Invitrogen

TRADD Polyclonal Antibody

TRADD Antibody in Immunocytochemistry (ICC/IF)

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TRADD Antibody (PA5-98439) in ICC/IF

Immunofluorescent analysis of TRADD in U251 cells using a TRADD polyclonal antibody (Product # PA5-98439) at a dilution of 1:100. Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibody was used.

TRADD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

PA5-98439

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:5,000

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

Assay-Dependent

Immunoprecipitation (IP)

1:200-1:2,000

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

RRID

AB_2813052

Target Information

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hs89862; MGC11078; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein

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Gene Aliases: Hs.89862; TRADD

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UniProt ID: (Human) Q15628

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Entrez Gene ID: (Human) 8717, (Rat) 246756

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Function(s)

signal transducer activity tumor necrosis factor receptor binding protein binding kinase binding protein complex binding identical protein binding binding, bridging death domain binding

Process(es)

apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling protein heterooligomerization positive regulation of hair follicle development extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death tumor necrosis factor-mediated signaling pathway positive regulation of apoptotic process positive regulation of NF-kappaB transcription factor activity death-inducing signaling complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRADD Polyclonal Antibody

TRADD Antibody (PA5-98439) in ICC/IF

Product Details

PA5-98439

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

References (0)

Bioinformatics

Performance Guarantee

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