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Invitrogen
4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (014), APC
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4-1BB Ligand Antibody (MA5-46776) in Flow
Product Details
MA5-46776
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Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL (CD137L) (Arg104-Glu309) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB Ligand; 4 1 BBL; 4-1BB ligand; 4-1BBL; 41BB Ligand; 41BBL; CD 137 Ligand; CD 137L; CD137 Ligand; CDw137L; TNFRSF9; Tumor necrosis factor ligand superfamily member 9
Gene Aliases: 4-1BB-L; 4-1BBL; AI848817; Cd137l; Cd157l; Ly63l; Tnfsf9
UniProt ID: (Mouse) P41274
Entrez Gene ID: (Mouse) 21950
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