Product References
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment.
Cellular & molecular biology letters
Meng Y,Pospiech M,Ali A,Chandwani R,Vergel M,Onyemaechi S,Yaghmour G,Lu R,Alachkar H
47-1171-82 was used in Flow cytometry/Cell sorting to investigate whether targeting CD36 has any detrimental impact on normal hematopoietic cells.
Wed May 24 00:00:00 EDT 2023
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells.
Cell
Omer-Javed A,Pedrazzani G,Albano L,Ghaus S,Latroche C,Manzi M,Ferrari S,Fiumara M,Jacob A,Vavassori V,Nonis A,Canarutto D,Naldini L
47-1171-82 was used in flow cytometry to provide a potentially valuable strategy paving the way to broader and safer use of HSPC-GT.
Thu Jun 23 00:00:00 EDT 2022
CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture.
iScience
Koide S,Sigurdsson V,Radulovic V,Saito K,Zheng Z,Lang S,Soneji S,Iwama A,Miharada K
47-1171-82 was used in Flow Cytometry to suggest CD244 is a potent marker to exclude non-functional HSCs after in vitro culture thereby useful to elucidate mechanism of functional decline of HSCs during ex vivo treatment.
Fri Jan 21 00:00:00 EST 2022
Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation.
Frontiers in immunology
Bratti M,Vibhushan S,Longé C,Koumantou D,Ménasché G,Benhamou M,Varin-Blank N,Blank U,Saveanu L,Ben Mkaddem S
47-1171-82 was used in Flow cytometry/Cell sorting to illustrate that IRAP-positive endosomal compartments, in promoting SHP-1 inhibition during FcR signaling, control the extent of phosphorylation events at the plasma membrane and contribute to setting the intensity of immune-complex triggered inflammatory diseases.
Mon Nov 21 00:00:00 EST 2022
ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
Blood cancer discovery
Dickerson KM,Qu C,Gao Q,Iacobucci I,Gu Z,Yoshihara H,Backhaus EA,Chang Y,Janke LJ,Xu B,Wu G,Papachristou EK,D'Santos CS,Roberts KG,Mullighan CG
47-1171-82 was used in Flow cytometry/Cell sorting to reveal the interplay between cell of origin and expression of ZNF384 FO to mediate lineage ambiguity and leukemia development.
Thu May 05 00:00:00 EDT 2022
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation.
Nature cell biology
Meacham CE,Jeffery EC,Burgess RJ,Sivakumar CD,Arora MA,Stanley AM,Colby EM,Crane GM,Zhao Z,Morrison SJ
47-1171-82 was used in Flow cytometry/Cell sorting to find that adiponectin receptors are non-cell-autonomously required in haematopoietic cells to promote HSC quiescence and self-renewal.
Sun May 01 00:00:00 EDT 2022
In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation.
Genes & development
Mas G,Santoro F,Blanco E,Gamarra Figueroa GP,Le Dily F,Frigè G,Vidal E,Mugianesi F,Ballaré C,Gutierrez A,Sparavier A,Marti-Renom MA,Minucci S,Di Croce L
47-1171-82 was used in Flow cytometry/Cell sorting to demonstrate that ectopic Klf4 overexpression can suppress self-renewal and reverse the differentiation block induced by PML-RARα in leukemogenesis.
Fri Apr 01 00:00:00 EDT 2022
PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny.
Cell reports
Sá da Bandeira D,Kilpatrick AM,Marques M,Gomez-Salazar M,Ventura T,Gonzalez ZN,Stefancova D,Rossi F,Vermeren M,Vink CS,Beltran M,Henderson NC,Jung B,van der Linden R,van de Werken HJG,van Ijcken WFJ,Betsholtz C,Forbes SJ,Cuervo H,Crisan M
47-1171-82 was used in Flow cytometry/Cell sorting to demonstrate that PDGFRβ+ cells play a dual role in murine hematopoiesis.
Tue Jul 19 00:00:00 EDT 2022
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Nature
Yankova E,Blackaby W,Albertella M,Rak J,De Braekeleer E,Tsagkogeorga G,Pilka ES,Aspris D,Leggate D,Hendrick AG,Webster NA,Andrews B,Fosbeary R,Guest P,Irigoyen N,Eleftheriou M,Gozdecka M,Dias JML,Bannister AJ,Vick B,Jeremias I,Vassiliou GS,Rausch O,Tzelepis K,Kouzarides T
47-1171-82 was used in Flow Cytometry to investigate the therapeutic potential of targeting the enzymatic activity of METTL3 as an anti-leukaemic strategy.
Sat May 01 00:00:00 EDT 2021
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
Nature cell biology
Clapes T,Polyzou A,Prater P,Morales-Hernández A,Ferrarini MG,Kehrer N,Lefkopoulos S,Bergo V,Hummel B,Obier N,Maticzka D,Bridgeman A,Herman JS,Ilik I,Klaeylé L,Rehwinkel J,McKinney-Freeman S,Backofen R,Akhtar A,Cabezas-Wallscheid N,Sawarkar R,Rebollo R,Grün D,Trompouki E
47-1171-82 was used in Flow Cytometry to show that TE transcripts act as ligands that activate MDA5 during haematopoietic regeneration, thereby enabling HSCs to mount an inflammatory response necessary for their exit from quiescence.
Thu Jul 01 00:00:00 EDT 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
47-1171-82 was used in Flow cytometry/Cell sorting to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.
The Journal of clinical investigation
Yu W,Zhong L,Yao L,Wei Y,Gui T,Li Z,Kim H,Holdreith N,Jiang X,Tong W,Dyment N,Liu XS,Yang S,Choi Y,Ahn J,Qin L
47-1171 was used in Flow cytometry/Cell sorting to identify MALPs as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
Tue Jan 19 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
47-1171-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
Mesenchymal stem cells negatively regulate CD4+ T cell activation in patients with primary Sjögren syndrome through the miRNA‑125b and miRNA‑155 TCR pathway.
Molecular medicine reports
Gong B,Zheng L,Lu Z,Huang J,Pu J,Pan S,Zhang M,Liu J,Tang J
47-1171 was used in Flow cytometry/Cell sorting to indicate that the expression levels of miRNA‚125b‚5p and miRNA‚155 in TCR‚activated CD4+ T cells from patients with pSS may provide insight regarding autoimmune diseases and offer a novel target for prospective treatment.
Fri Jan 01 00:00:00 EST 2021
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function.
Cell stem cell
Mansell E,Sigurdsson V,Deltcheva E,Brown J,James C,Miharada K,Soneji S,Larsson J,Enver T
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that MMP is a source of heterogeneity in old HSCs, and its pharmacological manipulation can alter transcriptional programs with beneficial consequences for function.
Thu Feb 04 00:00:00 EST 2021
Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues.
eLife
DeVilbiss AW,Zhao Z,Martin-Sandoval MS,Ubellacker JM,Tasdogan A,Agathocleous M,Mathews TP,Morrison SJ
47-1171-82 was used in Flow Cytometry to facilitate the routine metabolomic analysis of rare cells from tissues.
Wed Jan 20 00:00:00 EST 2021
Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate.
Frontiers in cell and developmental biology
Tang W,He J,Huang T,Bai Z,Wang C,Wang H,Yang R,Ni Y,Hou J,Wang J,Zhou J,Yao Y,Gong Y,Hou S,Liu B,Lan Y
47-1171-82 was used in Flow cytometry/Cell sorting to develop an Hlf-tdTomato reporter mouse model and detected Hlf-tdTomato expression exclusively in the hematopoietic cells including part of the immunophenotypic CD45- and CD45+ pre-HSCs in the embryonic day (E) 10.5 AGM region.
Fri Oct 01 00:00:00 EDT 2021
Proximity Ligation Assay Detection of Protein-DNA Interactions-Is There a Link between Heme Oxygenase-1 and G-quadruplexes?
Antioxidants (Basel, Switzerland)
Krzeptowski W,Chudy P,Sokołowski G,Żukowska M,Kusienicka A,Seretny A,Kalita A,Czmoczek A,Gubała J,Baran S,Klóska D,Jeż M,Stępniewski J,Szade K,Szade A,Grochot-Przęczek A,Józkowicz A,Nowak WN
47-1171 was used in Flow cytometry/Cell sorting to conclude that HMOX1 influences G4 accumulation, but rather as one of the proteins regulating the heme availability, not as a rate-limiting factor.
Tue Jan 12 00:00:00 EST 2021
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Immunity
Tummers B,Mari L,Guy CS,Heckmann BL,Rodriguez DA,Rühl S,Moretti J,Crawford JC,Fitzgerald P,Kanneganti TD,Janke LJ,Pelletier S,Blander JM,Green DR
47-1171-82 was used in Flow Cytometry to suggest an in vivo role of the inflammatory RIPK1-caspase-8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role of caspase-8 that involves activation of an inflammasome.
Tue Jun 16 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
47-1171 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.
Mon May 11 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
47-1171-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.
Cell stem cell
Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD
47-1171 was used in Flow cytometry/Cell sorting to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.
Thu Mar 05 00:00:00 EST 2020
HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Cell reports
Chen C,Sun MA,Warzecha C,Bachu M,Dey A,Wu T,Adams PD,Macfarlan T,Love P,Ozato K
47-1171 was used in Flow cytometry/Cell sorting to show that HIRA provides a chromatin environment essential for HSCs, thereby steering their development and survival.
Tue Feb 18 00:00:00 EST 2020
Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.
eLife
Zaro BW,Noh JJ,Mascetti VL,Demeter J,George B,Zukowska M,Gulati GS,Sinha R,Flynn RA,Banuelos A,Zhang A,Wilkinson AC,Jackson P,Weissman IL
47-1171 was used in Flow cytometry/Cell sorting to report a proteomics resource from mass spectrometry of mouse young adult and old adult mouse hematopoietic stem cells, multipotent progenitors and oligopotent progenitors; 12 cell types in total.
Wed Nov 25 00:00:00 EST 2020
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Nature communications
Lang J,Bohn P,Bhat H,Jastrow H,Walkenfort B,Cansiz F,Fink J,Bauer M,Olszewski D,Ramos-Nascimento A,Duhan V,Friedrich SK,Becker KA,Krawczyk A,Edwards MJ,Burchert A,Huber M,Friebus-Kardash J,Göthert JR,Hardt C,Probst HC,Schumacher F,Köhrer K,Kleuser B,Babiychuk EB,Sodeik B,Seibel J,Greber UF,Lang PA,Gulbins E,Lang KS
47-1171-82 was used in Flow Cytometry to show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs).
Thu Mar 12 00:00:00 EDT 2020
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
eLife
Zhong L,Yao L,Tower RJ,Wei Y,Miao Z,Park J,Shrestha R,Wang L,Yu W,Holdreith N,Huang X,Zhang Y,Tong W,Gong Y,Ahn J,Susztak K,Dyment N,Li M,Long F,Chen C,Seale P,Qin L
47-1171 was used in Flow cytometry/Cell sorting to computationally define mesenchymal progenitors at different stages and delineate their bi-lineage differentiation paths in young, adult and aging mice.
Tue Apr 14 00:00:00 EDT 2020
Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.
eLife
Adapala NS,Swarnkar G,Arra M,Shen J,Mbalaviele G,Ke K,Abu-Amer Y
47-1171 was used in Flow cytometry/Cell sorting to suggest that NEMO serves as a toolkit to fine-tune specific signals in physiologic and pathologic conditions.
Mon Mar 23 00:00:00 EDT 2020
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
47-1171 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro.
Cell stem cell
Luchsinger LL,Strikoudis A,Danzl NM,Bush EC,Finlayson MO,Satwani P,Sykes M,Yazawa M,Snoeck HW
47-1171 was used in Flow cytometry/Cell sorting to reveal a physiological feature of HSCs that can be harnessed to improve their maintenance in vitro.
Thu Aug 01 00:00:00 EDT 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
47-1171 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 EDT 2019
Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Haematologica
Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB
47-1171-82 was used in Flow Cytometry to demonstrate that marrow adipose tissue provides stem cell factor essentially for hematopoiesis both at the steady state and upon metabolic stresses.
Sun Sep 01 00:00:00 EDT 2019
Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.
Experimental hematology
Malouf C,Ottersbach K
47-1171-82 was used in Flow Cytometry to assess if the cell-of-origin of t(4;11) MLL-AF4 acute leukemia is sensitive to a viral or bacterial mimic and if maternal immune activation can lead to a full-blown leukemia.
Thu Aug 01 00:00:00 EDT 2019
Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction.
Stem cell research & therapy
Lu D,Liao Y,Zhu SH,Chen QC,Xie DM,Liao JJ,Feng X,Jiang MH,He W
47-1171 was used in Flow cytometry/Cell sorting to show that Nestin is a useful marker for the identification of functional BMSCs and indicate that Nestin+ BMSCs could be a better therapeutic candidate for cardiac repair.
Sat Apr 27 00:00:00 EDT 2019
Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy.
Frontiers in immunology
Schwarzer M,Hermanova P,Srutkova D,Golias J,Hudcovic T,Zwicker C,Sinkora M,Akgün J,Wiedermann U,Tuckova L,Kozakova H,Schabussova I
47-1171 was used in Flow cytometry/Cell sorting to study the the relationship between gut microbiota and mucosal mast cells in the context of food allergies.
Thu Jan 16 00:00:00 EST 2020
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
47-1171 was used in Flow Cytometry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
47-1171 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
Nature genetics
Gozdecka M,Meduri E,Mazan M,Tzelepis K,Dudek M,Knights AJ,Pardo M,Yu L,Choudhary JS,Metzakopian E,Iyer V,Yun H,Park N,Varela I,Bautista R,Collord G,Dovey O,Garyfallos DA,De Braekeleer E,Kondo S,Cooper J,Göttgens B,Bullinger L,Northcott PA,Adams D,Vassiliou GS,Huntly BJP
Fri Jun 01 00:00:00 EDT 2018
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
47-1171 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation.
Cellular & molecular immunology
Bussières-Marmen S,Vinette V,Gungabeesoon J,Aubry I,Pérez-Quintero LA,Tremblay ML
47-1171 was used in Flow cytometry/Cell sorting to support the protective function of TC-PTP against inflammatory bowel diseases, independently of its previously demonstrated role in intestinal immunity.
Sun Apr 01 00:00:00 EDT 2018
Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta.
Nature communications
Baron CS,Kester L,Klaus A,Boisset JC,Thambyrajah R,Yvernogeau L,Kouskoff V,Lacaud G,van Oudenaarden A,Robin C
47-1171 was used in Flow cytometry/Cell sorting to study the molecular events controlling endothelial specification, endothelial-to-haematopoietic transition, and intra-aortic haematopoietic cluster formation, as it occurs in vivo inside the aorta.
Thu Jun 28 00:00:00 EDT 2018
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
47-1171-82 was used in Flow Cytometry to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.
Tue May 15 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
47-1171 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
Cell death & disease
Feng Y,Liao Y,Huang W,Lai X,Luo J,Du C,Lin J,Zhang Z,Qiu D,Liu Q,Shen H,Xiang AP,Zhang Q
47-1171 was used in Flow cytometry/Cell sorting to study the role of matrix Gla protein as a novel mediator of mesenchymal stromal cell-mediated immunomodulation in treating Crohn's disease.
Thu Jun 07 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
47-1171 was used in Flow cytometry/Cell sorting to demonstrate a method for the rapid/robust production of mast cells from pluripotent stem cells.
Tue Oct 09 00:00:00 EDT 2018
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains.
Stem cell reports
Morales-Hernández A,Martinat A,Chabot A,Kang G,McKinney-Freeman S
47-1171 was used in Flow cytometry/Cell sorting to report that J-haematopoietic stem and progenitor cells (HSPCs) display compromised short-term haematopoietic repopulating activity relative to N-HSPCs.
Tue Aug 14 00:00:00 EDT 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nature communications
Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that genetic/pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukaemic cell differentiation and prolonged survival of mice transplanted with MLL-rearranged AML.
Wed Dec 19 00:00:00 EST 2018
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
47-1171 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
47-1171-82 was used in Flow Cytometry to highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity.
Thu May 18 00:00:00 EDT 2017
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.
Science translational medicine
He S,Roberts PJ,Sorrentino JA,Bisi JE,Storrie-White H,Tiessen RG,Makhuli KM,Wargin WA,Tadema H,van Hoogdalem EJ,Strum JC,Malik R,Sharpless NE
47-1171 was used in Flow cytometry/Cell sorting to assess the combination of CDK4/6 inhibitors with cytotoxic chemotherapy as a means to attenuate therapy-induced bone marrow exhaustion in patients with cancer.
Wed Apr 26 00:00:00 EDT 2017
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Molecular therapy : the journal of the American Society of Gene Therapy
Debnath S,Jaako P,Siva K,Rothe M,Chen J,Dahl M,Gaspar HB,Flygare J,Schambach A,Karlsson S
47-1171 was used in Flow cytometry/Cell sorting to assess the efficacy of the human elongation factor 1α short promoter with or without the locus control region of the Β-globin gene for treatment of ribosomal protein S19-deficient Diamond-Blackfan anaemia.
Wed Aug 02 00:00:00 EDT 2017
Lacrimal Gland Repair Using Progenitor Cells.
Stem cells translational medicine
Gromova A,Voronov DA,Yoshida M,Thotakura S,Meech R,Dartt DA,Makarenkova HP
47-1171 was used in Flow cytometry/Cell sorting to provide evidence for use of adult epithelial progenitor cells cell transplantation to rescue lacrimal gland dysfunction in a model system.
Sun Jan 01 00:00:00 EST 2017
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells.
Investigative ophthalmology & visual science
Basova LV,Tang X,Umasume T,Gromova A,Zyrianova T,Shmushkovich T,Wolfson A,Hawley D,Zoukhri D,Shestopalov VI,Makarenkova HP
47-1171 was used in Flow cytometry/Cell sorting to show that blocking Panx1 and/or Casp4 activities is a beneficial strategy to enhance donor cell engraftment and lacrimal gland regeneration through the reduction of inflammation.
Wed Nov 01 00:00:00 EDT 2017
Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the haematopoietic stem cells.
Cancer biology & therapy
Gui J,Zhao B,Lyu K,Tong W,Fuchs SY
47-1171 was used in Flow cytometry/Cell sorting to determine the role of IFNAR1 downregulation in the maintenance of haematopoietic stem cells.
Mon Jul 03 00:00:00 EDT 2017
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
47-1171 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.
eLife
Dave K,Sur I,Yan J,Zhang J,Kaasinen E,Zhong F,Blaas L,Li X,Kharazi S,Gustafsson C,De Paepe A,Månsson R,Taipale J
47-1171 was used in Functional assays to show that a deletion in the gene desert upstream of the MYC oncogene on chromosome 8q24 can confer tumourigenic resistance.
Tue Jun 06 00:00:00 EDT 2017
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
47-1171 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Blood
Sinclair A,Park L,Shah M,Drotar M,Calaminus S,Hopcroft LE,Kinstrie R,Guitart AV,Dunn K,Abraham SA,Sansom O,Michie AM,Machesky L,Kranc KR,Graham GJ,Pellicano F,Holyoake TL
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.
Thu Jul 21 00:00:00 EDT 2016
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Blood
Sinclair A,Park L,Shah M,Drotar M,Calaminus S,Hopcroft LE,Kinstrie R,Guitart AV,Dunn K,Abraham SA,Sansom O,Michie AM,Machesky L,Kranc KR,Graham GJ,Pellicano F,Holyoake TL
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.
Thu Jul 21 00:00:00 EDT 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
47-1171 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.
Fri Jan 01 00:00:00 EST 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
47-1171 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia.
Oncotarget
Chen L,Sun Y,Wang J,Jiang H,Muntean AG
47-1171 was used in Flow cytometry/Cell sorting to examine the genome-wide expression profiles of leukemic cells transformed with different MLL fusion proteins.
Tue May 03 00:00:00 EDT 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
47-1171 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 EST 2016
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Blood
Hu W,Dooley J,Chung SS,Chandramohan D,Cimmino L,Mukherjee S,Mason CE,de Strooper B,Liston A,Park CY
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that miR-29a is critical for maintaining HSC function through its negative regulation of Dnmt3a.
Thu Apr 02 00:00:00 EDT 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
47-1171 was used in Flow cytometry/Cell sorting to investigate the critical niche components and resident signals required for hematopoietic stem cell induction and self-renewal ex vivo.
Fri May 01 00:00:00 EDT 2015
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
The Journal of experimental medicine
Tesio M,Tang Y,Müdder K,Saini M,von Paleske L,Macintyre E,Pasparakis M,Waisman A,Trumpp A
47-1171 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanisms regulating haematopoietic stem cell dormancy.
Mon Apr 06 00:00:00 EDT 2015
Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.
Biology open
Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE
47117182 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.
Fri May 15 00:00:00 EDT 2015
Sleep disruption impairs haematopoietic stem cell transplantation in mice.
Nature communications
Rolls A,Pang WW,Ibarra I,Colas D,Bonnavion P,Korin B,Heller HC,Weissman IL,de Lecea L
47-1171 was used in Flow cytometry/Cell sorting to provide insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs.
Wed Oct 14 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
47-1171 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
O-GlcNAcylation Negatively Regulates Cardiomyogenic Fate in Adult Mouse Cardiac Mesenchymal Stromal Cells.
PloS one
Zafir A,Bradley JA,Long BW,Muthusamy S,Li Q,Hill BG,Wysoczynski M,Prabhu SD,Bhatnagar A,Bolli R,Jones SP
47-1171 was used in Flow cytometry/Cell sorting to investigate how O-GlcNAcylation of intracellular proteins is involved in the regulation of mesenchymal stromal cell lineage commitment.
Wed Jun 29 00:00:00 EDT 2016
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
Nature communications
Lee CL,Castle KD,Moding EJ,Blum JM,Williams N,Luo L,Ma Y,Borst LB,Kim Y,Kirsch DG
47-1171 was used in Flow cytometry/Cell sorting to show that total-body irradiation promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D).
Thu Sep 24 00:00:00 EDT 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
47-1171 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
47-1171 was used in Flow cytometry/Cell sorting to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.
Wed Jan 01 00:00:00 EST 2014
LT-HSC Methylcellulose Assay.
Bio-protocol
Kerenyi MA
47-1171-82 was used in Flow cytometry/Cell sorting to describe an LT-HSCs methylcellulose colony-forming assay, as a fast complementary in vitro method to directly assess LT-HSC differentiation capacity.
Sat May 03 00:00:00 EDT 2014
Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Nature
Adorno M,Sikandar S,Mitra SS,Kuo A,Nicolis Di Robilant B,Haro-Acosta V,Ouadah Y,Quarta M,Rodriguez J,Qian D,Reddy VM,Cheshier S,Garner CC,Clarke MF
47-1171 was used in Flow cytometry/Cell sorting to demonstrate a role for USP16 in antagonising the self-renewal and senescence pathways in Down's syndrome.
Thu Sep 19 00:00:00 EDT 2013
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
47-1171 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
47-1171 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
47-1171 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
47-1171 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.
The Journal of allergy and clinical immunology
Oka T,Rios EJ,Tsai M,Kalesnikoff J,Galli SJ
47-1171 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying rapid desensitisation, with a focus on mast cells, using a mouse model.
Tue Oct 01 00:00:00 EDT 2013
AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL.
Leukemia
Stankiewicz MJ,Crispino JD
47-1171 was used in Flow cytometry/Cell sorting to discover that constitutive AKT signalling is associated with an increase in apoptosis of WT megakaryocytes but is blocked by ERG.
Sat Jun 01 00:00:00 EDT 2013
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
47-1171 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
47-1171 was used in Flow cytometry/Cell sorting to demonstrate how CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
Tue Jan 15 00:00:00 EST 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
47-1171 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 EDT 2013
Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.
Molecular and cellular biology
Yasunaga S,Ohtsubo M,Ohno Y,Saeki K,Kurogi T,Tanaka-Okamoto M,Ishizaki H,Shirai M,Mihara K,Brock HW,Miyoshi J,Takihara Y
47-1171 was used in Flow cytometry/Cell sorting to investigate the effects of Scmh1 on Geminin and Histone H2A, and the mechanisms therein.
Fri Feb 01 00:00:00 EST 2013
Murine bone marrow Lin⁻Sca⁻1⁺CD45⁻ very small embryonic-like (VSEL) cells are heterogeneous population lacking Oct-4A expression.
PloS one
Szade K,Bukowska-Strakova K,Nowak WN,Szade A,Kachamakova-Trojanowska N,Zukowska M,Jozkowicz A,Dulak J
47-1171 was used in Flow cytometry/Cell sorting to show that the murine Lin(-)Sca-1(+)CD45(-) population is heterogeneous in terms of c-Kit and KDR expression.
Tue Feb 18 00:00:00 EST 2014
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
Blood
Capitano ML,Nemeth MJ,Mace TA,Salisbury-Ruf C,Segal BH,McCarthy PL,Repasky EA
47-1171 was used in Flow cytometry/Cell sorting to study the factors limiting the immune system recovery process after chemo- and radiotherapy.
Thu Sep 27 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
47-1171 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.
Blood
Lancrin C,Mazan M,Stefanska M,Patel R,Lichtinger M,Costa G,Vargel O,Wilson NK,Möröy T,Bonifer C,Göttgens B,Kouskoff V,Lacaud G
47-1171 was used in Flow cytometry/Cell sorting to demonstrate a critical and specific role of the GFI1 transcription factors in the first steps of the process leading to the generation of hematopoietic progenitors.
Thu Jul 12 00:00:00 EDT 2012
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.
Blood
Lancrin C,Mazan M,Stefanska M,Patel R,Lichtinger M,Costa G,Vargel O,Wilson NK,Möröy T,Bonifer C,Göttgens B,Kouskoff V,Lacaud G
47-1171 was used in Flow cytometry/Cell sorting to demonstrate a critical and specific role of the GFI1 transcription factors in the first steps of the process leading to the generation of hematopoietic progenitors.
Thu Jul 12 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
47-1171 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Blood
Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S
47-1171 was used in Flow cytometry/Cell sorting to demonstrate the feasibility of transgenic RNA interference to generate models for diseases caused by haploinsufficient expression of a gene.
Thu Dec 01 00:00:00 EST 2011
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.
Cell stem cell
Chen MJ,Li Y,De Obaldia ME,Yang Q,Yzaguirre AD,Yamada-Inagawa T,Vink CS,Bhandoola A,Dzierzak E,Speck NA
47-1171 was used in Flow cytometry/Cell sorting to indicate that EMPs and HSCs differentiate from distinct populations of hemogenic endothelial cells.
Fri Dec 02 00:00:00 EST 2011
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
47-1171 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.
Thu Jun 17 00:00:00 EDT 2010
Characterization of endothelial progenitor cells mobilization following cutaneous wounding.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Morris LM,Klanke CA,Lang SA,Pokall S,Maldonado AR,Vuletin JF,Alaee D,Keswani SG,Lim FY,Crombleholme TM
47-1171 was used in Flow cytometry/Cell sorting to characterize bone marrow (BM)-derived endothelial progenitor cell (EPC) mobilization following cutaneous wounding in mice.
Mon Nov 15 00:00:00 EST 2010
A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP-Chip.
Biological procedures online
Weishaupt H,Attema JL
47-1171 was used in Flow cytometry/Cell sorting to document the genome-wide chromatin states of low abundant populations that comprise hematopoietic stem cells.
Sat May 15 00:00:00 EDT 2010
