Gibco

Human Pleiotrophin Recombinant Protein, PeproTech®

Product Details

450-15-20UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 8 publications 8 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species

Human

Published species

Bacteria, Chicken, Hamster, Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

Molecular weight

15.4 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.

Nature communications

Arnold ND,Pickworth JA,West LE,Dawson S,Carvalho JA,Casbolt H,Braithwaite AT,Iremonger J,Renshall L,Germaschewski V,McCourt M,Bland-Ward P,Kowash H,Hameed AG,Rothman AMK,Frid MG,Roger Thompson AA,Evans HR,Southwood M,Morrell NW,Crossman DC,Whyte MKB,Stenmark KR,Newman CM,Kiely DG,Francis SE,Lawrie A

Fri Nov 15 00:00:00 EST 2019

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.

Scientific reports

Lampropoulou E,Logoviti I,Koutsioumpa M,Hatziapostolou M,Polytarchou C,Skandalis SS,Hellman U,Fousteris M,Nikolaropoulos S,Choleva E,Lamprou M,Skoura A,Megalooikonomou V,Papadimitriou E

Thu Apr 12 00:00:00 EDT 2018

Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.

The Journal of biological chemistry

Koutsioumpa M,Polytarchou C,Courty J,Zhang Y,Kieffer N,Mikelis C,Skandalis SS,Hellman U,Iliopoulos D,Papadimitriou E

Fri Jan 04 00:00:00 EST 2013

Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.

The Journal of biological chemistry

Koutsioumpa M,Polytarchou C,Courty J,Zhang Y,Kieffer N,Mikelis C,Skandalis SS,Hellman U,Iliopoulos D,Papadimitriou E

Fri Jan 04 00:00:00 EST 2013

Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolin.

Vascular cell

Koutsioumpa M,Drosou G,Mikelis C,Theochari K,Vourtsis D,Katsoris P,Giannopoulou E,Courty J,Petrou C,Magafa V,Cordopatis P,Papadimitriou E

Fri Mar 16 00:00:00 EDT 2012

Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia.

The Prostate

Orr B,Vanpoucke G,Grace OC,Smith L,Anderson RA,Riddick AC,Franco OE,Hayward SW,Thomson AA

Tue Feb 15 00:00:00 EST 2011

Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.

The Journal of biological chemistry

Svensson SL,Pasupuleti M,Walse B,Malmsten M,Mörgelin M,Sjögren C,Olin AI,Collin M,Schmidtchen A,Palmer R,Egesten A

Fri May 21 00:00:00 EDT 2010

Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal.

Stem cells (Dayton, Ohio)

Mayshar Y,Rom E,Chumakov I,Kronman A,Yayon A,Benvenisty N

Sat Mar 01 00:00:00 EST 2008

The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity.

The Journal of biological chemistry

Li J,Wei H,Chesley A,Moon C,Krawczyk M,Volkova M,Ziman B,Margulies KB,Talan M,Crow MT,Boheler KR

Fri Nov 30 00:00:00 EST 2007

Pleiotrophin/Osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Tare RS,Oreffo RO,Clarke NM,Roach HI

Fri Nov 01 00:00:00 EST 2002

Bioinformatics

Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory protein; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; OSF-1; Osteoblast-specific factor 1; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); PTN

View more View less

Gene Aliases: HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF-1; PTN

Human Pleiotrophin Recombinant Protein, PeproTech®

Product Details

450-15-20UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

We're here to help

Your items have has been added!