Product References
Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas.
Scientific reports
Jaeger HK,Davis DA,Nair A,Shrestha P,Stream A,Yaparla A,Yarchoan R
16-0037-81 was used in In vitro Assay to indicate Pom acts through cereblon leading to degradation of Ikaros and activation of the PI3K/AKT/PU.1 pathway resulting in upregulation of B7-2 mRNA and protein expression.
Tue Jul 18 00:00:00 EDT 2023
Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood.
Immunotherapy advances
Lin M,Bhakdi SC,Tan D,Lee JJX,Tai DWM,Pavesi A,Wai LE,Wang T,Bertoletti A,Tan AT
16-0037-81 was used in Functional assays to demonstrate that a panel of antibodies (AFP, GPC3, Vimentin, pan-Cytokeratin, and CD45) specific for HCC tumour antigens and immune cells can effectively differentiate HCC-CTCs in whole blood.
Tue Aug 29 00:00:00 EDT 2023
Comprehensive analysis of prognosis and immune function of CD70-CD27 signaling axis in pan-cancer.
Functional & integrative genomics
Kong F,Ye Q,Xiong Y
16-0037-81 was used in Functional assays to undertake a pan-cancer study, providing a relatively comprehensive understanding of the carcinogenic role of the CD70-CD27 signaling axis in different tumors.
Thu Jan 26 00:00:00 EST 2023
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Journal of experimental & clinical cancer research : CR
Liu Y,Xu Q,Deng F,Zheng Z,Luo J,Wang P,Zhou J,Lu X,Zhang L,Chen Z,Zhang Q,Chen Q,Zuo D
16-0037-81 was used in Cell Culture to identify HERC2 functions as a previously unknown modulator of the JAK2/STAT3 pathway, thereby promoting inflammation-induced stemness and immune evasion in HCC.
Wed Feb 01 00:00:00 EST 2023
Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death.
BMC cancer
Selvin T,Berglund M,Lenhammar L,Jarvius M,Nygren P,Fryknäs M,Larsson R,Andersson CR
16-0037-81 was used in Immunocytochemistry, Flow Cytometry, Functional Assay to provide a n in vitro phenotypic screening approach for the identification of immunomodulatory agents and thus addresses a critical gap in the field of immuno-oncology.
Fri Feb 17 00:00:00 EST 2023
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Cell metabolism
Saveljeva S,Sewell GW,Ramshorn K,Cader MZ,West JA,Clare S,Haag LM,de Almeida Rodrigues RP,Unger LW,Iglesias-Romero AB,Holland LM,Bourges C,Md-Ibrahim MN,Jones JO,Blumberg RS,Lee JC,Kaneider NC,Lawley TD,Bradley A,Dougan G,Kaser A
16-0037-81 was used in Flow Cytometry to understand the mechanism behind FAMIN's role in autoimmunity and autoinflammation whilst specifically looking at Still's disease.
Tue Jan 04 00:00:00 EST 2022
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor.
Cells
Rode AKO,Buus TB,Mraz V,Al-Jaberi FAH,Lopez DV,Ford SL,Hennen S,Eliasen IP,Klewe IV,Gharehdaghi L,Dragan A,Rosenkilde MM,Woetmann A,Skov L,Ødum N,Bonefeld CM,Kongsbak-Wismann M,Geisler C
16-0037-81 was used in Immuno-assay to hypothesize that GLP-1R+ iTreg cells play a key role in the anti-inflammatory effects ascribed to GLP-1R agonists in humans.
Fri Aug 19 00:00:00 EDT 2022
Correction of multiple-blinking artifacts in photoactivated localization microscopy.
Nature methods
Jensen LG,Hoh TY,Williamson DJ,Griffié J,Sage D,Rubin-Delanchy P,Owen DM
16-0037-81 was used in Flow Cytometry, Functional Assay, Sample Prep to present a MBC workflow producing a corrected set of localization coordinates representing the true underlying fluorophore locations with enhanced localization precision.
Sun May 01 00:00:00 EDT 2022
Dissecting Heterogeneity Reveals a Unique BAMBIhigh MFGE8high Subpopulation of Human UC-MSCs.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen H,Wen X,Liu S,Sun T,Song H,Wang F,Xu J,Zhang Y,Zhao Y,Yu J,Sun L
16-0037-81 was used in Flow Cytometry to clarify the nature of human UC-MSCs and to choose optimal MSC types to treat specific diseases in the future.
Mon Nov 14 00:00:00 EST 2022
A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy.
JCI insight
Banerjee A,Li D,Guo Y,Mei Z,Lau C,Chen K,Westwick J,Klauda JB,Schrum A,Lazear ER,Krupnick AS
16-0037-81 was used in Flow cytometry/Cell sorting to describe the signaling properties of a potentially unique cytokine by design, where T cell surface binding and signaling are separated between 2 different families of receptors.
Mon May 23 00:00:00 EDT 2022
Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma.
Journal of innate immunity
Wang T,Zhou Q,Shang Y
16-0037 was used in Flow cytometry/Cell sorting to investigate the role of miRNA-451a in regulating ETS1 expression in CD4+ T cell.
Thu Nov 11 00:00:00 EST 2021
Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization.
American journal of translational research
Xun X,Zhang C,Wang S,Hu S,Xiang X,Cheng Q,Li Z,Wang Y,Zhu J
16-0037-81 was used in Magnetic cell separation to investigate the COX-2-dependent immune regulation pathway.
Tue Jun 22 00:00:00 EDT 2021
Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4+ T cells of patients with vitiligo.
Experimental and therapeutic medicine
Liu B,Xie Y,Mei X,Sun Y,Shi W,Wu Z
16-0037 was used in Flow cytometry/Cell sorting to determine the relationship between AhR activation and the secretion of IL17A and IL22 in CD4+ T cells in vitiligo.
Mon Feb 01 00:00:00 EST 2021
Episomal reprogramming of Duchenne muscular dystrophy patients derived CD3+ T cells towards induced pluripotent stem cells.
Pakistan journal of medical sciences
Zehravi M,Wahid M,Ashraf J
16-0037-81 was used in Flow Cytometry to derive Duchenne muscular dystrophy (DMD) patient specific induced pluripotent stem cells (iPSCs) from CD3+T cells of DMD patients and characterise these DMD-iPSCs.
Thu Apr 21 00:00:00 EDT 2022
Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.
Nature communications
Feldman T,Bercovich A,Moskovitz Y,Chapal-Ilani N,Mitchell A,Medeiros JJF,Biezuner T,Kaushansky N,Minden MD,Gupta V,Milyavsky M,Livneh Z,Tanay A,Shlush LI
16-0037-85 was used in Flow Cytometry to indicate an association between POLQ independent MMEJ and clonal hematopoiesis and elucidate mutational mechanisms involved in the very first steps of leukemia evolution.
Wed Apr 28 00:00:00 EDT 2021
Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma.
Cancers
Szanto CL,Cornel AM,Tamminga SM,Delemarre EM,de Koning CCH,van den Beemt DAMH,Dunnebach E,Tas ML,Dierselhuis MP,Tytgat LGAM,van Noesel MM,Kraal KCJM,Boelens JJ,Huitema ADR,Nierkens S
16-0037 was used in Flow cytometry/Cell sorting to explore the dynamics of immune cell subsets and their function in 25 HR-NBL patients at diagnosis, during induction chemotherapy, before high-dose chemotherapy, and during immunotherapy.
Mon Apr 26 00:00:00 EDT 2021
VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies.
mBio
Puertas MC,Bayón-Gil Á,Garcia-Guerrero MC,Salgado M,Urrea V,Morón-López S,Peña R,Jiménez-Moyano E,Clotet B,Prado JG,Martinez-Picado J
16-0037-81 was used in Flow Cytometry, Functional Assay, ELISA to provide a new platform for quantification of the functional HIV-1 reservoir at the single-cell level.
Tue Jun 29 00:00:00 EDT 2021
Deciphering the state of immune silence in fatal COVID-19 patients.
Nature communications
Bost P,De Sanctis F,Canè S,Ugel S,Donadello K,Castellucci M,Eyal D,Fiore A,Anselmi C,Barouni RM,Trovato R,Caligola S,Lamolinara A,Iezzi M,Facciotti F,Mazzariol A,Gibellini D,De Nardo P,Tacconelli E,Gottin L,Polati E,Schwikowski B,Amit I,Bronte V
16-0037 was used in Flow cytometry/Cell sorting to show a COVID-19 immune signature associated with severity by integrating single-cell RNA-seq analysis from blood samples and broncho-alveolar lavage fluids with clinical, immunological and functional ex vivo data.
Fri Mar 05 00:00:00 EST 2021
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li H,Kuang X,Liang L,Ye Y,Zhang Y,Li J,Ma F,Tao J,Lei G,Zhao S,Su J,Yang N,Peng C,Xu X,Hung MC,Han L,Liu H,Liu J,Chen X
16-0037 was used in Flow cytometry/Cell sorting to understand the role.
Fri Jan 01 00:00:00 EST 2021
Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains.
Frontiers in pharmacology
Siegemund M,Oak P,Hansbauer EM,Allersdorfer A,Utschick K,Winter A,Grasmüller C,Galler G,Mayer JP,Weiche B,Prassler J,Kontermann RE,Rothe C
16-0037-81 was used in Cell Culture to suggest that fusion to ABD or IgBD can be a versatile platform to tune the plasma half-life of Anticalin proteins in response to therapeutic needs.
Fri Nov 12 00:00:00 EST 2021
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment.
Nature communications
Rubio-Perez C,Planas-Rigol E,Trincado JL,Bonfill-Teixidor E,Arias A,Marchese D,Moutinho C,Serna G,Pedrosa L,Iurlaro R,Martínez-Ricarte F,Escudero L,Cordero E,Cicuendez M,Ruiz S,Parra G,Nuciforo P,Gonzalez J,Pineda E,Sahuquillo J,Tabernero J,Heyn H,Seoane J
16-0037 was used in Flow cytometry/Cell sorting to characterize immune cells present in brain lesions and matched cerebrospinal fluid (CSF) using single-cell RNA sequencing combined with T cell receptor genotyping.
Mon Mar 08 00:00:00 EST 2021
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Nature communications
Geuijen C,Tacken P,Wang LC,Klooster R,van Loo PF,Zhou J,Mondal A,Liu YB,Kramer A,Condamine T,Volgina A,Hendriks LJA,van der Maaden H,Rovers E,Engels S,Fransen F,den Blanken-Smit R,Zondag-van der Zande V,Basmeleh A,Bartelink W,Kulkarni A,Marissen W,Huang CY,Hall L,Harvey S,Kim S,Martinez M,O'Brien S,Moon E,Albelda S,Kanellopoulou C,Stewart S,Nastri H,Bakker ABH,Scherle P,Logtenberg T,Hollis G,de Kruif J,Huber R,Mayes PA,Throsby M
16-0037-81 was used in T-Cell Activation to describe a human CD137xPD-L1 bispecific antibody, MCLA-145, identified through functional screening of agonist- and immune checkpoint inhibitor arm combinations.
Wed Jul 21 00:00:00 EDT 2021
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Cell
Sadik A,Somarribas Patterson LF,Öztürk S,Mohapatra SR,Panitz V,Secker PF,Pfänder P,Loth S,Salem H,Prentzell MT,Berdel B,Iskar M,Faessler E,Reuter F,Kirst I,Kalter V,Foerster KI,Jäger E,Guevara CR,Sobeh M,Hielscher T,Poschet G,Reinhardt A,Hassel JC,Zapatka M,Hahn U,von Deimling A,Hopf C,Schlichting R,Escher BI,Burhenne J,Haefeli WE,Ishaque N,Böhme A,Schäuble S,Thedieck K,Trump S,Seiffert M,Opitz CA
16-0037 was used in Flow cytometry/Cell sorting to show that IL4I1 blockade opens new avenues for cancer therapy.
Thu Sep 03 00:00:00 EDT 2020
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
Cell
Su Y,Chen D,Yuan D,Lausted C,Choi J,Dai CL,Voillet V,Duvvuri VR,Scherler K,Troisch P,Baloni P,Qin G,Smith B,Kornilov SA,Rostomily C,Xu A,Li J,Dong S,Rothchild A,Zhou J,Murray K,Edmark R,Hong S,Heath JE,Earls J,Zhang R,Xie J,Li S,Roper R,Jones L,Zhou Y,Rowen L,Liu R,Mackay S,O'Mahony DS,Dale CR,Wallick JA,Algren HA,Zager MA,Wei W,Price ND,Huang S,Subramanian N,Wang K,Magis AT,Hadlock JJ,Hood L,Aderem A,Bluestone JA,Lanier LL,Greenberg PD,Gottardo R,Davis MM,Goldman JD,Heath JR
16-0037 was used in Flow cytometry/Cell sorting to show that moderate disease may provide the most effective setting for therapeutic intervention.
Thu Dec 10 00:00:00 EST 2020
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Immunity
Ferretti AP,Kula T,Wang Y,Nguyen DMV,Weinheimer A,Dunlap GS,Xu Q,Nabilsi N,Perullo CR,Cristofaro AW,Whitton HJ,Virbasius A,Olivier KJ,Buckner LR,Alistar AT,Whitman ED,Bertino SA,Chattopadhyay S,MacBeath G
16-0037 was used in Flow cytometry/Cell sorting to inform development of next-generation vaccines that better recapitulate natural CD8+ T cell immunity to SARS-CoV-2.
Tue Nov 17 00:00:00 EST 2020
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer.
The Journal of clinical investigation
Salazar Y,Zheng X,Brunn D,Raifer H,Picard F,Zhang Y,Winter H,Guenther S,Weigert A,Weigmann B,Dumoutier L,Renauld JC,Waisman A,Schmall A,Tufman A,Fink L,Brüne B,Bopp T,Grimminger F,Seeger W,Pullamsetti SS,Huber M,Savai R
16-0037-85 was used in In vitro Assay to explore the effect of tumor-infiltrating lymphocyte subpopulations on lung cancer biology by studying in vitro cocultures, in vivo mouse models, and human lung cancer tissue. Lymphocyte conditioned media (CM) induced epithelial-mesenchymal transition (EMT) and migration in both primary human lung cancer cells and cell lines.
Wed Jul 01 00:00:00 EDT 2020
Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands.
Nature protocols
Chang ZL,Hou AJ,Chen YY
16-0037-85 was used in Flow Cytometry to test novel T-cell therapies targeting soluble ligands in 2 weeks.
Wed Apr 01 00:00:00 EDT 2020
PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kwon M,Kim CG,Lee H,Cho H,Kim Y,Lee EC,Choi SJ,Park J,Seo IH,Bogen B,Song IC,Jo DY,Kim JS,Park SH,Choi I,Choi YS,Shin EC
16-0037-85 was used in T-Cell Activation to indicate that combined blockade of PD-1 and TGFβ may be useful for the treatment of multiple myeloma.
Wed Apr 01 00:00:00 EDT 2020
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.
Proceedings of the National Academy of Sciences of the United States of America
Crawford MP,Sinha S,Renavikar PS,Borcherding N,Karandikar NJ
16-0037-81 was used in ELISA to eveal a role for IL-17 cytokines in mediating CD4-intrinsic immune resistance.
Tue Aug 11 00:00:00 EDT 2020
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.
Proceedings of the National Academy of Sciences of the United States of America
Crawford MP,Sinha S,Renavikar PS,Borcherding N,Karandikar NJ
16-0037-81 was used in ELISA to eveal a role for IL-17 cytokines in mediating CD4-intrinsic immune resistance.
Tue Aug 11 00:00:00 EDT 2020
JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.
Cell death and differentiation
Simula L,Corrado M,Accordi B,Di Rita A,Nazio F,Antonucci Y,Di Daniele A,Caicci F,Caruana I,Soriano ME,Pigazzi M,Locatelli F,Cecconi F,Campello S
16-0037-85 was used in T-Cell Activation to find that Bim is also downregulated in T-cell Acute Lymphoblastic Leukemia (T-ALL) cells, this alteration favouring their escape from AICD-mediated control.
Thu Oct 01 00:00:00 EDT 2020
γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.
Cancer immunology research
Janssen A,Villacorta Hidalgo J,Beringer DX,van Dooremalen S,Fernando F,van Diest E,Terrizi AR,Bronsert P,Kock S,Schmitt-Gräff A,Werner M,Heise K,Follo M,Straetemans T,Sebestyen Z,Chudakov DM,Kasatskaya SA,Frenkel FE,Ravens S,Spierings E,Prinz I,Küppers R,Malkovsky M,Fisch P,Kuball J
16-0037 was used in Flow cytometry/Cell sorting to describe molecular and functional analyses of T-cell receptors from tumor-infiltrating T lymphocytes that were in direct contact with tumor cells in breast cancer lesions from archival material.
Wed Apr 01 00:00:00 EDT 2020
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.
Cell proliferation
Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL
16-0037 was used in Flow cytometry/Cell sorting to study the TGF-β1 expression and distribution of regulatory T cells (Tregs) along the placental-maternal circulation route.
Fri May 01 00:00:00 EDT 2020
A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency.
Journal of clinical immunology
Kuehn HS,Bernasconi A,Niemela JE,Almejun MB,Gallego WAF,Goel S,Stoddard JL,Sánchez RGP,Franco CAA,Oleastro M,Grunebaum E,Ballas Z,Cunningham-Rundles C,Fleisher TA,Franco JL,Danielian S,Rosenzweig SD
16-0037 was used in Western Blotting to demonstrate that bona fide NFKB2 haploinsufficiency is associated with clinical immunodeficiency.
Sun Nov 01 00:00:00 EDT 2020
T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8+ T cells in oral lichen planus.
Journal of cellular and molecular medicine
Yang JY,Zhang J,Lu R,Tan YQ,Du GF,Zhou G
16-0037 was used in Functional assays to study the effects of T cell-derived exosomes (T-exos) on the pathogenesis of OLP and its mechanism.
Tue Dec 01 00:00:00 EST 2020
IL-10 Restores MHC Class I Expression and Interferes With Immunity in Papillary Thyroid Cancer With Hashimoto Thyroiditis.
Endocrinology
Lu ZW,Hu JQ,Liu WL,Wen D,Wei WJ,Wang YL,Wang Y,Liao T,Ji QH
16-0037 was used in Flow cytometry/Cell sorting to investigate whether IL-10 interferes tumor immunity in PTC with concomitant HT.
Thu Oct 01 00:00:00 EDT 2020
IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro.
Journal of Cancer
Hu JQ,Lei BW,Wen D,Ma B,Zhang TT,Lu ZW,Wei WJ,Wang YL,Wang Y,Li DS,Ji QH,Liao T
16-0037 was used in Flow cytometry/Cell sorting to investigate the effect of IL-2 on MHC class I expression in PTC cells and immune activation with experimental treatment for PTC using PTC cell lines.
Mon Sep 28 00:00:00 EDT 2020
Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Sahin M,Sahin E
16-0037-85 was used in In vitro Assay to examine whether PGE2 contributes to the formation of iTregs treated with TGFB1 and 5-aza-2'-deoxycytidine (5-aza-dC).
Mon Jun 01 00:00:00 EDT 2020
Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1.
Genome medicine
Ye Y,Kuang X,Xie Z,Liang L,Zhang Z,Zhang Y,Ma F,Gao Q,Chang R,Lee HH,Zhao S,Su J,Li H,Peng J,Chen H,Yin M,Peng C,Yang N,Wang J,Liu J,Liu H,Han L,Chen X
16-0037-85 was used in In vitro Assay to enhance the efficacy of immunotherapy.
Mon Sep 28 00:00:00 EDT 2020
IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation.
Frontiers in immunology
Renavikar PS,Sinha S,Brate AA,Borcherding N,Crawford MP,Steward-Tharp SM,Karandikar NJ
16-0037 was used in Flow cytometry/Cell sorting to provide insights into the role of T-cell differentiation in CD8 suppressive biology and may reveal therapeutically targetable pathways to reverse suppressive deficit during immune-mediated disease.
Thu May 13 00:00:00 EDT 2021
Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy.
Scientific reports
Lee J,Sheen JH,Lim O,Lee Y,Ryu J,Shin D,Kim YY,Kim M
16-0037 was used in Flow cytometry/Cell sorting to eliminate T cell's HLA through the CRISPR/Cas9 gene editing system to evade donor HLA-mediated immune rejection.
Tue Oct 20 00:00:00 EDT 2020
Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity.
Aging
Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA
16-0037-81 was used in Cell Culture to find that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (α-glucosidase/α-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.
Sat Jan 04 00:00:00 EST 2020
A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells.
BMC cancer
Lund ME,Howard CB,Thurecht KJ,Campbell DH,Mahler SM,Walsh BJ
16-0037 was used in Functional assays to show the specificity and efficacy of Bispecific T cell Engager (BiTE) construct MIL-38-CD3 for targeting GPC-1 in prostate cancer.
Thu Dec 10 00:00:00 EST 2020
HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane.
The Journal of biological chemistry
Li WF,Aryal M,Shu ST,Smithgall TE
16-0037 was used in Flow cytometry/Cell sorting to conclude that direct activation of Itk and Btk by Nef at the membrane in HIV-infected cells may override normal immune receptor control of Tec-family kinase activity to enhance the viral life cycle.
Fri Apr 10 00:00:00 EDT 2020
Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome.
Scientific reports
Biemann R,Roomp K,Noor F,Krishnan S,Li Z,Shahzad K,Borucki K,Luley C,Schneider JG,Isermann B
16-0037 was used in Flow cytometry/Cell sorting to investigate whether lifestyle-induced weight loss modulates gene expression in circulating monocytes.
Tue Oct 20 00:00:00 EDT 2020
Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.
Nature communications
Boshuizen J,Vredevoogd DW,Krijgsman O,Ligtenberg MA,Blankenstein S,de Bruijn B,Frederick DT,Kenski JCN,Parren M,Brüggemann M,Madu MF,Rozeman EA,Song JY,Horlings HM,Blank CU,van Akkooi ACJ,Flaherty KT,Boland GM,Peeper DS
16-0037-85 was used in T-Cell Activation to demonstrate the existence of a stable and pre-existing NGFRhi multitherapy-refractory melanoma subpopulation.
Fri Aug 07 00:00:00 EDT 2020
T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Current protocols in immunology
Rollins MR,Spartz EJ,Stromnes IM
16-0037-81 was used in Flow Cytometry to synthesize and expand upon methodologies to generate, isolate, and engineer human T cells with tumor-reactive TCRs for adoptive cell therapy.
Mon Jun 01 00:00:00 EDT 2020
Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.
Cell reports
Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY
16-0037-81 was used in Immunohistochemistry to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.
Tue Mar 17 00:00:00 EDT 2020
High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile.
Cell reports
Wragg KM,Tan HX,Kristensen AB,Nguyen-Robertson CV,Kelleher AD,Parsons MS,Wheatley AK,Berzins SP,Pellicci DG,Kent SJ,Juno JA
16-0037-81 was used in Flow Cytometry to demonstrate if CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets.
Tue Jun 16 00:00:00 EDT 2020
Methodology for in vitro Assessment of Human T Cell Activation and Blockade.
Bio-protocol
Podojil JR,Ifergan I,Chiang MY,Meeks JJ,Miller SD
16-0037-81 was used in Cell Culture to present a protocol to assess in vitro functionality and mechanism for action in human T cells.
Fri Jun 05 00:00:00 EDT 2020
Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions.
Frontiers in immunology
Ferrara M,Chialli G,Ferreira LM,Ruggieri E,Careccia G,Preti A,Piccirillo R,Bianchi ME,Sitia G,Venereau E
16-0037 was used in Western Blotting to analyze the expression of HMGB1 redox isoforms in different inflammatory conditions in skeletal muscle.
Mon Apr 05 00:00:00 EDT 2021
Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung.
Immunity
Wang W,Cohen JA,Wallrapp A,Trieu KG,Barrios J,Shao F,Krishnamoorthy N,Kuchroo VK,Jones MR,Fine A,Bai Y,Ai X
16-0037-81 was used in lymphocyte isolation to investigate if the communication between dopaminergic nerves and CD4+ T cells provide an age-related mechanism underlying the susceptibility to allergic inflammation in the early lung.
Tue Dec 17 00:00:00 EST 2019
Endothelial Sox17 promotes allergic airway inflammation.
The Journal of allergy and clinical immunology
Ha EH,Choi JP,Kwon HS,Park HJ,Lah SJ,Moon KA,Lee SH,Kim I,Cho YS
16-0037-81 was used in Cell Culture to investigate the relationship between Sox17 and IL-33 and the possible role of Sox17 in the pathogenesis of asthma using a mouse model of airway inflammation.
Thu Aug 01 00:00:00 EDT 2019
BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Atay C,Kwak T,Lavilla-Alonso S,Donthireddy L,Richards A,Moberg V,Pilon-Thomas S,Schell M,Messina JL,Rebecca VW,Xiao M,Tan J,Zhang G,Weber JS,Herlyn M,Sarnaik AA,Gabrilovich DI
16-0037-85 was used in In vitro Assay to investigate the mechanism and potential therapeutic utility of combination of BRAF inhibitor (BRAFi) and adoptive T-cell therapy (ACT) in melanoma resistant to BRAFi.
Wed May 01 00:00:00 EDT 2019
Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth.
Journal of immunology (Baltimore, Md. : 1950)
Gomez-Lopez N,Romero R,Xu Y,Miller D,Arenas-Hernandez M,Garcia-Flores V,Panaitescu B,Galaz J,Hsu CD,Para R,Berry SM
16-0037 was used in Flow cytometry/Cell sorting to show that fetal T cells are a predominant leukocyte population in amniotic fluid during preterm gestrations, and that chord blood T cells obtained from women with idiopathic preterm labor and birth displayed enhanced ex vivo activation.
Tue Oct 01 00:00:00 EDT 2019
Triptolide reverses helper T cell inhibition and down-regulates IFN-γ induced PD-L1 expression in glioma cell lines.
Journal of neuro-oncology
Zhang L,Yu JS
16-0037 was used in Flow cytometry/Cell sorting to test the effects of Triptolide on T cell inhibition in glioma cells.
Mon Jul 01 00:00:00 EDT 2019
An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh.
Toxicology and applied pharmacology
Burchiel SW,Lauer FT,Factor-Litvak P,Liu X,Santella RM,Islam T,Eunus M,Alam N,Islam T,Rahman M,Ahmed A,Ahsan H,Graziano J,Parvez F
16-0037-81 was used in Cell Culture to demonstrate activation of the immune system during chronic exposure to cigarette smoke, which is a known risk factor for autoimmune diseases.
Sun Dec 01 00:00:00 EST 2019
Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.
Frontiers in immunology
Oda H,Beck DB,Kuehn HS,Sampaio Moura N,Hoffmann P,Ibarra M,Stoddard J,Tsai WL,Gutierrez-Cruz G,Gadina M,Rosenzweig SD,Kastner DL,Notarangelo LD,Aksentijevich I
16-0037-81 was used in Flow Cytometry to identify a genetic cause of a disease for an 8 year-old girl who presented with early-onset immune deficiency and autoinflammation.
Thu Sep 10 00:00:00 EDT 2020
Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process.
Cell reports
Davies SP,Reynolds GM,Wilkinson AL,Li X,Rose R,Leekha M,Liu YS,Gandhi R,Buckroyd E,Grove J,Barnes NM,May RC,Hubscher SG,Adams DH,Huang Y,Qureshi O,Stamataki Z
16-0037-81 was used in Flow cytometry/Cell sorting to demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes.
Tue Nov 05 00:00:00 EST 2019
Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.
Nature communications
Esfahani K,Al-Aubodah TA,Thebault P,Lapointe R,Hudson M,Johnson NA,Baran D,Bhulaiga N,Takano T,Cailhier JF,Piccirillo CA,Miller WH
16-0037 was used in Flow cytometry/Cell sorting to indicate that sirolimus has the potential to uncouple anti-PD-1 therapy toxicity and efficacy.
Thu Oct 17 00:00:00 EDT 2019
Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.
Cellular and molecular gastroenterology and hepatology
Bamidele AO,Svingen PA,Sagstetter MR,Sarmento OF,Gonzalez M,Braga Neto MB,Kugathasan S,Lomberk G,Urrutia RA,Faubion WA
16-0037 was used in Functional assays to study whether a physical interaction between FOXP3 and the epigenetic enzyme enhancer of zeste homologue 2 is essential for gene co-repressive function.
Mon Apr 29 00:00:00 EDT 2019
Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells.
PloS one
Tanaskovic O,Verga Falzacappa MV,Pelicci PG
16-0037 was used in Functional assays to suggest that (hCB)-CD34+ NSG mice are transient and/or incomplete carriers of the human immune system and, therefore, represent a suboptimal tool to study the interaction between tumor and immune cells.
Wed Mar 11 00:00:00 EDT 2020
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Nature communications
Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC
16-0037-81 was used in Western Blot to study the intrinsic mediators that render CD8+T cells dysfunctional in the tumour microenvironment.
Wed Mar 20 00:00:00 EDT 2019
Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane.
Cells
Rossatti P,Ziegler L,Schregle R,Betzler VM,Ecker M,Rossy J
16-0037-81 was used in Flow Cytometry to reveal a link between T cell receptor (TCR) internalization and the CLIC/GEEC endocytic route supported by Cdc42 and GRAF1.
Mon Nov 04 00:00:00 EST 2019
Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane.
Cells
Rossatti P,Ziegler L,Schregle R,Betzler VM,Ecker M,Rossy J
16-0037-81 was used in Flow Cytometry to reveal a link between T cell receptor (TCR) internalization and the CLIC/GEEC endocytic route supported by Cdc42 and GRAF1.
Mon Nov 04 00:00:00 EST 2019
Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells.
Scientific reports
Levring TB,Kongsbak-Wismann M,Rode AKO,Al-Jaberi FAH,Lopez DV,Met Ö,Woetmann A,Bonefeld CM,Ødum N,Geisler C
16-0037-81 was used in Flow Cytometry to demonstrate that TNF-induced TXNIP down-regulation is dependent on caspase activity and is caused by caspase-mediated cleavage of TXNIP.
Wed Nov 13 00:00:00 EST 2019
IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis.
Diagnostic pathology
Han LT,Hu JQ,Ma B,Wen D,Zhang TT,Lu ZW,Wei WJ,Wang YL,Wang Y,Liao T,Ji QH
16-0037 was used in Flow cytometry/Cell sorting to demonstrate papillary thyroid cancer with coexisting Hashimoto's thyroiditis displays enhanced T cell activation and MHC class I expression due to interleukin-17A.
Tue Jun 04 00:00:00 EDT 2019
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
Cell chemical biology
Mo X,Tang C,Niu Q,Ma T,Du Y,Fu H
16-0037 was used in Flow cytometry/Cell sorting to develop a high-throughput immunomodulator phenotypic screening platform, HTiP, which integrates the immune and cancer cell co-culture system with imaging- and biochemical-based multiplexed readouts.
Thu Mar 21 00:00:00 EDT 2019
Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells.
Oncoimmunology
Davis DA,Shrestha P,Aisabor AI,Stream A,Galli V,Pise-Masison CA,Tagawa T,Ziegelbauer JM,Franchini G,Yarchoan R
16-0037 was used in Functional assays to study Pomalidomide as a treatment for tumours caused by viruses.
Tue Jan 12 00:00:00 EST 2021
Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.
The Journal of clinical investigation
Boutboul D,Kuehn HS,Van de Wyngaert Z,Niemela JE,Callebaut I,Stoddard J,Lenoir C,Barlogis V,Farnarier C,Vely F,Yoshida N,Kojima S,Kanegane H,Hoshino A,Hauck F,Lhermitte L,Asnafi V,Roehrs P,Chen S,Verbsky JW,Calvo KR,Husami A,Zhang K,Roberts J,Amrol D,Sleaseman J,Hsu AP,Holland SM,Marsh R,Fischer A,Fleisher TA,Picard C,Latour S,Rosenzweig SD
16-0037 was used in Flow cytometry/Cell sorting to study 7 unrelated patients with a novel early-onset combined immunodeficiency associated with de novo germline IKZF1 heterozygous mutations affecting amino acid N159 located in the DNA-binding domain of IKZF1.
Mon Jul 02 00:00:00 EDT 2018
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Molecular cell
Cha JH,Yang WH,Xia W,Wei Y,Chan LC,Lim SO,Li CW,Kim T,Chang SS,Lee HH,Hsu JL,Wang HL,Kuo CW,Chang WC,Hadad S,Purdie CA,McCoy AM,Cai S,Tu Y,Litton JK,Mittendorf EA,Moulder SL,Symmans WF,Thompson AM,Piwnica-Worms H,Chen CH,Khoo KH,Hung MC
16-0037-81 was used in T-Cell Activation to identify a new regulatory mechanism of PD-L1 expression through the ERAD pathway and suggest that the metformin-CTLA4 blockade combination has the potential to increase the efficacy of immunotherapy.
Thu Aug 16 00:00:00 EDT 2018
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
16-0037 was used in Functional assays to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 EST 2018
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
16-0037 was used in a Functional assay to study the retrograde traffic of linker for activation of T cells from the plasma membrane to the Golgi-trans-Golgi network.
Mon Apr 02 00:00:00 EDT 2018
Characterization and analysis of scFv-IgG bispecific antibody size variants.
mAbs
Cao M,Wang C,Chung WK,Motabar D,Wang J,Christian E,Lin S,Hunter A,Wang X,Liu D
16-0037 was used in Functional assays to analyse and characterise single-chain variable fragments-IgG bispecific antibody size variants.
Mon Jun 24 00:00:00 EDT 2019
Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.
Nature communications
Song H,Giorgi EE,Ganusov VV,Cai F,Athreya G,Yoon H,Carja O,Hora B,Hraber P,Romero-Severson E,Jiang C,Li X,Wang S,Li H,Salazar-Gonzalez JF,Salazar MG,Goonetilleke N,Keele BF,Montefiori DC,Cohen MS,Shaw GM,Hahn BH,McMichael AJ,Haynes BF,Korber B,Bhattacharya T,Gao F
16-0037 was used in Functional assays to provide insight into molecular mechanisms by which viral recombination contributes to HIV-1 persistence and immunopathogenesis.
Tue May 15 00:00:00 EDT 2018
Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes.
Frontiers in immunology
Tran HTT,Herz C,Ruf P,Stetter R,Lamy E
16-0037 was used in Flow cytometry/Cell sorting to study T2R38 expression in resting and activated lymphocytes and T cell populations.
Wed Oct 09 00:00:00 EDT 2019
Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver.
Oncotarget
Shi Y,Zhang P,Wang G,Liu X,Sun X,Zhang X,Li H,Qi J,Ding L,Li T,Zhang R,Chen Y,Zhou J,Lv G,Tu Z
16-0037 was used in Functional assays to study the phenotype and function of tissue resident lymphocytes in peripheral blood, lymph node, spleen and liver.
Tue Mar 20 00:00:00 EDT 2018
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
Nature communications
Compeer EB,Kraus F,Ecker M,Redpath G,Amiezer M,Rother N,Nicovich PR,Kapoor-Kaushik N,Deng Q,Samson GPB,Yang Z,Lou J,Carnell M,Vartoukian H,Gaus K,Rossy J
16-0037 was used in Functional assays to examine the endocytic journey of the T cell receptor.
Mon Apr 23 00:00:00 EDT 2018
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
Lasers in surgery and medicine
Holien T,Gederaas OA,Darvekar SR,Christensen E,Peng Q
16-0037-81 was used in Flow Cytometry, Functional Assay, In Vitro Assay to suggest that 5-ALA/UV-A may have the potential for improving the efficacy of ECP.
Sun Jul 01 00:00:00 EDT 2018
Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Stem cell reports
Idelson M,Alper R,Obolensky A,Yachimovich-Cohen N,Rachmilewitz J,Ejzenberg A,Beider E,Banin E,Reubinoff B
16-0037 was used in Flow cytometry/Cell sorting to analyse the immunomodulatory properties of human embryonic stem cells-derived retinal pigment epithelium cells, and showed that they inhibit T cell responses.
Tue Sep 11 00:00:00 EDT 2018
Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell reports
Li Y,Tan S,Zhang C,Chai Y,He M,Zhang CW,Wang Q,Tong Z,Liu K,Lei Y,Liu WJ,Liu Y,Tian Z,Cao X,Yan J,Qi J,Tien P,Gao S,Gao GF
16-0037-81 was used in Western Blot to show insight into the binding of 4-1BB with its ligand and its agonist mAb.
Tue Oct 23 00:00:00 EDT 2018
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.
Cell
Zheng C,Zheng L,Yoo JK,Guo H,Zhang Y,Guo X,Kang B,Hu R,Huang JY,Zhang Q,Liu Z,Dong M,Hu X,Ouyang W,Peng J,Zhang Z
16-0037 was used in Flow cytometry/Cell sorting to characterise the RNA expression of infiltrating T cells in liver cancer.
Thu Jun 15 00:00:00 EDT 2017
Pooled CRISPR screening with single-cell transcriptome readout.
Nature methods
Datlinger P,Rendeiro AF,Schmidl C,Krausgruber T,Traxler P,Klughammer J,Schuster LC,Kuchler A,Alpar D,Bock C
16-0037 was used in Functional assays to combine pooled CRISPR screening with single-cell RNA sequencing, directly linking guide RNA expression to transcriptome responses in thousands of individual cells.
Wed Mar 01 00:00:00 EST 2017
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.
Cell stem cell
Carcamo-Orive I,Hoffman GE,Cundiff P,Beckmann ND,D'Souza SL,Knowles JW,Patel A,Papatsenko D,Abbasi F,Reaven GM,Whalen S,Lee P,Shahbazi M,Henrion MYR,Zhu K,Wang S,Roussos P,Schadt EE,Pandey G,Chang R,Quertermous T,Lemischka I
16-0037 was used in Functional assays to examine the sources of gene expression variability in 317 human induced pluripotent stem cell lines from 101 individuals.
Thu Apr 06 00:00:00 EDT 2017
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
The Journal of clinical investigation
Horng S,Therattil A,Moyon S,Gordon A,Kim K,Argaw AT,Hara Y,Mariani JN,Sawai S,Flodby P,Crandall ED,Borok Z,Sofroniew MV,Chapouly C,John GR
16-0037 was used in Immunohistochemistry to identify a inducible barrier to CNS entry at the glia limitans, which may be therapeutically targetable in inflammatory CNS disease.
Tue Aug 01 00:00:00 EDT 2017
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies.
Cancer immunology research
Tsai AK,Khan AY,Worgo CE,Wang LL,Liang Y,Davila E
16-0037 was used in Flow cytometry/Cell sorting to reveal that regorafenib and NU7441 influence the immunobiology of tumour and T cells, enhancing the efficacy of various immunotherapies.
Fri Sep 01 00:00:00 EDT 2017
Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription.
Antiviral research
Hayashi T,Jean M,Huang H,Simpson S,Santoso NG,Zhu J
16-0037 was used in Functional assays to identify levosimendan as a novel and promising anti-HIV-1 inhibitor.
Sun Oct 01 00:00:00 EDT 2017
Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.
Mucosal immunology
Kiniry BE,Ganesh A,Critchfield JW,Hunt PW,Hecht FM,Somsouk M,Deeks SG,Shacklett BL
16-0037 was used in Flow cytometry/Cell sorting to report on the gastrointestinal mucosa site during HIV infection and suggest that rectal CD8+ T-cells are primarily non-cytotoxic, and phenotypically shaped by the tissue microenvironment.
Sat Jul 01 00:00:00 EDT 2017
Micropipette force probe to quantify single-cell force generation: application to T-cell activation.
Molecular biology of the cell
Sawicka A,Babataheri A,Dogniaux S,Barakat AI,Gonzalez-Rodriguez D,Hivroz C,Husson J
16-0037 was used in Functional assays to demonstrate a new technique, the micropipette force probe, that tracks changes in cell morphology and mechanics in response to a molecule of interest.
Tue Nov 07 00:00:00 EST 2017
Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease.
JCI insight
Seignez A,Joly AL,Chaumonnot K,Hazoumé A,Sanka M,Marcion G,Boudesco C,Hammann A,Seigneuric R,Jégo G,Ducoroy P,Delarue P,Senet P,Castilla-Llorente C,Solary E,Durey MA,Rubio MT,Hermine O,Kohli E,Garrido C
16-0037 was used in Flow cytometry/Cell sorting to identify glycoprotein 96 and complement C3 as partner graft-versus-host disease-induced tissue damage-associated molecular pattern molecules.
Thu Mar 23 00:00:00 EDT 2017
T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab.
PloS one
Bughani U,Saha A,Kuriakose A,Nair R,Sadashivarao RB,Venkataraman R,Patel S,Deshchougule AT,S SK,Montero E,Pai HV,Palanivelu DV,Melarkode R,Nair P
16-0037 was used in Functional assays to investigate the effect of Itolizumab on T cels.
Fri Oct 06 00:00:00 EDT 2017
A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer.
Oncoimmunology
Martin SD,Wick DA,Nielsen JS,Little N,Holt RA,Nelson BH
16-0037 was used in Functional assays to show that neoantigen-specific T cells can be expanded from small volumes of blood during remission making pre-emptive ACT a plausible clinical strategy.
Tue Jan 12 00:00:00 EST 2021
A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association.
Frontiers in microbiology
Huang H,Liu S,Jean M,Simpson S,Huang H,Merkley M,Hayashi T,Kong W,Rodríguez-Sánchez I,Zhang X,Yosief HO,Miao H,Que J,Kobie JJ,Bradner J,Santoso NG,Zhang W,Zhu J
16-0037 was used in Functional assays to evaluate the potency of UMB-32 based methyl-triazolo bromodomain, and extra-terminal domain inhibitors as potential new latency-reversing agents.
Thu Oct 01 00:00:00 EDT 2020
Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity.
eLife
Saitakis M,Dogniaux S,Goudot C,Bufi N,Asnacios S,Maurin M,Randriamampita C,Asnacios A,Hivroz C
16-0037 was used in Flow cytometry/Cell sorting to characterise how human primary CD4(+) T cells respond to artificial surfaces of varying stiffness within a physiologically relevant rigidity range.
Thu Jun 08 00:00:00 EDT 2017
RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization.
Cell death & disease
Meng YH,Zhou WJ,Jin LP,Liu LB,Chang KK,Mei J,Li H,Wang J,Li DJ,Li MQ
16-0037 was used in Functional assays to investigate the effect of RANKL from human embryonic trophoblasts and maternal decidual stromal cells on decidual macrophage differentiation and maternal-fetal immune tolerance.
Thu Oct 12 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
16-0037-81 was used in Flow Cytometry to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
The Journal of experimental medicine
Hu H,Wang H,Xiao Y,Jin J,Chang JH,Zou Q,Xie X,Cheng X,Sun SC
16-0037 was used in Immunoprecipitation to reveal the importance of deubiquitination in regulating Zap70 function.
Mon Mar 07 00:00:00 EST 2016
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.
Proceedings of the National Academy of Sciences of the United States of America
Pageon SV,Tabarin T,Yamamoto Y,Ma Y,Nicovich PR,Bridgeman JS,Cohnen A,Benzing C,Gao Y,Crowther MD,Tungatt K,Dolton G,Sewell AK,Price DA,Acuto O,Parton RG,Gooding JJ,Rossy J,Rossjohn J,Gaus K
16-0037 was used in Functional assays to investigate how TCR-CD3 clusters can translate antigen recognition into signal initiation, and how cluster formation is a process of antigen discrimination.
Tue Sep 13 00:00:00 EDT 2016
Obesity decreases B cell responses in young and elderly individuals.
Obesity (Silver Spring, Md.)
Frasca D,Ferracci F,Diaz A,Romero M,Lechner S,Blomberg BB
Tue Mar 01 00:00:00 EST 2016
CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus.
Frontiers in immunology
Zhu H,Hu F,Sun X,Zhang X,Zhu L,Liu X,Li X,Xu L,Shi L,Gan Y,Su Y
16-0037 was used in Flow cytometry/Cell sorting to demonstrate that CD16+monocytes were enriched and played a critical role in driving the pathogenic T- and B-cell responses in patients with systemic lupus erythematosus.
Wed Nov 20 00:00:00 EST 2019
Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.
Frontiers in immunology
Kapoor-Kaushik N,Hinde E,Compeer EB,Yamamoto Y,Kraus F,Yang Z,Lou J,Pageon SV,Tabarin T,Gaus K,Rossy J
16-0037 was used in Western Blotting to identify two mechanisms governing the distribution of Lck, a T cell receptor kinase.
Fri Mar 25 00:00:00 EDT 2016
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
PLoS pathogens
Jones RB,Mueller S,O'Connor R,Rimpel K,Sloan DD,Karel D,Wong HC,Jeng EK,Thomas AS,Whitney JB,Lim SY,Kovacs C,Benko E,Karandish S,Huang SH,Buzon MJ,Lichterfeld M,Irrinki A,Murry JP,Tsai A,Yu H,Geleziunas R,Trocha A,Ostrowski MA,Irvine DJ,Walker BD
16-0037 was used in Functional assays to determine the efficacy of different latency-reversing agents in sensitising latency-infected cells or recognition by HIV-specific CD8+ T-cells, showing a subset of latency-reversing agents expose latency-infected cells for recognition.
Fri Apr 01 00:00:00 EDT 2016
LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse.
Journal of virology
Starling S,Jolly C
16-0037 was used in Flow cytometry/Cell sorting to investigate triggers of polarisation at HIV-1 virological synapses using an antibody-coupled bead assay as a model of these sites.
Tue Nov 01 00:00:00 EDT 2016
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases.
mAbs
Silacci M,Lembke W,Woods R,Attinger-Toller I,Baenziger-Tobler N,Batey S,Santimaria R,von der Bey U,Koenig-Friedrich S,Zha W,Schlereth B,Locher M,Bertschinger J,Grabulovski D
16-0037 was used in Functional assays to investigate the use of dual TNF/IL-17A inhibition to treat rheumatoid arthritis.
Fri Sep 30 00:00:00 EDT 2016
Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data.
Molecular biology of the cell
Pageon SV,Nicovich PR,Mollazade M,Tabarin T,Gaus K
16-0037 was used in Immunocytochemistry to develop Clus-DoC, an analysis strategy that quantifies both the spatial distribution of a protein and its colocalization status.
Mon Nov 07 00:00:00 EST 2016
Effect of cytokine-induced killer cells on immune function in patients with lung cancer.
Oncology letters
Pan Y,Wu Y,Ji J,Cai H,Wang H,Jiang Y,Sang L,Yang J,Gao Y,Liu Y,Yin L,Zhang LI
Fri Apr 01 00:00:00 EDT 2016
Cytokine-induced killer cell therapy for the treatment of primary hepatocellular carcinoma subsequent to liver transplantation: A case report.
Oncology letters
Li R,Yan F,Liu L,Li H,Ren B,Hui Z,Ren X
16-0037 was used in Functional assays to investigate a case of hepatocellular carcinoma treated with a mass of autologous activated T cells.
Tue Mar 01 00:00:00 EST 2016
Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient.
Journal for immunotherapy of cancer
Siddiqui I,Erreni M,van Brakel M,Debets R,Allavena P
16-0037 was used in Functional assays to show that CX3CR1 expressing T cells hone towards CX3CL1-producing tumours, increasing T cell infiltration in tumour tissues and decreasing tumour growth.
Wed Apr 20 00:00:00 EDT 2016
Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient.
Journal for immunotherapy of cancer
Siddiqui I,Erreni M,van Brakel M,Debets R,Allavena P
16-0037 was used in Functional assays to show that CX3CR1 expressing T cells hone towards CX3CL1-producing tumours, increasing T cell infiltration in tumour tissues and decreasing tumour growth.
Wed Apr 20 00:00:00 EDT 2016
Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy.
PloS one
Du SH,Li Z,Chen C,Tan WK,Chi Z,Kwang TW,Xu XH,Wang S
16-0037 was used in Functional assays to substantiate the feasibility of co-expanding CIK and γδ cells for adoptive cellular immunotherapy applications such as CAR T-cell therapy against cancer.
Wed Aug 02 00:00:00 EDT 2017
Simultaneous, Single-Cell Measurement of Messenger RNA, Cell Surface Proteins, and Intracellular Proteins.
Current protocols in cytometry
Soh KT,Tario JD,Colligan S,Maguire O,Pan D,Minderman H,Wallace PK
16-0037 was used in Flow cytometry/Cell sorting to develop a protocol for the simultaneous, single-cell measurement of mRNA, cell surface proteins, and intracellular proteins.
Wed Jan 06 00:00:00 EST 2016
Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells.
Scientific reports
Son CH,Lee HR,Koh EK,Shin DY,Bae JH,Yang K,Park YS
16-0037 was used in Flow cytometry/Cell sorting to investigate how decitabine may be used as a useful immunomodulator to sensitise tumour cells in combination with other tumour therapies.
Tue Sep 27 00:00:00 EDT 2016
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
PloS one
Momose F,Seo N,Akahori Y,Sawada S,Harada N,Ogura T,Akiyoshi K,Shiku H
16-0037 was used in Flow cytometry/Cell sorting to statistically analyse miRNA microarray data, revealing that guanine-rich sequences are a dominant feature of exosome-dominant miRNAs.
Wed Apr 05 00:00:00 EDT 2017
Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.
The Journal of clinical investigation
McCracken MN,Vatakis DN,Dixit D,McLaughlin J,Zack JA,Witte ON
16-0037 was used in Flow cytometry/Cell sorting to evaluate the use of hdCK3mut reporter imaging in immunotherapy models.
Fri May 01 00:00:00 EDT 2015
Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.
The Journal of clinical investigation
McCracken MN,Vatakis DN,Dixit D,McLaughlin J,Zack JA,Witte ON
16-0037 was used in Flow cytometry/Cell sorting to evaluate the use of hdCK3mut reporter imaging in immunotherapy models.
Fri May 01 00:00:00 EDT 2015
RAX2: a genome-wide detection method of condition-associated transcription variation.
Nucleic acids research
Tan YD,Deng J,Neilson JR
16-0037 was used in Flow cytometry/Cell sorting to showcase a ranking analysis of chi-squares, RAX2, for large-scale association analysis.
Thu Sep 03 00:00:00 EDT 2015
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.
eLife
Kumari S,Depoil D,Martinelli R,Judokusumo E,Carmona G,Gertler FB,Kam LC,Carman CV,Burkhardt JK,Irvine DJ,Dustin ML
16-0037 was used in Functional assays to assess the contribution of WASP to the architecture of the immunological synapse and to optimal immune responses.
Wed Mar 11 00:00:00 EDT 2015
HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes.
Journal of virology
Vassena L,Giuliani E,Koppensteiner H,Bolduan S,Schindler M,Doria M
16-0037 was used in Functional assays to investigate the role of CD62L during HIV-1 infection.
Fri May 01 00:00:00 EDT 2015
Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses.
Cancer gene therapy
Kuramitsu S,Ohno M,Ohka F,Shiina S,Yamamichi A,Kato A,Tanahashi K,Motomura K,Kondo G,Kurimoto M,Senga T,Wakabayashi T,Natsume A
16-0037-81 was used in Flow Cytometry, Functional Assay, Sample Prep to demonstrate that lentiviral-mediated transduction of CAR effectors targeting the EGFRvIII showed specific efficacy, and lenalidomide even intensified CAR cell therapy by enhanced formation of immunological synapses.
Thu Oct 01 00:00:00 EDT 2015
Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways.
Arthritis research & therapy
Liu C,Jiang J,Gao L,Wang X,Hu X,Wu M,Wu J,Xu T,Shi Q,Zhang X
16-0037 was used in Functional assays to study the role of soluble programmed death 1 (sPD-1) protein in the regulation of rheumatoid arthritis, showing that serum levels of sPD-1 were significantly correlated with titres of rheumatoid factor, and that it functionally blocked the inhibitory effect of PD-1 on T-cell activation, suggesting that sPD-1 may represent a biomarker or targer for rheumatoid arthritis.
Wed Nov 25 00:00:00 EST 2015
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
Journal of immunology (Baltimore, Md. : 1950)
Hsu P,Santner-Nanan B,Hu M,Skarratt K,Lee CH,Stormon M,Wong M,Fuller SJ,Nanan R
16-0037 was used in Flow cytometry/Cell sorting to investigate the action of IL-10 on regulatory T cells, and the potential therapeutic implications for the treatment of immune diseases that this may hold.
Thu Oct 15 00:00:00 EDT 2015
Collagen induces maturation of human monocyte-derived dendritic cells by signaling through osteoclast-associated receptor.
Journal of immunology (Baltimore, Md. : 1950)
Schultz HS,Nitze LM,Zeuthen LH,Keller P,Gruhler A,Pass J,Chen J,Guo L,Fleetwood AJ,Hamilton JA,Berchtold MW,Panina S
16-0037 was used in Functional assays to investigate the functional outcome of the OSCAR-collagen interaction in human monocyte-derived dendritic cells.
Wed Apr 01 00:00:00 EDT 2015
Wide-scale quantitative phosphoproteomic analysis reveals that cold treatment of T cells closely mimics soluble antibody stimulation.
Journal of proteome research
Ji Q,Salomon AR
16-0037 was used in Functional assays to investigate the mechanism by which T cell receptor signalling initiation occurs in response to low temperature, demonstrating that signalling patterns initiated by cold treatment are nearly identical to those initiated by soluble antibodies.
Fri May 01 00:00:00 EDT 2015
A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation.
Oncotarget
Wienke J,Janssen W,Scholman R,Spits H,van Gijn M,Boes M,van Montfrans J,Moes N,de Roock S
16-0037 was used in Flow cytometry/Cell sorting to explore whether increased Th17 activity can contribute to autoimmune pathology in patients with STAT3 mutations.
Fri Aug 21 00:00:00 EDT 2015
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Nature communications
Mikucki ME,Fisher DT,Matsuzaki J,Skitzki JJ,Gaulin NB,Muhitch JB,Ku AW,Frelinger JG,Odunsi K,Gajewski TF,Luster AD,Evans SS
16-0037 was used in Functional assays to investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma.
Thu Jun 25 00:00:00 EDT 2015
Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.
Oncotarget
Elkord E,Abd Al Samid M,Chaudhary B
16-0037 was used in Flow cytometry/Cell sorting to define reliable and specific markers that can distinguish different Treg subpopulations.
Fri Aug 21 00:00:00 EDT 2015
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab.
Journal for immunotherapy of cancer
Ramakrishna V,Sundarapandiyan K,Zhao B,Bylesjo M,Marsh HC,Keler T
16-0037 was used in Functional assays to reveal the requirements and T cell subtype-specific effects of CD27 costimulation.
Tue Oct 27 00:00:00 EDT 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
16-0037 was used in Functional assays to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.
Molecular & cellular proteomics : MCP
Ji Q,Ding Y,Salomon AR
16-0037 was used in Functional assays to expand our knowledge of the role of N-terminal phosphorylation of SLP-76 from three previously studied tyrosine sites.
Thu Jan 01 00:00:00 EST 2015
Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.
Molecular cell
Guo YE,Riley KJ,Iwasaki A,Steitz JA
Thu Apr 10 00:00:00 EDT 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
16-0037 was used in Functional assays to highlight a previously unrecognised CD8+ T cell/IFNγ/IDO axis that mediates the therapeutic effects of allogeneic MSCs in lupus patients.
Fri Aug 01 00:00:00 EDT 2014
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
Clinical cancer research : an official journal of the American Association for Cancer Research
Iversen TZ,Engell-Noerregaard L,Ellebaek E,Andersen R,Larsen SK,Bjoern J,Zeyher C,Gouttefangeas C,Thomsen BM,Holm B,Thor Straten P,Mellemgaard A,Andersen MH,Svane IM
16-0037 was used in Functional assays to investigate targeting of indoleamine-2,3-dioxygenase enzyme using a synthetic peptide vaccine to treat metastatic non-small cell lung cancer.
Wed Jan 01 00:00:00 EST 2014
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hartmann N,Giese NA,Giese T,Poschke I,Offringa R,Werner J,Ryschich E
16-0037 was used in Flow cytometry/Cell sorting to analyse how chemokines and extracellular matrix collagen interact in mediating T-cell infiltration in pancreatic ductal adenocarcinoma.
Tue Jul 01 00:00:00 EDT 2014
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
Proceedings of the National Academy of Sciences of the United States of America
Kumaresan PR,Manuri PR,Albert ND,Maiti S,Singh H,Mi T,Roszik J,Rabinovich B,Olivares S,Krishnamurthy J,Zhang L,Najjar AM,Huls MH,Lee DA,Champlin RE,Kontoyiannis DP,Cooper LJ
16-0037 was used in Functional assays to investigate the use of bioengineered T cells for treatment of fungal infection.
Tue Jul 22 00:00:00 EDT 2014
Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT.
Blood cancer journal
Li L,Kim HT,Nellore A,Patsoukis N,Petkova V,McDonough S,Politikos I,Nikiforow S,Soiffer R,Antin JH,Ballen K,Cutler C,Ritz J,Boussiotis VA
16-0037 was used in Functional assays to examine the effects of short-term exposure of umbilical cord blood T-cells to 16-dimethyl-prostaglandin E2 (dmPGE2).
Fri Jan 17 00:00:00 EST 2014
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B
16-0037 was used in Functional assays to investigate the potential for combining obatoclax with immunotherapeutic modalities.
Sat Mar 15 00:00:00 EDT 2014
Immunosuppressive activity of an aqueous Viola tricolor herbal extract.
Journal of ethnopharmacology
Hellinger R,Koehbach J,Fedchuk H,Sauer B,Huber R,Gruber CW,Gründemann C
16-0037 was used in Functional assays to provide a rationale for use of herbal Viola preparations in the therapy of disorders related to an overactive immune system.
Mon Sep 08 00:00:00 EDT 2014
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.
Cellular signalling
Schafer PH,Parton A,Capone L,Cedzik D,Brady H,Evans JF,Man HW,Muller GW,Stirling DI,Chopra R
16-0037 was used in Flow cytometry/Cell sorting to show that the pharmacological effects of apremilast are consistent with those of a targeted PDE4 inhibitor.
Mon Sep 01 00:00:00 EDT 2014
Tumor-activated TCRγδ⁺ T cells from gastric cancer patients induce the antitumor immune response of TCRαβ⁺ T cells via their antigen-presenting cell-like effects.
Journal of immunology research
Mao C,Mou X,Zhou Y,Yuan G,Xu C,Liu H,Zheng T,Tong J,Wang S,Chen D
16-0037 was used in in vitro experiments to study how tumour-activated γδ T cells may induce adaptive immune responses through their APC-like functions.
Wed Jan 07 00:00:00 EST 2015
Alterations in both the activatory and inhibitory potential of peripheral blood CD4+ T cells in rheumatoid arthritis patients correlate with disease progression.
Pathology oncology research : POR
Kosmaczewska A,Ciszak L,Swierkot J,Szteblich A,Wiland P,Frydecka I
16-0037 was used in Functional assays to demonstrate that the dysregulated expression of molecules interfering with CD4+ T cell signaling may result in functional impairment of the effector T cells.
Tue Apr 01 00:00:00 EDT 2014
Cell-based measurements of mitochondrial function in human subjects.
Methods in enzymology
Kang JG,Wang PY,Hwang PM
16-0037 was used in Functional assays to describe methods for measuring the mitochondrial metabolism of blood lymphocytes and skeletal muscle myoblasts.
Tue May 26 00:00:00 EDT 2015
Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation.
Journal of translational medicine
Quandt D,Jasinski-Bergner S,Müller U,Schulze B,Seliger B
16-0037 was used in Functional assays to investigate the cellular alterations observable in tumour cells upon cytokine treatment.
Fri May 30 00:00:00 EDT 2014
Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients.
PloS one
Cenit MC,Martínez-Florensa M,Consuegra M,Bonet L,Carnero-Montoro E,Armiger N,Caballero-Baños M,Arias MT,Benitez D,Ortego-Centeno N,de Ramón E,Sabio JM,García-Hernández FJ,Tolosa C,Suárez A,González-Gay MA,Bosch E,Martín J,Lozano F
16-0037 was used in Functional assays to investigate the potential role of CD5 on the development of systemic lupus erythematosus and/or systemic lupus erythematosus nephritis.
Tue Jan 19 00:00:00 EST 2016
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.
The Journal of biological chemistry
Mellergaard M,Skovbakke SL,Schneider CL,Lauridsen F,Andresen L,Jensen H,Skov S
16-0037 was used in Functional assays to determine the specific mode of regulation of NKG2D ligand surface expression by N-glycosylation.
Fri Jul 18 00:00:00 EDT 2014
Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis.
Brain : a journal of neurology
Abrahamsson SV,Angelini DF,Dubinsky AN,Morel E,Oh U,Jones JL,Carassiti D,Reynolds R,Salvetti M,Calabresi PA,Coles AJ,Battistini L,Martin R,Burt RK,Muraro PA
16-0037 was used in Functional assays to investigate the changes in the reconstituted immune repertoire following haematopoietic stem cell transplant.
Sun Sep 01 00:00:00 EDT 2013
Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation.
Matrix biology : journal of the International Society for Matrix Biology
Miller TW,Kaur S,Ivins-O'Keefe K,Roberts DD
16-0037 was used in Functional assays to investigate the mechanism of inhibition of T cell activation by thrombospondin-1.
Thu Aug 08 00:00:00 EDT 2013
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Journal of immunology (Baltimore, Md. : 1950)
Palin AC,Ramachandran V,Acharya S,Lewis DB
16-0037 was used in Functional assays to investigate the developmental differences in immune function between human neonates and adults, showing that neonatal naive CD4+ T cells have enhanced activation-dependent signalling.
Fri Mar 15 00:00:00 EDT 2013
An efficient low cost method for gene transfer to T lymphocytes.
PloS one
Chicaybam L,Sodre AL,Curzio BA,Bonamino MH
16-0037 was used in Functional assays to describe a novel protocol for electroporation based modification of T lymphocytes.
Mon Sep 30 00:00:00 EDT 2013
Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression.
Epigenetics & chromatin
Grzenda A,Lomberk G,Svingen P,Mathison A,Calvo E,Iovanna J,Xiong Y,Faubion W,Urrutia R
16-0037 was used in Functional assays to demonstrate that an expanded repertoire of EZH2 writers can modulate histone code instruction during histone 3 lysine 27-mediated gene silencing.
Thu Feb 28 00:00:00 EST 2013
IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.
PloS one
Lindenberg JJ,Oosterhoff D,Sombroek CC,Lougheed SM,Hooijberg E,Stam AG,Santegoets SJ,Tijssen HJ,Buter J,Pinedo HM,van den Eertwegh AJ,Scheper RJ,Koenen HJ,van de Ven R,de Gruijl TD
16-0037 was used in Functional assays to investigate how migration and T cell-stimulatory abilities of dendritic cell subsets in the skin are affected by conditioning of the dermal microenvironment.
Thu Feb 13 00:00:00 EST 2014
Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells.
PloS one
Singh H,Figliola MJ,Dawson MJ,Olivares S,Zhang L,Yang G,Maiti S,Manuri P,Senyukov V,Jena B,Kebriaei P,Champlin RE,Huls H,Cooper LJ
16-0037 was used in Functional assays to reveal how the platform technologies of SB-mediated transposition and CAR-dependent propagation on aAPC were adapted for human application.
Tue Feb 18 00:00:00 EST 2014
Functional characterization of a STAT3-dependent dendritic cell-derived CD14+ cell population arising upon IL-10-driven maturation.
Oncoimmunology
Lindenberg JJ,van de Ven R,Lougheed SM,Zomer A,Santegoets SJ,Griffioen AW,Hooijberg E,van den Eertwegh AJ,Thijssen VL,Scheper RJ,Oosterhoff D,de Gruijl TD
16-0037 was used in Flow cytometry/Cell sorting to model tumor-conditioned DC maturation to functionally assess CD14(-) and CD14(+) DCs that matured in vitro upon exposure to IL-10.
Mon Apr 01 00:00:00 EDT 2013
NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors.
PloS one
Lin G,Field JJ,Yu JC,Ken R,Neuberg D,Nathan DG,Linden J
16-0037 was used in Functional assays to culture human invariant natural killer T cells and study their activation.
Fri Jul 11 00:00:00 EDT 2014
GFP affects human T cell activation and cytokine production following in vitro stimulation.
PloS one
Koelsch KA,Wang Y,Maier-Moore JS,Sawalha AH,Wren JD
16-0037 was used in Functional assays to explore and characterise the effects of TurboGFP on the activation of primary T cells.
Tue Oct 22 00:00:00 EDT 2013
Production and first-in-man use of T cells engineered to express a HSVTK-CD34 sort-suicide gene.
PloS one
Zhan H,Gilmour K,Chan L,Farzaneh F,McNicol AM,Xu JH,Adams S,Fehse B,Veys P,Thrasher A,Gaspar H,Qasim W
16-0037 was used in Flow cytometry/Cell sorting to demonstrate the suitability of tCD34 as a GMP-compliant selection marker and demonstrate the potential of HSVTK-tCD34 suicide gene-modified donor T-cells.
Tue Aug 26 00:00:00 EDT 2014
Snapin, positive regulator of stimulation- induced Ca²⁺ release through RyR, is necessary for HIV-1 replication in T cells.
PloS one
Kinoshita SM,Kogure A,Taguchi S,Nolan GP
16-0037 was used in Flow cytometry/Cell sorting to demonstrate that Snapin is a critical regulator of Ca²+ signaling and T-cell activation through its interaction with RyR.
Mon Jun 02 00:00:00 EDT 2014
The infectious synapse formed between mature dendritic cells and CD4(+) T cells is independent of the presence of the HIV-1 envelope glycoprotein.
Retrovirology
Rodriguez-Plata MT,Puigdomènech I,Izquierdo-Useros N,Puertas MC,Carrillo J,Erkizia I,Clotet B,Blanco J,Martinez-Picado J
16-0037 was used in Flow cytometry/Cell sorting to study a determinant role for immune activation driven by mDC-CD4(+) T-cell contacts in viral dissemination and that this activation likely contributes to the pathogenesis of HIV-1 infection.
Tue Apr 16 00:00:00 EDT 2013
Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species.
Hepatology (Baltimore, Md.)
Tacke RS,Lee HC,Goh C,Courtney J,Polyak SJ,Rosen HR,Hahn YS
16-0037 was used in Magnetic cell separation to examine the mechanism for HCV-mediated T-cell dysfunction.
Wed Feb 01 00:00:00 EST 2012
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.
Brain : a journal of neurology
Larochelle C,Cayrol R,Kebir H,Alvarez JI,Lécuyer MA,Ifergan I,Viel É,Bourbonnière L,Beauseigle D,Terouz S,Hachehouche L,Gendron S,Poirier J,Jobin C,Duquette P,Flanagan K,Yednock T,Arbour N,Prat A
16-0037 was used in Flow cytometry/Cell sorting to identify MCAM as a marker of a subset of memory CD4(+) lymphocytes and as a potential marker for multiple sclerosis.
Mon Oct 01 00:00:00 EDT 2012
Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis.
Clinical immunology (Orlando, Fla.)
Bandyopadhyay G,Bankey PE,Miller-Graziano CL
16-0037 was used in Flow cytometry/Cell sorting to study the contribution of elevated tumor necrosis related apoptosis inducing ligand (TRAIL) in trauma patients to increased T cell apoptosis.
Mon Oct 01 00:00:00 EDT 2012
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα.
Rheumatology (Oxford, England)
Bikker A,Moret FM,Kruize AA,Bijlsma JW,Lafeber FP,van Roon JA
16-0037 was used in Magnetic cell separation to study the phenotypes of and the balance between systemic IL-7Rα+ and IL-7Rα- Tregs in primary Sjögren's syndrome patients compared with healthy controls.
Fri Jun 01 00:00:00 EDT 2012
Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade.
Journal of immunology (Baltimore, Md. : 1950)
Olson BM,Jankowska-Gan E,Becker JT,Vignali DA,Burlingham WJ,McNeel DG
16-0037 was used in Flow cytometry/Cell sorting to test the hypothesis that in addition to natural CD4(+)CD25(+) regulatory T cells (Tregs) and myeloid-derived suppressor cells, tumor Ag-specific Tregs interfere with the detection of anti-tumor immunity after immunotherapy.
Sat Dec 15 00:00:00 EST 2012
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Zhang T,Wu MR,Sentman CL
16-0037 was used in Functional assays to demonstrate the specificity and therapeutic potential of adoptive immunotherapy with NKp30 CAR-expressing T-cells against B7-H6+ tumour cells.
Sat Sep 01 00:00:00 EDT 2012
Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Ioannou M,Alissafi T,Lazaridis I,Deraos G,Matsoukas J,Gravanis A,Mastorodemos V,Plaitakis A,Sharpe A,Boumpas D,Verginis P
16-0037 was used in Flow cytometry/Cell sorting to study granulocytic myeloid-derived suppressor cells in the natural resolution of experimental autoimmune encephalomyelitis in mice.
Wed Feb 01 00:00:00 EST 2012
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3.
FEBS letters
Pennington MW,Harunur Rashid M,Tajhya RB,Beeton C,Kuyucak S,Norton RS
16-0037 was used in Functional assays to describe a new ShK analogue with an additional C-terminus Lys residue and amide.
Fri Nov 16 00:00:00 EST 2012
Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: effects on regulatory T cells.
Muscle & nerve
Rowin J,Thiruppathi M,Arhebamen E,Sheng J,Prabhakar BS,Meriggioli MN
16-0037 was used in Functional assays to investigate treatment with GM-CSF on a patient with a prolonged myasthenic crisis refractory to conventional immunomodulatory therapy.
Sat Sep 01 00:00:00 EDT 2012
Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.
PloS one
Cao L,Ding Y,Hung N,Yu K,Ritz A,Raphael BJ,Salomon AR
16-0037 was used in Immunoprecipitation to characterise SLP-76-dependent phosphorylation events in TCR signalling.
Tue Apr 02 00:00:00 EDT 2013
Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.
PloS one
Anangi R,Koshy S,Huq R,Beeton C,Chuang WJ,King GF
16-0037 was used in Functional assays to develop a Pichia pastoris expression system for production of K(v)1.3 blockers.
Mon Jun 24 00:00:00 EDT 2013
Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-γ-mediated suppressor activities.
PloS one
Bahri R,Bollinger A,Bollinger T,Orinska Z,Bulfone-Paus S
16-0037 was used in Flow cytometry/Cell sorting to study how the expression of ectoenzyme receptor family members positively correlates with suppressor functions and identifies CD8(+)CD38(high) T cells as potential inhibitors of excessive immune responses.
Thu Feb 28 00:00:00 EST 2013
Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype.
PloS one
Forget MA,Huon Y,Reuben A,Grange C,Liberman M,Martin J,Mes-Masson AM,Arbour N,Lapointe R
16-0037 was used in Flow cytometry/Cell sorting to evaluate whether T memory stem cells can be obtained from human mature CD8(+) T cells through treatment with 4,6-disubstituted pyrrolopyrimidine.
Thu Apr 11 00:00:00 EDT 2013
MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.
PloS one
Li M,Cao W,Liu H,Zhang W,Liu X,Cai Z,Guo J,Wang X,Hui Z,Zhang H,Wang J,Wang L
16-0037 was used in Western Blotting to study how MCPIP1 may play an important role in the down-regulation of IL-2 in activated T lymphocytes by an ARE-independent pathway.
Thu May 30 00:00:00 EDT 2013
Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease.
PloS one
Zha B,Wang L,Liu X,Liu J,Chen Z,Xu J,Sheng L,Li Y,Chu Y
16-0037 was used in an ELISA assay to demonstrate that B10 cells in human peripheral blood belongs to a CD24(hi)CD27(+) B cell subpopulation.
Thu May 16 00:00:00 EDT 2013
Hydrogen sulfide is an endogenous potentiator of T cell activation.
The Journal of biological chemistry
Miller TW,Wang EA,Gould S,Stein EV,Kaur S,Lim L,Amarnath S,Fowler DH,Roberts DD
16-0037 was used in Flow cytometry/Cell sorting to study the effects of H(2)S exposure on T cell activation, and as a novel immunomodulatory molecule in T cells.
Fri Feb 03 00:00:00 EST 2012
Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human.
Nucleic acids research
Birzele F,Fauti T,Stahl H,Lenter MC,Simon E,Knebel D,Weith A,Hildebrandt T,Mennerich D
16-0037 was used in Functional assays to study the role of FoxP3 in generating transcriptional differences between primary human CD4(+) T helper and regulatory T-cells.
Sat Oct 01 00:00:00 EDT 2011
Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia.
The Journal of allergy and clinical immunology
de la Fuente MA,Recher M,Rider NL,Strauss KA,Morton DH,Adair M,Bonilla FA,Ochs HD,Gelfand EW,Pessach IM,Walter JE,King A,Giliani S,Pai SY,Notarangelo LD
16-0037 was used in Functional assays to define thymic output and characterise immune function in a patient with cartilage-hair hypoplasia.
Fri Jul 01 00:00:00 EDT 2011
B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response.
Clinical cancer research : an official journal of the American Association for Cancer Research
Quandt D,Fiedler E,Boettcher D,Marsch WCh,Seliger B
16-0037 was used in Functional assays to provide evidence of B7-H4 expression on melanoma cells as a mechanism controlling tumour immunity.
Sun May 15 00:00:00 EDT 2011
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy.
Leukemia
Merims S,Li X,Joe B,Dokouhaki P,Han M,Childs RW,Wang ZY,Gupta V,Minden MD,Zhang L
16-0037 was used in Flow cytometry/Cell sorting to demonstrate that DNT cells from AML patients can be expanded ex vivo and are effective at killing both allogeneic and autologous primary leukemic blasts.
Thu Sep 01 00:00:00 EDT 2011
CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Landrigan A,Wong MT,Utz PJ
16-0037 was used in Functional assays to study the ability of oligodeoxynucleotides to activate and polarise T cells.
Thu Sep 15 00:00:00 EDT 2011
The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Baeke F,Korf H,Overbergh L,Verstuyf A,Thorrez L,Van Lommel L,Waer M,Schuit F,Gysemans C,Mathieu C
16-0037 was used in Flow cytometry/Cell sorting to conclude that TX527 directly affects human T cell function, thereby inhibiting effector T cell reactivity while inducing regulatory T cell characteristics.
Sat Jan 01 00:00:00 EST 2011
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Pollara J,Hart L,Brewer F,Pickeral J,Packard BZ,Hoxie JA,Komoriya A,Ochsenbauer C,Kappes JC,Roederer M,Huang Y,Weinhold KJ,Tomaras GD,Haynes BF,Montefiori DC,Ferrari G
16-0037 was used in Functional assays to develop a high-throughput platform to detect the presence of HIV-1 and SIV-specific ADCC-mediating antibody responses.
Mon Aug 01 00:00:00 EDT 2011
The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
Gene therapy
Jin Z,Maiti S,Huls H,Singh H,Olivares S,Mátés L,Izsvák Z,Ivics Z,Lee DA,Champlin RE,Cooper LJ
16-0037 was used in Functional assays to compare the ability of the transposases SB11 and SB100X to generate CAR(+) T cells from human peripheral blood mononuclear cells.
Thu Sep 01 00:00:00 EDT 2011
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation.
Cellular immunology
Williams KM,Dotson AL,Otto AR,Kohlmeier JE,Benedict SH
16-0037 was used in Flow cytometry/Cell sorting to investigate the effects of costimulating surface proteins CD28 and ICAM-1 on naive T cell differentiation.
Fri Dec 02 00:00:00 EST 2011
Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment.
Immunobiology
Richardt-Pargmann D,Wechsler M,Krieg AM,Vollmer J,Jurk M
16-0037 was used in Functional assays to investigate the role of TLR7/8 stimulation in T cells.
Mon Jul 18 00:00:00 EDT 2011
Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells.
Human immunology
Parmigiani A,Pallin MF,Schmidtmayerova H,Lichtenheld MG,Pahwa S
16-0037 was used in Functional assays to analyse the ability of interleukin-21 to modulate the properties of human CD8 T cell responses in comparison with other γ(c)-sharing cytokines.
Tue Feb 01 00:00:00 EST 2011
Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12.
PloS one
Magrini E,Szabò I,Doni A,Cibella J,Viola A
16-0037 was used in Functional assays to analyse the possible role of serotonin in T cell migration.
Mon Dec 19 00:00:00 EST 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
16-0037 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 EDT 2011
Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression.
PloS one
Kirshberg S,Izhar U,Amir G,Demma J,Vernea F,Beider K,Shlomai Z,Wald H,Zamir G,Shapira OM,Peled A,Wald O
16-0037 was used in an ELISA assay to investigate how the CCL20/CCR6 axis promotes NSCLC disease progression.
Mon Jan 30 00:00:00 EST 2012
Hypoxia potentiates glioma-mediated immunosuppression.
PloS one
Wei J,Wu A,Kong LY,Wang Y,Fuller G,Fokt I,Melillo G,Priebe W,Heimberger AB
16-0037 was used in Flow cytometry/Cell sorting to compare the immunosuppressive properties of glioblastoma multiforme associated cancer stem cells under normoxic and hypoxic conditions, showing that hypoxia potentiated inhibition of T cell activity and macrophage phagocytosis, mediated by STAT3, HIF-1α and VEGF.
Thu Jan 20 00:00:00 EST 2011
Tracking immune cell proliferation and cytotoxic potential using flow cytometry.
Methods in molecular biology (Clifton, N.J.)
Tario JD,Muirhead KA,Pan D,Munson ME,Wallace PK
16-0037 was used in Functional assays to illustrate how tracking dye fluorescence profiles could be used to ascertain the precursor frequencies of different subsets in the T-cell pool.
Mon May 23 00:00:00 EDT 2011
The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation.
Blood
Knight A,Madrigal AJ,Grace S,Sivakumaran J,Kottaridis P,Mackinnon S,Travers PJ,Lowdell MW
16-0037 was used in Blocking experiments to investigate the role of γδ T cells in cytomegalovirus reactivation following allogeneic stem cell transplantation.
Thu Sep 23 00:00:00 EDT 2010
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets.
Blood
Hislop AD,Palendira U,Leese AM,Arkwright PD,Rohrlich PS,Tangye SG,Gaspar HB,Lankester AC,Moretta A,Rickinson AB
16-0037 was used in Magnetic cell separation to investigate Epstein-Barr virus-specific immunity in X-linked lymphoproliferative disease patients.
Thu Oct 28 00:00:00 EDT 2010
The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations.
Clinical cancer research : an official journal of the American Association for Cancer Research
Comin-Anduix B,Chodon T,Sazegar H,Matsunaga D,Mock S,Jalil J,Escuin-Ordinas H,Chmielowski B,Koya RC,Ribas A
16-0037 was used in Functional assays to investigate the effect of PLX4032 on immune cells.
Wed Dec 15 00:00:00 EST 2010
Glioma cancer stem cells induce immunosuppressive macrophages/microglia.
Neuro-oncology
Wu A,Wei J,Kong LY,Wang Y,Priebe W,Qiao W,Sawaya R,Heimberger AB
16-0037 was used in Functional assays to investigate the role of glioma cancer stem cells (gCSCs) in recruiting and polarising macrophages/microglia, showing that gCSCs modulate innate immunity by inducing immunosuppressive MΦs/microglia.
Mon Nov 01 00:00:00 EDT 2010
Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes.
European journal of immunology
Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F
16-0037 was used in Immunohistochemistry to investigate the production and function of the phenylalanine catabolising enzyme, IL-4-induced gene 1.
Wed Sep 01 00:00:00 EDT 2010
Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes.
European journal of immunology
Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F
16-0037 was used in Immunohistochemistry to investigate the production and function of the phenylalanine catabolising enzyme, IL-4-induced gene 1.
Wed Sep 01 00:00:00 EDT 2010
Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway.
Molecular cancer therapeutics
Wei J,Barr J,Kong LY,Wang Y,Wu A,Sharma AK,Gumin J,Henry V,Colman H,Priebe W,Sawaya R,Lang FF,Heimberger AB
16-0037 was used in Functional assays to investigate the mechanism by which glioblastoma cancer-initiating cells inhibit T cell proliferation and effector responses.
Fri Jan 01 00:00:00 EST 2010
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.
Journal of immunology (Baltimore, Md. : 1950)
Pan W,Zhu S,Yuan M,Cui H,Wang L,Luo X,Li J,Zhou H,Tang Y,Shen N
16-0037 was used in Functional assays to identify two miRNAs for regulating methylation in the autoimmune disease lupus through direct and indirect mechanisms, which may allow the development of future therapies.
Tue Jun 15 00:00:00 EDT 2010
T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.
The Biochemical journal
Stevens CN,Simeone AM,John S,Ahmed Z,Lucherini OM,Baldari CT,Ladbury JE
16-0037 was used in Western Blotting to investigate signalling through the IFNalphaR (interferon-alpha receptor) and TCR (T-cell receptor) in Jurkat T lymphocytes which results in distinct immune responses.
Thu May 27 00:00:00 EDT 2010
Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients.
The Journal of clinical investigation
Andersen MH,Sørensen RB,Brimnes MK,Svane IM,Becker JC,thor Straten P
16-0037 was used to stimulate T cells in Inhibition experiments to study the first natural target for CD8+ regulatory T cells.
Sat Aug 01 00:00:00 EDT 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
16-0037 was used in Functional assays to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 EST 2009
Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance.
Journal of immunology (Baltimore, Md. : 1950)
Godin-Ethier J,Pelletier S,Hanafi LA,Gannon PO,Forget MA,Routy JP,Boulassel MR,Krzemien U,Tanguay S,Lattouf JB,Arbour N,Lapointe R
16-0037 was used in Functional assays to demonstrate that activated T-cells can induce functional IDO expression in breast and kidney tumor cell lines through Th1/Th2 balance.
Tue Dec 15 00:00:00 EST 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
16-0037 was used in Functional assays to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950)
Takamatsu H,Espinoza JL,Lu X,Qi Z,Okawa K,Nakao S
16-0037-81 was used in Flow Cytometry, Functional Assay, Sample Prep to determine the roles of anti-moesin Abs derived from the serum of patients with aplastic anemia (AA) in the pathophysiology of bone marrow failure.
Thu Jan 01 00:00:00 EST 2009
Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency.
European journal of pediatrics
Turul T,Tezcan I,Artac H,de Bruin-Versteeg S,Barendregt BH,Reisli I,Sanal O,van Dongen JJ,van der Burg M
16-0037 was used in Flow cytometry/Cell sorting to illustrate that awareness of the clinical heterogeneity of ZAP70 deficiency is of utmost importance for making a fast and accurate diagnosis.
Thu Jan 01 00:00:00 EST 2009
The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation.
PloS one
Gur-Wahnon D,Borovsky Z,Liebergall M,Rachmilewitz J
16-0037 was used in an ELISA assay to study the mechanisms by which STAT3 controls antigen presenting cell maturation.
Mon Aug 31 00:00:00 EDT 2009
A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation.
Molecular & cellular proteomics : MCP
Nguyen V,Cao L,Lin JT,Hung N,Ritz A,Yu K,Jianu R,Ulin SP,Raphael BJ,Laidlaw DH,Brossay L,Salomon AR
16-0037 was used in Immunoprecipitation to dissect the tyrosine phosphoproteome of isogenic Zap-70 tyrosine kinase null and reconstituted Jurkat T cells.
Sun Nov 01 00:00:00 EDT 2009
Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.
PloS one
Correia DV,d'Orey F,Cardoso BA,Lança T,Grosso AR,deBarros A,Martins LR,Barata JT,Silva-Santos B
16-0037-81 was used in Flow Cytometry to study the molecular mechanisms responsible for phosphoantigen-mediated activation of human gammadelta T-cells.
Thu May 21 00:00:00 EDT 2009
miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression.
PloS one
Stahl HF,Fauti T,Ullrich N,Bopp T,Kubach J,Rust W,Labhart P,Alexiadis V,Becker C,Hafner M,Weith A,Lenter MC,Jonuleit H,Schmitt E,Mennerich D
16-0037 was used in Flow cytometry/Cell sorting to demonstrate a crucial role of miR-155 in nTreg cell-mediated tolerance.
Thu Sep 24 00:00:00 EDT 2009
Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity.
PloS one
Mailer RK,Falk K,Rötzschke O
16-0037 was used in Functional assays to investigate the role of exon 7 of Foxp3 in dimerisation.
Wed Jul 01 00:00:00 EDT 2009
The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells.
Haematologica
Zappasodi R,Di Nicola M,Carlo-Stella C,Mortarini R,Molla A,Vegetti C,Albani S,Anichini A,Gianni AM
16-0037 was used in Flow cytometry/Cell sorting to examine the T-cell expansion efficiency of a new artificial antigen-presenting cell-based system.
Wed Oct 01 00:00:00 EDT 2008
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
PloS one
Puhar A,Dal Molin F,Horvath S,Ladant D,Montecucco C
16-0037 was used in Conjugation experiments to evaluate the ability of anthrax edema toxin to modulate cAMP-dependent signalling in Jurkat T cells.
Mon Feb 23 00:00:00 EST 2009
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America
Yu X,Sun JP,He Y,Guo X,Liu S,Zhou B,Hudmon A,Zhang ZY
16-0037 was used in Functional assays to determine the crystal structures of the Lyp PTP domain either alone or in complex with a selective small-molecule inhibitor.
Tue Dec 11 00:00:00 EST 2007
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.
Molecular and cellular biology
Zeng H,Di L,Fu G,Chen Y,Gao X,Xu L,Lin X,Wen R
16-0037 was used in Flow cytometry/Cell sorting to study how NF-kappaB activation is negatively regulated by phosphorylation of Bcl10.
Sun Jul 01 00:00:00 EDT 2007
Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands.
BMC biotechnology
Chin LT,Chu C,Chen HM,Hsu SC,Weng BC,Chu CH
16-0037 was used in Functional assays to develop an optimised protocol for the in vitro immunisation of peripheral blood mononuclear cells using a selected epitope of human CD152.
Thu Aug 23 00:00:00 EDT 2007
