Product References
Exhaustion‑like dysfunction of T and NKT cells in an X‑linked severe combined immunodeficiency patient with maternal engraftment by single‑cell analysis.
International journal of molecular medicine
Dong W,Li W,Zhang S,Zeng X,Qin Q,Fan H,Tang Z,Wu X,Lu G
12-9500-42 was used in Flow cytometry/Cell sorting to report an X-SCID patient with a de novo c.677C>T (p.R226H) variant in exon 5 of IL2RG, exhibiting recurrent and persistent infections from 3-months-old.
Wed Mar 01 00:00:00 EST 2023
Increased expression of TIGIT and KLRG1 correlates with impaired CD56bright NK cell immunity in HPV16-related cervical intraepithelial neoplasia.
Virology journal
Nie Y,Liu D,Yang W,Li Y,Zhang L,Cheng X,Chen R,Yuan B,Zhang G,Wang H
12-9500-42 was used in Flow cytometry/Cell sorting to examine the potential role of natural killer (NK) cell non-MHC-I specific inhibitory receptors expression in immune escape from HPV16(+)cervical intraepithelial neoplasia (CIN) patients.
Tue Apr 12 00:00:00 EDT 2022
CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Christian ML,Dapp MJ,Scharffenberger SC,Jones H,Song C,Frenkel LM,Krumm A,Mullins JI,Rawlings DJ
12-9500-42 was used in Flow cytometry/Cell sorting to model the effects of HIV integration within BACH2 Integration of the HIV long terminal repeat (LTR) and major splice donor increased BACH2 mRNA and protein levels, altered gene expression, and promoted selective outgrowth of an activated, proliferative, and T regulatory-like cell population.
Fri Apr 01 00:00:00 EDT 2022
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell
Béziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet É,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Habib T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot É,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Prétet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL
12-9500-42 was used in Flow cytometry/Cell sorting to conclude that human CD28-dependent T cell responses are largely redundant for protective immunity.
Thu Jul 08 00:00:00 EDT 2021
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Cancer cell
Srivastava S,Furlan SN,Jaeger-Ruckstuhl CA,Sarvothama M,Berger C,Smythe KS,Garrison SM,Specht JM,Lee SM,Amezquita RA,Voillet V,Muhunthan V,Yechan-Gunja S,Pillai SPS,Rader C,Houghton AM,Pierce RH,Gottardo R,Maloney DG,Riddell SR
12-9500-42 was used in Flow Cytometry to test strategies for enhancing efficacy of CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like orphan receptor 1 (ROR1) infiltrating tumors.
Mon Feb 08 00:00:00 EST 2021
Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis.
Frontiers in immunology
Deng C,Li W,Fei Y,Wang L,Chen Y,Zeng X,Zhang F,Li Y
12-9500 was used in Flow cytometry/Cell sorting to look at PBC patients (n = 42) showing significantly higher proportions of peripheral CD8+ T and CD4+ T cells expressing either CD226 or TIGIT than disease (n = 25) and healthy (n = 30) controls.
Mon Apr 19 00:00:00 EDT 2021
A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
Frontiers in oncology
Li X,Wang R,Fan P,Yao X,Qin L,Peng Y,Ma M,Asley N,Chang X,Feng Y,Hu Y,Zhang Y,Li C,Fanning G,Jones S,Verrill C,Maldonado-Perez D,Sopp P,Waugh C,Taylor S,Mcgowan S,Cerundolo V,Conlon C,McMichael A,Lu S,Wang X,Li N,Dong T
12-9500-42 was used in Flow Cytometry to investigate mono-blockade or combinatorial blockade regimens and how they may reinvigorate anti tumor T-cell immunity in those cancer patients while limiting immune-related adverse effects.
Sun Jan 10 00:00:00 EST 2021
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Nature medicine
Thommen DS,Koelzer VH,Herzig P,Roller A,Trefny M,Dimeloe S,Kiialainen A,Hanhart J,Schill C,Hess C,Savic Prince S,Wiese M,Lardinois D,Ho PC,Klein C,Karanikas V,Mertz KD,Schumacher TN,Zippelius A
12-9500 was used in Flow cytometry/Cell sorting to compare transcriptional, metabolic and functional signatures of intratumoral CD8+ T lymphocyte populations with high, intermediate and no PD-1 expression from non-small-cell lung cancer patients.
Sun Jul 01 00:00:00 EDT 2018
Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.
Frontiers in immunology
Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M
12-9500 was used in Flow cytometry/Cell sorting to suggest that ELCs harbor a "healthy" state of inhibitory receptor expression on CD4+ T cells that might play part in maintenance of their control status.
Thu Feb 14 00:00:00 EST 2019
An Autocrine TNFα-Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro.
Frontiers in immunology
Urbano PCM,Koenen HJPM,Joosten I,He X
12-9500 was used in Flow cytometry/Cell sorting to explore the underlying mechanisms of rapamycin and tumour necrosis factor receptor 2 agonist-mediated regulatory T cell stability.
Tue May 28 00:00:00 EDT 2019
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals.
PLoS pathogens
Clarridge KE,Blazkova J,Einkauf K,Petrone M,Refsland EW,Justement JS,Shi V,Huiting ED,Seamon CA,Lee GQ,Yu XG,Moir S,Sneller MC,Lichterfeld M,Chun TW
12-9500 was used in Flow cytometry/Cell sorting to evaluate if there's a correlation between analytical treatment interruption of ART in HIV patients, and the size of the persistent HIV reservoir.
Mon Jan 01 00:00:00 EST 2018
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells.
Frontiers in immunology
Stecher C,Battin C,Leitner J,Zettl M,Grabmeier-Pfistershammer K,Höller C,Zlabinger GJ,Steinberger P
Wed Mar 30 00:00:00 EDT 2022
Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Scientific reports
Tauriainen J,Scharf L,Frederiksen J,Naji A,Ljunggren HG,Sönnerborg A,Lund O,Reyes-Terán G,Hecht FM,Deeks SG,Betts MR,Buggert M,Karlsson AC
12950042 was used in flow cytometry to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment
Fri Jan 13 00:00:00 EST 2017
A cellular platform for the evaluation of immune checkpoint molecules.
Oncotarget
Jutz S,Hennig A,Paster W,Asrak Ö,Dijanovic D,Kellner F,Pickl WF,Huppa JB,Leitner J,Steinberger P
12-9500 was used in Flow cytometry/Cell sorting to evaluate the potential of fluorescence-based transcriptional reporters based on the human Jurkat T cell line in conjunction with engineered T cell stimulator cell lines for investigating coinhibitory pathways.
Tue Sep 12 00:00:00 EDT 2017
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.
Nature communications
Hurst J,Hoffmann M,Pace M,Williams JP,Thornhill J,Hamlyn E,Meyerowitz J,Willberg C,Koelsch KK,Robinson N,Brown H,Fisher M,Kinloch S,Cooper DA,Schechter M,Tambussi G,Fidler S,Babiker A,Weber J,Kelleher AD,Phillips RE,Frater J
12-9500 was used in Flow cytometry/Cell sorting to show that immunological biomarkers can predict time to viral rebound after stopping antiretroviral therapy.
Fri Oct 09 00:00:00 EDT 2015
