Product References
Sex-specific differences in T-cell immune dysregulation and aberrant response to inflammatory stimuli in offspring exposed to maternal chronic inflammation.
American journal of reproductive immunology (New York, N.Y. : 1989)
Liu J,Liu Y,Kirschen G,Liu A,Lei J,Burd I
11-5773-82 was used in Flow cytometry/Cell sorting to investigate how MI affects the T-cell immune development from the fetal to the neonatal period and how offspring responded to postnatal IL-1β challenge when exposed to an adverse intrauterine environment.
Wed Mar 01 00:00:00 EST 2023
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.
Cell
Rosain J,Neehus AL,Manry J,Yang R,Le Pen J,Daher W,Liu Z,Chan YH,Tahuil N,Türel Ö,Bourgey M,Ogishi M,Doisne JM,Izquierdo HM,Shirasaki T,Le Voyer T,Guérin A,Bastard P,Moncada-Vélez M,Han JE,Khan T,Rapaport F,Hong SH,Cheung A,Haake K,Mindt BC,Pérez L,Philippot Q,Lee D,Zhang P,Rinchai D,Al Ali F,Ahmad Ata MM,Rahman M,Peel JN,Heissel S,Molina H,Kendir-Demirkol Y,Bailey R,Zhao S,Bohlen J,Mancini M,Seeleuthner Y,Roelens M,Lorenzo L,Soudée C,Paz MEJ,González ML,Jeljeli M,Soulier J,Romana S,L'Honneur AS,Materna M,Martínez-Barricarte R,Pochon M,Oleaga-Quintas C,Michev A,Migaud M,Lévy R,Alyanakian MA,Rozenberg F,Croft CA,Vogt G,Emile JF,Kremer L,Ma CS,Fritz JH,Lemon SM,Spaan AN,Manel N,Abel L,MacDonald MR,Boisson-Dupuis S,Marr N,Tangye SG,Di Santo JP,Zhang Q,Zhang SY,Rice CM,Béziat V,Lachmann N,Langlais D,Casanova JL,Gros P,Bustamante J
11-5773-82 was used in Flow Cytometry to show that human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity.
Thu Feb 02 00:00:00 EST 2023
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males.
Nature communications
Abou-El-Hassan H,Rezende RM,Izzy S,Gabriely G,Yahya T,Tatematsu BK,Habashy KJ,Lopes JR,de Oliveira GLV,Maghzi AH,Yin Z,Cox LM,Krishnan R,Butovsky O,Weiner HL
11-5773-82 was used in Flow cytometry/Cell sorting to provide new insights on the role of different γδ T cell subsets after brain injury and lay down the principles for the development of targeted γδ T-cell-based therapy for TBI.
Tue Jul 18 00:00:00 EDT 2023
Identification of astrocyte regulators by nucleic acid cytometry.
Nature
Clark IC,Wheeler MA,Lee HG,Li Z,Sanmarco LM,Thaploo S,Polonio CM,Shin SW,Scalisi G,Henry AR,Rone JM,Giovannoni F,Charabati M,Akl CF,Aleman DM,Zandee SEJ,Prat A,Douek DC,Boritz EA,Quintana FJ,Abate AR
11-5773-82 was used in Flow cytometry/Cell sorting to develop focused interrogation of cells by nucleic acid detection and sequencing (FIND-seq), a high-throughput microfluidic cytometry method that combines encapsulation of cells in droplets, PCR-based detection of target nucleic acids and droplet sorting to enable in-depth transcriptomic analyses of cells of interest at single-cell resolution.
Wed Feb 01 00:00:00 EST 2023
Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice.
JCI insight
Mittermüller D,Otto L,Long Z,Kraus A,Beer A,Hasenberg A,Zelinskyy G,Westmeier J,Hasenkrug KJ,Dittmer U,Gunzer M
11-5773-82 was used in Flow cytometry/Cell sorting to identify an effect of Tregs on cytotoxic T lymphocytes motility as part of their mechanism of functional impairment in chronic viral infections.
Mon Jul 10 00:00:00 EDT 2023
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
Nature communications
Liang S,Tran E,Du X,Dong J,Sudholz H,Chen H,Qu Z,Huntington ND,Babon JJ,Kershaw NJ,Zhang ZY,Baell JB,Wiede F,Tiganis T
11-5773-82 was used in Flow Cytometry to enhance anti-tumor immunity and combat cancer.
Thu Jul 27 00:00:00 EDT 2023
Single-cell analysis of immune cells on gingiva-derived mesenchymal stem cells in experimental autoimmune uveitis.
iScience
Gao Y,Duan R,Li H,Jiang L,Tao T,Liu X,Zhu L,Li Z,Chen B,Zheng S,Lin X,Su W
11-5773-82 was used in Flow cytometry/Cell sorting to generate a lymph node single-cell transcriptomic atlas of GMSC-treated experimental autoimmune uveitis mice.
Fri May 19 00:00:00 EDT 2023
Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
Frontiers in immunology
Bowakim-Anta N,Acolty V,Azouz A,Yagita H,Leo O,Goriely S,Oldenhove G,Moser M
11-5773-82 was used in Flow cytometry/Cell sorting to conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.
Thu Apr 06 00:00:00 EDT 2023
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.
Cell reports
Brandi P,Conejero L,Cueto FJ,Martínez-Cano S,Dunphy G,Gómez MJ,Relaño C,Saz-Leal P,Enamorado M,Quintas A,Dopazo A,Amores-Iniesta J,Del Fresno C,Nistal-Villán E,Ardavín C,Nieto A,Casanovas M,Subiza JL,Sancho D
11-5773-82 was used in Flow cytometry/Cell sorting to show that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice.
Tue Jan 04 00:00:00 EST 2022
Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.
iScience
Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS
11-5773-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.
Fri Jun 17 00:00:00 EDT 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.
Cell host & microbe
Pandey SP,Bender MJ,McPherson AC,Phelps CM,Sanchez LM,Rana M,Hedden L,Sangani KA,Chen L,Shapira JH,Siller M,Goel C,Verdú EF,Jabri B,Chang A,Chandran UR,Mullett SJ,Wendell SG,Singhi AD,Tilstra JS,Pierre JF,Arteel GE,Hinterleitner R,Meisel M
11-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that I3A is required for L. reuteri-induced Tc1 cell differentiation in vitro and AIH-like pathology in vivo, both of which are restrained by Tet2 within CD8 T cells.
Wed Jul 13 00:00:00 EDT 2022
Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Nature cancer
Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.
Sat Jan 01 00:00:00 EST 2022
Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.
Cell reports
Shao TY,Kakade P,Witchley JN,Frazer C,Murray KL,Ene IV,Haslam DB,Hagan T,Noble SM,Bennett RJ,Way SS
11-5773-82 was used in Flow cytometry/Cell sorting to show that dynamic gene expression fluctuations by C. albicans during symbiotic colonization are essential for priming host immunity against disseminated infection.
Tue May 17 00:00:00 EDT 2022
B-cell response to seasonal influenza vaccine in mice is amenable to pharmacological modulation through β-adrenoceptor.
Life sciences
Bufan B,Arsenović-Ranin N,Živković I,Petrović R,Leposavić G
11-5773-82 was used in Flow cytometry/Cell sorting to indicate that chronic propranolol treatment may impair response to QIV.
Fri Jul 15 00:00:00 EDT 2022
Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression.
Innate immunity
Xu H,Yu AL,Zhao DP,Meng GY,Wang L,Shan M,Hu NX,Liu YL
11-5773-82 was used in Flow cytometry/Cell sorting to explore the effects of UA on Th17 cell differentiation and Schwann cell(SCs)-mediated migration and the potential mechanism.
Fri Jul 01 00:00:00 EDT 2022
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
Cell reports
VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.
Tue Oct 18 00:00:00 EDT 2022
Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways.
Frontiers in immunology
Dong X,Zhang J,Zhang Q,Liang Z,Xu Y,Zhao Y,Zhang B
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to reveal that Dhx9, a cytosolic nuclear sensor recognizes viral DNA or RNA, playing an important role in mTEC development and function in mice.
Tue Jun 21 00:00:00 EDT 2022
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
Nature
Sanmarco LM,Wheeler MA,Gutiérrez-Vázquez C,Polonio CM,Linnerbauer M,Pinho-Ribeiro FA,Li Z,Giovannoni F,Batterman KV,Scalisi G,Zandee SEJ,Heck ES,Alsuwailm M,Rosene DL,Becher B,Chiu IM,Prat A,Quintana FJ
11-5773-82 was used in Flow Cytometry to show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
Mon Feb 01 00:00:00 EST 2021
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
11-5773-82 was used in Flow Cytometry to determine response to chemical signalling caused by endogenous retrovirus in skin microbiota.
Thu Jul 08 00:00:00 EDT 2021
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Immunity
Shmuel-Galia L,Humphries F,Lei X,Ceglia S,Wilson R,Jiang Z,Ketelut-Carneiro N,Foley SE,Pechhold S,Houghton J,Muneeruddin K,Shaffer SA,McCormick BA,Reboldi A,Ward D,Marshak-Rothstein A,Fitzgerald KA
11-5773-82 was used in Flow cytometry/Cell sorting to suggest a positive feedback loop wherein dysbiosis foments the accumulation of STING in intestinal myeloid cells, driving intestinal inflammation.
Tue Jun 08 00:00:00 EDT 2021
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.
Cell host & microbe
Huang X,Hurabielle C,Drummond RA,Bouladoux N,Desai JV,Sim CK,Belkaid Y,Lionakis MS,Segre JA
11-5773-82 was used in Flow Cytometry to develop a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients.
Wed Feb 10 00:00:00 EST 2021
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets.
The Journal of experimental medicine
Bhatt D,Kang B,Sawant D,Zheng L,Perez K,Huang Z,Sekirov L,Wolak D,Huang JY,Liu X,DeVoss J,Manzanillo PS,Pierce N,Zhang Z,Symons A,Ouyang W
11-5773-82 was used in Flow Cytometry to show that CCR8-depleting antibody treatment provided therapeutic benefit in CT26 tumors and synergized with anti-PD-1 treatment in MC38 and B16F10 tumor models.
Mon Jun 07 00:00:00 EDT 2021
STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production.
The Journal of allergy and clinical immunology
Du Z,Chen A,Huang L,Dai X,Chen Q,Yang D,Li L,Miller H,Westerberg L,Ding Y,Tang X,Kubo M,Jiang L,Zhao X,Wang H,Liu C
11-5773 was used in Flow cytometry/Cell sorting to determine the underlying molecular mechanism of how STAT3 regulates B-cell receptor (BCR) signaling, B-cell differentiation, and IgE production.
Sat May 01 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
11-5773-82 was used in Flow Cytometry to reveal that the expression of epigenetic regulator Sirt6 in TECs is crucial for the development and differentiation of mTECs, which highlights the importance of Sirt6 in the establishment of central immune tolerance.
Wed Apr 21 00:00:00 EDT 2021
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.
iScience
Gabriely G,Ma D,Siddiqui S,Sun L,Skillin NP,Abou-El-Hassan H,Moreira TG,Donnelly D,da Cunha AP,Fujiwara M,Walton LR,Patel A,Krishnan R,Levine SS,Healy BC,Rezende RM,Murugaiyan G,Weiner HL
11-5773-82 was used in Flow cytometry/Cell sorting to identify a previously unknown function by which LAPHi MCs promote tumor growth and offer therapeutic intervention to target these cells in cancer.
Fri Nov 19 00:00:00 EST 2021
Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2.
iScience
Park JG,Oladunni FS,Rohaim MA,Whittingham-Dowd J,Tollitt J,Hodges MDJ,Fathallah N,Assas MB,Alhazmi W,Almilaibary A,Iqbal M,Chang P,Escalona R,Shivanna V,Torrelles JB,Worthington JJ,Jackson-Jones LH,Martinez-Sobrido L,Munir M
11-5773-82 was used in Flow Cytometry to evaluate a Newcastle disease virus (NDV)-based vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy against SARS-CoV-2.
Fri Sep 24 00:00:00 EDT 2021
Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation.
Cell reports
Li J,Xu B,He M,Zong X,Cunningham T,Sha C,Fan Y,Cross R,Hanna JH,Feng Y
11-5773-82 was used in Chromatin immunoprecipitation to investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifying factor Foxp3.
Tue Dec 14 00:00:00 EST 2021
Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis.
Molecular nutrition & food research
Beukema M,Akkerman R,Jermendi É,Koster T,Laskewitz A,Kong C,Schols HA,Faas MM,de Vos P
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to show that pectins prevent C. rodentium induced colonic inflammation by lowering the C. rodentium load in the caecum independently of the DB.
Fri Oct 01 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
11-5773-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.
Tue Nov 23 00:00:00 EST 2021
Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections.
Immunity
Russler-Germain EV,Jung J,Miller AT,Young S,Yi J,Wehmeier A,Fox LE,Monte KJ,Chai JN,Kulkarni DH,Funkhouser-Jones LJ,Wilke G,Durai V,Zinselmeyer BH,Czepielewski RS,Greco S,Murphy KM,Newberry RD,Sibley LD,Hsieh CS
11-5773-82 was used in Flow cytometry/Cell sorting to show that Cryptosporidium tyzzeri (Ct-STL) represents a commensal pathobiont that elicits Th1-mediated intestinal homeostasis that may reflect asymptomatic human Cryptosporidium infection.
Tue Nov 09 00:00:00 EST 2021
Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer.
Aging
Huang C,Li Z,Zhu J,Chen X,Hao Y,Yang R,Huang R,Zhou J,Wang Z,Xiao W,Zheng C,Wang Y
11-5773-82 was used in Immunohistochemistry to show that the systems pharmacology strategy offers an important paradigm to understand the mechanism of polypharmacology of natural products targeting TME (the tumor microenvironment).
Sun Jan 17 00:00:00 EST 2021
Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation.
eLife
Russler-Germain EV,Yi J,Young S,Nutsch K,Wong HS,Ai TL,Chai JN,Durai V,Kaplan DH,Germain RN,Murphy KM,Hsieh CS
11-5773-82 was used in Flow Cytometry to suggest a model where DC-mediated effector T cell differentiation is 'dominant', necessitating that all DC subsets presenting antigen are permissive for pTreg cell induction to maintain gut tolerance.
Wed Feb 03 00:00:00 EST 2021
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
11-5773 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Immunosuppression by Mutated Calreticulin Released from Malignant Cells.
Molecular cell
Liu P,Zhao L,Loos F,Marty C,Xie W,Martins I,Lachkar S,Qu B,Waeckel-Énée E,Plo I,Vainchenker W,Perez F,Rodriguez D,López-Otin C,van Endert P,Zitvogel L,Kepp O,Kroemer G
11-5773-82 was used in Flow Cytometry to demonstrate the paracrine immunosuppressive effects for exon-9-mutated C-terminally modified calreticulin.
Thu Feb 20 00:00:00 EST 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
11-5773-82 was used in Flow Cytometry to demonstrate that colonic macrophage-intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages.
Mon Apr 06 00:00:00 EDT 2020
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
11-5773 was used in Flow cytometry/Cell sorting to determine whether WNT974 would impair tumor growth, affect gene expression patterns, and improve the immune response in human and murine ovarian cancer models.
Thu Apr 14 00:00:00 EDT 2022
Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment.
Cancers
Goldsberry WN,Meza-Perez S,Londoño AI,Katre AA,Mott BT,Roane BM,Goel N,Wall JA,Cooper SJ,Norian LA,Randall TD,Birrer MJ,Arend RC
11-5773 was used in Flow cytometry/Cell sorting to study Wnt activity within the microenvironment of ovarian tumors.
Tue Mar 24 00:00:00 EDT 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
11-5773 was used in Flow cytometry/Cell sorting to identify NAM as a potential strategy for the prevention and treatment of HR+ BC.
Thu Jul 30 00:00:00 EDT 2020
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver.
Cell reports
Wara AK,Wang S,Wu C,Fang F,Haemmig S,Weber BN,Aydogan CO,Tesmenitsky Y,Aliakbarian H,Hawse JR,Subramaniam M,Zhao L,Sage PT,Tavakkoli A,Garza A,Lynch L,Banks AS,Feinberg MW
11-5773-82 was used in Flow Cytometry to explore the role of KLF10 in high-fat-diet-induced obesity and insulin resistance.
Tue Dec 29 00:00:00 EST 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
11-5773-82 was used in Flow Cytometry to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 EST 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
11-5773 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
PloS one
Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ
11-5773 was used in Flow cytometry/Cell sorting to describe the generation of specific, species cross-reactive, agonist antibodies to ICOS, including the humanized clinical candidate, JTX-2011 (vopratelimab).
Mon Nov 16 00:00:00 EST 2020
Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.
Science advances
Si Y,Tian Q,Zhao F,Kelly SH,Shores LS,Camacho DF,Sperling AI,Andrade MS,Collier JH,Chong AS
11-5773 was used in Flow cytometry/Cell sorting to show that antigens displayed on self-assembling nanofiber scaffolds and delivered intranasally are presented by CD103+ and CD11b+ lung dendritic cells that up-regulate CD80 and migrate into the draining lymph node (LN).
Sat Aug 01 00:00:00 EDT 2020
PD-1/PD-L1 Immune Checkpoint Inhibition with Radiation in Bladder Cancer: In Situ and Abscopal Effects.
Molecular cancer therapeutics
Rompré-Brodeur A,Shinde-Jadhav S,Ayoub M,Piccirillo CA,Seuntjens J,Brimo F,Mansure JJ,Kassouf W
11-5773-82 was used in Flow cytometry/Cell sorting to assess combined therapy of radiation with immune checkpoint inhibitors on both radiated and nonradiated bladder tumours.
Wed Jan 01 00:00:00 EST 2020
Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts.
Frontiers in immunology
Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D
11-5773-82 was used in Flow Cytometry to compare targeting Malt1 versus using calcineurin inhibitors as immunosuppression in a stringent experimental transplantation model.
Fri Jun 18 00:00:00 EDT 2021
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
11-5773 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 EST 2020
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
11-5773 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 EDT 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
11-5773 was used in Flow cytometry/Cell sorting to identify two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets.
Thu Oct 31 00:00:00 EDT 2019
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
Immunity
Tibbitt CA,Stark JM,Martens L,Ma J,Mold JE,Deswarte K,Oliynyk G,Feng X,Lambrecht BN,De Bleser P,Nylén S,Hammad H,Arsenian Henriksson M,Saeys Y,Coquet JM
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to provide insight into the differentiation of pathogenic Th2 cells in the context of allergy.
Tue Jul 16 00:00:00 EDT 2019
Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.
Cell death and differentiation
Wirasinha RC,Chan A,Yap JY,Hu DY,Teh CE,Gray DHD,Goodnow CC,Daley SR
11-5773-82 was used in Flow Cytometry to demonstrate efficiency, and some redundancy, in the APC types that mediate wave 1 deletion in the normal mouse thymus.
Sun Dec 01 00:00:00 EST 2019
GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses.
Cancer immunology research
Kim IK,Koh CH,Jeon I,Shin KS,Kang TS,Bae EA,Seo H,Ko HJ,Kim BS,Chung Y,Kang CY
11-5773-82 was used in Flow Cytometry to demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing Th (Th9) cells.
Fri Mar 01 00:00:00 EST 2019
Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.
Mucosal immunology
Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y
11-5773 was used in Flow cytometry/Cell sorting to explore the regulation of GABA transporter-2 on the differentiation of Th17 cells.
Fri Mar 01 00:00:00 EST 2019
T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis.
Molecular cancer research : MCR
Cataisson C,Salcedo R,Michalowski AM,Klosterman M,Naik S,Li L,Pan MJ,Sweet A,Chen JQ,Kostecka LG,Karwan M,Smith L,Dai RM,Stewart CA,Lyakh L,Hsieh WT,Khan A,Yang H,Lee M,Trinchieri G,Yuspa SH
11-5773-80 was used in Flow Cytometry to produce a permissive microenvironment and tumor formation.
Thu Aug 01 00:00:00 EDT 2019
Circulating CD56bright NK cells inversely correlate with survival of melanoma patients.
Scientific reports
de Jonge K,Ebering A,Nassiri S,Maby-El Hajjami H,Ouertatani-Sakouhi H,Baumgaertner P,Speiser DE
11-5773 was used in Flow cytometry/Cell sorting to characterise natural killer cells from peripheral blood obtained from late stage (III/IV) melanoma patients.
Thu Mar 14 00:00:00 EDT 2019
Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer.
Frontiers in immunology
Martinez LM,Robila V,Clark NM,Du W,Idowu MO,Rutkowski MR,Bos PD
11-5773-82 was used in Flow cytometry/Cell sorting to investigate Treg cell function in the progression from non-invasive to invasive breast cancer lesions.
Tue Sep 29 00:00:00 EDT 2020
IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors.
Journal for immunotherapy of cancer
Chen J,Ye X,Pitmon E,Lu M,Wan J,Jellison ER,Adler AJ,Vella AT,Wang K
11-5773-82 was used in Flow cytometry/Cell sorting to show that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear.
Wed Nov 27 00:00:00 EST 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
11-5773-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance.
Scientific reports
Ayoub M,Shinde-Jadhav S,Mansure JJ,Alvarez F,Connell T,Seuntjens J,Piccirillo CA,Kassouf W
11-5773 was used in Flow cytometry/Cell sorting to identify extracellular HMGB1 is involved in the promotion of pro-tumor immune mechanisms in bladder cancer radioresistance.
Tue Apr 23 00:00:00 EDT 2019
Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.
Nature materials
Headen DM,Woodward KB,Coronel MM,Shrestha P,Weaver JD,Zhao H,Tan M,Hunckler MD,Bowen WS,Johnson CT,Shea L,Yolcu ES,García AJ,Shirwan H
11-5773 was used in Flow cytometry/Cell sorting to study the effects of localised immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin in diabetic mice.
Wed Aug 01 00:00:00 EDT 2018
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Immunity
Sharma MD,Rodriguez PC,Koehn BH,Baban B,Cui Y,Guo G,Shimoda M,Pacholczyk R,Shi H,Lee EJ,Xu H,Johnson TS,He Y,Mergoub T,Venable C,Bronte V,Wolchok JD,Blazar BR,Munn DH
11-5773 was used in Flow cytometry/Cell sorting to show that during immunotherapy large numbers of cells expressing CD103 arose in murine tumours via direct differentiation of Ly6c+ monocytic precursors.
Tue Jan 16 00:00:00 EST 2018
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.
Immunity
Lino AC,Dang VD,Lampropoulou V,Welle A,Joedicke J,Pohar J,Simon Q,Thalmensi J,Baures A,Flühler V,Sakwa I,Stervbo U,Ries S,Jouneau L,Boudinot P,Tsubata T,Adachi T,Hutloff A,Dörner T,Zimber-Strobl U,de Vos AF,Dahlke K,Loh G,Korniotis S,Goosmann C,Weill JC,Reynaud CA,Kaufmann SHE,Walter J,Fillatreau S
11-5773 was used in Flow cytometry/Cell sorting to identify a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo.
Tue Jul 17 00:00:00 EDT 2018
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
Cancer cell
Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD
11-5773-82 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.
Mon Jun 11 00:00:00 EDT 2018
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
11-5773-82 was used in Immunohistochemistry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
11-5773-82 was used in Immunohistochemistry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
Microglia are required for protection against lethal coronavirus encephalitis in mice.
The Journal of clinical investigation
Wheeler DL,Sariol A,Meyerholz DK,Perlman S
11-5773 was used in Flow cytometry/Cell sorting to study the specific roles of microglia in response to infection with the mouse hepatitis virus.
Thu Mar 01 00:00:00 EST 2018
Dual role of YM1+ M2 macrophages in allergic lung inflammation.
Scientific reports
Draijer C,Robbe P,Boorsma CE,Hylkema MN,Melgert BN
11-5773 was used in Flow cytometry/Cell sorting to assess the therapeutic potential of modulating M2 macrophages in allergic lung inflammation.
Fri Mar 23 00:00:00 EDT 2018
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Nature communications
Efremova M,Rieder D,Klepsch V,Charoentong P,Finotello F,Hackl H,Hermann-Kleiter N,Löwer M,Baier G,Krogsdam A,Trajanoski Z
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that neutral evolution is another force that contributes to sculpting the tumor and that checkpoint blockade effectively enforces T-cell-dependent immunoselective pressure.
Tue Jan 02 00:00:00 EST 2018
Inhibition of experimental autoimmune encephalomyelitis by tolerance-promoting DNA vaccination focused to dendritic cells.
PloS one
Castor T,Yogev N,Blank T,Barwig C,Prinz M,Waisman A,Bros M,Reske-Kunz AB
11-5773 was used in Flow cytometry/Cell sorting to analyse the effects of prophylactic biolistic DNA vaccination with plasmids encoding the encephalitogenic protein myelin oligodendrocyte glycoprotein (MOG) on the severity of a subsequently MOGp35-55-induced EAE and on the underlying immune response.
Mon Apr 02 00:00:00 EDT 2018
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
Adipose PD-L1 Modulates PD-1/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer.
Oncoimmunology
Wu B,Sun X,Gupta HB,Yuan B,Li J,Ge F,Chiang HC,Zhang X,Zhang C,Zhang D,Yang J,Hu Y,Curiel TJ,Li R
11-5773 was used in Flow cytometry/Cell sorting to compare the expression of PD-L1 in mature adipocytes versus preadipocytes.
Wed Oct 04 00:00:00 EDT 2023
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nature communications
Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G
11-5773 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.
Wed Apr 18 00:00:00 EDT 2018
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Arteriosclerosis, thrombosis, and vascular biology
Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L
11-5773-82 was used in Flow Cytometry, Immunohistochemistry (Frozen) to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.
Sat Sep 01 00:00:00 EDT 2018
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
Cell metabolism
Kälin S,Becker M,Ott VB,Serr I,Hosp F,Mollah MMH,Keipert S,Lamp D,Rohner-Jeanrenaud F,Flynn VK,Scherm MG,Nascimento LFR,Gerlach K,Popp V,Dietzen S,Bopp T,Krishnamurthy P,Kaplan MH,Serrano M,Woods SC,Tripal P,Palmisano R,Jastroch M,Blüher M,Wolfrum C,Weigmann B,Ziegler AG,Mann M,Tschöp MH,Daniel C
11-5773-82 was used in Flow Cytometry to study the link between adipose tissue function and regulatory T cells.
Tue Sep 05 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
11-5773-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Cell death and differentiation
Hu DY,Wirasinha RC,Goodnow CC,Daley SR
Thu Jun 01 00:00:00 EDT 2017
Capacity of tTreg generation is not impaired in the atrophied thymus.
PLoS biology
Oh J,Wang W,Thomas R,Su DM
11-5773 was used in Flow cytometry/Cell sorting to mechanistically study thymic Treg cell generation in the atrophied thymus using postnatal thymic epithelial cell-defective and naturally aged mouse models.
Wed Nov 01 00:00:00 EDT 2017
Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA
11-5773 was used in Flow cytometry/Cell sorting to study how the tissue environment established by Toxoplasma gondii leads to a pathogenic role for regulatory T cells.
Sun Jan 01 00:00:00 EST 2017
Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Immunity, inflammation and disease
Fisher SA,Aston WJ,Chee J,Khong A,Cleaver AL,Solin JN,Ma S,Lesterhuis WJ,Dick I,Holt RA,Creaney J,Boon L,Robinson B,Lake RA
11-5773 was used in Flow cytometry/Cell sorting to study the effect of regulatory T cell depletion on the efficacy of anti-cancer vaccines.
Wed Mar 01 00:00:00 EST 2017
Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model.
Scientific reports
Huang CT,Hung CY,Chen TC,Lin CY,Lin YC,Chang CS,He YC,Huang YL,Dutta A
11-5773 was used in Flow cytometry/Cell sorting to study the effect of Rapamycin, alone or in combination with Oseltamivir, for severe influenza in BALB/c mice.
Fri Jun 23 00:00:00 EDT 2017
C3d regulates immune checkpoint blockade and enhances antitumor immunity.
JCI insight
Platt JL,Silva I,Balin SJ,Lefferts AR,Farkash E,Ross TM,Carroll MC,Cascalho M
11-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which tumours engage T cell checkpoint regulators and expanding Tregs, showing that C3d regulates immune checkpoint blockade and enhances antitumor immunity.
Thu May 04 00:00:00 EDT 2017
Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?
Immunity, inflammation and disease
Sordé L,Spindeldreher S,Palmer E,Karle A
11-5773 was used in Flow cytometry/Cell sorting to study the potential impact of IVIg on the ability of antigen presenting cells to present peptides.
Fri Dec 01 00:00:00 EST 2017
Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.
Scientific reports
Eri T,Kawahata K,Kanzaki T,Imamura M,Michishita K,Akahira L,Bannai E,Yoshikawa N,Kimura Y,Satoh T,Uematsu S,Tanaka H,Yamamoto K
11-5773 was used in Flow cytometry/Cell sorting to study the relationship between lymphopenia and murine autoimmunity, mediated by the intestinal microbiota.
Wed Apr 26 00:00:00 EDT 2017
Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas.
Medical science monitor : international medical journal of experimental and clinical research
Li J,Liu X,Duan Y,Liu Y,Wang H,Lian S,Zhuang G,Fan Y
11-5773 was used in Flow cytometry/Cell sorting to indicate that combined blockade of T cell immunoglobulin and mucin domain 3 and carcinoembryonic antigen-related cell adhesion molecule 1 generates robust therapeutic efficacy in mice with intracranial tumours.
Mon Jul 24 00:00:00 EDT 2017
Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter.
Respiratory research
Jaligama S,Saravia J,You D,Yadav N,Lee GI,Shrestha B,Cormier SA
11-5773 was used in Flow cytometry/Cell sorting to show that murine neonate exposure to environmentally persistent free radicals induces regulatory T Cells and IL10 resulting in suppressed adaptive T cell responses and increased severity of influenza.
Fri Jan 13 00:00:00 EST 2017
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
Nature communications
Jandl C,Liu SM,Cañete PF,Warren J,Hughes WE,Vogelzang A,Webster K,Craig ME,Uzel G,Dent A,Stepensky P,Keller B,Warnatz K,Sprent J,King C
11-5773 was used in Flow cytometry/Cell sorting to identify a mechanism by which IL-21 reinforces humoural immunity by influencing the phenotype of T follicular cells to limit their expansion.
Fri Mar 17 00:00:00 EDT 2017
Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models.
Scientific reports
Chen CY,Wang PY,Hutzen B,Sprague L,Swain HM,Love JK,Stanek JR,Boon L,Conner J,Cripe TP
11-5773 was used in Flow cytometry/Cell sorting to show the combination of PD-1 blockade and oHSV-1 may be an effective treatment strategy for childhood soft tissue sarcoma.
Wed May 24 00:00:00 EDT 2017
The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.
Frontiers in immunology
Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE
11-5773 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.
Fri Jul 22 00:00:00 EDT 2016
Effect of cold stress on immunity in rats.
Experimental and therapeutic medicine
Hu GZ,Yang SJ,Hu WX,Wen Z,He D,Zeng LF,Xiang Q,Wu XM,Zhou WY,Zhu QX
11-5773 was used in Flow cytometry/Cell sorting to determine the effect of a sudden ambient temperature drop on the levels of stress hormones and T-lymphocyte cytokines in the plasma of mice.
Fri Jan 01 00:00:00 EST 2016
Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model.
Evidence-based complementary and alternative medicine : eCAM
Nie B,Li X,Wei Y,Chen M,Zhou J,Lou L,Dong B,Wu A,Zhang D,Zhu L,Zhao J,Chai L
11-5773 was used in Flow cytometry/Cell sorting to indicate that xianfanghuomingyin can restore the balance of T lymphocytes and reestablish immunological tolerance to inhibit rheumatoid arthritis autoinflammatory disorder.
Thu Sep 22 00:00:00 EDT 2016
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Scientific reports
Shi Y,Liu T,He L,Dougherty U,Chen L,Adhikari S,Alpert L,Zhou G,Liu W,Wang J,Deb DK,Hart J,Liu SQ,Kwon J,Pekow J,Rubin DT,Zhao Q,Bissonnette M,Li YC
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that the renin-angiotensin II cascade promotes colitis by stimulating intestinal epithelial cell apoptosis and mucosal TH17 responses in a blood pressure-independent manner.
Wed Jun 08 00:00:00 EDT 2016
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
PloS one
Tengvall S,Eneljung T,Jirholt P,Turesson O,Wing K,Holmdahl R,Kihlberg J,Stern A,Mårtensson IL,Henningsson L,Gustafsson K,Gjertsson I
11-5773 was used in Flow cytometry/Cell sorting to investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis.
Mon Jul 17 00:00:00 EDT 2017
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Nature communications
Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C
11-5773 was used in Flow cytometry/Cell sorting to show induced human Tregs show increased expression of Treg signature genes such as Foxp3, CTLA4, IL-2Rα and TIGIT.
Tue Mar 15 00:00:00 EDT 2016
Recombinant HLA-G as Tolerogenic Immunomodulant in Experimental Small Bowel Transplantation.
PloS one
von Websky MW,Kitamura K,Ludwig-Portugall I,Kurts C,von Laffert M,LeMaoult J,Carosella ED,Abu-Elmagd K,Kalff JC,Schäfer N
11-5773 was used in Flow cytometry/Cell sorting to examine the therapeutic approach of immunosuppression using HLA-G in solid organ transplantation, showing a significant immunosuppressive effect in a model of allogenic experimental intestinal transplantation.
Mon Jul 31 00:00:00 EDT 2017
Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner.
Biology of sex differences
Elderman M,van Beek A,Brandsma E,de Haan B,Savelkoul H,de Vos P,Faas M
11-5773 was used in Flow cytometry/Cell sorting to study sex differences in the intestinal and peripheral immune cell populations of two mouse strains with different susceptibility for developing colitis.
Thu Apr 07 00:00:00 EDT 2016
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Nature
Brestoff JR,Kim BS,Saenz SA,Stine RR,Monticelli LA,Sonnenberg GF,Thome JJ,Farber DL,Lutfy K,Seale P,Artis D
11-5773 was used in Flow cytometry/Cell sorting to study how ILC2s can regulate adipose function and metabolic homeostasis.
Thu Mar 12 00:00:00 EDT 2015
CD4+VEGFR1(HIGH) T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice.
Cellular & molecular immunology
Shin JY,Yoon IH,Lim JH,Shin JS,Nam HY,Kim YH,Cho HS,Hong SH,Kim JS,Lee WW,Park CG
11-5773 was used in Flow cytometry/Cell sorting to report CD4(+) VEGFR1(high) T cells as a novel subset of Tregs that regulate the inflammatory response in the intestinal tract.
Tue Sep 01 00:00:00 EDT 2015
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication.
Cancer research
Chaoul N,Fayolle C,Desrues B,Oberkampf M,Tang A,Ladant D,Leclerc C
11-5773 was used in Flow cytometry/Cell sorting to demonstrate the effects of mTOR inhibition in abolishing T-cell-mediated antitumor immune responses essential for the therapeutic efficacy of cancer vaccines.
Sat Aug 15 00:00:00 EDT 2015
Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.
Cancer immunology research
Wang L,Amoozgar Z,Huang J,Saleh MH,Xing D,Orsulic S,Goldberg MS
11-5773 was used in Immunohistochemistry to show that the efficacy of anti-CTLA-4 was potentiated by combination with decitabine, which could improve treatment of drug-resistant ovarian cancer.
Tue Sep 01 00:00:00 EDT 2015
Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.
Frontiers in immunology
Carson WF,Guernsey LA,Singh A,Secor ER,Wohlfert EA,Clark RB,Schramm CM,Kunkel SL,Thrall RS
11-5773 was used in Flow cytometry/Cell sorting to implicate a role for Cbl-b in the resolution of allergic airway inflammation.
Fri Dec 04 00:00:00 EST 2015
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
PLoS pathogens
Wiesner DL,Specht CA,Lee CK,Smith KD,Mukaremera L,Lee ST,Lee CG,Elias JA,Nielsen JN,Boulware DR,Bohjanen PR,Jenkins MK,Levitz SM,Nielsen K
11-5773 was used in Flow cytometry/Cell sorting to investigate Th2 cell responses to pulmonary fungal infection, showing that chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
Sun Mar 01 00:00:00 EST 2015
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway.
Journal of inflammation (London, England)
Min SY,Yan M,Kim SB,Ravikumar S,Kwon SR,Vanarsa K,Kim HY,Davis LS,Mohan C
11-5773 was used in Flow cytometry/Cell sorting to examine the immunomodulatory effects and mechanisms of action of EGCG on experimental arthritis in mice.
Fri Sep 18 00:00:00 EDT 2015
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice.
The American journal of pathology
Galipeau HJ,McCarville JL,Huebener S,Litwin O,Meisel M,Jabri B,Sanz Y,Murray JA,Jordana M,Alaedini A,Chirdo FG,Verdu EF
11-5773 was used in Flow cytometry/Cell sorting to assess whether specific microbiota compositions influence immune responses to gluten in mice expressing the human DQ8 gene, which confers moderate CD genetic susceptibility.
Sun Nov 01 00:00:00 EDT 2015
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.
Journal of immunology (Baltimore, Md. : 1950)
Siggs OM,Miosge LA,Daley SR,Asquith K,Foster PS,Liston A,Goodnow CC
11-5773 was used in Flow cytometry/Cell sorting to investigate whether outcomes of null mutations of SLP-76 are due to biochemical uncoupling of tolerogenic signaling, showing that reduction of SLP-76 unbalances immunity and immune regulation.
Sun Mar 15 00:00:00 EDT 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
11-5773 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.
Journal of immunology (Baltimore, Md. : 1950)
Yaciuk JC,Pan Y,Schwarz K,Pan ZJ,Maier-Moore JS,Kosanke SD,Lawrence C,Farris AD
11-5773 was used in Flow cytometry/Cell sorting to investigate cellular tolerance and autoimmunity to the ubiquitous RNA-binding La Ag often targeted in systemic lupus erythematosus and Sjögren's syndrome.
Sun Feb 15 00:00:00 EST 2015
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Journal of immunology (Baltimore, Md. : 1950)
Cabrera-Perez J,Condotta SA,James BR,Kashem SW,Brincks EL,Rai D,Kucaba TA,Badovinac VP,Griffith TS
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that the recovery of CD4 T cells from sepsis-induced lymphopenia is accompanied by alterations to the composition and function of the Ag-specific CD4 T cell repertoire.
Sun Feb 15 00:00:00 EST 2015
Dimethyl sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells.
Toxicology and applied pharmacology
Lin GJ,Sytwu HK,Yu JC,Chen YW,Kuo YL,Yu CC,Chang HM,Chan DC,Huang SH
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that in vivo DMSO treatment suppresses spontaneous diabetes and autoimmune recurrence in NOD mice.
Thu Jan 15 00:00:00 EST 2015
CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells.
Cellular immunology
Zhao C,Marrero I,Narsale A,Moya R,Davies JD
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD44(v.low) cells are neither recent thymic emigrants nor stem cell-like memory T cells.
Sat Aug 01 00:00:00 EDT 2015
Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.
Infection and immunity
Redpath SA,van der Werf N,MacDonald AS,Maizels RM,Taylor MD
11-5773 was used in Flow cytometry/Cell sorting to explore the induction and role of Foxp3(+) Treg cells during the early, prepatent, larval stage of S. mansoni infection.
Thu Oct 01 00:00:00 EDT 2015
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
11-5773 was used in Flow cytometry/Cell sorting to study the effect of iron in attenuating CXCR3-mediated T cell chemotaxis and migration to the brain and therefore inhibiting Experimental Cerebral Malaria pathology.
Thu Jan 21 00:00:00 EST 2016
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Nature communications
Hsiao HW,Hsu TS,Liu WH,Hsieh WC,Chou TF,Wu YJ,Jiang ST,Lai MZ
11-5773 was used in Flow cytometry/Cell sorting to investigate how Foxp3 and Treg stability is regulated in vivo, showing that Deltex1 antagonizes HIF-1α and sustains the stability of Tregs.
Thu Feb 19 00:00:00 EST 2015
Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties.
Stem cell research & therapy
Khatri M,O'Brien TD,Chattha KS,Saif LJ
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that MSCs can be isolated from porcine lung and that these cells, similar to human lung MSCs, possess in vitro proliferation, differentiation and immunomodulatory functions.
Wed Nov 11 00:00:00 EST 2015
IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection.
Nature communications
Dutta A,Huang CT,Chen TC,Lin CY,Chiu CH,Lin YC,Chang CS,He YC
11-5773 was used in Flow cytometry/Cell sorting to reveal a previously unrecognized function of Th1 cell-derived IL-10 in vivo.
Mon Mar 02 00:00:00 EST 2015
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature communications
Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F
11-5773 was used in Flow cytometry/Cell sorting to study the regulation of Aire expression in medullary thymic epithelial cells.
Wed Nov 04 00:00:00 EST 2015
Mice with an absent stress response are protected against ischemic renal injury.
Kidney international
Sreedharan R,Chen S,Miller M,Haribhai D,Williams CB,Van Why SK
11-5773 was used in Flow cytometry/Cell sorting to study how HSF-KO mice are protected from ischemic renal injury by a mechanism that depends on an increase in the T-regulatory cells in the kidney associated with altered T-cell infiltration early in reflow.
Mon Sep 01 00:00:00 EDT 2014
CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Engeland CE,Grossardt C,Veinalde R,Bossow S,Lutz D,Kaufmann JK,Shevchenko I,Umansky V,Nettelbeck DM,Weichert W,Jäger D,von Kalle C,Ungerechts G
11-5773 was used in Flow cytometry/Cell sorting to suggest rapid translation of combining immune checkpoint modulation with oncolytic viruses into clinical application.
Sat Nov 01 00:00:00 EDT 2014
Episomal expression of truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4+FoxP3- and CD8+ T cells.
Cancer immunology research
Chen Z,Ozbun L,Chong N,Wallecha A,Berzofsky JA,Khleif SN
11-5773 was used in Flow cytometry/Cell sorting to identify that the vector LmddA induces a decrease in the proportion of regulatory T cells by preferentially expanding CD4(+)FoxP3(-) T cells and CD8(+) T cells using listeriolysin O.
Mon Sep 01 00:00:00 EDT 2014
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Diabetes
Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C
11-5773 was used in Immunofluorescence to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.
Sun Jun 01 00:00:00 EDT 2014
NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Sui Q,Zhang J,Sun X,Zhang C,Han Q,Tian Z
11-5773 was used in Flow cytometry/Cell sorting to show that blocking STAT3 in hepatocellular carcinoma cells can initiate innate immunity in vivo.
Fri Aug 15 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
11-5773 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Transient low-dose methotrexate generates B regulatory cells that mediate antigen-specific tolerance to alglucosidase alfa.
Journal of immunology (Baltimore, Md. : 1950)
Joly MS,Martin RP,Mitra-Kaushik S,Phillips L,D'Angona A,Richards SM,Joseph AM
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that single cycle, low-dose methotrexate can be as effective as three cycles of methotrexate in reducing alglucosidase alfa-specific ADA.
Wed Oct 15 00:00:00 EDT 2014
Immune suppression via glucocorticoid-stimulated monocytes: a novel mechanism to cope with inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Varga G,Ehrchen J,Brockhausen A,Weinhage T,Nippe N,Belz M,Tsianakas A,Ross M,Bettenworth D,Spieker T,Wolf M,Lippe R,Tenbrock K,Leenen PJ,Roth J,Sunderkötter C
11-5773 was used in Flow cytometry/Cell sorting to study the in vivo immunosuppressive potential of glucocorticoid-stimulated monocytes in CD4(+) T cell-induced colitis.
Fri Aug 01 00:00:00 EDT 2014
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
11-5773 was used in Immunofluorescence to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
11-5773 was used in Immunofluorescence to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.
Particle and fibre toxicology
Lee GI,Saravia J,You D,Shrestha B,Jaligama S,Hebert VY,Dugas TR,Cormier SA
11-5773 was used in Flow cytometry/Cell sorting to study how EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.
Thu Oct 30 00:00:00 EDT 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
11-5773 was used in Flow cytometry/Cell sorting to investigate the effect of in vivo CTLA4Ig expression using a minicircle vector on rheumatoid arthritis.
Thu Nov 06 00:00:00 EST 2014
Synergic silencing of costimulatory molecules prevents cardiac allograft rejection.
Journal of translational medicine
Zhang X,Liu Y,Zhang G,Shi J,Zhang X,Zheng X,Jiang AT,Zhang ZX,Johnston N,Siu KS,Chen R,Lian D,Koos D,Quan D,Min WP
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that the simultaneous silencing of CD40 and CD80 prevents allograft rejection.
Thu May 22 00:00:00 EDT 2014
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
PloS one
Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S
11-5773 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.
Thu Dec 17 00:00:00 EST 2015
Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.
Journal of translational medicine
Fisher SA,Cleaver A,Lakhiani DD,Khong A,Connor T,Wylie B,Lesterhuis WJ,Robinson BW,Lake RA
11-5773 was used in Flow cytometry/Cell sorting to characterise changes in the proportion and activation status of immune cells associated with anti-tumour immunity.
Thu Sep 04 00:00:00 EDT 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
11-5773 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Loebbermann J,Durant L,Thornton H,Johansson C,Openshaw PJ
11-5773 was used in Flow cytometry/Cell sorting to identify an unexpected mechanism of vaccine-induced disease augmentation, indicating that selective chemoattraction of regulatory T cells into diseased sites may offer a novel approach to the modulation of tissue-specific inflammation.
Tue Feb 19 00:00:00 EST 2013
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Cancer immunology, immunotherapy : CII
Akhmetzyanova I,Zelinskyy G,Schimmer S,Brandau S,Altenhoff P,Sparwasser T,Dittmer U
11-5773 was used in Flow cytometry/Cell sorting to explore the role of effector CD4(+) T cells in the immune control of tumours.
Fri Feb 01 00:00:00 EST 2013
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Qiao G,Zhao Y,Li Z,Tang PQ,Langdon WY,Yang T,Zhang J
11-5773 was used in Flow cytometry/Cell sorting to investigate the role of Casitas-B-lineage lymphoma protein-b in activation of iTregs.
Mon Jul 15 00:00:00 EDT 2013
Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model.
Journal of immunology (Baltimore, Md. : 1950)
Chattha KS,Vlasova AN,Kandasamy S,Rajashekara G,Saif LJ
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that probiotics LGG+Bb12 exert divergent immunomodulating effects in a neonatal gnotobiotic piglet disease model.
Sun Sep 01 00:00:00 EDT 2013
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.
PLoS computational biology
Carbo A,Hontecillas R,Kronsteiner B,Viladomiu M,Pedragosa M,Lu P,Philipson CW,Hoops S,Marathe M,Eubank S,Bisset K,Wendelsdorf K,Jarrah A,Mei Y,Bassaganya-Riera J
11-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms controlling differentiation and plasticity of CD4+ T cells in the gut of mice.
Mon Apr 01 00:00:00 EDT 2013
Schedule-dependent therapeutic efficacy of L19mTNF-α and melphalan combined with gemcitabine.
Cancer medicine
Mortara L,Orecchia P,Castellani P,Borsi L,Carnemolla B,Balza E
11-5773 was used in Flow cytometry/Cell sorting to study the antitumor activity of single L19mTNF-a treatment in combination with melphalan and gemcitabine.
Thu Aug 01 00:00:00 EDT 2013
Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites.
Veterinary research
Correia A,Ferreirinha P,Costa AA,Dias J,Melo J,Costa R,Ribeiro A,Faustino A,Teixeira L,Rocha A,Vilanova M
11-5773 was used in Flow cytometry/Cell sorting to indicate that TCRαβ+ CD8+ cells contribute to host protection by producing IFN-γ during gastrointestinal infection with Neospora caninum tachyzoites.
Sat Aug 10 00:00:00 EDT 2013
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.
Infection and immunity
Kronsteiner B,Bassaganya-Riera J,Philipson C,Viladomiu M,Carbo A,Pedragosa M,Vento S,Hontecillas R
11-5773 was used in Flow cytometry/Cell sorting to investigate the phenotypic and functional changes in PMBC populations during Helicobacter pylori infection, showing that infection is dominated by Th1 and cytotoxic CD8+ T cell responses.
Tue Oct 01 00:00:00 EDT 2013
IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.
Journal of neuroimmunology
Phares TW,DiSano KD,Hinton DR,Hwang M,Zajac AJ,Stohlman SA,Bergmann CC
11-5773 was used in Flow cytometry/Cell sorting to demonstrate the role of IL-21 in regulating CNS immunity.
Tue Oct 15 00:00:00 EDT 2013
Expression of Foxp3, CD25 and IL-2 in the B16F10 cancer cell line and melanoma is correlated with tumor growth in mice.
Oncology letters
Miranda-Hernández DF,Franco-Molina MA,Mendoza-Gamboa E,Zapata-Benavides P,Sierra-Rivera CA,Coronado-Cerda EE,Rosas-Taraco AG,Taméz-Guerra RS,Rodríguez-Padilla C
11-5773 was used in Immunofluorescence to analyse Foxp3 expression in B16F10 melanoma cells in vitro and to determine whether this expression is affected during tumour growth.
Fri Nov 01 00:00:00 EDT 2013
Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis.
Clinical & developmental immunology
Eneljung T,Tengvall S,Jirholt P,Henningsson L,Holmdahl R,Gustafsson K,Gjertsson I
11-5773 was used in Flow cytometry/Cell sorting to show antigen-specific gene therapy is effective when administered during the inflammatory course of arthritis.
Mon Aug 04 00:00:00 EDT 2014
Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine.
PloS one
Smelt MJ,de Haan BJ,Bron PA,van Swam I,Meijerink M,Wells JM,Faas MM,de Vos P
11-5773 was used in Flow cytometry/Cell sorting to study how different bacterial strains modulate the healthy intestinal immune system.
Mon Feb 03 00:00:00 EST 2014
Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma.
Nature medicine
Krishnamoorthy N,Khare A,Oriss TB,Raundhal M,Morse C,Yarlagadda M,Wenzel SE,Moore ML,Peebles RS,Ray A,Ray P
11-5773 was used in Flow cytometry/Cell sorting to highlight a mechanism by which viral infection targets a host-protective mechanism in early life and increases susceptibility to allergic disease.
Mon Oct 01 00:00:00 EDT 2012
Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice.
Circulation
Hofmann U,Beyersdorf N,Weirather J,Podolskaya A,Bauersachs J,Ertl G,Kerkau T,Frantz S
11-5773 was used in Flow cytometry/Cell sorting to investigate the role of CD4+ T lymphocytes in wound healing after experimental myocardial infarction in mice.
Tue Apr 03 00:00:00 EDT 2012
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
The Journal of clinical investigation
Takiishi T,Korf H,Van Belle TL,Robert S,Grieco FA,Caluwaerts S,Galleri L,Spagnuolo I,Steidler L,Van Huynegem K,Demetter P,Wasserfall C,Atkinson MA,Dotta F,Rottiers P,Gysemans C,Mathieu C
11-5773 was used in Immunofluorescence to show that diabetes can be reversed in NOD mice using gut mucosal delivery of the whole proinsulin autoantigen by a genetically modified Lactococcus lactis bacteria.
Tue May 01 00:00:00 EDT 2012
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
The Journal of experimental medicine
Rivollier A,He J,Kole A,Valatas V,Kelsall BL
11-5773 was used in Immunocytochemistry to demonstrate the dual capacity of Ly6C(hi) blood MOs, which is dictated by microenvironmental conditions.
Mon Jan 16 00:00:00 EST 2012
Smoking during pregnancy influences the maternal immune response in mice and humans.
American journal of obstetrics and gynecology
Prins JR,Hylkema MN,Erwich JJ,Huitema S,Dekkema GJ,Dijkstra FE,Faas MM,Melgert BN
11-5773 was used in Flow cytometry/Cell sorting to analyse the effects of smoking on the maternal immune system.
Sun Jul 01 00:00:00 EDT 2012
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Mucosal immunology
Loebbermann J,Thornton H,Durant L,Sparwasser T,Webster KE,Sprent J,Culley FJ,Johansson C,Openshaw PJ
11-5773 was used in Flow cytometry/Cell sorting to study the various effects of the selective depletion of Tregs during acute RSV infection.
Thu Mar 01 00:00:00 EST 2012
Maximizing tumor immunity with fractionated radiation.
International journal of radiation oncology, biology, physics
Schaue D,Ratikan JA,Iwamoto KS,McBride WH
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that radiation can be an immune adjuvant but the response varies with the size of dose per fraction.
Sun Jul 15 00:00:00 EDT 2012
A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium.
Journal of clinical periodontology
Bezerra Bde B,Andriankaja O,Kang J,Pacios S,Bae HJ,Li Y,Tsiagbe V,Schreiner H,Fine DH,Graves DT
11-5773 was used in Flow cytometry/Cell sorting to link A. actinomycetemcomitans infection with important characteristics of periodontal destruction.
Sun Apr 01 00:00:00 EDT 2012
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.
PLoS pathogens
Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.
Tue Jan 29 00:00:00 EST 2013
Seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory T cell phenotypes.
Journal of virology
Li W,Klein SL
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that AMs and LMVECs play distinct roles in hantavirus persistence by creating a regulatory environment.
Thu Nov 01 00:00:00 EDT 2012
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.
Wed Feb 15 00:00:00 EST 2012
IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950)
Roffê E,Rothfuchs AG,Santiago HC,Marino AP,Ribeiro-Gomes FL,Eckhaus M,Antonelli LR,Murphy PM
11-5773 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-10 protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.
Sun Jan 15 00:00:00 EST 2012
A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg.
Journal of immunology (Baltimore, Md. : 1950)
Schoenbrunn A,Frentsch M,Kohler S,Keye J,Dooms H,Moewes B,Dong J,Loddenkemper C,Sieper J,Wu P,Romagnani C,Matzmohr N,Thiel A
11-5773 was used in Flow cytometry/Cell sorting to understand the effects of a converse 4-1BB and CD40 ligand expression pattern on T cells.
Sat Dec 15 00:00:00 EST 2012
Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis.
Infection and immunity
Kang J,de Brito Bezerra B,Pacios S,Andriankaja O,Li Y,Tsiagbe V,Schreiner H,Fine DH,Graves DT
11-5773 was used in Flow cytometry/Cell sorting to investigate whether diabetes aggravates periodontal destruction induced by A. actinomycetemcomitans infection, showing that infection enhances apoptosis in vivo through a caspase-3-dependent mechanism.
Fri Jun 01 00:00:00 EDT 2012
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.
Cell & bioscience
Qu Z,Fu J,Ma H,Zhou J,Jin M,Mapara MY,Grusby MJ,Xiao G
11-5773 was used in Flow cytometry/Cell sorting to investigate PDLIM2 as a key modulator of T-cell-mediated immune responses and its role in preventing autoimmune disease.
Mon Jun 25 00:00:00 EDT 2012
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
11-5773 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
PloS one
Loebbermann J,Schnoeller C,Thornton H,Durant L,Sweeney NP,Schuijs M,O'Garra A,Johansson C,Openshaw PJ
11-5773 was used in Flow cytometry/Cell sorting to study experimental respiratory syncytial virus infection in IL-10 deficient mice and mice treated with anti-IL-10 receptor antibody.
Mon Jul 23 00:00:00 EDT 2012
Phenotypical and functional analysis of intraepithelial lymphocytes from small intestine of mice in oral tolerance.
Clinical & developmental immunology
Ruberti M,Fernandes LG,Simioni PU,Gabriel DL,Yamada AT,Tamashiro WM
11-5773 was used in Flow cytometry/Cell sorting to evaluate the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes.
Fri Mar 01 00:00:00 EST 2013
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
11-5773 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
Prolongation of cardiac allograft survival by a novel population of autologous CD117+ bone marrow-derived progenitor cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Grazia TJ,Plenter RJ,Lepper HM,Victorino F,Miyamoto SD,Crossno JT,Pietra BA,Gill RG,Zamora MR
11-5773 was used in Flow cytometry/Cell sorting to determine whether autologous bone marrow-derived CD117+ progenitor cells could benefit cardiac allograft survival.
Sat Jan 01 00:00:00 EST 2011
Radiation enhances regulatory T cell representation.
International journal of radiation oncology, biology, physics
Kachikwu EL,Iwamoto KS,Liao YP,DeMarco JJ,Agazaryan N,Economou JS,McBride WH,Schaue D
11-5773 was used in Flow cytometry/Cell sorting to suggest that Tregs are a radio-resistant subset of lymphocytes that may play a role in tumour evasion during radiotherapy.
Tue Nov 15 00:00:00 EST 2011
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation.
European journal of immunology
Bayer AL,Chirinos J,Cabello C,Yang J,Matsutani T,Malek TR,Levy RB
11-5773 was used in Flow cytometry/Cell sorting to examine the role of STAT-5 signaling cytokines in the expansion of residual T(reg) cells after autologous HSCT.
Thu Dec 01 00:00:00 EST 2011
Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice.
Journal of immunology (Baltimore, Md. : 1950)
Galipeau HJ,Rulli NE,Jury J,Huang X,Araya R,Murray JA,David CS,Chirdo FG,McCoy KD,Verdu EF
11-5773 was used in Flow cytometry/Cell sorting to investigate whether gliadin contributes to enteropathy and insulitis in NOD-DQ8 mice.
Sat Oct 15 00:00:00 EDT 2011
Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.
Journal of immunology (Baltimore, Md. : 1950)
Coffelt SB,Chen YY,Muthana M,Welford AF,Tal AO,Scholz A,Plate KH,Reiss Y,Murdoch C,De Palma M,Lewis CE
11-5773 was used in Immunofluorescence to suggest that ANGPT2-stimulated TIE2-expressing monocytes/macrophages represent a novel, potent immunosuppressive force in tumours.
Fri Apr 01 00:00:00 EDT 2011
Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Miranda-Hernandez S,Gerlach N,Fletcher JM,Biros E,Mack M,Körner H,Baxter AG
11-5773 was used in Flow cytometry/Cell sorting to examine the effects of targeted deletions of specific TLRs on the induction of toxin-induced autoimmune encephalomyelitis.
Fri Jul 15 00:00:00 EDT 2011
Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Collins EL,Jager LD,Dabelic R,Benitez P,Holdstein K,Lau K,Haider MI,Johnson HM,Larkin J
11-5773 was used in Flow cytometry/Cell sorting to show that CD4(+)/SOCS1-KIR combined treatment can synergistically promote the long-term survival of perinatal lethal SOCS1(-/-) mice.
Thu Sep 01 00:00:00 EDT 2011
Dichotomous response to transforming growth factor β after T cell receptor activation by naive CD4+ T cells from DBA/1 mice: enhanced retinoic acid receptor-related orphan nuclear receptor γt expression yet reduced FoxP3 expression.
Arthritis and rheumatism
Morita Y,Ismail DM,Elkon KB,Chu CQ
11-5773 was used in Flow cytometry/Cell sorting to investigate the molecular mechanism for biased interleukin-17 production by DBA/1 CD4+ T cells upon T cell receptor and transforming growth factor β stimulation.
Sat Jan 01 00:00:00 EST 2011
OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice.
Clinical and vaccine immunology : CVI
Gaisford W,Pritchard DI,Cooke A
11-5773 was used in Flow cytometry/Cell sorting to study the effects of Pseudomona aeruginosa OdDHL on the onset of type 1 diabetes in the non-obese diabetic mouse model.
Mon Aug 01 00:00:00 EDT 2011
CD4+FoxP3+ regulatory T cells from Gαi2-/- mice are functionally active in vitro, but do not prevent colitis.
PloS one
Götlind YY,Raghavan S,Bland PW,Hörnquist EH
11-5773 was used in Flow cytometry/Cell sorting to examine whether a CD4(+)FoxP3(+) Treg defect underpins the pathogenesis of colitis in the Gαi2(-/-) colitis model.
Fri Jun 08 00:00:00 EDT 2012
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
11-5773 was used in Flow cytometry/Cell sorting to investigate whether T regulatory cells regulate haematopoiesis via the production of cytokine effector molecules.
Thu Jun 10 00:00:00 EDT 2010
A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells.
The Journal of experimental medicine
Zhao C,Davies JD
11-5773 was used in Flow cytometry/Cell sorting to support a key role for CD4(+) CD44(v.low) cells as peripheral precursors that maintain the integrity of the CD4(+) T cell pool.
Mon Dec 20 00:00:00 EST 2010
ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.
Journal of autoimmunity
Hondowicz BD,Batheja AO,Metzgar MH,Caton AJ,Erikson J
11-5773 was used in Flow cytometry/Cell sorting to study the effect of elevated effector T-cell ICOS levels on immunity and immune cells.
Tue Jun 01 00:00:00 EDT 2010
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes.
Molecular therapy : the journal of the American Society of Gene Therapy
Bresson D,Fradkin M,Manenkova Y,Rottembourg D,von Herrath M
11-5773 was used in Immunohistofluorescence to show that efficacy of combination therapies to reverse new-onset T1D is dependent upon genetic background.
Mon Feb 01 00:00:00 EST 2010
Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma.
Cancer gene therapy
Huang P,Kaku H,Chen J,Kashiwakura Y,Saika T,Nasu Y,Urata Y,Fujiwara T,Watanabe M,Kumon H
11-5773 was used in Flow cytometry/Cell sorting to assess the effectiveness of a combined virus-interleukin therapy against carcinoma.
Thu Jul 01 00:00:00 EDT 2010
CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells.
The American journal of pathology
Dobaczewski M,Xia Y,Bujak M,Gonzalez-Quesada C,Frangogiannis NG
11-5773 was used in Flow cytometry/Cell sorting to suggest that CCR5-mediated Treg recruitment may restrain postinfarction inflammation, preventing excessive matrix degradation and attenuating adverse remodeling.
Sat May 01 00:00:00 EDT 2010
Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Phares TW,Stohlman SA,Hinton DR,Atkinson R,Bergmann CC
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that B7-H1-mediated protection from viral-induced immune pathology associated with encephalomyelitis resides in limiting T cell-mediated axonal bystander damage.
Mon Nov 01 00:00:00 EDT 2010
IL-17- and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Esposito M,Ruffini F,Bergami A,Garzetti L,Borsellino G,Battistini L,Martino G,Furlan R
11-5773 was used in Flow cytometry/Cell sorting to show unprecedented plasticity in naive CD4(+) T cells and that integrating inflammatory signals may change their lineage commitment.
Wed Dec 15 00:00:00 EST 2010
Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy.
Journal of immunology (Baltimore, Md. : 1950)
Rolla S,Ria F,Occhipinti S,Di Sante G,Iezzi M,Spadaro M,Nicolò C,Ambrosino E,Merighi IF,Musiani P,Forni G,Cavallo F
11-5773 was used in Flow cytometry/Cell sorting to assess the therapeutic efficacy of a combination anti-rErbb2 vaccine treatment for blocking tumour progression.
Tue Jun 01 00:00:00 EDT 2010
Interplay between CD45RA+ regulatory T cells and TNF-alpha in the regulation of human Th17 differentiation.
International immunology
Baba N,Rubio M,Sarfati M
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD45RA1+ regulatory T-cells positively govern human Th17 development, which is impaired by TNF-α.
Thu Apr 01 00:00:00 EDT 2010
Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.
Infection and immunity
Correia A,Lermann U,Teixeira L,Cerca F,Botelho S,da Costa RM,Sampaio P,Gärtner F,Morschhäuser J,Vilanova M,Pais C
11-5773 was used in Flow cytometry/Cell sorting to investigate the role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence in a murine model of hematogenously disseminated candidiasis.
Mon Nov 01 00:00:00 EDT 2010
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 EST 2010
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
PloS one
Rynda A,Maddaloni M,Ochoa-Repáraz J,Callis G,Pascual DW
11-5773 was used in Flow cytometry/Cell sorting to demonstrate the potential for IL-28 as an alternative therapy for EAE.
Thu Jan 14 00:00:00 EST 2010
Chemoimmunotherapy reduces the progression of multiple myeloma in a mouse model.
Cancer prevention research (Philadelphia, Pa.)
Sharabi A,Laronne-Bar-On A,Meshorer A,Haran-Ghera N
11-5773 was used in Flow cytometry/Cell sorting to determine the effects, and their modes of action, of CYC treatment on MM progression.
Fri Oct 01 00:00:00 EDT 2010
Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition.
The Journal of biological chemistry
Graham JA,Fray M,de Haseth S,Lee KM,Lian MM,Chase CM,Madsen JC,Markmann J,Benichou G,Colvin RB,Cosimi AB,Deng S,Kim J,Alessandrini A
11-5773 was used in Flow cytometry/Cell sorting to study the affect of glycogen synthase kinase 3β inhibition on Treg cell activity for immune tolerance applications.
Fri Oct 22 00:00:00 EDT 2010
Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
PloS one
Melzi R,Antonioli B,Mercalli A,Battaglia M,Valle A,Pluchino S,Galli R,Sordi V,Bosi E,Martino G,Bonifacio E,Doglioni C,Piemonti L
11-5773 was used in Flow cytometry/Cell sorting to define whether neural stem/precursor cells administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model.
Tue Apr 27 00:00:00 EDT 2010
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
Immunity
Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD
11-5773 was used in Flow cytometry/Cell sorting to suggest that mTOR kinase signaling regulates decisions between effector and regulatory T cell lineage commitment.
Fri Jun 19 00:00:00 EDT 2009
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood
Peng B,Ye P,Rawlings DJ,Ochs HD,Miao CH
11-5773 was used in Flow cytometry/Cell sorting to study how anti-CD3 can reduce the titers of preexisting anti-FVIII inhibitory antibodies in hemophilia A mice.
Thu Nov 12 00:00:00 EST 2009
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.
The Journal of clinical investigation
Bending D,De la Peña H,Veldhoen M,Phillips JM,Uyttenhove C,Stockinger B,Cooke A
11-5773 was used in Flow cytometry/Cell sorting to show that purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice, secrete IFN-γ and induce diabetes.
Sun Mar 01 00:00:00 EST 2009
Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.
The Journal of experimental medicine
Fallarino F,Luca G,Calvitti M,Mancuso F,Nastruzzi C,Fioretti MC,Grohmann U,Becchetti E,Burgevin A,Kratzer R,van Endert P,Boon L,Puccetti P,Calafiore R
11-5773 was used in Flow cytometry/Cell sorting to report that neonatal porcine sertoli cell administration led to diabetes prevention and reversion in overtly diabetic NOD mice.
Mon Oct 26 00:00:00 EDT 2009
CD1d-based combination therapy eradicates established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Teng MW,Sharkey J,McLaughlin NM,Exley MA,Smyth MJ
11-5773 was used in Flow cytometry/Cell sorting to test an approach to directly activate/mature antigen presenting cells using anti-CD1d mAbs for the treatment of cancer.
Sat Aug 01 00:00:00 EDT 2009
Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction.
Journal of immunology (Baltimore, Md. : 1950)
Forward NA,Furlong SJ,Yang Y,Lin TJ,Hoskin DW
11-5773 was used in Flow cytometry/Cell sorting to study the effect of activated bone marrow-derived mast cells on CD4(+)CD25(+) T(reg) cells activity.
Tue Sep 01 00:00:00 EDT 2009
A continuous infusion of a minor histocompatibility antigen-immunodominant peptide induces a delay of male skin graft rejection.
Immunobiology
Sireci G,Barera A,Macaluso P,Di Sano C,Bonanno CT,Pio La Manna M,Di Liberto D,Dieli F,Salerno A
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that continuous infusion of immunodominant HY peptides induces a T-CD8 suppressor subset that inhibits immune responses to male tissues and cells.
Tue Oct 13 00:00:00 EDT 2009
Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
PloS one
Scalapino KJ,Daikh DI
11-5773 was used in Flow cytometry/Cell sorting to investigate the suppression of glomerulonephritis by adoptive transfer of ex-vivo expanded regulatory T cells.
Wed Jun 24 00:00:00 EDT 2009
In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice.
PloS one
Arazi A,Sharabi A,Zinger H,Mozes E,Neumann AU
11-5773 was used in Immunofluorescence to study the interactions between CD4, CD8 Tregs and effector T cells and the effect on regulatory function.
Thu Dec 24 00:00:00 EST 2009
Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis.
PloS one
Poffenberger MC,Straka N,El Warry N,Fang D,Shanina I,Horwitz MS
11-5773 was used in Flow cytometry/Cell sorting to investigate the mechanism by which coxsackievirus infection leads to chronic autoimmune pathology, showing that lack of IL-6 heightens the early immune response.
Thu Jul 09 00:00:00 EDT 2009
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease.
Nature immunology
Hadeiba H,Sato T,Habtezion A,Oderup C,Pan J,Butcher EC
11-5773 was used in Flow cytometry/Cell sorting to identify a highly immunosuppressive population of pDCs present in lymphoid tissues.
Sat Nov 01 00:00:00 EDT 2008
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood
Peng B,Ye P,Blazar BR,Freeman GJ,Rawlings DJ,Ochs HD,Miao CH
11-5773 was used in Flow cytometry/Cell sorting to study the formation of inhibitory antibodies during treatment of hemophilia, showing that transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII.
Mon Sep 01 00:00:00 EDT 2008
Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production.
The Journal of experimental medicine
Jain R,Tartar DM,Gregg RK,Divekar RD,Bell JJ,Lee HH,Yu P,Ellis JS,Hoeman CM,Franklin CL,Zaghouani H
11-5773 was used in Flow cytometry/Cell sorting to show that IFNgamma induced by an adjuvant free antigen restores normoglycemia by suppressing pathogenic IL-17 producing cells.
Mon Jan 21 00:00:00 EST 2008
Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.
Journal of autoimmunity
Hondowicz BD,Fields ML,Nish SA,Larkin J,Caton AJ,Erikson J
11-5773 was used in Flow cytometry/Cell sorting to show that Treg cells block lpr/lpr gld/gld Th cells from providing help to anti-chromatin B cells in an in vivo transfer system.
Mon Sep 01 00:00:00 EDT 2008
Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma.
World journal of gastroenterology
Chen YL,Fang JH,Lai MD,Shan YS
11-5773 was used in Flow Cytometry to elucidate the distribution of CD4(+)CD25(+) regulatory T cells in different lymphoid tissues and its local enhancement on tumour growth before and after depletion of CD4(+)CD25(+) Tregs.
Tue Oct 14 00:00:00 EDT 2008
Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model.
International archives of allergy and immunology
Carson WF,Guernsey LA,Singh A,Vella AT,Schramm CM,Thrall RS
11-5773 was used in Flow cytometry/Cell sorting to indicate that regulatory lymphocytes are increased and sustained in local lung compartments at LIT, their appearance correlates with the resolution of lung inflammation.
Tue Mar 18 00:00:00 EDT 2008
Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells.
Veterinary immunology and immunopathology
Lankford S,Petty C,LaVoy A,Reckling S,Tompkins W,Dean GA
11-5773 was used in Flow cytometry/Cell sorting to clone and sequence feline FOXP3 for the purpose of developing assays to enhance studies of feline Treg.
Sat Mar 15 00:00:00 EDT 2008
Detection of Foxp3 protein expression in porcine T lymphocytes.
Veterinary immunology and immunopathology
Käser T,Gerner W,Hammer SE,Patzl M,Saalmüller A
Mon Sep 15 00:00:00 EDT 2008
Detection of Foxp3 protein expression in porcine T lymphocytes.
Veterinary immunology and immunopathology
Käser T,Gerner W,Hammer SE,Patzl M,Saalmüller A
Mon Sep 15 00:00:00 EDT 2008
Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells.
International journal of biomedical science : IJBS
Tao X,Ma J,Zhang Y,Yu J,Cai L,Wang J,Zheng SG
11-5773 was used in Flow cytometry/Cell sorting to determine cytokine factors that can affect the ability of TGF-β to induce Foxp3 expression.
Sat Mar 01 00:00:00 EST 2008
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator.
Arthritis and rheumatism
Oya Y,Watanabe N,Owada T,Oki M,Hirose K,Suto A,Kagami S,Nakajima H,Kishimoto T,Iwamoto I,Murphy TL,Murphy KM,Saito Y
11-5773 was used in Flow cytometry/Cell sorting to suggest that BTLA plays an important role in the maintenance of immune tolerance and the prevention of autoimmune diseases.
Fri Aug 01 00:00:00 EDT 2008
Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology
Mor A,Planer D,Luboshits G,Afek A,Metzger S,Chajek-Shaul T,Keren G,George J
11-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD4+CD25+ Tregs may be protective in atherosclerosis progression and could be considered a therapeutic tool.
Sun Apr 01 00:00:00 EDT 2007
Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice.
Journal of leukocyte biology
Zhao L,Sun L,Wang H,Ma H,Liu G,Zhao Y
11-5773 was used in Flow cytometry/Cell sorting to investigate the levels, phenotypes, and function of CD4(+)CD25(+) regulatory T cells in Balb/c mice, which are older than 20 months.
Fri Jun 01 00:00:00 EDT 2007
Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer.
Veterinary immunology and immunopathology
Biller BJ,Elmslie RE,Burnett RC,Avery AC,Dow SW
Thu Mar 15 00:00:00 EDT 2007
Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer.
Veterinary immunology and immunopathology
Biller BJ,Elmslie RE,Burnett RC,Avery AC,Dow SW
Thu Mar 15 00:00:00 EDT 2007
Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.
Cancer research
Ambrosino E,Spadaro M,Iezzi M,Curcio C,Forni G,Musiani P,Wei WZ,Cavallo F
11-5773 was used in Flow cytometry/Cell sorting to investigate role of CD4(+)CD25(+)Foxp3(+) Tregs in overcoming immunosurveillance of Erbb2 mammary lesions, showing that immunosurveillance is concealed by a dominant regulatory T-cell self-tolerance.
Tue Aug 01 00:00:00 EDT 2006
