Annals of neurology
Gheyara AL,Ponnusamy R,Djukic B,Craft RJ,Ho K,Guo W,Finucane MM,Sanchez PE,Mucke L
AHB0042 was used in immunohistochemistry to assess if tau reduction benefits intractable genetic epilepsies
Mon Sep 01 00:00:00 EDT 2014
Microtubule-associated protein tau is essential for long-term depression in the hippocampus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Kimura T,Whitcomb DJ,Jo J,Regan P,Piers T,Heo S,Brown C,Hashikawa T,Murayama M,Seok H,Sotiropoulos I,Kim E,Collingridge GL,Takashima A,Cho K
AHB0042 was used in Western Blotting to study the synaptic role of Tau.
Sun Jan 05 00:00:00 EST 2014
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Frontiers in aging neuroscience
Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP
AHB0042 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology
Mon Oct 13 00:00:00 EDT 2014
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Molecular neurodegeneration
Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL
AHB0042 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice
Fri Nov 28 00:00:00 EST 2014
Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice.
Age (Dordrecht, Netherlands)
Manich G,del Valle J,Cabezón I,Camins A,Pallàs M,Pelegrí C,Vilaplana J
AHB0042 was used in immunohistochemistry (frozen) to study the composition of pathological granules that appear in degenerative brain diseases.
Sat Feb 01 00:00:00 EST 2014
Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Biochimica et biophysica acta
Pedrós I,Petrov D,Allgaier M,Sureda F,Barroso E,Beas-Zarate C,Auladell C,Pallàs M,Vázquez-Carrera M,Casadesús G,Folch J,Camins A
AHB0042 was used in western blot to investigate the abnormalites in hippocampal energy metabolism in the pathogenesis of Alzheimer disease
Mon Sep 01 00:00:00 EDT 2014
Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells.
PloS one
Liu X,Zhou J,Abid MD,Yan H,Huang H,Wan L,Feng Z,Chen J
AHB0042 was used in western blot to study how induction of Calyculin A in N2a cells can attenuate axonal transport impairment and axonopathy by Berberine
Tue Jan 06 00:00:00 EST 2015
Cellular prion protein modulates β-amyloid deposition in aged APP/PS1 transgenic mice.
Neurobiology of aging
Ordóñez-Gutiérrez L,Torres JM,Gavín R,Antón M,Arroba-Espinosa AI,Espinosa JC,Vergara C,Del Río JA,Wandosell F
AHB0042 was used in western blot to test if β-amyloid accumulation affects prion infectivity and if different amounts of PrP affect β-amyloid accumulation.
Sun Dec 01 00:00:00 EST 2013
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.
Anesthesiology
Le Freche H,Brouillette J,Fernandez-Gomez FJ,Patin P,Caillierez R,Zommer N,Sergeant N,Buée-Scherrer V,Lebuffe G,Blum D,Buée L
AHB0042 was used in Western Blotting to investigate the effects, in normothermic conditions, of acute or repeated exposure to sevoflurane on hippocampal tau phosphorylation and spatial memory in adult mice.
Sun Apr 01 00:00:00 EDT 2012
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.
Oncogene
Papagiannakopoulos T,Friedmann-Morvinski D,Neveu P,Dugas JC,Gill RM,Huillard E,Liu C,Zong H,Rowitch DH,Barres BA,Verma IM,Kosik KS
AHB0042 was used in Western Blotting to investigate the function of miR-128 as a tumour suppressor in glioma.
Thu Apr 12 00:00:00 EDT 2012
Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression and neurodegeneration in adult hippocampus.
Toxicological sciences : an official journal of the Society of Toxicology
Karlsson O,Berg AL,Lindström AK,Hanrieder J,Arnerup G,Roman E,Bergquist J,Lindquist NG,Brittebo EB,Andersson M
AHB0042 was used in immunohistochemistry to examine the brains of 6-month-old rats treated neonatally with the glutamatergic beta-N-methylamino-L-alanine
Sat Dec 01 00:00:00 EST 2012
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
FEBS letters
Tian M,Zhu D,Xie W,Shi J
AHB0042 was used in western blot to investigate the contribution of Ang II to Alzheimer disease.
Fri Oct 19 00:00:00 EDT 2012
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
The Journal of biological chemistry
Sontag JM,Nunbhakdi-Craig V,White CL,Halpain S,Sontag E
Fri Apr 27 00:00:00 EDT 2012
Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho proteins associated with neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology
Fujimura M,Usuki F
Sun Apr 01 00:00:00 EDT 2012
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
Neurobiology of aging
Hall EC,Lee SY,Mairuae N,Simmons Z,Connor JR
AHB0042 was used in ELISA to test if HFE polymorphisms are associated with alterations in tau phosphorylation in a human neuroblastoma cell line
Mon Aug 01 00:00:00 EDT 2011
Salivary tau species are potential biomarkers of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Shi M,Sui YT,Peskind ER,Li G,Hwang H,Devic I,Ginghina C,Edgar JS,Pan C,Goodlett DR,Furay AR,Gonzalez-Cuyar LF,Zhang J
AHB0042 was used in Immunoprecipitation to identify salivary Tau species as potential biomarkers of Alzheimer's disease.
Thu Aug 16 00:00:00 EDT 2012
Ischemic preconditioning attenuates of ischemia-induced degradation of spectrin and tau: implications for ischemic tolerance.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Nakajima T,Ochi S,Oda C,Ishii M,Ogawa K
AHB0042 was used in immunohistochemistry - paraffin section and western blot to elucidate the molecular mechanisms of ischemic tolerance
Fri Apr 01 00:00:00 EDT 2011
Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease.
The European journal of neuroscience
Haggerty T,Credle J,Rodriguez O,Wills J,Oaks AW,Masliah E,Sidhu A
AHB0042 was used in western blot to examine tauopathy in mice that overexpress human alpha-synuclein as a model of Parkinson's disease.
Sun May 01 00:00:00 EDT 2011
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.
BMC neuroscience
Kaul T,Credle J,Haggerty T,Oaks AW,Masliah E,Sidhu A
AHB0042 was used in immunohistochemistry to determine the distribution of tauopathy in different regions of the brain using the alpha-Syn overexpressing mouse model
Wed Aug 03 00:00:00 EDT 2011
Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.
PloS one
Wills J,Credle J,Haggerty T,Lee JH,Oaks AW,Sidhu A
AHB0042 was used in western blot to study the tauopathic changes in the striatum of the alpha-synuclein A53T mutant mouse
Mon Mar 21 00:00:00 EDT 2011
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.
Human molecular genetics
Falzone TL,Gunawardena S,McCleary D,Reis GF,Goldstein LS
AHB0042 was used in Western Blotting to show that non-lethal reductions in axonal transport, and perhaps other types of minor axonal stress, are sufficient to induce and/or accelerate abnormal tau behaviour characteristic of Alzheimer's disease and other neurodegenerative tauopathies.
Mon Nov 15 00:00:00 EST 2010
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Life sciences
Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY
AHB0042 was used in western blot to investigate the potential neuroprotective effects of caffeic acid against Abeta-induced toxicity
Fri Feb 27 00:00:00 EST 2009
2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.
Toxicology
Sul D,Kim HS,Cho EK,Lee M,Kim HS,Jung WW,Hwang KW,Park SY
AHB0042 was used in western blot to investigate the neurotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Thu Jan 08 00:00:00 EST 2009
Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Bioscience, biotechnology, and biochemistry
Kim HS,Sul D,Lim JY,Lee D,Joo SS,Hwang KW,Park SY
AHB0042 was used in western blot to assess the neuroprotective effects of delphinidin against Abeta-induced toxicity
Wed Jul 01 00:00:00 EDT 2009
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology.
Proceedings of the National Academy of Sciences of the United States of America
Meyer DA,Richer E,Benkovic SA,Hayashi K,Kansy JW,Hale CF,Moy LY,Kim Y,O'Callaghan JP,Tsai LH,Greengard P,Nairn AC,Cowan CW,Miller DB,Antich P,Bibb JA
AHB0042 was used in Western Blot to determine the effect of spatial dysregulation of cyclin-dependent kinase 5 in the striatum.
Tue Nov 25 00:00:00 EST 2008
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Park SY,Kim HS,Cho EK,Kwon BY,Phark S,Hwang KW,Sul D
AHB0042 was used in western blot to elucidate the neuroprotective mechanisms by which curcumin protects against Abeta-induced toxicity
Fri Aug 01 00:00:00 EDT 2008
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Journal of cellular and molecular medicine
Liu R,Zhou XW,Tanila H,Bjorkdahl C,Wang JZ,Guan ZZ,Cao Y,Gustafsson JA,Winblad B,Pei JJ
AHB0042 was used in western blot to determine that Abeta deposition or oestrogen deficiency increases PP2A phosphorylation to compromise tau dephosphorylation and cause neurofibrillary tangle formation in Alzheimer's disease
Tue Jul 22 00:00:00 EDT 2008
Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits.
Neuroscience letters
Fukuzaki E,Takuma K,Himeno Y,Yoshida S,Funatsu Y,Kitahara Y,Mizoguchi H,Ibi D,Koike K,Inoue M,Yamada K
AHB0042 was used in western blot to evaluate if OVX/stress affects levels of Alzheimer's disease-related molecules in the mouse hippocampus
Wed Mar 12 00:00:00 EDT 2008
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation.
British journal of pharmacology
Selenica ML,Jensen HS,Larsen AK,Pedersen ML,Helboe L,Leist M,Lotharius J
AHB0042 was used in western blot to evaluate five glycogen synthase kinase-3beta inhibitors and lithium in lowering phosphorylated tau and glycogen synthase kinase-3beta enzyme activity levels in 12-day old postnatal rats
Thu Nov 01 00:00:00 EDT 2007
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.
Molecular and cellular biology
Jossin Y,Goffinet AM
AHB0042 was used in western blot identify and investigate Reelin-regulated signaling pathways in the brain
Mon Oct 01 00:00:00 EDT 2007
Identification of small molecules that interfere with radial neuronal migration and early cortical plate development.
Cerebral cortex (New York, N.Y. : 1991)
Zhou L,Jossin Y,Goffinet AM
AHB0042 was used in IP/Western Blotting to identify molecules which may provide new tools to study a neuronal migration and cortical plate development.
Mon Jan 01 00:00:00 EST 2007
Identification of small molecules that interfere with radial neuronal migration and early cortical plate development.
Cerebral cortex (New York, N.Y. : 1991)
Zhou L,Jossin Y,Goffinet AM
AHB0042 was used in IP/Western Blotting to identify molecules which may provide new tools to study a neuronal migration and cortical plate development.
Mon Jan 01 00:00:00 EST 2007
Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.
Neuroscience
Park SY,Tournell C,Sinjoanu RC,Ferreira A
AHB0042 was used in western blot to test if sex hormones prevent tau cleavage and Abeta toxicity
Fri Jan 05 00:00:00 EST 2007
Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons.
Neuroscience
Bergstrom RA,Sinjoanu RC,Ferreira A
AHB0042 was used in Immunocytochemistry-immunoflourescence to provide further insights into the potential molecular mechanisms underlying the effects of agrin on neurite outgrowth in rat central neurons.
Fri Nov 09 00:00:00 EST 2007
Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.
Toxicologic pathology
Saturno G,Pesenti M,Cavazzoli C,Rossi A,Giusti AM,Gierke B,Pawlak M,Venturi M
Sat Dec 01 00:00:00 EST 2007
Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.
Toxicologic pathology
Saturno G,Pesenti M,Cavazzoli C,Rossi A,Giusti AM,Gierke B,Pawlak M,Venturi M
Sat Dec 01 00:00:00 EST 2007
Mitochondrial oxidative stress causes hyperphosphorylation of tau.
PloS one
Melov S,Adlard PA,Morten K,Johnson F,Golden TR,Hinerfeld D,Schilling B,Mavros C,Masters CL,Volitakis I,Li QX,Laughton K,Hubbard A,Cherny RA,Gibson B,Bush AI
AHB0042 was used in Immunoprecipitation to find that mitochondrial SOD2 deficiency exacerbates amyloid burden and significantly reduces metal levels in the brain, while increasing levels of Ser-396 phosphorylated tau.
Wed Jun 20 00:00:00 EDT 2007
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.
The American journal of pathology
Schindowski K,Bretteville A,Leroy K,Bégard S,Brion JP,Hamdane M,Buée L
AHB0042 was used in immunohistochemistry - paraffin section and western blot to characterize a new mouse model of Alzheimer's disease
Tue Aug 01 00:00:00 EDT 2006
Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus.
Journal of neural transmission (Vienna, Austria : 1996)
Yoshida S,Maeda M,Kaku S,Ikeya H,Yamada K,Nakaike S
AHB0042 was used in western blot to assess the effects lithium chloride on cold water stress-induced changes in tau phosphorylation in the mouse hippocampus
Wed Nov 01 00:00:00 EST 2006
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.
The EMBO journal
Zheng YL,Kesavapany S,Gravell M,Hamilton RS,Schubert M,Amin N,Albers W,Grant P,Pant HC
Wed Jan 12 00:00:00 EST 2005
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.
The EMBO journal
Zheng YL,Kesavapany S,Gravell M,Hamilton RS,Schubert M,Amin N,Albers W,Grant P,Pant HC
Wed Jan 12 00:00:00 EST 2005
Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.
Proceedings of the National Academy of Sciences of the United States of America
Lobsiger CS,Garcia ML,Ward CM,Cleveland DW
AHB0042 was used in western blot to elucidate how the removal of assembled neurofilaments from axons or misaccumulating neurofilaments in motor neuron cell bodies slows disease in a mouse model of amyotrophic lateral sclerosis
Tue Jul 19 00:00:00 EDT 2005
Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.
Journal of cell science
Paganoni S,Ferreira A
Sat Jan 15 00:00:00 EST 2005
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
Chemistry & biology
Ahn JS,Radhakrishnan ML,Mapelli M,Choi S,Tidor B,Cuny GD,Musacchio A,Yeh LA,Kosik KS
Fri Jul 01 00:00:00 EDT 2005
Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration.
Molecular biology of the cell
Bunker JM,Wilson L,Jordan MA,Feinstein SC
Tue Jun 01 00:00:00 EDT 2004
Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
Journal of biomolecular screening
Ahn JS,Musacchio A,Mapelli M,Ni J,Scinto L,Stein R,Kosik KS,Yeh LA
Mon Mar 01 00:00:00 EST 2004
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
The Journal of biological chemistry
Liu SJ,Zhang JY,Li HL,Fang ZY,Wang Q,Deng HM,Gong CX,Grundke-Iqbal I,Iqbal K,Wang JZ
AHB0042 was used in Western Blotting to provide a novel mechanism of the hyperphosphorylation of tau and identify both PKA and GSK-3 as promising therapeutic targets for AD and other tauopathies.
Fri Nov 26 00:00:00 EST 2004
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.
The Journal of biological chemistry
Takahashi S,Saito T,Hisanaga S,Pant HC,Kulkarni AB
Fri Mar 21 00:00:00 EST 2003
Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type.
Acta neuropathologica
Forno LS,Langston JW,Herrick MK,Wilson JD,Murayama S
Sat Jun 01 00:00:00 EDT 2002
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Biochemical and biophysical research communications
Kerokoski P,Suuronen T,Salminen A,Soininen H,Pirttilä T
AHB0042 was used in western blot to test if calpain cleave the cyclin-dependent kinase 5 activator p35 to a p25 fragment and results in tau hyperphosphorylation.
Fri Nov 15 00:00:00 EST 2002
