Product References
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma.
Nature cancer
Kourtis N,Wang Q,Wang B,Oswald E,Adler C,Cherravuru S,Malahias E,Zhang L,Golubov J,Wei Q,Lemus S,Ni M,Ding Y,Wei Y,Atwal GS,Thurston G,Macdonald LE,Murphy AJ,Dhanik A,Sleeman MA,Tykodi SS,Skokos D
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2022
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.
Cell reports
McMurray JL,von Borstel A,Taher TE,Syrimi E,Taylor GS,Sharif M,Rossjohn J,Remmerswaal EBM,Bemelman FJ,Vieira Braga FA,Chen X,Teichmann SA,Mohammed F,Berry AA,Lyke KE,Williamson KC,Stubbington MJT,Davey MS,Willcox CR,Willcox BE
50-4877-42 was used in Flow Cytometry to show that adult Vδ1+ T cells segregate into TCF7+LEF1+Granzyme Bneg (Tnaive) or T-bet+Eomes+BLIMP-1+Granzyme B+.
Tue May 24 00:00:00 EDT 2022
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.
Cell reports
McMurray JL,von Borstel A,Taher TE,Syrimi E,Taylor GS,Sharif M,Rossjohn J,Remmerswaal EBM,Bemelman FJ,Vieira Braga FA,Chen X,Teichmann SA,Mohammed F,Berry AA,Lyke KE,Williamson KC,Stubbington MJT,Davey MS,Willcox CR,Willcox BE
50-4877-42 was used in Flow Cytometry to show that adult Vδ1+ T cells segregate into TCF7+LEF1+Granzyme Bneg (Tnaive) or T-bet+Eomes+BLIMP-1+Granzyme B+.
Tue May 24 00:00:00 EDT 2022
TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.
Science advances
Hou QQ,Xiao Q,Sun XY,Ju XC,Luo ZG
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Immunohistochemistry
Fri Jan 01 00:00:00 EST 2021
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells.
STAR protocols
Sia WR,Hey YY,Foo R,Wang LF,Leeansyah E
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
Norovirus-Specific CD8+ T Cell Responses in Human Blood and Tissues.
Cellular and molecular gastroenterology and hepatology
Pattekar A,Mayer LS,Lau CW,Liu C,Palko O,Bewtra M,Consortium H,Lindesmith LC,Brewer-Jensen PD,Baric RS,Betts MR,Naji A,Wherry EJ,Tomov VT
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Tue Mar 08 00:00:00 EST 2022
Homeostatic Function and Inflammatory Activation of Ileal CD8+ Tissue-Resident T Cells Is Dependent on Mucosal Location.
Cellular and molecular gastroenterology and hepatology
Lutter L,Roosenboom B,Brand EC,Ter Linde JJ,Oldenburg B,van Lochem EG,Horjus Talabur Horje CS,van Wijk F
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Mon Mar 28 00:00:00 EDT 2022
Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.
The Journal of clinical investigation
Méndez-Lagares G,Chin N,Chang WLW,Lee J,Rosás-Umbert M,Kieu HT,Merriam D,Lu W,Kim S,Adamson L,Brander C,Luciw PA,Barry PA,Hartigan-O'Connor DJ
50-4877-42 was used in Flow Cytometry /test) to investigate the effects of rhesus CMV (RhCMV) on composition and function of the immune system in young macaques.
Mon Aug 02 00:00:00 EDT 2021
Cell-type-specific 3D epigenomes in the developing human cortex.
Nature
Song M,Pebworth MP,Yang X,Abnousi A,Fan C,Wen J,Rosen JD,Choudhary MNK,Cui X,Jones IR,Bergenholtz S,Eze UC,Juric I,Li B,Maliskova L,Lee J,Liu W,Pollen AA,Li Y,Wang T,Hu M,Kriegstein AR,Shen Y
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells.
eLife
Bhattacharya P,Ellegård R,Khalid M,Svanberg C,Govender M,Keita ÅV,Söderholm JD,Myrelid P,Shankar EM,Nyström S,Larsson M
50-4877 was used in Flow cytometry/Cell sorting to suggest that HIV-opsonization alters the activation and signaling pathways in the colorectal mucosa, which promotes viral establishment by creating an environment that stimulates mucosal T cell activation and inflammatory Th cells.
Wed Sep 02 00:00:00 EDT 2020
Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells.
eLife
Bhattacharya P,Ellegård R,Khalid M,Svanberg C,Govender M,Keita ÅV,Söderholm JD,Myrelid P,Shankar EM,Nyström S,Larsson M
50-4877 was used in Flow cytometry/Cell sorting to suggest that HIV-opsonization alters the activation and signaling pathways in the colorectal mucosa, which promotes viral establishment by creating an environment that stimulates mucosal T cell activation and inflammatory Th cells.
Wed Sep 02 00:00:00 EDT 2020
The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections.
Cell reports
Katsuyama E,Suarez-Fueyo A,Bradley SJ,Mizui M,Marin AV,Mulki L,Krishfield S,Malavasi F,Yoon J,Sui SJH,Kyttaris VC,Tsokos GC
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Tue Jan 07 00:00:00 EST 2020
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Cancers
Tao L,Farooq MA,Gao Y,Zhang L,Niu C,Ajmal I,Zhou Y,He C,Zhao G,Yao J,Liu M,Jiang W
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Sun Sep 13 00:00:00 EDT 2020
The Identity of Human Tissue-Emigrant CD8+ T Cells.
Cell
Buggert M,Vella LA,Nguyen S,Wu VH,Chen Z,Sekine T,Perez-Potti A,Maldini CR,Manne S,Darko S,Ransier A,Kuri-Cervantes L,Japp AS,Brody IB,Ivarsson MA,Gorin JB,Rivera-Ballesteros O,Hertwig L,Antel JP,Johnson ME,Okoye A,Picker L,Vahedi G,Sparrelid E,Llewellyn-Lacey S,Gostick E,Sandberg JK,Björkström N,Bar-Or A,Dori Y,Naji A,Canaday DH,Laufer TM,Wells AD,Price DA,Frank I,Douek DC,Wherry EJ,Itkin MG,Betts MR
50-4877-42 was used in Flow cytometry/Cell sorting to employ an integrated approach to characterize tissue-emigrant lineages in thoracic duct lymph (TDL).
Wed Dec 23 00:00:00 EST 2020
C reactive protein impairs adaptive immunity in immune cells of patients with melanoma.
Journal for immunotherapy of cancer
Yoshida T,Ichikawa J,Giuroiu I,Laino AS,Hao Y,Krogsgaard M,Vassallo M,Woods DM,Stephen Hodi F,Weber J
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.
Immunity
Gruber CN,Calis JJA,Buta S,Evrony G,Martin JC,Uhl SA,Caron R,Jarchin L,Dunkin D,Phelps R,Webb BD,Saland JM,Merad M,Orange JS,Mace EM,Rosenberg BR,Gelb BD,Bogunovic D
50-4877-42 was used in Flow Cytometry to offer a platform for personalized medicine with the concurrent discovery of fundamental biological principles.
Tue Sep 15 00:00:00 EDT 2020
The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro.
Scientific reports
Papagno L,Kuse N,Lissina A,Gostick E,Price DA,Appay V,Nicoli F
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Wed Jul 15 00:00:00 EDT 2020
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.
Nature communications
Marquardt N,Kekäläinen E,Chen P,Lourda M,Wilson JN,Scharenberg M,Bergman P,Al-Ameri M,Hård J,Mold JE,Ljunggren HG,Michaëlsson J
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Mon Aug 26 00:00:00 EDT 2019
Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine.
Nature communications
Sagebiel AF,Steinert F,Lunemann S,Körner C,Schreurs RRCE,Altfeld M,Perez D,Reinshagen K,Bunders MJ
Published figure using EOMES monoclonal antibody (Product # 50-4877-42) in Flow Cytometry
Thu Feb 28 00:00:00 EST 2019
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Nature medicine
Thommen DS,Koelzer VH,Herzig P,Roller A,Trefny M,Dimeloe S,Kiialainen A,Hanhart J,Schill C,Hess C,Savic Prince S,Wiese M,Lardinois D,Ho PC,Klein C,Karanikas V,Mertz KD,Schumacher TN,Zippelius A
50-4877 was used in Flow cytometry/Cell sorting to compare transcriptional, metabolic and functional signatures of intratumoral CD8+ T lymphocyte populations with high, intermediate and no PD-1 expression from non-small-cell lung cancer patients.
Sun Jul 01 00:00:00 EDT 2018
Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect.
JCI insight
Felices M,Lenvik AJ,McElmurry R,Chu S,Hinderlie P,Bendzick L,Geller MA,Tolar J,Blazar BR,Miller JS
50-4877 was used in Flow cytometry/Cell sorting to show that human NK cells continuously treated with IL-15 undergo a process consistent with exhaustion that is accompanied by a reduction in fatty acid oxidation.
Thu Feb 08 00:00:00 EST 2018
Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases.
Frontiers in immunology
Barbarin A,Cayssials E,Jacomet F,Nunez NG,Basbous S,Lefèvre L,Abdallah M,Piccirilli N,Morin B,Lavoue V,Catros V,Piaggio E,Herbelin A,Gombert JM
50-4877 was used in Flow cytometry/Cell sorting to study the role of natural killer like CD8+ T cells in cancer.
Wed Nov 20 00:00:00 EST 2019
The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells.
Frontiers in immunology
Oja AE,Vieira Braga FA,Remmerswaal EB,Kragten NA,Hertoghs KM,Zuo J,Moss PA,van Lier RA,van Gisbergen KP,Hombrink P
50-4877 was used in Flow cytometry/Cell sorting to suggest a shared differentiation pathway in CD4+, CD8+, and γδ+ T cells that may involve Hobit-driven acquisition of long-lived cytotoxic effector function.
Mon Jan 31 00:00:00 EST 2022
Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection.
Journal of virology
Srivastava R,Khan AA,Garg S,Syed SA,Furness JN,Vahed H,Pham T,Yu HT,Nesburn AB,BenMohamed L
50-4877 was used in Flow cytometry/Cell sorting to outline the phenotypic and functional features of protective HSV-specific CD8 T cells that should guide the development of a safe and effective T-cell-based herpes simplex vaccine.
Sun Jan 15 00:00:00 EST 2017
High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.
JCI insight
Falanga YT,Frascoli M,Kaymaz Y,Forconi C,Ong'echa JM,Bailey JA,Berg LJ,Moormann AM
50-4877 was used in Flow cytometry/Cell sorting to suggest that the unconventional CD8dim T cells arise in a very particular immunological context and may provide a deeper understanding of the heterogeneity in human immune responses.
Thu Aug 03 00:00:00 EDT 2017
Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Scientific reports
Tauriainen J,Scharf L,Frederiksen J,Naji A,Ljunggren HG,Sönnerborg A,Lund O,Reyes-Terán G,Hecht FM,Deeks SG,Betts MR,Buggert M,Karlsson AC
50487742 was used in flow cytometry to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment
Fri Jan 13 00:00:00 EST 2017
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Nature methods
Thomsen ER,Mich JK,Yao Z,Hodge RD,Doyle AM,Jang S,Shehata SI,Nelson AM,Shapovalova NV,Levi BP,Ramanathan S
50487742 was used in flow cytometry to design Fixed and Recovered Intact Single-cell RNA (FRISCR), a method for profiling the transcriptomes of individual fixed, stained and sorted cells
Fri Jan 01 00:00:00 EST 2016
The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia.
Frontiers in immunology
Jacomet F,Cayssials E,Barbarin A,Desmier D,Basbous S,Lefèvre L,Levescot A,Robin A,Piccirilli N,Giraud C,Guilhot F,Roy L,Herbelin A,Gombert JM
Wed Nov 20 00:00:00 EST 2019
Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.
PLoS pathogens
Demers KR,Makedonas G,Buggert M,Eller MA,Ratcliffe SJ,Goonetilleke N,Li CK,Eller LA,Rono K,Maganga L,Nitayaphan S,Kibuuka H,Routy JP,Slifka MK,Haynes BF,McMichael AJ,Bernard NF,Robb ML,Betts MR
50-4877 was used in Flow cytometry/Cell sorting to assess the CD8+ T cell functional evolution from primary to chronic HIV infection, demonstrating that progressive transcriptional dysregulation leads to the reduced CD8+ T cell perforin expression and loss of cytolytic potential characteristic of chronic HIV infection.
Mon Aug 01 00:00:00 EDT 2016
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.
PLoS pathogens
Hoffmann M,Pantazis N,Martin GE,Hickling S,Hurst J,Meyerowitz J,Willberg CB,Robinson N,Brown H,Fisher M,Kinloch S,Babiker A,Weber J,Nwokolo N,Fox J,Fidler S,Phillips R,Frater J
50-4877 was used in Flow cytometry/Cell sorting to identify CD8 T cell exhaustion markers which correlate with HIV-1 disease progression.
Fri Jul 01 00:00:00 EDT 2016
Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Ivarsson MA,Sundström E,Åkesson E,Martini E,Eidsmo L,Mjösberg J,Friberg D,Kublickas M,Ek S,Tegerstedt G,Seiger Å,Westgren M,Michaëlsson J
50-4877 was used in Flow cytometry/Cell sorting to indicate that CD103+ ILC3s accumulate with gestation in the fetal intestine before egress to the amniotic fluid.
Sat Oct 15 00:00:00 EDT 2016
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.
Journal of virology
Johnson S,Eller M,Teigler JE,Maloveste SM,Schultz BT,Soghoian DZ,Lu R,Oster AF,Chenine AL,Alter G,Dittmer U,Marovich M,Robb ML,Michael NL,Bolton D,Streeck H
50-4877 was used in Flow cytometry/Cell sorting to show that a subset of HIV-specific CD4+ T cells cooperate in the cytolytic control of HIV replication.
Sat Aug 01 00:00:00 EDT 2015
Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes.
Journal of virology
Khan AA,Srivastava R,Spencer D,Garg S,Fremgen D,Vahed H,Lopes PP,Pham TT,Hewett C,Kuang J,Ong N,Huang L,Scarfone VM,Nesburn AB,Wechsler SL,BenMohamed L
50-4877 was used in Flow cytometry/Cell sorting to provide insights into the role of HSV-specific CD8+ TEM cells in protection against herpes, with implications for effective vaccine design.
Wed Apr 01 00:00:00 EDT 2015
Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Béziat V,Nyström S,Hengst J,Ivarsson MA,Kekäläinen E,Johansson H,Mjösberg J,Westgren M,Lankisch TO,Wedemeyer H,Ellis EC,Ljunggren HG,Michaëlsson J,Björkström NK
50-4877 was used in Flow cytometry/Cell sorting to study the unique lineage of CD49a(+)DX5(-) NK cells, showing that they are readily detectable in the liver but not in hepatic venous or peripheral blood.
Sun Mar 15 00:00:00 EDT 2015
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.
PLoS pathogens
Buggert M,Tauriainen J,Yamamoto T,Frederiksen J,Ivarsson MA,Michaëlsson J,Lund O,Hejdeman B,Jansson M,Sönnerborg A,Koup RA,Betts MR,Karlsson AC
50-4877 was used in Flow cytometry/Cell sorting to investigate the inability of HIV-specific CD8(+) T cells to control the viral replication post-ART cessation.
Tue Jul 01 00:00:00 EDT 2014
