Invitrogen

CD11c Monoclonal Antibody (N418), PE, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

97 Published Figures

274 References

View all (154) CD11c antibodies

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CD11c Antibody (12-0114-82) in Flow

Staining of C57BL/6 splenocytes with Anti-Human/Mouse CD45R (B220) APC (Product # 17-0452-82) and 0.25 µg of Armenian Hamster IgG Isotype Control PE (Product # 12-4888-81) (left) or 0.25 µg of Anti-Mouse CD11c PE (right). Total viable cells were used for analysis.

Product Image Gallery

CD11c Antibody — Figure 6 The effect of HO-1 function upon macrophage differentiation in vitro . Suspension cultures of Hmox-1 +/+ , +/- , and -/- bone marrow-derived stem cells were grown in M-CSF conditioned medium for 6 days. Wild-type cells were grown in the presence or absence of the highly specific HO-1 inhibitor CrMP throughout their maturation. Hmox-1 -/- and wild-type HO-1 inhibited BMDMs were considerably ( a ) more numerous than control wild-type BMDMs. Flow cytometry demonstrated development of a large F4/80- population in ( b, c ) HO-1 inhibited cultures. ( d ) Dot plots indicated that Ly6c and CD11c markers were seen on mutually exclusive populations. Calculation of cell numbers demonstrated that HO-1 inhibition led to expansion of a large pro-inflammatory ( e ) Ly6c+, ( f ) CD11c- population. LPS stimulus of BMDMs in vitro led to increased TNF-alpha production in conditions of ( g ) HO-1 inhibition and ( h ) decreased TNF-alpha secretion when HO-1 was induced. {TM}

Product Details

12-0114-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

0.5 µg/test

View 260 publications 260 publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

N418

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_465552

Product Specific Information

Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.

Applications Reported: The N418 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.

EMBO molecular medicine

Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2023

Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model.

The Journal of biological chemistry

Ohkawa Y,Kanto N,Nakano M,Fujinawa R,Kizuka Y,Johnson EL,Harada Y,Tamura JI,Taniguchi N

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine.

Cell reports. Medicine

Dan J,Cai J,Zhong Y,Wang C,Huang S,Zeng Y,Fan Z,Xu C,Hu L,Zhang J,Hu J,Liu Y,Su X,Zhu W,Yan G,Liang J,Lin Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2023

CD11c⁺ microglia promote white matter repair after ischemic stroke.

Cell death & disease

Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Feb 24 00:00:00 EST 2023

Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.

Cancer nanotechnology

Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Apr 25 00:00:00 EDT 2023

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy.

NPJ vaccines

Teymournejad O,Li Z,Beesetty P,Yang C,Montgomery CP

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Jan 24 00:00:00 EST 2023

LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer.

Journal for immunotherapy of cancer

Zhao T,Liu S,Hanna NH,Jalal S,Ding X,Wan J,Yan C,Du H

12-0114-82 was used in Flow cytometry/Cell sorting to demonstrate that LAL and the associated expansion of MDSCs could serve as targets and biomarkers for anticancer immunotherapy in humans.

Wed Mar 01 00:00:00 EST 2023

ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Jiang Y,Ma C,Hu Y,Yang Y,Ma C,Wu C,Liu L,Wen S,Moynagh PN,Wang B,Yang S

12-0114-82 was used in Flow cytometry/Cell sorting to demonstrate the important role of ECSIT in regulating YAP protein translation to control intestinal homeostasis and tumorigenesis.

Fri Sep 01 00:00:00 EDT 2023

Topical Diacerein Decreases Skin and Splenic CD11c⁺ Dendritic Cells in Psoriasis.

International journal of molecular sciences

Brunner SM,Ramspacher A,Rieser C,Leitner J,Heil H,Ablinger M,Tevini J,Wimmer M,Koller A,Piñón Hofbauer J,Felder TK,Bauer JW,Kofler B,Lang R,Wally V

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Feb 21 00:00:00 EST 2023

Outer Membrane Vesicle-Coated Nanoparticle Vaccine Protects Against Acinetobacter baumannii Pneumonia and Sepsis.

Advanced nanobiomed research

Bjanes E,Zhou J,Qayum T,Krishnan N,Zurich RH,Menon ND,Hoffman A,Fang RH,Zhang L,Nizet V

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.

Cancer immunology research

Ren J,Han X,Lohner H,Hoyle RG,Li J,Liang S,Wang H

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma.

International journal of molecular sciences

Sklepkiewicz P,Dymek B,Mlacki M,Zagozdzon A,Salamon M,Siwińska AM,Mazurkiewicz MP,de Souza Xavier Costa N,Mazur M,Mauad T,Gołębiowski A,Dzwonek K,Gołąb J,Zasłona Z

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Zhao J,Jia L,Tao Y,Zhao X,Yang J,Lu Y,Yan Y,Mao L,Hu L,Lu J,Guo M,Chen C,Zhou Y,Wen Z,He Z,Xu L

12-0114-82 was used in Flow cytometry/Cell sorting to suggest that the clone selection in thymus in Endotoxin tolerance may confer protection against microbial sepsis.

Wed Mar 01 00:00:00 EST 2023

Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.

Cell research

Zhou C,Ma L,Xu H,Huo Y,Luo J

12-0114-82 was used in Flow Cytometry to suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity, and highlight the potential of VEGF-C mRNA for brain tumor therapy.

Wed Jun 01 00:00:00 EDT 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.

Nature immunology

Subramanian S,Busch CJ,Molawi K,Geirsdottir L,Maurizio J,Vargas Aguilar S,Belahbib H,Gimenez G,Yuda RAA,Burkon M,Favret J,Gholamhosseinian Najjar S,de Laval B,Kandalla PK,Sarrazin S,Alexopoulou L,Sieweke MH

12-0114-82 was used in Flow Cytometry to study long-term mouse ex vivo alveolar macrophage gene expression and culture adaptations.

Tue Mar 01 00:00:00 EST 2022

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.

eLife

Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Dec 21 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

PLoS neglected tropical diseases

Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.

Cancers

Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2022

Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.

JCI insight

Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C

12-0114-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.

Thu Sep 08 00:00:00 EDT 2022

Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.

Autophagy

Liu J,Li S,Fei X,Nan X,Shen Y,Xiu H,Cormier SA,Lu C,Guo C,Wang S,Cai Z,Wang P

12-0114-82 was used in Flow cytometry/Cell sorting to demonstrate the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis.

Sun May 01 00:00:00 EDT 2022

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.

Cellular & molecular immunology

Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D

12-0114 was used in Flow cytometry/Cell sorting to reveal that the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.

Tue Jun 01 00:00:00 EDT 2021

Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.

Cell death and differentiation

Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.

Cell death and differentiation

Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade.

PLoS pathogens

Snyder LM,Doherty CM,Mercer HL,Denkers EY

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.

Cellular and molecular gastroenterology and hepatology

Delvecchio FR,Fincham REA,Spear S,Clear A,Roy-Luzarraga M,Balkwill FR,Gribben JG,Bombardieri M,Hodivala-Dilke K,Capasso M,Kocher HM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Mar 28 00:00:00 EDT 2022

T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.

JCI insight

Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Dec 22 00:00:00 EST 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer.

Journal for immunotherapy of cancer

Carbone C,Piro G,Agostini A,Delfino P,De Sanctis F,Nasca V,Spallotta F,Sette C,Martini M,Ugel S,Corbo V,Cappello P,Bria E,Scarpa A,Tortora G

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Sep 01 00:00:00 EDT 2021

Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx.

Life science alliance

Johnson LA,Banerji S,Lagerholm BC,Jackson DG

12-0114 was used in Flow cytometry/Cell sorting to show that hyaluronan is anchored and spatially organized into a 400-500 nm dense glycocalyx by the leukocyte receptor CD44.

Sat May 01 00:00:00 EDT 2021

Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ives A,Le Roy D,Théroude C,Bernhagen J,Roger T,Calandra T

12-0114-82 was used in Flow Cytometry to investigate whether migration inhibitory factor promoted the migration of Dendritic cells.

Sat May 01 00:00:00 EDT 2021

DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.

Cell death & disease

Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S

12-0114 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.

Mon May 17 00:00:00 EDT 2021

Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.

Nature communications

Dunker C,Polke M,Schulze-Richter B,Schubert K,Rudolphi S,Gressler AE,Pawlik T,Prada Salcedo JP,Niemiec MJ,Slesiona-Künzel S,Swidergall M,Martin R,Dandekar T,Jacobsen ID

12-0114-82 was used in Flow Cytometry to challenge the long-standing hypothesis that hyphae are essential for pathogenesis of systemic candidiasis by C. albicans.

Wed Jun 23 00:00:00 EDT 2021

Photothermal therapy combined with neoantigen cancer vaccination for effective immunotherapy against large established tumors and distant metastasis.

Advanced therapeutics

Nam J,Son S,Park KS,Moon JJ

12-0114-82 was used in Flow cytometry/Cell sorting to conclude that PTT combined with neoantigen cancer vaccine is a promising nano-immunotherapy for personalized therapy of advanced cancer.

Sun Aug 01 00:00:00 EDT 2021

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential.

Nature immunology

Derecka M,Herman JS,Cauchy P,Ramamoorthy S,Lupar E,Grün D,Grosschedl R

12-0114-82 was used in Flow Cytometry to investigate how transcriptional changes in bone marrow (BM) mesenchymal stromal cells result in long-lasting effects on hematopoietic stem cells.

Sun Mar 01 00:00:00 EST 2020

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.

EMBO molecular medicine

Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Oct 07 00:00:00 EDT 2020

Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr Mice.

Arteriosclerosis, thrombosis, and vascular biology

Lian Z,Perrard XD,Peng X,Raya JL,Hernandez AA,Johnson CG,Lagor WR,Pownall HJ,Hoogeveen RC,Simon SI,Sacks FM,Ballantyne CM,Wu H

12-0114 was used in Flow cytometry/Cell sorting to describe how adopting a diet enriched in extra-virgin olive oil and nuts (unsaturated fats) lowers plasma cholesterol and triglycerides, inhibits foamy monocyte formation and reduces atherosclerosis in Ldlr-/- mice.

Wed Jan 01 00:00:00 EST 2020

Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.

British journal of pharmacology

De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

12-0114-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.

Sat Feb 01 00:00:00 EST 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

Sat Feb 01 00:00:00 EST 2020

IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis.

Clinical and experimental immunology

Abe M,Rastelli DD,Gomez AC,Cingolani E,Lee Y,Soni PR,Fishbein MC,Lehman TJA,Shimada K,Crother TR,Chen S,Noval Rivas M,Arditi M

12-0114 was used in Immunohistochemistry to show that these ECG changes are recapitulated in the Lactobacillus casei cell wall extract (LCWE)-induced KD vasculitis mouse model.

Sun Mar 01 00:00:00 EST 2020

RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway.

OncoTargets and therapy

Zhou B,Li C,Yang Y,Wang Z

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.

Nature communications

Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon May 04 00:00:00 EDT 2020

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.

eLife

Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Hepatocytes trap and silence coxsackieviruses, protecting against systemic disease in mice.

Communications biology

Kimura T,Flynn CT,Whitton JL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Oct 16 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.

Cell reports

Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P

12-0114 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.

Tue Sep 22 00:00:00 EDT 2020

Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.

Cell & bioscience

Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L

12-0114-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.

Sun Apr 17 00:00:00 EDT 2022

Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.

Cell reports

Sato H,Taketomi Y,Miki Y,Murase R,Yamamoto K,Murakami M

12-0114 was used in Flow cytometry/Cell sorting to present findings underscore the contribution of the macrophage-driven PLA2G2D-ω3 PUFA axis to metabolic health.

Tue May 05 00:00:00 EDT 2020

Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.

Cell reports

Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP

12-0114 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.

Tue Apr 14 00:00:00 EDT 2020

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.

Nature communications

Damal Villivalam S,You D,Kim J,Lim HW,Xiao H,Zushin PH,Oguri Y,Amin P,Kang S

12-0114 was used in Flow cytometry/Cell sorting to investigate the effects of the cold and stimulators of beige adipocyte thermogenesis on subcutaneous adipose expression of TET1.

Thu Aug 27 00:00:00 EDT 2020

Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.

Cell reports

Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T

12-0114 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.

Tue Jun 16 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.

iScience

Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T

12-0114 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.

Fri Jul 24 00:00:00 EDT 2020

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y

12-0114-82 was used in Flow Cytometry to unravel a promising biphotonic strategy for precision treatment of cancer.

Tue Dec 01 00:00:00 EST 2020

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Nature immunology

Bagadia P,Huang X,Liu TT,Durai V,Grajales-Reyes GE,Nitschké M,Modrusan Z,Granja JM,Satpathy AT,Briseño CG,Gargaro M,Iwata A,Kim S,Chang HY,Shaw AS,Murphy TL,Murphy KM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2019

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.

The Journal of experimental medicine

Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S

12-0114-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.

Mon Nov 04 00:00:00 EST 2019

Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis.

Diabetologia

Herrero-Cervera A,Vinué Á,Burks DJ,González-Navarro H

12-0114 was used in Flow cytometry/Cell sorting to explore the role of LIGHT in non-alcoholic fatty liver disease jn type 2 diabetes.

Fri Nov 01 00:00:00 EDT 2019

Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Garcia-Agudo LF,Janova H,Sendler LE,Arinrad S,Steixner AA,Hassouna I,Balmuth E,Ronnenberg A,Schopf N,van der Flier FJ,Begemann M,Martens H,Weber MS,Boretius S,Nave KA,Ehrenreich H

12-0114 was used in Flow cytometry/Cell sorting to conclude that even though microglia depletion is temporarily beneficial and worth pursuing, complementary treatment strategies are needed for full and lasting recovery.

Mon Jul 01 00:00:00 EDT 2019

CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.

Oncology reports

Li Y,Zhao C,Liu J,Lu Z,Lu M,Gu J,Liu R

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.

Cell reports

Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS

12-0114-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.

Tue Sep 17 00:00:00 EDT 2019

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.

Cell reports

Matsumura T,Ikebe T,Arikawa K,Hosokawa M,Aiko M,Iguchi A,Togashi I,Kai S,Ohara S,Ohara N,Ohnishi M,Watanabe H,Kobayashi K,Takeyama H,Yamasaki S,Takahashi Y,Ato M

12-0114-82 was used in Flow Cytometry to show IFN-γ-producing immature myeloid cells can provide protection to mice in invasive group A Streptococcus infection.

Tue Apr 09 00:00:00 EDT 2019

Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses.

Journal of neuroinflammation

Quan MY,Song XJ,Liu HJ,Deng XH,Hou HQ,Chen LP,Ma TZ,Han X,He XX,Jia Z,Guo L

12-0114-82 was used in Flow Cytometry to study the effect of ALX on the maturation of dendritic cells and the responses of effector and regulatory T cells.

Fri Mar 01 00:00:00 EST 2019

Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases.

JCI insight

Li C,Menoret A,Farragher C,Ouyang Z,Bonin C,Holvoet P,Vella AT,Zhou B

12-0114-82 was used in Flow Cytometry to develop a single-cell transcriptome annotation system that can capture adipose tissue macrophages multifaceted activation profiles.

Tue Apr 16 00:00:00 EDT 2019

Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models.

Scientific reports

Kang SA,Park MK,Park SK,Choi JH,Lee DI,Song SM,Yu HS

12-0114-82 was used in Flow cytometry/Cell sorting to compare the effects of M1 and M2 macrophages obtained from Trichinella spiralis-infected mice with those of T. spiralis excretory/secretory (ES) protein-treated macrophages on experimental intestinal inflammation and allergic airway inflammation.

Thu Apr 25 00:00:00 EDT 2019

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.

Journal of clinical medicine

Kurelac I,Abarrategi A,Ragazzi M,Iommarini L,Umesh Ganesh N,Snoeks T,Bonnet D,Porcelli AM,Malanchi I,Gasparre G

12-0114 was used in Flow cytometry/Cell sorting to characterize the tumour microenvironment of mitochondrial complex I deficient tumors in a model that represents osteosarcoma development.

Wed Dec 11 00:00:00 EST 2019

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.

Nature communications

Serradell MC,Rupil LL,Martino RA,Prucca CG,Carranza PG,Saura A,Fernández EA,Gargantini PR,Tenaglia AH,Petiti JP,Tonelli RR,Reinoso-Vizcaino N,Echenique J,Berod L,Piaggio E,Bellier B,Sparwasser T,Klatzmann D,Luján HD

12-0114 was used in Flow cytometry/Cell sorting to study the use of bioengineered virus-like particles with protozoan surface proteins in oral vaccination.

Mon Jan 21 00:00:00 EST 2019

c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.

Cell reports

Shikatani EA,Besla R,Ensan S,Upadhye A,Khyzha N,Li A,Emoto T,Chiu F,Degousee N,Moreau JM,Perry HM,Thayaparan D,Cheng HS,Pacheco S,Smyth D,Noyan H,Zavitz CCJ,Bauer CMT,Hilgendorf I,Libby P,Swirski FK,Gommerman JL,Fish JE,Stampfli MR,Cybulsky MI,Rubin BB,Paige CJ,Bender TP,McNamara CA,Husain M,Robbins CS

12-0114-82 was used in Flow Cytometry to identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice.

Tue May 21 00:00:00 EDT 2019

Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Huang WC,Wu CC,Hsu YT,Chang CL

12-0114-82 was used in Flow Cytometry to compare the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) and conventional IP chemotherapy on bone marrow suppression and evaluated whether HIPEC increased neutrophil recovery.

Fri Apr 10 00:00:00 EDT 2020

Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.

Oncoimmunology

Dajon M,Iribarren K,Petitprez F,Marmier S,Lupo A,Gillard M,Ouakrim H,Victor N,Vincenzo DB,Joubert PE,Kepp O,Kroemer G,Alifano M,Damotte D,Cremer I

12-0114 was used in Flow cytometry/Cell sorting to identify the role of TLR7 in the recruitment of myeloid derived suppressor cells resulting in accelerated tumor growth and metastasis in lung adenocarcinoma.

Tue Jan 12 00:00:00 EST 2021

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell

Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jan 25 00:00:00 EST 2018

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Cell

Böttcher JP,Bonavita E,Chakravarty P,Blees H,Cabeza-Cabrerizo M,Sammicheli S,Rogers NC,Sahai E,Zelenay S,Reis e Sousa C

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Feb 22 00:00:00 EST 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Nature neuroscience

Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.

Mon Oct 01 00:00:00 EDT 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.

Frontiers in immunology

Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L

12-0114-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.

Wed Apr 10 00:00:00 EDT 2019

Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice.

Molecular medicine reports

Wang X,Zhang Y,Wang Z,Liu X,Zhu G,Han G,Chen G,Hou C,Wang T,Shen B,Li Y,Xiao H,Ma N,Wang R

Mon Jan 01 00:00:00 EST 2018

Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.

Oncology letters

Zhang F,Zhu Y,Fan G,Hu S

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2018

FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.

Journal of immunological methods

Geslewitz WE,Percopo CM,Rosenberg HF

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.

International journal of molecular sciences

Lee CR,Lee W,Cho SK,Park SG

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Mar 15 00:00:00 EDT 2018

Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.

Nature communications

Lorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D

12-0114 was used in Flow cytometry/Cell sorting to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo.

Thu Apr 26 00:00:00 EDT 2018

miR-21 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Preventing Epithelial Cell Apoptosis and Inhibiting Dendritic Cell Maturation.

Frontiers in physiology

Song N,Zhang T,Xu X,Lu Z,Yu X,Fang Y,Hu J,Jia P,Teng J,Ding X

12-0114 was used in Flow cytometry/Cell sorting to examine whether miR-21 protects the kidney from ischaemia/reperfusion injury by suppressing epithelial cell damage and inflammatory reaction.

Fri Apr 08 00:00:00 EDT 2022

Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague.

NPJ vaccines

Levy Y,Vagima Y,Tidhar A,Aftalion M,Gur D,Nili U,Chitlaru T,Zauberman A,Mamroud E

Thu Oct 01 00:00:00 EDT 2020

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.

Nature communications

Cambré I,Gaublomme D,Burssens A,Jacques P,Schryvers N,De Muynck A,Meuris L,Lambrecht S,Carter S,de Bleser P,Saeys Y,Van Hoorebeke L,Kollias G,Mack M,Simoens P,Lories R,Callewaert N,Schett G,Elewaut D

12-0114 was used in Flow cytometry/Cell sorting to study the role of mechanical strain in controlling site-specific localisation of inflammation and tissue damage in arthritis.

Mon Nov 05 00:00:00 EST 2018

Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.

Scientific reports

Leroux LP,Nasr M,Valanparambil R,Tam M,Rosa BA,Siciliani E,Hill DE,Zarlenga DS,Jaramillo M,Weinstock JV,Geary TG,Stevenson MM,Urban JF,Mitreva M,Jardim A

12-0114 was used in Flow cytometry/Cell sorting to analyse the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.

Mon Oct 29 00:00:00 EDT 2018

TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis.

Nature communications

Conrad C,Di Domizio J,Mylonas A,Belkhodja C,Demaria O,Navarini AA,Lapointe AK,French LE,Vernez M,Gilliet M

12-0114 was used in Flow cytometry/Cell sorting to study the pathogenesis of paradoxical psoriasis and its distinction from classical psoriasis.

Tue Jan 02 00:00:00 EST 2018

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.

Cell

Ying W,Riopel M,Bandyopadhyay G,Dong Y,Birmingham A,Seo JB,Ofrecio JM,Wollam J,Hernandez-Carretero A,Fu W,Li P,Olefsky JM

12-0114 was used in Flow cytometry/Cell sorting to study the secretion of exosomes containing miRNA cargo by adipose tissue macrophages.

Thu Oct 05 00:00:00 EDT 2017

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

12-0114 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

The Journal of clinical investigation

Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM

12-0114 was used in Flow cytometry/Cell sorting to demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitising therapeutics.

Wed Mar 01 00:00:00 EST 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.

Frontiers in immunology

Pan YG,Yu YL,Lin CC,Lanier LL,Chu CL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.

Frontiers in immunology

Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL

Wed Nov 20 00:00:00 EST 2019

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.

The Journal of cell biology

Sun T,Yang L,Kaur H,Pestel J,Looso M,Nolte H,Krasel C,Heil D,Krishnan RK,Santoni MJ,Borg JP,Bünemann M,Offermanns S,Swiercz JM,Worzfeld T

12-0114 was used in Flow cytometry/Cell sorting to characterize a reverse signaling pathway downstream of Sema4A, which controls cell migration.

Mon Jan 02 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.

Journal of immunology (Baltimore, Md. : 1950)

Braune J,Weyer U,Hobusch C,Mauer J,Brüning JC,Bechmann I,Gericke M

12-0114 was used in Flow cytometry/Cell sorting to study how IL-6 acts as a Th2 cytokine in obesity by stimulating M2 polarisation and local adipose tissue macrophages proliferation.

Sat Apr 01 00:00:00 EDT 2017

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Goverse G,Molenaar R,Macia L,Tan J,Erkelens MN,Konijn T,Knippenberg M,Cook EC,Hanekamp D,Veldhoen M,Hartog A,Roeselers G,Mackay CR,Mebius RE

12-0114 was used in Flow cytometry/Cell sorting to study the effect of dietary fiber and short chain fatty acids on the vitamin A converting enzyme RALDH1 in intestinal epithelial cells.

Wed Mar 01 00:00:00 EST 2017

Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy.

International journal of molecular medicine

Zhu Y,Zhang L,Lu Q,Gao Y,Cai Y,Sui A,Su T,Shen X,Xie B

12-0114 was used in Flow cytometry/Cell sorting to investigate how macrophages may play an active role in oxygen-induced retinopathy by contributing to the different steps of neovascularisation.

Tue Aug 01 00:00:00 EDT 2017

TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression.

International journal of molecular medicine

Hu T,Fan X,Ma L,Liu J,Chang Y,Yang P,Qiu S,Chen T,Yang L,Liu Z

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that the interaction of T-cell immunoglobulin and mucin domain (TIM)4/TIM1 promotes T helper 2-cell proliferation through enhancing silent information regulator 1 expression in mice with nasal allergic rhinitis.

Wed Nov 01 00:00:00 EDT 2017

Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.

Molecular medicine reports

Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.

Experimental and therapeutic medicine

Wang J,Gao ZP,Qin S,Liu CB,Zou LL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Feb 17 00:00:00 EST 2017

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Feb 17 00:00:00 EST 2017

BEX1 is an RNA-dependent mediator of cardiomyopathy.

Nature communications

Accornero F,Schips TG,Petrosino JM,Gu SQ,Kanisicak O,van Berlo JH,Molkentin JD

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity.

Scientific reports

Cheng M,Chen Y,Wang L,Chen W,Yang L,Shen G,Xu T,Shen G,Tian Z,Hu S

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Aug 07 00:00:00 EDT 2017

L-selectin mechanochemistry restricts neutrophil priming in vivo.

Nature communications

Liu Z,Yago T,Zhang N,Panicker SR,Wang Y,Yao L,Mehta-D'souza P,Xia L,Zhu C,McEver RP

12-0114 was used in Flow cytometry/Cell sorting to study the role of L-selectin mechanochemistry in limiting the premature activation of neutrophils.

Fri May 12 00:00:00 EDT 2017

Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.

PLoS neglected tropical diseases

Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG

12-0114 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.

Sun Oct 01 00:00:00 EDT 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

12-0114 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.

Mon Feb 06 00:00:00 EST 2017

MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.

Particle and fibre toxicology

Winkler HC,Kornprobst J,Wick P,von Moos LM,Trantakis I,Schraner EM,Bathke B,Hochrein H,Suter M,Naegeli H

12-0114 was used in Flow cytometry/Cell sorting to unexpectedly show that food-grade SAS particles are able to directly initiate the endosomal MyD88-dependent pathogen pattern recognition and signaling pathway in steady-state DCs.

Fri Jun 23 00:00:00 EDT 2017

CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.

The Journal of biological chemistry

Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC

12-0114 was used in Flow cytometry/Cell sorting to study the function of CD36 in malaria immunity.

Fri Jun 02 00:00:00 EDT 2017

Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells.

Journal of visualized experiments : JoVE

Lyons-Cohen MR,Thomas SY,Cook DN,Nakano H

12-0114 was used in in vivo experiments to contribute to a comprehensive understanding of cellular events that underlie allergic and inflammatory diseases of the lung.

Wed Apr 05 00:00:00 EDT 2017

Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.

Frontiers in microbiology

Lai CY,Strange DP,Wong TAS,Lehrer AT,Verma S

12-0114 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo.

Tue Sep 29 00:00:00 EDT 2020

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

12-0114 was used in Flow cytometry/Cell sorting to identify functionally distinct adaptive GPCR heterogeneity patternation in mice.

Thu Aug 03 00:00:00 EDT 2017

Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.

Scientific reports

Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z

12-0114 was used in Flow cytometry/Cell sorting to investigate whether Dermatophagoides farinae-31 modulates airway epithelial cell functions, and increases the frequency of lung-resident group 2 innate lymphoid cells.

Thu Aug 17 00:00:00 EDT 2017

Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells.

Immunity

Martin CE,Spasova DS,Frimpong-Boateng K,Kim HO,Lee M,Kim KS,Surh CD

12-0114-82 was used in Flow Cytometry to demonstrate that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells.

Tue Jul 18 00:00:00 EDT 2017

Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.

Science advances

Kim E,Beon J,Lee S,Park SJ,Ahn H,Kim MG,Park JE,Kim W,Yuk JM,Kang SJ,Lee SH,Jo EK,Seong RH,Kim S

12-0114 was used in Flow cytometry/Cell sorting to investigate how TRAF6 protein stability is controlled in TLR signalling, showing that Inositol polyphosphate multikinase stabilises TRAF6 and promotes TLR-induced inflammation.

Sat Apr 01 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.

The Journal of clinical investigation

Menheniott TR,O'Connor L,Chionh YT,Däbritz J,Scurr M,Rollo BN,Ng GZ,Jacobs S,Catubig A,Kurklu B,Mercer S,Minamoto T,Ong DE,Ferrero RL,Fox JG,Wang TC,Sutton P,Judd LM,Giraud AS

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

IRF3 promotes adipose inflammation and insulin resistance and represses browning.

The Journal of clinical investigation

Kumari M,Wang X,Lantier L,Lyubetskaya A,Eguchi J,Kang S,Tenen D,Roh HC,Kong X,Kazak L,Ahmad R,Rosen ED

12-0114 was used in Flow cytometry/Cell sorting to investigate whether members of the interferon regulatory factor family play a role in adipocyte inflammation.

Mon Aug 01 00:00:00 EDT 2016

NLRP2 controls age-associated maternal fertility.

The Journal of experimental medicine

Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M

12-0114 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.

Mon Dec 12 00:00:00 EST 2016

Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation.

Experimental & molecular medicine

Woo SJ,Lee SM,Lim HS,Hah YS,Jung ID,Park YM,Kim HO,Cheon YH,Jeon MG,Jang KY,Kim KM,Park BH,Lee SI

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that myeloid cell-specific deletion of SIRT1 may suppress CIA by modulating dendritic cell maturation.

Fri Mar 18 00:00:00 EDT 2016

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.

Frontiers in immunology

Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L

12-0114 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.

Wed Mar 16 00:00:00 EDT 2022

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants.

Stem cells (Dayton, Ohio)

Hoornaert CJ,Luyckx E,Reekmans K,Dhainaut M,Guglielmetti C,Le Blon D,Dooley D,Fransen E,Daans J,Verbeeck L,Quarta A,De Vocht N,Lemmens E,Goossens H,Van der Linden A,Roobrouck VD,Verfaillie C,Hendrix S,Moser M,Berneman ZN,Ponsaerts P

Fri Jul 01 00:00:00 EDT 2016

Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation.

The FEBS journal

Jin X,Liu L,Zhou Z,Ge J,Yao T,Shen C

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that pioglitazone blocks classical activation of macrophages and attenuates inflammation in mouse models of diabetes.

Wed Jun 01 00:00:00 EDT 2016

PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming.

Journal of immunology (Baltimore, Md. : 1950)

Armbruster NS,Richardson JR,Schreiner J,Klenk J,Günter M,Kretschmer D,Pöschel S,Schenke-Layland K,Kalbacher H,Clark K,Autenrieth SE

12-0114 was used in Flow cytometry/Cell sorting to analyse the effects of phenol-soluble modulin peptides on signaling pathway modulation downstream of TLR2.

Mon Feb 01 00:00:00 EST 2016

Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Hilpert C,Sitte S,Matthies A,Voehringer D

12-0114 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.

Sat Oct 01 00:00:00 EDT 2016

Effects of ketanserin on experimental colitis in mice and macrophage function.

International journal of molecular medicine

Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F

12-0114 was used in Flow cytometry/Cell sorting to study the effects of ketanserin on experimental colitis in mice and macrophage function.

Tue Mar 01 00:00:00 EST 2016

Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.

Infection and immunity

Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM

12-0114 was used in Flow cytometry/Cell sorting to investigate T. cruzi infection as a trigger of vasculitis.

Fri Apr 01 00:00:00 EDT 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice.

Experimental and therapeutic medicine

Li JG,DU YM,Yan ZD,Yan J,Zhuansun YX,Chen R,Zhang W,Feng SL,Ran PX

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells.

Scientific reports

Däbritz J,Judd LM,Chalinor HV,Menheniott TR,Giraud AS

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Feb 05 00:00:00 EST 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Thymic exosomes promote the final maturation of thymocytes.

Scientific reports

Lundberg V,Berglund M,Skogberg G,Lindgren S,Lundqvist C,Gudmundsdottir J,Thörn K,Telemo E,Ekwall O

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Nov 08 00:00:00 EST 2016

Epidermal RAF prevents allergic skin disease.

eLife

Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Jul 19 00:00:00 EDT 2016

Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.

Biochimica et biophysica acta

Hersrud SL,Kovács AD,Pearce DA

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.

Scientific reports

Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B

12-0114 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.

Mon Feb 01 00:00:00 EST 2016

Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions.

PLoS neglected tropical diseases

Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

12-0114 was used in Flow cytometry/Cell sorting to study the immunomodulatory effects of excretory-secretory products derived from M. corti tetrathyridia.

Sat Oct 01 00:00:00 EDT 2016

IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells.

Scientific reports

Ding Z,Dahlin JS,Xu H,Heyman B

12-0114 was used in Flow cytometry/Cell sorting to elucidate the dendritic cell population involved in the presentation of IgE-Ag complexes during enhanced specific antibody and CD4+ T cell responses.

Thu Jun 16 00:00:00 EDT 2016

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

JCI insight

Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M

12-0114 was used in Immunofluorescence to show how the inhibition of tertiary lymphoid tissue may constitute a therapeutic approach for treating acute kidney injury in the elderly.

Thu Jul 21 00:00:00 EDT 2016

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.

Nature communications

Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X

12-0114 was used in Flow cytometry/Cell sorting to explore a role of REGγ in the regulation of NFκB and the effect of this on the development of bowel inflammation and associated tumour formation.

Mon Feb 22 00:00:00 EST 2016

Effects of interleukin-1 receptor-associated kinase 1 RNA interference in dendritic cells on inflammatory cytokine release and T-cell proliferation.

Molecular medicine reports

Gao Y,Xu X,Feng J,Ma Y,Zheng D,Meng Y,Shan F

12-0114-82 was used in Flow cytometry/Cell sorting to reduce the expression of interleukin-1 receptor-associated kinase 1 in dendritic cells by RNA interference.

Thu Dec 01 00:00:00 EST 2016

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.

Scientific reports

Chng SH,Kundu P,Dominguez-Brauer C,Teo WL,Kawajiri K,Fujii-Kuriyama Y,Mak TW,Pettersson S

12-0114 was used in Flow cytometry/Cell sorting to explore the contribution of the Aryl hydrocarbon Receptor signalling pathway to the regulation of innate immunity.

Tue Apr 12 00:00:00 EDT 2016

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.

Nature communications

Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

12-0114 was used in Flow cytometry/Cell sorting to show that TFF2 is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.

Thu Feb 04 00:00:00 EST 2016

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.

The Journal of biological chemistry

Miki Y,Kidoguchi Y,Sato M,Taketomi Y,Taya C,Muramatsu K,Gelb MH,Yamamoto K,Murakami M

12-0114 was used in Flow cytometry/Cell sorting to show that psoriasis and contact dermatitis were exacerbated in Pla2g2d-null mice, whereas they were ameliorated in Pla2g2d-overexpressing transgenic mice, relative to littermate wild-type mice.

Fri Jul 22 00:00:00 EDT 2016

Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges.

Bioengineering & translational medicine

Margul DJ,Park J,Boehler RM,Smith DR,Johnson MA,McCreedy DA,He T,Ataliwala A,Kukushliev TV,Liang J,Sohrabi A,Goodman AG,Walthers CM,Shea LD,Seidlits SK

12-0114 was used in Flow cytometry/Cell sorting to study the role of anti-inflammatory factors in modulating the inflammatory response following spinal cord injury.

Wed Jun 01 00:00:00 EDT 2016

Intratracheal myriocin enhances allergen-induced Th2 inflammation and airway hyper-responsiveness.

Immunity, inflammation and disease

Edukulla R,Rehn KL,Liu B,McAlees JW,Hershey GK,Wang YH,Lewkowich I,Lindsley AW

12-0114 was used in Flow cytometry/Cell sorting to evaluate the immune regulatory role of de novo ceramide generation in vitro and in vivo.

Thu Sep 01 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

12-0114 was used in Flow cytometry/Cell sorting to advocate the use of protein oxidation-inducing modalities like irradiation for increasing the immunogenicity of tumour lysate/cells used for pulsing DC vaccines.

Mon Feb 01 00:00:00 EST 2016

Dendritic cell function and pathogen-specific T cell immunity are inhibited in mice administered levonorgestrel prior to intranasal Chlamydia trachomatis infection.

Scientific reports

Quispe Calla NE,Vicetti Miguel RD,Mei A,Fan S,Gilmore JR,Cherpes TL

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that levonorgestrel suppresses dendritic cell activation and function, and inhibits formation of pathogen-specific T-cell immunity.

Mon Nov 28 00:00:00 EST 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

Nature

Kimmey JM,Huynh JP,Weiss LA,Park S,Kambal A,Debnath J,Virgin HW,Stallings CL

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Dec 24 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

The Journal of clinical investigation

Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B

12-0114 was used in Flow cytometry/Cell sorting to investigate the regulatory network of polarised activation of adipose tissue macrophages.

Mon Nov 02 00:00:00 EST 2015

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells.

The Journal of allergy and clinical immunology

Oczypok EA,Milutinovic PS,Alcorn JF,Khare A,Crum LT,Manni ML,Epperly MW,Pawluk AM,Ray A,Oury TD

12-0114 was used in Flow cytometry/Cell sorting to demonstrate how the parenchymal factor RAGE mediates lung-specific accumulation of ILC2s that drive allergic airway inflammation in mice.

Tue Sep 01 00:00:00 EDT 2015

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.

EMBO molecular medicine

Bretscher P,Egger J,Shamshiev A,Trötzmüller M,Köfeler H,Carreira EM,Kopf M,Freigang S

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research

Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

eLife

Freedman TS,Tan YX,Skrzypczynska KM,Manz BN,Sjaastad FV,Goodridge HS,Lowell CA,Weiss A

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Oct 30 00:00:00 EDT 2015

The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.

The Journal of investigative dermatology

Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.

American journal of physiology. Endocrinology and metabolism

Chen Z,Shen H,Sun C,Yin L,Tang F,Zheng P,Liu Y,Brink R,Rui L

12-0114 was used in Flow cytometry/Cell sorting to show that myeloid cell TRAF3 is required for metabolic inflammation and metabolic disease progression in obesity.

Sun Mar 15 00:00:00 EDT 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2015

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.

Human vaccines & immunotherapeutics

Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2016

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

Molecular medicine reports

Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

BioMed research international

Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Mar 18 00:00:00 EDT 2016

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

BioMed research international

Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Mar 18 00:00:00 EDT 2016

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus.

BioMed research international

Nagatomo D,Taniai M,Ariyasu H,Taniguchi M,Aga M,Ariyasu T,Ohta T,Fukuda S

12-0114 was used in Flow cytometry/Cell sorting to show that TNF/CHP nanoparticles effectively enhance both humoral and cellular immunity.

Mon Jul 11 00:00:00 EDT 2016

Perivascular mast cells regulate vein graft neointimal formation and remodeling.

PeerJ

Wu J,Grassia G,Cambrook H,Ialenti A,MacRitchie N,Carberry J,Wadsworth RM,Lawrence C,Kennedy S,Maffia P

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of perivascular mast cells in vascular inflammatory and proliferative responses and subsequent vein graft neointimal formation and remodeling.

Fri Aug 28 00:00:00 EDT 2015

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

The Journal of biological chemistry

Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nature communications

Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Wed Jun 24 00:00:00 EDT 2015

Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.

Scientific reports

Frodermann V,van Duijn J,van Pel M,van Santbrink PJ,Bot I,Kuiper J,de Jager SC

12-0114 was used in Flow cytometry/Cell sorting to study how MSC treatment affects not only inflammatory responses but also significantly reduces dyslipidaemia in mice.

Thu Oct 22 00:00:00 EDT 2015

Alveolar macrophage phenotype expression in airway-instilled bone marrow cells in mice.

SpringerPlus

Okui M,Goto T,Asakura K,Kamiyama I,Ohtsuka T

12-0114 was used in Flow cytometry/Cell sorting to study how intratracheally instilled bone marrow cells adapt to the surrounding microenvironment, directly differentiating into alveolar macrophages, and remain in the alveolar space for at least 3 months.

Mon Dec 21 00:00:00 EST 2015

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.

Nature communications

Kim AY,Park YJ,Pan X,Shin KC,Kwak SH,Bassas AF,Sallam RM,Park KS,Alfadda AA,Xu A,Kim JB

12-0114 was used in Flow cytometry/Cell sorting to highlight a critical role of adiponectin gene epigenetic control by DNMT1 in governing energy homeostasis.

Fri Jul 03 00:00:00 EDT 2015

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.

Oncoimmunology

Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that sunitinib can create a favourable microenvironment depleted of MDSCs, and act synergistically with a cancer vaccine, resulting in enhanced levels of active tumor-antigen specific CTLs.

Sun Mar 01 00:00:00 EST 2015

Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes.

Parasites & vectors

Lieskovská J,Páleníková J,Langhansová H,Campos Chagas A,Calvo E,Kotsyfakis M,Kopecký J

12-0114 was used in Flow cytometry/Cell sorting to investigate the impact of cystatins on Borrelia growth in vivo.

Fri May 15 00:00:00 EDT 2015

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Nature communications

Chan MP,Onji M,Fukui R,Kawane K,Shibata T,Saitoh S,Ohto U,Shimizu T,Barber GN,Miyake K

12-0114 was used in Flow cytometry/Cell sorting to study the response to two types of TLR9 ligands in the dendritic cells of DNase II-deficient mice.

Tue Jan 20 00:00:00 EST 2015

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.

Nature medicine

Clatworthy MR,Aronin CE,Mathews RJ,Morgan NY,Smith KG,Germain RN

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.

Nature

Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Oct 23 00:00:00 EDT 2014

α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.

Blood

Marcondes AM,Karoopongse E,Lesnikova M,Margineantu D,Welte T,Dinarello CA,Hockenbery D,Janciauskiene S,Deeg HJ

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of α-1-antitrypsin in graft-versus-host disease, showing that α-1-Antitrypsin-modified donor cells suppress graft-versus-host disease but enhance the graft-versus-leukemia effect.

Thu Oct 30 00:00:00 EDT 2014

Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance.

Diabetes

Liu PS,Lin YW,Lee B,McCrady-Spitzer SK,Levine JA,Wei LN

12-0114 was used in Flow cytometry/Cell sorting to investigate the mechanisms that regulate the dynamics of adipose tissue macrophages and contribute to adipose tissue remodelling.

Mon Dec 01 00:00:00 EST 2014

Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.

Journal of virology

Fensterl V,Wetzel JL,Sen GC

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of Ifit2 in vesicular stomatitis virus infection.

Mon Sep 01 00:00:00 EDT 2014

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.

Immunology and cell biology

Le Blon D,Hoornaert C,Daans J,Santermans E,Hens N,Goossens H,Berneman Z,Ponsaerts P

12-0114 was used in Flow cytometry/Cell sorting to characterise the distribution of microglia and macrophages in the mouse brain following mesenchymal stem cell implantation, showing that resident immune cells surround the graft site while peripheral immune cells invade the graft.

Mon Sep 01 00:00:00 EDT 2014

A TNF-α-CCL20-CCR6 axis regulates Nod1-induced B cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Paradis M,Mindt BC,Duerr CU,Rojas OL,Ng D,Boulianne B,McCarthy DD,Yu MD,Summers deLuca LE,Ward LA,Waldron JB,Philpott DJ,Gommerman JL,Fritz JH

12-0114 was used in Flow cytometry/Cell sorting to reveal a novel mechanism of B cells during inflammation and shed light on how B cells participate in innate immune responses to microbial stimulation.

Sat Mar 15 00:00:00 EDT 2014

Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.

Carcinogenesis

Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB

12-0114 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.

Tue Apr 01 00:00:00 EDT 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Astragalus mongholicus regulate the Toll-like-receptor 4 meditated signal transduction of dendritic cells to restrain stomach cancer cells.

African journal of traditional, complementary, and alternative medicines : AJTCAM

Tian Y,Li X,Li H,Lu Q,Sun G,Chen H

12-0114 was used in Flow cytometry/Cell sorting to discuss the effect and mechanism of Astragalus mongholicus (AMs) to human stomach cancer.

Tue Jul 07 00:00:00 EDT 2015

The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.

PloS one

Johnston-Cox H,Eisenstein AS,Koupenova M,Carroll S,Ravid K

12-0114 was used in Flow cytometry/Cell sorting to determine a mechanism for high fat diet-induced tissue inflammation and insulin resistance.

Mon Jan 12 00:00:00 EST 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of P2X7 in a murine model of silicosis, showing that P2X7 KO mice had reduced lung pathology compared to WT mice, and that P2X7 participates in silica phagocytosis, IL-1β secretion, ROS and NO production.

Thu Sep 17 00:00:00 EDT 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Thu Sep 17 00:00:00 EDT 2015

Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.

Scientific reports

Ahlawat S,Xie F,Zhu Y,D'Hondt R,Ding X,Zhang QY,Mantis NJ

12-0114 was used in Immunofluorescence to investigate the role of P450 enzymes in intestinal inflammation and immunity.

Thu Jul 03 00:00:00 EDT 2014

Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.

The Journal of experimental medicine

Miki Y,Yamamoto K,Taketomi Y,Sato H,Shimo K,Kobayashi T,Ishikawa Y,Ishii T,Nakanishi H,Ikeda K,Taguchi R,Kabashima K,Arita M,Arai H,Lambeau G,Bollinger JM,Hara S,Gelb MH,Murakami M

12-0114 was used in Immunohistochemistry to highlight PLA2G2D as a "resolving sPLA2" that ameliorates inflammation through mobilizing pro-resolving lipid mediators.

Mon Jun 03 00:00:00 EDT 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.

Mucosal immunology

Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses.

Mucosal immunology

Mosconi I,Geuking MB,Zaiss MM,Massacand JC,Aschwanden C,Kwong Chung CK,McCoy KD,Harris NL

12-0114 was used in Flow cytometry/Cell sorting to show that steady-state thymic stromal lymphopoietin expression requires intestinal bacteria and has an important role in limiting the expansion T helper cells in the colon.

Fri Nov 01 00:00:00 EDT 2013

A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression.

Mucosal immunology

Settem RP,Honma K,Nakajima T,Phansopa C,Roy S,Stafford GP,Sharma A

12-0114 was used in Flow cytometry/Cell sorting to show how the glycan core of Tannerella forsythia acts to modulate the immune response in mice via dendritic cell effector functions.

Fri Mar 01 00:00:00 EST 2013

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.

PLoS pathogens

Wagner FM,Brizic I,Prager A,Trsan T,Arapovic M,Lemmermann NA,Podlech J,Reddehase MJ,Lemnitzer F,Bosse JB,Gimpfl M,Marcinowski L,MacDonald M,Adler H,Koszinowski UH,Adler B

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that MCK-2 has a dual role in cytomegalovirus infection, as a regulator of immune response and also in promoting viral entry into cells.

Tue Feb 18 00:00:00 EST 2014

IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

Journal of immunology (Baltimore, Md. : 1950)

Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST

12-0114 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.

Sun Sep 01 00:00:00 EDT 2013

Sox4 is required for the survival of pro-B cells.

Journal of immunology (Baltimore, Md. : 1950)

Sun B,Mallampati S,Gong Y,Wang D,Lefebvre V,Sun X

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of Sox4 in development of mature B cells, showing that it is required for pro-B cell survival.

Fri Mar 01 00:00:00 EST 2013

Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.

Journal of immunology (Baltimore, Md. : 1950)

Zhang F,Wei W,Chai H,Xie X

12-0114 was used in Flow cytometry/Cell sorting to investigate the effect of aurintricarboxylic acid (ATA) on experimental autoimmune encephalomyelitis (EAE), showing that ATA ameliorates EAE by blocking chemokine-mediated pathogenic cell migration and infiltration.

Fri Feb 01 00:00:00 EST 2013

Aeroallergen challenge promotes dendritic cell proliferation in the airways.

Journal of immunology (Baltimore, Md. : 1950)

Veres TZ,Voedisch S,Spies E,Valtonen J,Prenzler F,Braun A

12-0114 was used in Flow cytometry/Cell sorting to study dendritic cell proliferation in the airways of mice in the steady state and after local aeroallergen provocation.

Fri Feb 01 00:00:00 EST 2013

Uterine natural killer cells severely decrease in number at gestation day 6 in mice.

Biology of reproduction

Takashima A,Ishikawa F,Kuwabara T,Tanaka Y,Kinoshita T,Ito M,Kakiuchi T

12-0114 was used in Flow cytometry/Cell sorting to study how uterine NK cells or their precursors migrate into the uterus, mature, and produce interferon-gamma to support pregnancy in mice.

Tue Oct 01 00:00:00 EDT 2013

CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.

Shock (Augusta, Ga.)

Bosmann M,Grailer JJ,Russkamp NF,Ruemmler R,Zetoune FS,Sarma JV,Ward PA

12-0114 was used in Flow cytometry/Cell sorting to investigate the production and downstream effects of IL-23 using a mouse model of lipopolysaccharide-induced acute lung injury.

Wed May 01 00:00:00 EDT 2013

Migration of CD11b+ accessory cells during murine lung regeneration.

Stem cell research

Chamoto K,Gibney BC,Lee GS,Ackermann M,Konerding MA,Tsuda A,Mentzer SJ

12-0114 was used in Flow cytometry/Cell sorting to characterise the factors contributing to neoalveolarization within 21 days of pneumonectomy.

Wed May 01 00:00:00 EDT 2013

DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.

BMC immunology

Cao J,Jin Y,Li W,Zhang B,He Y,Liu H,Xia N,Wei H,Yan J

12-0114 was used in Flow cytometry/Cell sorting to investigate anti-tumoural efficacy and underlying mechanisms of DC-targeting DNA vaccines in mouse breast cancer models, showing that it induces potent anti-tumour immunity in mice.

Wed Aug 14 00:00:00 EDT 2013

Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.

PloS one

Medeiros MM,da Silva HB,Reis AS,Barboza R,Thompson J,Lima MR,Marinho CR,Tadokoro CE

12-0114 was used in Flow cytometry/Cell sorting to determine that malaria parasite accumulation could be an escape mechanism to avoid sterile immunity sponsored by a tolerogenic environment.

Wed Dec 17 00:00:00 EST 2014

Vaginal immunization to elicit primary T-cell activation and dissemination.

PloS one

Pettini E,Prota G,Ciabattini A,Boianelli A,Fiorino F,Pozzi G,Vicino A,Medaglini D

12-0114 was used in Flow cytometry/Cell sorting to show that vaginal immunization is very efficient in priming antigen-specific CD4+ T-cells and inducing their dissemination.

Thu Sep 25 00:00:00 EDT 2014

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.

Journal of hematology & oncology

Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW

12-0114 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.

Tue Oct 01 00:00:00 EDT 2013

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.

PloS one

Chen ZG,Zhang TT,Li HT,Chen FH,Zou XL,Ji JZ,Chen H

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Aug 20 00:00:00 EDT 2013

IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.

Blood

Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y

12-0114-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.

Thu Jun 07 00:00:00 EDT 2012

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.

The Journal of clinical investigation

Charles JF,Hsu LY,Niemi EC,Weiss A,Aliprantis AO,Nakamura MC

12-0114 was used in Flow cytometry/Cell sorting to identify a CD11b(-/lo)Ly6C(hi) bone marrow population with osteoclast precursor activity.

Sat Dec 01 00:00:00 EST 2012

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.

The Journal of experimental medicine

Cherrier M,Sawa S,Eberl G

12-0114 was used in Flow cytometry/Cell sorting to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.

Mon Apr 09 00:00:00 EDT 2012

Activation of NF-κB in CD8+ dendritic cells Ex Vivo by the γ134.5 null mutant correlates with immunity against herpes simplex virus 1.

Journal of virology

Jin H,Ma Y,Yan Z,Prabhakar BS,He B

12-0114 was used in Flow cytometry/Cell sorting to elucidate the mechanism by which the γ(1)34.5 null mutant triggers protective immunity.

Sun Jan 01 00:00:00 EST 2012

Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bosmann M,Sarma JV,Atefi G,Zetoune FS,Ward PA

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that C5a alters the production of cytokines to regulate inflammatory functions.

Sun Apr 01 00:00:00 EDT 2012

Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties.

Journal of immunology (Baltimore, Md. : 1950)

Kerzerho J,Yu ED,Barra CM,Alari-Pahissa E,Girardi E,Harrak Y,Lauzurica P,Llebaria A,Zajonc DM,Akbari O,Castaño AR

12-0114 was used in Flow cytometry/Cell sorting to assess the potential for the use of HS44 as a reagent for immune manipulation.

Thu Mar 01 00:00:00 EST 2012

Mouse β-defensin 14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner.

Journal of immunology (Baltimore, Md. : 1950)

Röhrl J,Huber B,Koehl GE,Geissler EK,Hehlgans T

12-0114 was used in Flow cytometry/Cell sorting to analyse the expression of mBD14 in cultured mice fibrosarcoma tumour cells and its effect on tumour growth.

Tue May 15 00:00:00 EDT 2012

Activated T cell exosomes promote tumor invasion via Fas signaling pathway.

Journal of immunology (Baltimore, Md. : 1950)

Cai Z,Yang F,Yu L,Yu Z,Jiang L,Wang Q,Yang Y,Wang L,Cao X,Wang J

12-0114 was used in Flow cytometry/Cell sorting to investigate the effect of FasL-containing exosomes on cell apoptosis in tumours, showing that they promote tumour invasion.

Fri Jun 15 00:00:00 EDT 2012

B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.

Journal of immunology (Baltimore, Md. : 1950)

Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B

12-0114 was used in Flow cytometry/Cell sorting to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.

Wed Aug 01 00:00:00 EDT 2012

Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury.

International journal of molecular medicine

Liu J,Zhang PS,Yu Q,Liu L,Yang Y,Guo FM,Qiu HB

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that losartan suppresses conventional dendritic cell maturation and Th1 and Th17 polarization responses.

Wed Feb 01 00:00:00 EST 2012

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro.

Immunology letters

Ghimire TR,Benson RA,Garside P,Brewer JM

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2012

Differential gene expression in mice infected with distinct Toxoplasma strains.

Infection and immunity

Hill RD,Gouffon JS,Saxton AM,Su C

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.

PloS one

Abdalla H,Srinivasan L,Shah S,Mayer-Barber KD,Sher A,Sutterwala FS,Briken V

12-0114 was used in Flow cytometry/Cell sorting to characterise the response of the dendritic cell inflammasome during Mtb infections.

Fri Apr 19 00:00:00 EDT 2013

Murine corneal stroma cells inhibit LPS-induced dendritic cell maturation partially through TGF-β2 secretion in vitro.

Molecular vision

Lu JM,Song XJ,Wang HF,Li XL,Zhang XR

12-0114 was used in Flow cytometry/Cell sorting to investigate the factors that inhibit the maturation of DCs in the central cornea.

Fri Dec 21 00:00:00 EST 2012

Langerhans cells are negative regulators of the anti-Leishmania response.

The Journal of experimental medicine

Kautz-Neu K,Noordegraaf M,Dinges S,Bennett CL,John D,Clausen BE,von Stebut E

12-0114 was used in Flow cytometry/Cell sorting to analyse the role of Langerin(+) skin-derived DCs in the Leishmania model, showing that Langerhans cells are negative regulators of the anti-Leishmania response.

Mon May 09 00:00:00 EDT 2011

STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.

PLoS pathogens

Perry ST,Buck MD,Lada SM,Schindler C,Shresta S

12-0114 was used in Flow cytometry/Cell sorting to determine the molecular basis of the STAT1-independent pathway that confers resistance to Dengue virus-induced disease in STAT1-deficient mice.

Tue Feb 01 00:00:00 EST 2011

Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A.

Journal of immunology (Baltimore, Md. : 1950)

Molenaar R,Knippenberg M,Goverse G,Olivier BJ,de Vos AF,O'Toole T,Mebius RE

12-0114 was used in Flow cytometry/Cell sorting to show that during postnatal development, dietary vitamin A is essential for the induction of retinaldehyde dehydrogenases in mucosal DCs and MLN stromal cells.

Tue Feb 15 00:00:00 EST 2011

Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Tong J,Wu WN,Kong X,Wu PF,Tian L,Du W,Fang M,Zheng F,Chen JG,Tan Z,Gong F

12-0114 was used in Immunocytochemistry to investigate the expression and role of acid-sensing ion channels in mouse bone marrow-derived dendritic cells.

Tue Mar 15 00:00:00 EDT 2011

Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.

The Journal of surgical research

Schneider DF,Palmer JL,Tulley JM,Kovacs EJ,Gamelli RL,Faunce DE

12-0114 was used in Flow cytometry/Cell sorting to explore the effects of purposefully inhibiting natural killer T cell activation on the response to injury.

Tue Nov 01 00:00:00 EDT 2011

PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

PloS one

Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2011

Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.

PloS one

Ciabattini A,Pettini E,Fiorino F,Prota G,Pozzi G,Medaglini D

12-0114 was used in Flow cytometry/Cell sorting to elucidate the trafficking of antigen-specific primed T cells to non-draining peripheral and mucosa-associated lymph nodes following nasal immunisation.

Fri Apr 29 00:00:00 EDT 2011

Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.

PloS one

Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML

12-0114 was used in Flow cytometry/Cell sorting to investigate how C. albicans invasive infection with a low virulence strain results in a rapid expansion of HSPCs.

Tue Feb 28 00:00:00 EST 2012

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.

PloS one

Hasenberg M,Köhler A,Bonifatius S,Borucki K,Riek-Burchardt M,Achilles J,Männ L,Baumgart K,Schraven B,Gunzer M

12-0114 was used in Flow cytometry/Cell sorting to develop a novel protocol for isolating pure polymorphonuclear neutrophils from murine bone marrow.

Wed Feb 23 00:00:00 EST 2011

Unraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biology.

PloS one

Lindqvist M,Nookaew I,Brinkenberg I,Samuelson E,Thörn K,Nielsen J,Harandi AM

12-0114 was used in Flow cytometry/Cell sorting to identify molecular signatures that can be used as biomarkers for mucosal adjuvant potency.

Fri Dec 09 00:00:00 EST 2011

Japanese encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells.

Virology journal

Cao S,Li Y,Ye J,Yang X,Chen L,Liu X,Chen H

12-0114 was used in Flow cytometry/Cell sorting to show that JEV severely infects and alters the phenotype of murine DCs to increase Tregs, and indicate a possible cause of immunosuppression in JIE.

Wed Jan 26 00:00:00 EST 2011

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.

PloS one

Yang C,Kim SH,Bianco NR,Robbins PD

12-0114 was used in Flow cytometry/Cell sorting to study the role of tumour-derived exosomes in inducing tumour antigen-specific immunosuppression.

Tue Dec 27 00:00:00 EST 2011

Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

Immunity

Ohnmacht C,Schwartz C,Panzer M,Schiedewitz I,Naumann R,Voehringer D

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation.

Fri Sep 24 00:00:00 EDT 2010

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.

Blood

Huber S,Hoffmann R,Muskens F,Voehringer D

12-0114 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.

Thu Oct 28 00:00:00 EDT 2010

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.

The Journal of experimental medicine

Thompson ED,Enriquez HL,Fu YX,Engelhard VH

12-0114 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.

Mon Aug 02 00:00:00 EDT 2010

MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus.

Proceedings of the National Academy of Sciences of the United States of America

Xie X,Stadnisky MD,Coats ER,Ahmed Rahim MM,Lundgren A,Xu W,Makrigiannis AP,Brown MG

12-0114 was used in Flow cytometry/Cell sorting to reveal a role for NK cell interaction with D(k)-bearing haematopoietic and nonhaematopoietic cells to shape NK-mediated virus immunity.

Tue May 11 00:00:00 EDT 2010

Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity.

The Journal of investigative dermatology

Noordegraaf M,Flacher V,Stoitzner P,Clausen BE

12-0114 was used in Flow cytometry/Cell sorting to investigate the role of langerhan cells and langerin+ dermal dendritic cells in regulating contact hypersensivity responses.

Wed Dec 01 00:00:00 EST 2010

Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.

PLoS pathogens

Charmoy M,Brunner-Agten S,Aebischer D,Auderset F,Launois P,Milon G,Proudfoot AE,Tacchini-Cottier F

12-0114 was used in Flow cytometry/Cell sorting to determine that the selective release of neutrophil-secreted chemokines may regulate the development of immune responses to pathogens.

Fri Feb 05 00:00:00 EST 2010

Moderate oxygen augments lipopolysaccharide-induced lung injury in mice.

American journal of physiology. Lung cellular and molecular physiology

Aggarwal NR,D'Alessio FR,Tsushima K,Files DC,Damarla M,Sidhaye VK,Fraig MM,Polotsky VY,King LS

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2010

Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.

Journal of immunology (Baltimore, Md. : 1950)

Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S

12-0114 was used in Flow cytometry/Cell sorting to assess the role of MCP-1 in immunity to acute pneumonia caused by gram-negative bacteria.

Mon Feb 01 00:00:00 EST 2010

Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Vallerskog T,Martens GW,Kornfeld H

12-0114 was used in Flow cytometry/Cell sorting to conclude that TB increased susceptibility in DM results from a delayed innate immune response to the presence of M. tuberculosis-infected alveolar macrophages.

Tue Jun 01 00:00:00 EDT 2010

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Jain P,Coisne C,Enzmann G,Rottapel R,Engelhardt B

12-0114 was used in Flow cytometry/Cell sorting to provide evidence that circulating DCs can migrate across the inflamed BBB during EAE.

Tue Jun 15 00:00:00 EDT 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.

Molecular therapy : the journal of the American Society of Gene Therapy

Devey L,Ferenbach D,Mohr E,Sangster K,Bellamy CO,Hughes J,Wigmore SJ

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.

PLoS pathogens

Tewalt EF,Grant JM,Granger EL,Palmer DC,Heuss ND,Gregerson DS,Restifo NP,Norbury CC

12-0114 was used in Flow cytometry/Cell sorting to describe an evasion mechanism employed by pathogens to prevent entry into the cross-presentation pathway.

Fri May 01 00:00:00 EDT 2009

The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.

European journal of immunology

Aoshi T,Carrero JA,Konjufca V,Koide Y,Unanue ER,Miller MJ

12-0114 was used in Immunohistochemistry to illustrate the changeable nature of the cellular niche of Listeria monocytogenes.

Sun Feb 01 00:00:00 EST 2009

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.

European journal of immunology

Glanville SH,Bekiaris V,Jenkinson EJ,Lane PJ,Anderson G,Withers DR

12-0114 was used in Flow cytometry/Cell sorting to analyse the cellular and molecular requirements for the development and organisation of splenic microenvironments.

Thu Jan 01 00:00:00 EST 2009

Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity.

Cancer science

Song X,Ye D,Liu B,Cui J,Zhao X,Yi L,Liang J,Song J,Zhang Z,Zhao Q

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Sun Feb 01 00:00:00 EST 2009

Lymph node stromal cells support dendritic cell-induced gut-homing of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Molenaar R,Greuter M,van der Marel AP,Roozendaal R,Martin SF,Edele F,Huehn J,Förster R,O'Toole T,Jansen W,Eestermans IL,Kraal G,Mebius RE

12-0114 was used in Flow cytometry/Cell sorting to demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells,.

Sun Nov 15 00:00:00 EST 2009

4-1BB functions as a survival factor in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS

12-0114 was used in Immunofluorescence on frozen tissues to investigate the function of CD137 on dendritic cells, showing that it functions as a survival factor.

Wed Apr 01 00:00:00 EDT 2009

Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution.

The Journal of endocrinology

Gruver AL,Ventevogel MS,Sempowski GD

12-0114-82 was used in Immunohistochemistry to support an intrathymic role for the metabolic hormone leptin in maintaining healthy thymic epithelium and promoting thymopoiesis, which is revealed when thymus homeostasis is perturbed by endotoxemia.

Thu Oct 01 00:00:00 EDT 2009

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

Cellular immunology

Drage MG,Pecora ND,Hise AG,Febbraio M,Silverstein RL,Golenbock DT,Boom WH,Harding CV

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jun 12 00:00:00 EDT 2009

Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.

Cellular immunology

Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Jan 02 00:00:00 EST 2009

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.

Immunity

Tsuji M,Suzuki K,Kitamura H,Maruya M,Kinoshita K,Ivanov II,Itoh K,Littman DR,Fagarasan S

12-0114 was used in Flow cytometry/Cell sorting to investigate the sites and mechanisms for T cell-independent IgA synthesis.

Fri Aug 15 00:00:00 EDT 2008

Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development.

Proceedings of the National Academy of Sciences of the United States of America

Spence PJ,Green EA

12-0114 was used in Flow cytometry/Cell sorting to investigate Foxp3+ Treg development, showing that CD154 is critical during thymic development of Foxp3+ Tregs.

Tue Jan 22 00:00:00 EST 2008

Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.

The Journal of biological chemistry

Röhrl J,Yang D,Oppenheim JJ,Hehlgans T

12-0114 was used in Flow cytometry/Cell sorting to identify and describe a novel beta-defensin, mouse beta-defensin 14.

Fri Feb 29 00:00:00 EST 2008

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

Haematopoietic development and immunological function in the absence of cathepsin D.

BMC immunology

Tulone C,Uchiyama Y,Novelli M,Grosvenor N,Saftig P,Chain BM

12-0114 was used in Flow cytometry/Cell sorting to examine the reconstitution and function of the immune system in the absence of cathepsin D.

Wed Sep 26 00:00:00 EDT 2007

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo.

The Journal of experimental medicine

Ohteki T,Tada H,Ishida K,Sato T,Maki C,Yamada T,Hamuro J,Koyasu S

Mon Oct 02 00:00:00 EDT 2006

Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.

Journal of virology

Xin KQ,Mizukami H,Urabe M,Toda Y,Shinoda K,Yoshida A,Oomura K,Kojima Y,Ichino M,Klinman D,Ozawa K,Okuda K

Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2006

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.

International immunology

Zhang J,Kawashima N,Suda H,Nakano Y,Takano Y,Azuma M

Fri Sep 01 00:00:00 EDT 2006

Type I interferons protect mice against enterovirus 71 infection.

The Journal of general virology

Liu ML,Lee YP,Wang YF,Lei HY,Liu CC,Wang SM,Su IJ,Wang JR,Yeh TM,Chen SH,Yu CK

12-0114 was used in Flow cytometry/Cell sorting to investigate the contribution of type I interferons to protection against infection with enterovirus 71, showing that they are protective.

Thu Dec 01 00:00:00 EST 2005

Bioinformatics

Protein Aliases: CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Integrin alpha-X; integrin aX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95

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Gene Aliases: AI449405; Cd11c; Cr4; Itgax; N418

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UniProt ID: (Mouse) Q9QXH4

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Entrez Gene ID: (Mouse) 16411

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Function(s)

metal ion binding integrin

Process(es)

cell adhesion integrin-mediated signaling pathway heterotypic cell-cell adhesion activated T cell proliferation defense response to virus positive regulation of protein targeting to mitochondrion

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CD11c Monoclonal Antibody (N418), PE, eBioscience™

CD11c Antibody (12-0114-82) in Flow

Product Details

12-0114-82

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

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