Product References
CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity.
PloS one
Sullivan KMC,Vilalta M,Ertl LS,Wang Y,Dunlap C,Ebsworth K,Zhao BN,Li S,Zeng Y,Miao Z,Fan P,Mali V,Lange C,McMurtrie D,Yang J,Lui R,Scamp R,Chhina V,Kumamoto A,Yau S,Dang T,Easterday A,Liu S,Miao S,Charo I,Schall TJ,Zhang P
12-5983-42 was used in Flow Cytometry to present the pharmacology of the orally-available, small molecule PD-L1 inhibitor CCX559 for cancer immunotherapy.
Fri Jun 09 00:00:00 EDT 2023
A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2- Breast Cancer.
Cancers
Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Körner C,Ben-Baruch A
12-5983-42 was used in Flow cytometry/Cell sorting to find regulatory roles for Y705-STAT3 and p65 in tumor microenvironment-stimulated HR+/HER2- tumors, with the ability to limit cancer stem cells enrichment.
Wed Apr 12 00:00:00 EDT 2023
NK cells limit therapeutic vaccine-induced CD8+T cell immunity in a PD-L1-dependent manner.
Science translational medicine
Diniz MO,Schurich A,Chinnakannan SK,Duriez M,Stegmann KA,Davies J,Kucykowicz S,Suveizdyte K,Amin OE,Alcock F,Cargill T,Barnes E,Maini MK
12-5983-42 was used in Flow Cytometry /test) to delineate an immunotherapeutic combination that can boost the response to therapeutic vaccination in CHB and highlight the broader importance of PD-L1-dependent regulation of T cells by cytokine-activated NK cells.
Wed Apr 13 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
12-5983-42 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function.
Experimental & molecular medicine
Yoon HJ,Kim GC,Oh S,Kim H,Kim YK,Lee Y,Kim MS,Kwon G,Ok YS,Kwon HK,Kim HS
12-5983-42 was used in Flow cytometry/Cell sorting to highlight that WNK lysine deficient protein kinase 3 inhibition might serve as a potential therapeutic strategy for cancer immunotherapy through its concurrent impact on cancer cells and immune cells.
Tue Nov 01 00:00:00 EDT 2022
Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming.
Theranostics
Zhao T,Zeng J,Xu Y,Su Z,Chong Y,Ling T,Xu H,Shi H,Zhu M,Mo Q,Huang X,Li Y,Zhang X,Ni H,You Q
12-5983-42 was used in Flow cytometry/Cell sorting to reveal that CHI3L1 facilitated NF-κB pathway activation within glioma cells and reprogramed the TME, thereby serving as a promising therapeutic target for glioma.
Thu Oct 27 00:00:00 EDT 2022
PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells.
Journal for immunotherapy of cancer
Bajor M,Graczyk-Jarzynka A,Marhelava K,Burdzinska A,Muchowicz A,Goral A,Zhylko A,Soroczynska K,Retecki K,Krawczyk M,Klopotowska M,Pilch Z,Paczek L,Malmberg KJ,Wälchli S,Winiarska M,Zagozdzon R
12-5983-42 was used in Flow Cytometry to demonstrate that CAR-effector cells trigger the expression of PD-L1 on target cells, which in case of PD-L1-CAR results in the unique self-amplification phenomenon.
Sat Jan 01 00:00:00 EST 2022
Cancer genes disfavoring T cell immunity identified via integrated systems approach.
Cell reports
Kishton RJ,Patel SJ,Decker AE,Vodnala SK,Cam M,Yamamoto TN,Patel Y,Sukumar M,Yu Z,Ji M,Henning AN,Gurusamy D,Palmer DC,Stefanescu RA,Girvin AT,Lo W,Pasetto A,Malekzadeh P,Deniger DC,Wood KC,Sanjana NE,Restifo NP
12-5983-42 was used in Flow cytometry/Cell sorting to establish that BIRC2 limits antigen presentation and T cell recognition of tumor cells by suppressing IRF1 activity and provide evidence that BIRC2 inhibition in combination with Adoptive T cell therapies is an effective strategy to increase efficacy.
Tue Aug 02 00:00:00 EDT 2022
Cargo and Functional Profile of Saliva-Derived Exosomes Reveal Biomarkers Specific for Head and Neck Cancer.
Frontiers in medicine
Hofmann L,Medyany V,Ezić J,Lotfi R,Niesler B,Röth R,Engelhardt D,Laban S,Schuler PJ,Hoffmann TK,Brunner C,Jackson EK,Theodoraki MN
12-5983-42 was used in Flow cytometry/Cell sorting to investigate the cargo and functional profile of saliva-derived exosomes from HNSCC patients and their potential as non-invasive biomarkers for disease detection and immunomodulation.
Fri Jul 29 00:00:00 EDT 2022
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
12-5983-42 was used in Flow Cytometry to investigate if the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to the natural killer (NK) cell receptor KIR2DL4.
Wed Jun 23 00:00:00 EDT 2021
Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients.
British journal of cancer
Theodoraki MN,Laban S,Jackson EK,Lotfi R,Schuler PJ,Brunner C,Hoffmann TK,Whiteside TL,Hofmann L
12-5983-42 was used in Flow Cytometry to examine circulating exosomes as early detectors of treatment success in a cohort of head and neck cancer patients.
Wed Dec 01 00:00:00 EST 2021
Epithelial to Mesenchymal Transition Regulates Surface PD-L1 via CMTM6 and CMTM7 Induction in Breast Cancer.
Cancers
Xiao M,Hasmim M,Lequeux A,Moer KV,Tan TZ,Gilles C,Hollier BG,Thiery JP,Berchem G,Janji B,Noman MZ
12-5983-42 was used in Flow cytometry/Cell sorting to highlight the importance of CMTM6 and CMTM7 in EMT-induced PD-L1 and suggests that EMT, CMTM6 or CMTM7 modulators can be combined with anti-PD-L1 in patients with highly aggressive breast cancer.
Tue Mar 09 00:00:00 EST 2021
Inhibition of PI3Kδ Differentially Regulates Poly I:C- and Human Metapneumovirus-Induced PD-L1 and PD-L2 Expression in Human Bronchial Epithelial Cells.
Frontiers in immunology
Ogawa T,Kan-O K,Shiota A,Fujita A,Ishii Y,Fukuyama S,Matsumoto K
12-5983-42 was used in Flow Cytometry to suggest that inhibition of PI3Kδ differentially regulates PD-L1 and PD-L2 expression in bronchial epithelial cells during viral infections.
Mon Feb 14 00:00:00 EST 2022
Protocol for high-throughput compound screening using flow cytometry in THP-1 cells.
STAR protocols
Spangenberg SH,Zavareh RB,Lairson LL
12-5983 was used in Flow cytometry/Cell sorting to describe a methodology for identifying compounds that regulate PD-L1 surface expression in IFN-γ-stimulated cells.
Fri Jun 18 00:00:00 EDT 2021
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion.
The Journal of experimental medicine
Du L,Lee JH,Jiang H,Wang C,Wang S,Zheng Z,Shao F,Xu D,Xia Y,Li J,Zheng Y,Qian X,Li X,Kim HR,Xing D,Liu P,Lu Z,Lyu J
12-5983 was used in Flow cytometry/Cell sorting to show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression.
Mon Nov 02 00:00:00 EST 2020
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia.
EMBO molecular medicine
Gibellini L,De Biasi S,Paolini A,Borella R,Boraldi F,Mattioli M,Lo Tartaro D,Fidanza L,Caro-Maldonado A,Meschiari M,Iadisernia V,Bacca E,Riva G,Cicchetti L,Quaglino D,Guaraldi G,Busani S,Girardis M,Mussini C,Cossarizza A
12-5983 was used in Flow cytometry/Cell sorting to analyze peripheral blood monocytes from patients with COVID-19 pneumonia.
Mon Dec 07 00:00:00 EST 2020
Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.
Cancer immunology research
Liang J,Wang L,Wang C,Shen J,Su B,Marisetty AL,Fang D,Kassab C,Jeong KJ,Zhao W,Lu Y,Jain AK,Zhou Z,Liang H,Sun SC,Lu C,Xu ZX,Yu Q,Shao S,Chen X,Gao M,Claret FX,Ding Z,Chen J,Chen P,Barton MC,Peng G,Mills GB,Heimberger AB
12-5983 was used in Flow cytometry/Cell sorting to investigate if verteporfin can effectively target PD-L1 through transcriptional and posttranslational mechanisms.
Wed Jul 01 00:00:00 EDT 2020
Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling.
International journal of oncology
Cui B,Chen J,Luo M,Wang L,Chen H,Kang Y,Wang J,Zhou X,Feng Y,Zhang P
12-5983 was used in Flow cytometry/Cell sorting to broaden the understanding of the biological function of protein kinase D3 (PKD3), suggesting that PKD is a potential therapeutic target for oral squamous cell carcinoma (OSCC).
Wed Apr 01 00:00:00 EDT 2020
PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status.
Journal of neuropathology and experimental neurology
Martin AM,Bell WR,Yuan M,Harris L,Poore B,Arnold A,Engle EL,Asnaghi L,Lim M,Raabe EH,Eberhart CG
12-5983 was used in Flow cytometry/Cell sorting to examine the expression of PD-L1 in pediatric high- and low-grade glioma cell lines as well as a cohort of pediatric low-grade glioma patient samples.
Wed Jan 01 00:00:00 EST 2020
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Cell communication and signaling : CCS
Wang Y,Sun Q,Mu N,Sun X,Wang Y,Fan S,Su L,Liu X
12-5983 was used in Flow cytometry/Cell sorting to investigate the function of USP22 upon PD-L1 in human cancer cells.
Tue Jul 14 00:00:00 EDT 2020
NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer.
Nature communications
Qin G,Wang X,Ye S,Li Y,Chen M,Wang S,Qin T,Zhang C,Li Y,Long Q,Hu H,Shi D,Li J,Zhang K,Zhai Q,Tang Y,Kang T,Lan P,Xie F,Lu J,Deng W
12-5983-42 was used in Flow Cytometry to verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes.
Fri Apr 03 00:00:00 EDT 2020
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
12-5983-42 was used in Flow Cytometry to find that combining DNMTi and HDAC6i results in an amplified type I interferon response, leading to increased cytokine and chemokine expression and higher expression of the MHC I antigen presentation complex in human and mouse ovarian cancer cell lines.
Wed Feb 26 00:00:00 EST 2020
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.
Cell
Poggio M,Hu T,Pai CC,Chu B,Belair CD,Chang A,Montabana E,Lang UE,Fu Q,Fong L,Blelloch R
12-5983-42 was used in Flow Cytometry to describe an alternative mechanism of PD-L1 activity involving its secretion in tumor-derived exosomes.
Thu Apr 04 00:00:00 EDT 2019
miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1.
Molecular cancer research : MCR
Ashizawa M,Okayama H,Ishigame T,Thar Min AK,Saito K,Ujiie D,Murakami Y,Kikuchi T,Nakayama Y,Noda M,Tada T,Endo H,Fujita S,Sakamoto W,Saito M,Saze Z,Momma T,Ohki S,Mimura K,Kono K
12-5983 was used in Flow cytometry/Cell sorting to identify miRNAs that posttranscriptionally control PD-L1 expression on tumor cells and also regulate immune evasion.
Sat Jun 01 00:00:00 EDT 2019
Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer.
International journal of oncology
Nakayama Y,Mimura K,Tamaki T,Shiraishi K,Kua LF,Koh V,Ohmori M,Kimura A,Inoue S,Okayama H,Suzuki Y,Nakazawa T,Ichikawa D,Kono K
12-5983 was used in Flow cytometry/Cell sorting to show phosphorylated STAT1 in positive breast cancer cells is co-expressed with PD-L1 and HLA class I indicating STAT1 could act as a biomarker for anti-PD-1/anti-PD-L1 immunotherapy.
Sat Jun 01 00:00:00 EDT 2019
A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nouri K,Azad T,Lightbody E,Khanal P,Nicol CJ,Yang X
12-5983-42 was used in Flow Cytometry to identify novel regulars of the Hippo pathway.
Fri Nov 01 00:00:00 EDT 2019
Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.
Stem cells and development
Fujii S,Yoshida S,Inagaki E,Hatou S,Tsubota K,Takahashi M,Shimmura S,Sugita S
12-5983 was used in Flow cytometry/Cell sorting to assess the immunological properties of human induced pluripotent stem cells-neural crest cells.
Tue Jan 01 00:00:00 EST 2019
PD-1 of Sigmodon hispidus: Gene identification, characterization and preliminary evaluation of expression in inactivated RSV vaccine-induced enhanced respiratory disease.
Scientific reports
Muralidharan A,Larocque L,Russell M,Creskey M,Li C,Chen W,Van Domselaar G,Cao J,Cyr T,Rosu-Myles M,Wang L,Li X
12-5983-42 was used in Flow Cytometry to report the isolation of mRNA encoding the cotton rat PD-1 (crPD-1) and characterization of the PD-1 protein.
Mon Aug 12 00:00:00 EDT 2019
Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT.
Oncoimmunology
Theodoraki MN,Yerneni S,Gooding WE,Ohr J,Clump DA,Bauman JE,Ferris RL,Whiteside TL
12-5983-42 was used in Flow cytometry/Cell sorting to support the potential role of exosomes as a non-invasive tumor and immune cell biomarkers in cancer.
Tue Jan 12 00:00:00 EST 2021
Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.
Oncoimmunology
Wang JJ,Siu MK,Jiang YX,Leung TH,Chan DW,Cheng RR,Cheung AN,Ngan HY,Chan KK
12-5983-42 was used in Flow cytometry/Cell sorting to provide a novel explanation of how PDK1 contributes to upregulation of PD-L1 in ovarian cancer and highlight its potential as a target therapeutic molecule that cooperates with the immune checkpoint blockade.
Tue Jan 12 00:00:00 EST 2021
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Oncoimmunology
Triulzi T,Forte L,Regondi V,Di Modica M,Ghirelli C,Carcangiu ML,Sfondrini L,Balsari A,Tagliabue E
12-5983 was used in Flow cytometry/Cell sorting to investigate the relationship between HER2 activity and the pro-trastuzumab tumour immune milieu.
Tue Jan 12 00:00:00 EST 2021
Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.
Oncotarget
Ivanov VN,Wu J,Wang TJC,Hei TK
12-5983 was used in Flow cytometry/Cell sorting to study the impact of increasing the cytotoxic effects of cannabidiol and γ-irradiation in glioblastoma cells.
Fri Jan 25 00:00:00 EST 2019
PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models.
Oncotarget
Mitchell LA,Yagiz K,Hofacre A,Viaud S,Munday AW,Espinoza FL,Mendoza D,Rodriguez-Aguirre ME,Bergqvist S,Haghighi A,Miner MV,Accomando WP,Burrascano C,Gammon D,Gruber HE,Jolly DJ,Lin AH
12-5983 was used in Flow cytometry/Cell sorting to study the role of retroviral replicating vector delivery of scFv in PD-1/PD-L1 mediated immune suppression.
Tue Mar 19 00:00:00 EDT 2019
TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2.
Frontiers in immunology
Baruah P,Bullenkamp J,Wilson POG,Lee M,Kaski JC,Dumitriu IE
12-5983-42 was used in Flow Cytometry to study the role of PD-1 ligands, PD-L1, and particularly PD-L2, in the tumor-stromal cell interactions that cause a tumor-permissive environment in head and neck squamous cell carcinoma.
Wed Oct 14 00:00:00 EDT 2020
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.
Journal of leukocyte biology
Rolvering C,Zimmer AD,Ginolhac A,Margue C,Kirchmeyer M,Servais F,Hermanns HM,Hergovits S,Nazarov PV,Nicot N,Kreis S,Haan S,Behrmann I,Haan C
12-5983 was used in Flow cytometry/Cell sorting to study the effects of α-PD-L1 or α-IL6 antibodies in preventing the dampening of the IL27/STAT1 anticancer responses.
Thu Nov 01 00:00:00 EDT 2018
Separation of plasma-derived exosomes into CD3(+) and CD3(-) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients.
Clinical and experimental immunology
Theodoraki MN,Hoffmann TK,Whiteside TL
12-5983 was used in Flow cytometry/Cell sorting to investigate whether tumour- or T cell-derived exosomes in head and neck squamous cell carcinoma patients' plasma are immunosuppressive and impact upon disease activity.
Fri Jun 01 00:00:00 EDT 2018
Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
Oncology reports
Zhao H,Jia H,Han Q,Zhang J
12-5983 was used in Flow cytometry/Cell sorting to show homeobox containing 1 (HMBOX1) expression shows reduces the clinical stages of liver cancer.
Sat Sep 01 00:00:00 EDT 2018
Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis.
Cell death discovery
Wang X,Gray Z,Willette-Brown J,Zhu F,Shi G,Jiang Q,Song NY,Dong L,Hu Y
12-5983 was used in Flow cytometry/Cell sorting to demonstrate that macrophage NOS2 promotes lung squamous cell carcinoma development by circulating inflammation, enhancing macrophage survival, and impairing lipid metabolism.
Sat Jan 09 00:00:00 EST 2021
PD-L1 expression by tumor cell lines: A predictive marker in melanoma.
Experimental dermatology
Knol AC,Nguyen JM,Pandolfino MC,Denis MG,Khammari A,Dréno B
12-5983-42 was used in Flow cytometry/Cell sorting to determine using an in vitro model, whether immune-related biomarkers, such as MHC-class I and II, melanoma-associated antigens, IDO1 and PD-L1, could also be relevant to predict the risk of relapse of patients with stage III melanoma after lymph node resection.
Fri Jun 01 00:00:00 EDT 2018
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy.
Oncogene
Zhu B,Tang L,Chen S,Yin C,Peng S,Li X,Liu T,Liu W,Han C,Stawski L,Xu ZX,Zhou G,Chen X,Gao X,Goding CR,Xu N,Cui R,Cao P
12-5983-42 was used in Flow cytometry/Cell sorting to identify a critical and targetable PD-L1 upstream regulator and provide an alternative strategy to inhibit the PD-1/PD-L1 signaling in melanoma treatment.
Sat Sep 01 00:00:00 EDT 2018
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy.
Oncogene
Zhu B,Tang L,Chen S,Yin C,Peng S,Li X,Liu T,Liu W,Han C,Stawski L,Xu ZX,Zhou G,Chen X,Gao X,Goding CR,Xu N,Cui R,Cao P
12-5983-42 was used in Flow cytometry/Cell sorting to identify a critical and targetable PD-L1 upstream regulator and provide an alternative strategy to inhibit the PD-1/PD-L1 signaling in melanoma treatment.
Sat Sep 01 00:00:00 EDT 2018
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.
Journal of experimental & clinical cancer research : CR
Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H
12-5983 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.
Mon Oct 29 00:00:00 EDT 2018
Status of programmed death-ligand 1 expression in sarcomas.
Journal of translational medicine
Park HK,Kim M,Sung M,Lee SE,Kim YJ,Choi YL
12-5983 was used in Flow cytometry/Cell sorting to highlight the difference of programmed death-ligand 1 expression in sarcomas depending on histologic subtype and antibody clones.
Tue Nov 06 00:00:00 EST 2018
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.
Proceedings of the National Academy of Sciences of the United States of America
Maute RL,Gordon SR,Mayer AT,McCracken MN,Natarajan A,Ring NG,Kimura R,Tsai JM,Manglik A,Kruse AC,Gambhir SS,Weissman IL,Ring AM
12-5983 was used in Flow cytometry/Cell sorting to determine if PD-1:PD-L1-directed immunotherapy could be improved with smaller, nonantibody therapeutics.
Tue Nov 24 00:00:00 EST 2015
PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.
Cancer immunology research
Rodić N,Anders RA,Eshleman JR,Lin MT,Xu H,Kim JH,Beierl K,Chen S,Luber BS,Wang H,Topalian SL,Pardoll DM,Taube JM
12-5983 was used in Flow cytometry/Cell sorting to phenotypically assess melanocytic lesions for multiple traits to identify possible interactions and correlations.
Sun Feb 01 00:00:00 EST 2015
Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion.
Oncoimmunology
Demoulin SA,Somja J,Duray A,Guénin S,Roncarati P,Delvenne PO,Herfs MF,Hubert PM
12-5983 was used in Flow cytometry/Cell sorting to investigate how the emergence of tolerogenic dendritic cells via RANKL secretion is promoted by cervical (pre)neoplastic microenvironment.
Mon Jun 01 00:00:00 EDT 2015
Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro.
European journal of immunology
Luheshi N,Davies G,Poon E,Wiggins K,McCourt M,Legg J
12-5983 was used in Flow cytometry/Cell sorting to investigate whether T-cell-derived cytokines license anti-tumour functions in CD40-activated human macrophages.
Wed Jan 01 00:00:00 EST 2014
Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment.
Cancer science
Mimura K,Kua LF,Shiraishi K,Kee Siang L,Shabbir A,Komachi M,Suzuki Y,Nakano T,Yong WP,So J,Kono K
12-5983 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which HLA class I and PD-L1 are regulated by MAPK inhibitors and interferon-γ.
Wed Oct 01 00:00:00 EDT 2014
Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients.
PloS one
Waschbisch A,Sanderson N,Krumbholz M,Vlad G,Theil D,Schwab S,Mäurer M,Derfuss T
12-5983 was used in Flow cytometry/Cell sorting to investigate whether the immunoregulatory receptors immunoglobulin-like transcript 3 and 4 mediate the therapeutic effect of interferon beta in multiple sclerosis.
Tue Sep 08 00:00:00 EDT 2015
Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.
PLoS neglected tropical diseases
O'Regan NL,Steinfelder S,Venugopal G,Rao GB,Lucius R,Srikantam A,Hartmann S
12-5983 was used in Flow cytometry/Cell sorting to show that monocytes stimulated with Brugia malayi microfilarial lysate develop a defined regulatory phenotype.
Wed Oct 01 00:00:00 EDT 2014
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
12-5983 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bloch O,Crane CA,Kaur R,Safaee M,Rutkowski MJ,Parsa AT
12-5983 was used in Flow cytometry/Cell sorting to demonstrate that gliomas can upregulate B7-H1 expression in circulating monocytes and tumor-infiltrative macrophages through modulation of autocrine/paracrine IL-10 signaling.
Sat Jun 15 00:00:00 EDT 2013
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
Oncotarget
Wrangle J,Wang W,Koch A,Easwaran H,Mohammad HP,Vendetti F,Vancriekinge W,Demeyer T,Du Z,Parsana P,Rodgers K,Yen RW,Zahnow CA,Taube JM,Brahmer JR,Tykodi SS,Easton K,Carvajal RD,Jones PA,Laird PW,Weisenberger DJ,Tsai S,Juergens RA,Topalian SL,Rudin CM,Brock MV,Pardoll D,Baylin SB
12-5983-42 was used in Flow cytometry/Cell sorting to define a biomarker strategy to examine if epigenetic therapy can sensitize patients with non-small cell lung cancer to PD-1 immune checkpoint blockade.
Fri Nov 01 00:00:00 EDT 2013
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer.
Blood
Ramsay AG,Clear AJ,Fatah R,Gribben JG
12-5983 was used in Flow cytometry/Cell sorting to study a feature of cancer pathology which allows the evasion of normal immune function via impairment at the T-cell immunologic synapse.
Thu Aug 16 00:00:00 EDT 2012
Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Andorsky DJ,Yamada RE,Said J,Pinkus GS,Betting DJ,Timmerman JM
12-5983 was used in Immunohistochemistry to characterise the spectrum of PD-L1 expression in non-Hodgkin lymphomas and evaluate the role of PD-L1 in suppressing tumour-associated T-cell responses.
Fri Jul 01 00:00:00 EDT 2011
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950)
Kim YJ,Park SJ,Broxmeyer HE
12-5983 was used in Flow cytometry/Cell sorting to identify a potential mechanism by which IFN-γ-producing CD8(+) T cells are tolerised after type 1 immune responses to chronic virus or tumour.
Thu Sep 01 00:00:00 EDT 2011
Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Koeleman BP,Nikolic T,Roep BO
12-5983 was used in Flow cytometry/Cell sorting to study the mechanism by which infectious tolerance applies to human dendritic cells.
Thu Dec 15 00:00:00 EST 2011
Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Hsu MC,Hsiao JR,Chang KC,Wu YH,Su IJ,Jin YT,Chang Y
12-5983 was used in Immunofluorescence to propose that PD-1 expression in CD8 cells reflects the selective suppression of cytotoxic lymphocytes in the tumor microenvironment.
Fri Oct 01 00:00:00 EDT 2010
Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Zaldumbide A,Nikolic T,Roep BO
12-5983 was used in Flow cytometry/Cell sorting to study the role of TNF in the induction of human antigen-specific regulatory T-cells by tolerogenic vitamin D3-modulated human dendritic cells.
Sun Aug 01 00:00:00 EDT 2010
Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy.
Arthritis and rheumatism
Kavousanaki M,Makrigiannakis A,Boumpas D,Verginis P
12-5983 was used in Flow cytometry/Cell sorting to explore the contribution of dendritic cells to the development of regulatory T cells in a human autoimmune disease setting.
Fri Jan 01 00:00:00 EST 2010
Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype.
Journal of immunology (Baltimore, Md. : 1950)
van Velzen M,Laman JD,Kleinjan A,Poot A,Osterhaus AD,Verjans GM
12-5983 was used in Flow cytometry/Cell sorting to indicate a role for TG-glial cells as resident APCs with potential T cell modulatory properties.
Sat Aug 15 00:00:00 EDT 2009
TLR-mediated induction of negative regulatory ligands on dendritic cells.
Journal of molecular medicine (Berlin, Germany)
Gröschel S,Piggott KD,Vaglio A,Ma-Krupa W,Singh K,Goronzy JJ,Weyand CM
12-5983 was used in Flow cytometry/Cell sorting to demonstrate that dendritic cell stimulation through the TLR3 ligand dsRNA [poly(I:C)] limits CD4 T-cell proliferation.
Tue Apr 01 00:00:00 EDT 2008
Expression and function of PDCD1 at the human maternal-fetal interface.
Biology of reproduction
Taglauer ES,Trikhacheva AS,Slusser JG,Petroff MG
12-5983 was used in Flow cytometry/Cell sorting to examine whether human maternal T cells express PDCD1.
Mon Sep 01 00:00:00 EDT 2008
Expression of B7-H1 in inflammatory renal tubular epithelial cells.
Nephron. Experimental nephrology
Chen Y,Zhang J,Li J,Zou L,Zhao T,Tang Y,Wu Y
Fri Apr 21 00:00:00 EDT 2006
Expression of B7-H1 in inflammatory renal tubular epithelial cells.
Nephron. Experimental nephrology
Chen Y,Zhang J,Li J,Zou L,Zhao T,Tang Y,Wu Y
Fri Apr 21 00:00:00 EDT 2006
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ohigashi Y,Sho M,Yamada Y,Tsurui Y,Hamada K,Ikeda N,Mizuno T,Yoriki R,Kashizuka H,Yane K,Tsushima F,Otsuki N,Yagita H,Azuma M,Nakajima Y
Fri Apr 15 00:00:00 EDT 2005
