Invitrogen

ACE2 Monoclonal Antibody (OTI4D2)

ACE2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

ACE2 Antibody (MA5-26628) in IHC (P)

Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a ACE2 monoclonal antibody (Product # MA5-26628).

Product Image Gallery

Product Details

MA5-26628

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI4D2

Immunogen

Human recombinant protein fragment corresponding to amino acids 18-237 of ACE2 produced in E.coli

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2723831

Target Information

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2.

Molecular therapy. Methods & clinical development

Scott TA,Supramaniam A,Idris A,Cardoso AA,Shrivastava S,Kelly G,Grepo NA,Soemardy C,Ray RM,McMillan NAJ,Morris KV

MA5-26628 was used in Western Blot to develop an EV-targeting platform to target and inhibit the early stages of SARS-CoV-2 infection.

Thu Mar 10 00:00:00 EST 2022

Bioinformatics

Protein Aliases: ACE 2; ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A

View more View less

Gene Aliases: ACE2; ACEH; UNQ868/PRO1885

View more View less

UniProt ID: (Human) Q9BYF1

View more View less

Entrez Gene ID: (Human) 59272

View more View less

Function(s)

virus receptor activity glycoprotein binding endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding metalloprotease

Process(es)

regulation of cytokine production angiotensin maturation angiotensin catabolic process in blood angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin tryptophan transport regulation of vasoconstriction receptor biosynthetic process regulation of cell proliferation regulation of vasodilation viral entry into host cell receptor-mediated virion attachment to host cell regulation of inflammatory response positive regulation of cardiac muscle contraction positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of reactive oxygen species metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

ACE2 Monoclonal Antibody (OTI4D2)

ACE2 Antibody (MA5-26628) in IHC (P)

Product Details

MA5-26628

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!