Product References
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
Genome biology
Lu P,Yang J,Li M,Wen S,Zhang T,Yan C,Liu R,Xiao Y,Wang X,Jiang W
100-19 was used in In vitro experiments to suggest that desert lncRNA HIDEN facilitates the interaction between IMP1 and FZD5 mRNA, stabilizing FZD5 mRNA which activates WNT signaling and promotes human definitive endoderm differentiation.
Mon Apr 24 00:00:00 EDT 2023
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment.
Stem cell reports
Rudraraju R,Gartner MJ,Neil JA,Stout ES,Chen J,Needham EJ,See M,Mackenzie-Kludas C,Yang Lee LY,Wang M,Pointer H,Karavendzas K,Abu-Bonsrah D,Drew D,Yang Sun YB,Tan JP,Sun G,Salavaty A,Charitakis N,Nim HT,Currie PD,Tham WH,Porrello E,Polo JM,Humphrey SJ,Ramialison M,Elliott DA,Subbarao K
100-19 was used in Cell Culture to provide new insights into rational drug combinations for effective treatment of a virus that affects multiple organ systems.
Tue Jun 13 00:00:00 EDT 2023
Influence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Chun YY,Tan KS,Yu L,Pang M,Wong MHM,Nakamoto R,Chua WZ,Huee-Ping Wong A,Lew ZZR,Ong HH,Chow VT,Tran T,Yun Wang D,Sham LT
100-19 was used in Cell Culture to reveal glycomotifs of surface polysaccharides that are likely to be important for colonization and survival in the human airway.
Tue Mar 28 00:00:00 EDT 2023
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage.
Cell research
Cao S,Feng H,Yi H,Pan M,Lin L,Zhang YS,Feng Z,Liang W,Cai B,Li Q,Xiong Z,Shen Q,Ke M,Zhao X,Chen H,He Q,Min M,Cai Q,Liu H,Wang J,Pei D,Chen J,Ma Y
100-19 was used in In vitro experiments to elucidate the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development.
Thu Jun 01 00:00:00 EDT 2023
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
The EMBO journal
Sun D,Llora Batlle O,van den Ameele J,Thomas JC,He P,Lim K,Tang W,Xu C,Meyer KB,Teichmann SA,Marioni JC,Jackson SP,Brand AH,Rawlins EL
100-19 was used in Cell Culture to establish a new workflow for using primary human organoids to elucidate detailed functional mechanisms underlying normal development and disease.
Wed Nov 02 00:00:00 EDT 2022
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection.
Nature communications
Yang N,Luna JM,Dai P,Wang Y,Rice CM,Deng L
100-19 was used in Cell Culture to provide insights into how innate immune sensing of viral infection by lung AECIIs influences the activation and differentiation of CCR2+ inflammatory monocytes to defend against pulmonary poxvirus infection.
Tue Mar 29 00:00:00 EDT 2022
Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus.
Frontiers in cellular and infection microbiology
Ekanger CT,Zhou F,Bohan D,Lotsberg ML,Ramnefjell M,Hoareau L,Røsland GV,Lu N,Aanerud M,Gärtner F,Salminen PR,Bentsen M,Halvorsen T,Ræder H,Akslen LA,Langeland N,Cox R,Maury W,Stuhr LEB,Lorens JB,Engelsen AST
100-19 was used in Immunohistochemistry to investigate virulent affects of SARS-CoV-2 mutations on organoid models.
Tue Apr 05 00:00:00 EDT 2022
FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.
Molecular oncology
Milton CI,Selfe J,Aladowicz E,Man SYK,Bernauer C,Missiaglia E,Walters ZS,Gatz SA,Kelsey A,Generali M,Box G,Valenti M,de Haven-Brandon A,Galiwango D,Hayes A,Clarke M,Izquierdo E,Gonzalez De Castro D,Raynaud FI,Kirkin V,Shipley JM
100-19 was used in Cell Culture to investigate the effects of Fibroblast growth factor receptor inhibitors to rhabdomyosarcoma progression.
Tue Mar 01 00:00:00 EST 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
100-19 was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 EDT 2022
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.
Current protocols
Ngan SY,Quach HT,Laselva O,Huang EN,Mangos M,Xia S,Bear CE,Wong AP
Sat Jan 01 00:00:00 EST 2022
Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Cell
Chaturvedi S,Vasen G,Pablo M,Chen X,Beutler N,Kumar A,Tanner E,Illouz S,Rahgoshay D,Burnett J,Holguin L,Chen PY,Ndjamen B,Ott M,Rodick R,Rogers T,Smith DM,Weinberger LS
100-19 was used in Cell Culture to provide proof of concept for a class of single-administration antivirals that may circumvent current requirements to continually update medical countermeasures against new variants.
Thu Dec 09 00:00:00 EST 2021
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 EST 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 EDT 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 EDT 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
100-19 was used in Cell Culture to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 EDT 2021
Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.
Biomaterials
Ikeo S,Yamamoto Y,Ikeda K,Sone N,Korogi Y,Tomiyama L,Matsumoto H,Hirai T,Hagiwara M,Gotoh S
100-19 was used in Cell Culture to establish an expansion system of hLPs based on their three-dimensional culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II (AT2) cells.
Wed Sep 01 00:00:00 EDT 2021
Modelling of primary ciliary dyskinesia using patient-derived airway organoids.
EMBO reports
van der Vaart J,Böttinger L,Geurts MH,van de Wetering WJ,Knoops K,Sachs N,Begthel H,Korving J,Lopez-Iglesias C,Peters PJ,Eitan K,Gileles-Hillel A,Clevers H
Mon Dec 06 00:00:00 EST 2021
Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.
Stem cells (Dayton, Ohio)
Kanagaki S,Ikeo S,Suezawa T,Yamamoto Y,Seki M,Hirai T,Hagiwara M,Suzuki Y,Gotoh S
Mon Feb 01 00:00:00 EST 2021
Transplantation of human corneal limbal epithelial cell sheet harvested on synthesized carboxymethyl cellulose and dopamine in a limbal stem cell deficiency.
Journal of tissue engineering and regenerative medicine
Lee H,Lee JH,Hong S,Sunwoo JH,Kim HT,Kim ES,Kim JY,Hwang C,Tchah H
100-19 was used in Cell Culture to evaluate the efficacy and safety of transplantation with human corneal limbal epithelial (HCLE) cell sheets cultured on carboxymethyl cellulose (CMC)-dopamine (DA)-coated substrates and harvested via enzymatic digestion of CMC with cellulase in a rabbit animal model of limbal stem cell deficiency (LSCD).
Mon Feb 01 00:00:00 EST 2021
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Cell reports
Ghosh S,Nataraj NB,Noronha A,Patkar S,Sekar A,Mukherjee S,Winograd-Katz S,Kramarski L,Verma A,Lindzen M,Garcia DD,Green J,Eisenberg G,Gil-Henn H,Basu A,Lender Y,Weiss S,Oren M,Lotem M,Geiger B,Ruppin E,Yarden Y
Tue May 25 00:00:00 EDT 2021
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple-Negative Breast Cancer Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Y,Zhou Y,Ma X,Chen L
Mon Feb 01 00:00:00 EST 2021
Protocol for generation of lung adenocarcinoma organoids from clinical samples.
STAR protocols
Li Z,Yu L,Chen D,Meng Z,Chen W,Huang W
Fri Mar 19 00:00:00 EDT 2021
Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model.
Cell reports
Sharma K,Thacker VV,Dhar N,Clapés Cabrer M,Dubois A,Signorino-Gelo F,Mullenders J,Knott GW,Clevers H,McKinney JD
Tue Jul 20 00:00:00 EDT 2021
Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.
STAR protocols
Breunig M,Merkle J,Melzer MK,Heller S,Seufferlein T,Meier M,Hohwieler M,Kleger A
100-19 was used in In vitro experiments to describe a scalable in vitro differentiation protocol to guide human pluripotent stem cells stepwise into pancreatic duct-like organoids.
Fri Dec 17 00:00:00 EST 2021
Angiopoietins stimulate pancreatic islet development from stem cells.
Scientific reports
Karanth SS,Sun S,Bi H,Ye K,Jin S
Wed Jun 30 00:00:00 EDT 2021
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells.
Nature communications
Liu H,Li R,Liao HK,Min Z,Wang C,Yu Y,Shi L,Dan J,Hayek A,Martinez Martinez L,Nuñez Delicado E,Izpisua Belmonte JC
Mon Jun 07 00:00:00 EDT 2021
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Life (Basel, Switzerland)
Liu LM,Tang Q,Hu X,Zhao JJ,Zhang Y,Ying GG,Zhang F
100-19 was used in Cell Culture to show that p53 function is regulated by PRMT1 in breast cancer cells.
Thu Aug 05 00:00:00 EDT 2021
Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells.
Metabolic engineering
Haellman V,Saxena P,Jiang Y,Fussenegger M
100-19 was used in In vitro experiments to show that the VanA system can be multiplexed with the well-established reverse tetracycline-controlled transcriptional activator (rtTA) system to enable independent control of the expression of different transcription factors in human induced PSCs in order to enhance lineage specification towards early pancreatic progenitors.
Sat May 01 00:00:00 EDT 2021
Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor.
Scientific reports
Fattahi P,Rahimian A,Slama MQ,Gwon K,Gonzalez-Suarez AM,Wolf J,Baskaran H,Duffy CD,Stybayeva G,Peterson QP,Revzin A
Tue Mar 30 00:00:00 EDT 2021
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion.
Nature communications
Gonçalves CA,Larsen M,Jung S,Stratmann J,Nakamura A,Leuschner M,Hersemann L,Keshara R,Perlman S,Lundvall L,Thuesen LL,Hare KJ,Amit I,Jørgensen A,Kim YH,Del Sol A,Grapin-Botton A
Tue May 25 00:00:00 EDT 2021
Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19.
bioRxiv : the preprint server for biology
Tindle C,Fuller M,Fonseca A,Taheri S,Ibeawuchi SR,Beutler N,Katkar G,Claire A,Castillo V,Hernandez M,Russo H,Duran J,Crotty Alexander LE,Tipps A,Lin G,Thistlethwaite PA,Chattopadhyay R,Rogers TF,Sahoo D,Ghosh P,Das S
Wed May 05 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
100-19 was used in In vitro experiments to establish an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
Tue Jun 08 00:00:00 EDT 2021
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.
Cell reports
Busslinger GA,Weusten BLA,Bogte A,Begthel H,Brosens LAA,Clevers H
Tue Mar 09 00:00:00 EST 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
Mon Aug 10 00:00:00 EDT 2020
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Cell stem cell
Yang L,Han Y,Nilsson-Payant BE,Gupta V,Wang P,Duan X,Tang X,Zhu J,Zhao Z,Jaffré F,Zhang T,Kim TW,Harschnitz O,Redmond D,Houghton S,Liu C,Naji A,Ciceri G,Guttikonda S,Bram Y,Nguyen DT,Cioffi M,Chandar V,Hoagland DA,Huang Y,Xiang J,Wang H,Lyden D,Borczuk A,Chen HJ,Studer L,Pan FC,Ho DD,tenOever BR,Evans T,Schwartz RE,Chen S
100-19 was used in Sample Prep to study SARS-CoV-2 infection using human disease-relevant cells using an experimental platform comprised of cell and organoid derivatives from human pluripotent stem cells.
Thu Jul 02 00:00:00 EDT 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
Thu Dec 03 00:00:00 EST 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
Thu Dec 03 00:00:00 EST 2020
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
The EMBO journal
Cinque L,De Leonibus C,Iavazzo M,Krahmer N,Intartaglia D,Salierno FG,De Cegli R,Di Malta C,Svelto M,Lanzara C,Maddaluno M,Wanderlingh LG,Huebner AK,Cesana M,Bonn F,Polishchuk E,Hübner CA,Conte I,Dikic I,Mann M,Ballabio A,Sacco F,Grumati P,Settembre C
Tue Sep 01 00:00:00 EDT 2020
Conjunctival reconstruction via enrichment of human conjunctival epithelial stem cells by p75 through the NGF-p75-SALL2 signaling axis.
Stem cells translational medicine
Wu N,Yan C,Chen J,Yao Q,Lu Y,Yu F,Sun H,Fu Y
Sun Nov 01 00:00:00 EDT 2020
Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene.
Hepatology communications
Abbey D,Elwyn S,Hand NJ,Musunuru K,Rader DJ
Tue Sep 01 00:00:00 EDT 2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Nature communications
Chang KC,Diermeier SD,Yu AT,Brine LD,Russo S,Bhatia S,Alsudani H,Kostroff K,Bhuiya T,Brogi E,Pappin DJ,Bennett CF,Rigo F,Spector DL
Tue Dec 22 00:00:00 EST 2020
microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2.
Cell death & disease
Li N,Jiang D,He Q,He F,Li Y,Deng C,Li F
Mon Jun 15 00:00:00 EDT 2020
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Cell stem cell
Geurts MH,de Poel E,Amatngalim GD,Oka R,Meijers FM,Kruisselbrink E,van Mourik P,Berkers G,de Winter-de Groot KM,Michel S,Muilwijk D,Aalbers BL,Mullenders J,Boj SF,Suen SWF,Brunsveld JE,Janssens HM,Mall MA,Graeber SY,van Boxtel R,van der Ent CK,Beekman JM,Clevers H
Thu Apr 02 00:00:00 EDT 2020
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation.
Stem cell reports
Yang J,Lu P,Li M,Yan C,Zhang T,Jiang W
Tue Sep 08 00:00:00 EDT 2020
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America
Mullenders J,de Jongh E,Brousali A,Roosen M,Blom JPA,Begthel H,Korving J,Jonges T,Kranenburg O,Meijer R,Clevers HC
Tue Mar 05 00:00:00 EST 2019
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America
Mullenders J,de Jongh E,Brousali A,Roosen M,Blom JPA,Begthel H,Korving J,Jonges T,Kranenburg O,Meijer R,Clevers HC
Tue Mar 05 00:00:00 EST 2019
Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability.
Stem cells international
Bjørlykke Y,Søviknes AM,Hoareau L,Vethe H,Mathisen AF,Chera S,Vaudel M,Ghila LM,Ræder H
100-19 was used in Sample Preparation (FC/FACS) to analyze and compare the proteome landscape of 20 reprogrammed cell lines classified as stable colony morphologies to find different defined patterns of colony morphology in reprogrammed cells which were associated with distinct proteomic profiles and different outcomes in differentiation capacity.
Thu Oct 01 00:00:00 EDT 2020
Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells.
Scientific reports
Konagaya S,Iwata H
Thu Jan 24 00:00:00 EST 2019
Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant.
Scientific reports
Ito K,Matsuura K,Mihara Y,Sakamoto Y,Hasegawa K,Kokudo N,Shimizu T
Thu Apr 11 00:00:00 EDT 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
NPJ Regenerative medicine
Weiner AI,Jackson SR,Zhao G,Quansah KK,Farshchian JN,Neupauer KM,Littauer EQ,Paris AJ,Liberti DC,Scott Worthen G,Morrisey EE,Vaughan AE
Tue Sep 29 00:00:00 EDT 2020
YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.
Nature communications
Rosado-Olivieri EA,Anderson K,Kenty JH,Melton DA
Mon Apr 01 00:00:00 EDT 2019
KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.
The Journal of biological chemistry
Peng Y,Wu S,Tang Q,Li S,Peng C
Fri May 24 00:00:00 EDT 2019
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
Thu Feb 08 00:00:00 EST 2018
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 EST 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis.
Cell death & disease
Kim KK,Dotson MR,Agarwal M,Yang J,Bradley PB,Subbotina N,Osterholzer JJ,Sisson TH
Wed Oct 17 00:00:00 EDT 2018
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Nature communications
Scavuzzo MA,Hill MC,Chmielowiec J,Yang D,Teaw J,Sheng K,Kong Y,Bettini M,Zong C,Martin JF,Borowiak M
Wed Aug 22 00:00:00 EDT 2018
Discovery of a drug candidate for GLIS3-associated diabetes.
Nature communications
Amin S,Cook B,Zhou T,Ghazizadeh Z,Lis R,Zhang T,Khalaj M,Crespo M,Perera M,Xiang JZ,Zhu Z,Tomishima M,Liu C,Naji A,Evans T,Huangfu D,Chen S
Wed Jul 11 00:00:00 EDT 2018
Generation of orthotopically functional salivary gland from embryonic stem cells.
Nature communications
Tanaka J,Ogawa M,Hojo H,Kawashima Y,Mabuchi Y,Hata K,Nakamura S,Yasuhara R,Takamatsu K,Irié T,Fukada T,Sakai T,Inoue T,Nishimura R,Ohara O,Saito I,Ohba S,Tsuji T,Mishima K
Thu Oct 11 00:00:00 EDT 2018
Stem cells in middle ear cholesteatoma contribute to its pathogenesis.
Scientific reports
Nagel J,Wöllner S,Schürmann M,Brotzmann V,Müller J,Greiner JF,Goon P,Kaltschmidt B,Kaltschmidt C,Sudhoff H
Wed Apr 18 00:00:00 EDT 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-19 was used in In vitro experiments to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 EST 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
Lineage dynamics of murine pancreatic development at single-cell resolution.
Nature communications
Byrnes LE,Wong DM,Subramaniam M,Meyer NP,Gilchrist CL,Knox SM,Tward AD,Ye CJ,Sneddon JB
Tue Sep 25 00:00:00 EDT 2018
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Nature medicine
Crespo M,Vilar E,Tsai SY,Chang K,Amin S,Srinivasan T,Zhang T,Pipalia NH,Chen HJ,Witherspoon M,Gordillo M,Xiang JZ,Maxfield FR,Lipkin S,Evans T,Chen S
Sat Jul 01 00:00:00 EDT 2017
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.
Cancer cell
Justilien V,Ali SA,Jamieson L,Yin N,Cox AD,Der CJ,Murray NR,Fields AP
Mon Feb 13 00:00:00 EST 2017
FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1.
International journal of oncology
Huang T,Wang L,Liu D,Li P,Xiong H,Zhuang L,Sun L,Yuan X,Qiu H
Mon May 01 00:00:00 EDT 2017
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.
eLife
Nikolić MZ,Caritg O,Jeng Q,Johnson JA,Sun D,Howell KJ,Brady JL,Laresgoiti U,Allen G,Butler R,Zilbauer M,Giangreco A,Rawlins EL
100-19 was used in Tissue/organ culture to investigate human pluripotent stem cell differentiation to lung epithelium.
Fri Jun 30 00:00:00 EDT 2017
In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.
Stem cell reports
Yuri S,Nishikawa M,Yanagawa N,Jo OD,Yanagawa N
Tue Feb 14 00:00:00 EST 2017
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.
Nature communications
Ghazizadeh Z,Kao DI,Amin S,Cook B,Rao S,Zhou T,Zhang T,Xiang Z,Kenyon R,Kaymakcalan O,Liu C,Evans T,Chen S
Mon Aug 21 00:00:00 EDT 2017
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Molecular therapy. Nucleic acids
Lee PC,Truong B,Vega-Crespo A,Gilmore WB,Hermann K,Angarita SA,Tang JK,Chang KM,Wininger AE,Lam AK,Schoenberg BE,Cederbaum SD,Pyle AD,Byrne JA,Lipshutz GS
Tue Nov 29 00:00:00 EST 2016
Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases.
Scientific reports
Yang D,Scavuzzo MA,Chmielowiec J,Sharp R,Bajic A,Borowiak M
Thu Feb 18 00:00:00 EST 2016
FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma.
Oncotarget
Qi L,Song W,Li L,Cao L,Yu Y,Song C,Wang Y,Zhang F,Li Y,Zhang B,Cao W
Tue Nov 08 00:00:00 EST 2016
A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.
The Journal of cell biology
Chetty S,Engquist EN,Mehanna E,Lui KO,Tsankov AM,Melton DA
Mon Sep 28 00:00:00 EDT 2015
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer.
Oncotarget
Chang J,Wang S,Zhang Z,Liu X,Wu Z,Geng R,Ge X,Dai C,Liu R,Zhang Q,Li W,Li J
Tue Feb 10 00:00:00 EST 2015
Differentiated human stem cells resemble fetal, not adult, β cells.
Proceedings of the National Academy of Sciences of the United States of America
Hrvatin S,O'Donnell CW,Deng F,Millman JR,Pagliuca FW,DiIorio P,Rezania A,Gifford DK,Melton DA
Tue Feb 25 00:00:00 EST 2014
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.
PloS one
Robbez-Masson LJ,Bödör C,Jones JL,Hurst HC,Fitzgibbon J,Hart IR,Grose RP
Fri Jul 25 00:00:00 EDT 2014
Mutant surfactant A2 proteins associated with familial pulmonary fibrosis and lung cancer induce TGF-β1 secretion.
Proceedings of the National Academy of Sciences of the United States of America
Maitra M,Cano CA,Garcia CK
Tue Dec 18 00:00:00 EST 2012
Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis.
The Journal of biological chemistry
Ulsamer A,Wei Y,Kim KK,Tan K,Wheeler S,Xi Y,Thies RS,Chapman HA
Fri Feb 10 00:00:00 EST 2012
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
PloS one
Jarosz M,Robbez-Masson L,Chioni AM,Cross B,Rosewell I,Grose R
Fri Dec 14 00:00:00 EST 2012
A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1.
PloS one
Huang Z,Zhu G,Sun C,Zhang J,Zhang Y,Zhang Y,Ye C,Wang X,Ilghari D,Li X
Mon Sep 10 00:00:00 EDT 2012
Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
PloS one
Herencia C,Martínez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almadén Y,de la Mata M,Rodríguez-Ariza A,Muñoz-Castañeda JR
Wed Oct 17 00:00:00 EDT 2012
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Jiang W,Sui X,Zhang D,Liu M,Ding M,Shi Y,Deng H
Fri Apr 01 00:00:00 EDT 2011
Isolation of alveolar epithelial type II progenitor cells from adult human lungs.
Laboratory investigation; a journal of technical methods and pathology
Fujino N,Kubo H,Suzuki T,Ota C,Hegab AE,He M,Suzuki S,Suzuki T,Yamada M,Kondo T,Kato H,Yamaya M
Tue Mar 01 00:00:00 EST 2011
Expression of keratinocyte growth factor and its receptor in rat tracheal cartilage: possible involvement in wound healing of the damaged cartilage.
Acta histochemica et cytochemica
Abo T,Nagayasu T,Hishikawa Y,Tagawa T,Nanashima A,Yamayoshi T,Matsumoto K,An S,Koji T
Mon Jun 28 00:00:00 EDT 2010
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.
PloS one
Ware KE,Marshall ME,Heasley LR,Marek L,Hinz TK,Hercule P,Helfrich BA,Doebele RC,Heasley LE
Mon Nov 29 00:00:00 EST 2010
Fibroblast growth factor-10 promotes cardiomyocyte differentiation from embryonic and induced pluripotent stem cells.
PloS one
Chan SS,Li HJ,Hsueh YC,Lee DS,Chen JH,Hwang SM,Chen CY,Shih E,Hsieh PC
Tue Dec 28 00:00:00 EST 2010
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell research
Song Z,Cai J,Liu Y,Zhao D,Yong J,Duo S,Song X,Guo Y,Zhao Y,Qin H,Yin X,Wu C,Che J,Lu S,Ding M,Deng H
Sun Nov 01 00:00:00 EDT 2009
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
The Journal of clinical investigation
Kim KK,Wei Y,Szekeres C,Kugler MC,Wolters PJ,Hill ML,Frank JA,Brumwell AN,Wheeler SE,Kreidberg JA,Chapman HA
Thu Jan 01 00:00:00 EST 2009
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.
The Journal of cell biology
Chong HC,Tan MJ,Philippe V,Tan SH,Tan CK,Ku CW,Goh YY,Wahli W,Michalik L,Tan NS
Mon Mar 23 00:00:00 EDT 2009
Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis.
The Journal of investigative dermatology
Harper EG,Guo C,Rizzo H,Lillis JV,Kurtz SE,Skorcheva I,Purdy D,Fitch E,Iordanov M,Blauvelt A
Tue Sep 01 00:00:00 EDT 2009
Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Penna G,Fibbi B,Amuchastegui S,Cossetti C,Aquilano F,Laverny G,Gacci M,Crescioli C,Maggi M,Adorini L
Wed Apr 01 00:00:00 EDT 2009
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proceedings of the National Academy of Sciences of the United States of America
Dutt A,Salvesen HB,Chen TH,Ramos AH,Onofrio RC,Hatton C,Nicoletti R,Winckler W,Grewal R,Hanna M,Wyhs N,Ziaugra L,Richter DJ,Trovik J,Engelsen IB,Stefansson IM,Fennell T,Cibulskis K,Zody MC,Akslen LA,Gabriel S,Wong KK,Sellers WR,Meyerson M,Greulich H
Tue Jun 24 00:00:00 EDT 2008
Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis. Recruitment of the epidermal growth factor receptor and activation of MAP kinases.
The Journal of biological chemistry
Farley SM,Purdy DE,Ryabinina OP,Schneider P,Magun BE,Iordanov MS
Fri Jan 11 00:00:00 EST 2008
Both Pdx-1 and NeuroD1 genes are requisite for the maintenance of insulin gene expression in ES-derived differentiated cells.
Diabetes research and clinical practice
Saitoh K,Yamato E,Miyazaki S,Miyazaki J
Sat Sep 01 00:00:00 EDT 2007
Investigating transcriptional regulation of Prdx6 in mouse liver cells.
Free radical biology & medicine
Gallagher BM,Phelan SA
Sun Apr 15 00:00:00 EDT 2007
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Metzger DE,Xu Y,Shannon JM
Tue May 01 00:00:00 EDT 2007
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Metzger DE,Xu Y,Shannon JM
Tue May 01 00:00:00 EDT 2007
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
Proceedings of the National Academy of Sciences of the United States of America
Kim KK,Kugler MC,Wolters PJ,Robillard L,Galvez MG,Brumwell AN,Sheppard D,Chapman HA
Tue Aug 29 00:00:00 EDT 2006
Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis.
The Journal of investigative dermatology
Farley SM,Dotson AD,Purdy DE,Sundholm AJ,Schneider P,Magun BE,Iordanov MS
Wed Nov 01 00:00:00 EST 2006
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.
Development (Cambridge, England)
White AC,Xu J,Yin Y,Smith C,Schmid G,Ornitz DM
Sat Apr 01 00:00:00 EST 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 EDT 2006
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry
McDowell LM,Frazier BA,Studelska DR,Giljum K,Chen J,Liu J,Yu K,Ornitz DM,Zhang L
Fri Mar 17 00:00:00 EST 2006
Hemoglobin is expressed by alveolar epithelial cells.
The Journal of biological chemistry
Newton DA,Rao KM,Dluhy RA,Baatz JE
Fri Mar 03 00:00:00 EST 2006
Hemoglobin is expressed by alveolar epithelial cells.
The Journal of biological chemistry
Newton DA,Rao KM,Dluhy RA,Baatz JE
Fri Mar 03 00:00:00 EST 2006
ERM is required for transcriptional control of the spermatogonial stem cell niche.
Nature
Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Thu Aug 18 00:00:00 EDT 2005
Pulmonary surfactant secretion in briefly cultured mouse type II cells.
American journal of physiology. Lung cellular and molecular physiology
Gobran LI,Rooney SA
Sun Feb 01 00:00:00 EST 2004
Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer.
Laboratory investigation; a journal of technical methods and pathology
Tamaru N,Hishikawa Y,Ejima K,Nagasue N,Inoue S,Muramatsu M,Hayashi T,Koji T
Mon Nov 01 00:00:00 EST 2004
Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice.
The Journal of biological chemistry
Bridges JP,Wert SE,Nogee LM,Weaver TE
Fri Dec 26 00:00:00 EST 2003
BMP4 modulates fibroblast growth factor-mediated induction of proximal and distal lung differentiation in mouse embryonic tracheal epithelium in mesenchyme-free culture.
Developmental dynamics : an official publication of the American Association of Anatomists
Hyatt BA,Shangguan X,Shannon JM
Tue Oct 01 00:00:00 EDT 2002
Induction of bud formation of embryonic mouse tracheal epithelium by fibroblast growth factor plus transferrin in mesenchyme-free culture.
Developmental dynamics : an official publication of the American Association of Anatomists
Ohtsuka N,Urase K,Momoi T,Nogawa H
Mon Oct 01 00:00:00 EDT 2001
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.
Proceedings of the National Academy of Sciences of the United States of America
Murakami S,Kan M,McKeehan WL,de Crombrugghe B
Tue Feb 01 00:00:00 EST 2000
