Product References
Cognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type.
Life science alliance
Carús-Cadavieco M,Berenguer López I,Montoro Canelo A,Serrano-Lope MA,González-de la Fuente S,Aguado B,Fernández-Rodrigo A,Saido TC,Frank García A,Venero C,Esteban JA,Guix F,Dotti CG
44-758G was used in Western Blotting to show that T2DM produces more severe behavioral, electrophysiological, and structural alterations in these mice compared with wild-type mice.
Thu Jun 01 00:00:00 EDT 2023
A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet.
Cell & bioscience
Espinosa-Jiménez T,Cano A,Sánchez-López E,Olloquequi J,Folch J,Bulló M,Verdaguer E,Auladell C,Pont C,Muñoz-Torrero D,Parcerisas A,Camins A,Ettcheto M
44-758G was used in Immunohistochemistry (Paraffin), Western Blot to suggest that RHE-HUP could be a new candidate for the treatment of AD, even for individuals with high risk due to peripheral metabolic disturbances, given its multi-target profile which allows for the improvement of some of the most important hallmarks of the disease.
Thu Mar 09 00:00:00 EST 2023
A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease.
Acta neuropathologica
García-Escudero V,Ruiz-Gabarre D,Gargini R,Pérez M,García E,Cuadros R,Hernández IH,Cabrera JR,García-Escudero R,Lucas JJ,Hernández F,Ávila J
44-758G was used in Western Blot to present evidence suggesting this new Tau isoform could be linked to the inhibition of GSK3β, which would mediate intron 12 retention by modulating the serine/arginine rich splicing factor 2 (SRSF2).
Thu Jul 01 00:00:00 EDT 2021
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Brain pathology (Zurich, Switzerland)
Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH
44-758G was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.
Fri Jan 01 00:00:00 EST 2021
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Acta neuropathologica communications
Perez Garcia G,De Gasperi R,Gama Sosa MA,Perez GM,Otero-Pagan A,Pryor D,Abutarboush R,Kawoos U,Hof PR,Dickstein DL,Cook DG,Gandy S,Ahlers ST,Elder GA
44-758G was used in Western Blotting to test the hypothesis that region-specific patterns of Thr181 phosphorylation correlate with behavioral measures also previously determined and reported in the same animals.
Mon Mar 01 00:00:00 EST 2021
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Acta neuropathologica communications
Perez Garcia G,De Gasperi R,Gama Sosa MA,Perez GM,Otero-Pagan A,Pryor D,Abutarboush R,Kawoos U,Hof PR,Dickstein DL,Cook DG,Gandy S,Ahlers ST,Elder GA
44-758G was used in Western Blotting to test the hypothesis that region-specific patterns of Thr181 phosphorylation correlate with behavioral measures also previously determined and reported in the same animals.
Mon Mar 01 00:00:00 EST 2021
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Cell reports
Brigas HC,Ribeiro M,Coelho JE,Gomes R,Gomez-Murcia V,Carvalho K,Faivre E,Costa-Pereira S,Darrigues J,de Almeida AA,Buée L,Dunot J,Marie H,Pousinha PA,Blum D,Silva-Santos B,Lopes LV,Ribot JC
44-758G was used in Western Blot to support the idea that cognition relies on a finely regulated balance of "inflammatory" cytokines derived from the meningeal immune system.
Tue Aug 31 00:00:00 EDT 2021
Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Schueller E,Paiva I,Blanc F,Wang XL,Cassel JC,Boutillier AL,Bousiges O
44-758G was used in Western Blot, Immunohistochemistry to establish changes in the acetylation-associated pathway in two key brain regions affected in AD: the hippocampus and the F2 area of frontal cortex in end-stage AD patients and age-matched controls.
Wed Apr 01 00:00:00 EDT 2020
Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Schueller E,Paiva I,Blanc F,Wang XL,Cassel JC,Boutillier AL,Bousiges O
44-758G was used in Western Blot, Immunohistochemistry to establish changes in the acetylation-associated pathway in two key brain regions affected in AD: the hippocampus and the F2 area of frontal cortex in end-stage AD patients and age-matched controls.
Wed Apr 01 00:00:00 EDT 2020
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Immunohistochemistry
Mon Feb 24 00:00:00 EST 2020
Truncation of Tau selectively facilitates its pathological activities.
The Journal of biological chemistry
Gu J,Xu W,Jin N,Li L,Zhou Y,Chu D,Gong CX,Iqbal K,Liu F
44-758G was used in Western Blotting to suggest that the first 150 aa and the last 50 aa protect Tau from pathological characteristics and that their deletions facilitate pathological activities.
Fri Oct 02 00:00:00 EDT 2020
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
Frontiers in aging neuroscience
Miao J,Shi R,Li L,Chen F,Zhou Y,Tung YC,Hu W,Gong CX,Iqbal K,Liu F
44-758G was used in Western Blotting to speculate that AD P-tau seeds hyperphosphorylated tau to form aggregates, which resist to the dephosphorylation by PP2A, resulting in hyperphosphorylation and pathology of tau.
Thu Oct 01 00:00:00 EDT 2020
High Dietary Iron Disrupts Iron Homeostasis and Induces Amyloid-β and Phospho-τ Expression in the Hippocampus of Adult Wild-Type and APP/PS1 Transgenic Mice.
The Journal of nutrition
Chen M,Zheng J,Liu G,Zeng C,Xu E,Zhu W,Anderson GJ,Chen H
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Sun Dec 01 00:00:00 EST 2019
Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Martín-Maestro P,Gargini R,García E,Simón D,Avila J,García-Escudero V
44-758G was used in Western Blot to understand the contribution of the main proteins involved in Alzheimer's disease such as amyloid-β protein precursor and tau.
Thu Oct 01 00:00:00 EDT 2020
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain.
Acta neuropathologica communications
Ercan-Herbst E,Ehrig J,Schöndorf DC,Behrendt A,Klaus B,Gomez Ramos B,Prat Oriol N,Weber C,Ehrnhoefer DE
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in ELISA
Tue Dec 03 00:00:00 EST 2019
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
EMBO molecular medicine
Chatterjee S,Cassel R,Schneider-Anthony A,Merienne K,Cosquer B,Tzeplaeff L,Halder Sinha S,Kumar M,Chaturbedy P,Eswaramoorthy M,Le Gras S,Keime C,Bousiges O,Dutar P,Petsophonsakul P,Rampon C,Cassel JC,Buée L,Blum D,Kundu TK,Boutillier AL
44-758G was used in Western Blotting to study the use of CSP-TTK21 in the treatment of spatial memory and plasticity deficits in a mouse model of tauopathy.
Thu Nov 01 00:00:00 EDT 2018
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.
Frontiers in aging neuroscience
Zhou Y,Shi J,Chu D,Hu W,Guan Z,Gong CX,Iqbal K,Liu F
44-758G was used in Western Blotting to suggest that tau pathogenesis involves both hyperphosphorylation and dominantly N-terminal truncation of tau in AD.
Sat Apr 09 00:00:00 EDT 2022
Phosphorylation of nuclear Tau is modulated by distinct cellular pathways.
Scientific reports
Ulrich G,Salvadè A,Boersema P,Calì T,Foglieni C,Sola M,Picotti P,Papin S,Paganetti P
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Fri Dec 07 00:00:00 EST 2018
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Journal of neuroinflammation
Huang C,Irwin MG,Wong GTC,Chang RCC
44-758G was used in Western Blotting to characterise the neuroinflammation and cellular changes induced by systemic inflammation, and their responses to anti-inflammatory treatment.
Thu May 17 00:00:00 EDT 2018
Tau deletion promotes brain insulin resistance.
The Journal of experimental medicine
Marciniak E,Leboucher A,Caron E,Ahmed T,Tailleux A,Dumont J,Issad T,Gerhardt E,Pagesy P,Vileno M,Bournonville C,Hamdane M,Bantubungi K,Lancel S,Demeyer D,Eddarkaoui S,Vallez E,Vieau D,Humez S,Faivre E,Grenier-Boley B,Outeiro TF,Staels B,Amouyel P,Balschun D,Buee L,Blum D
44-758G was used in Western Blotting to find that tau deletion leads to an impaired hippocampal response to insulin, caused by altered IRS-1 and PTEN activity.
Mon Aug 07 00:00:00 EDT 2017
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
44758G was used in western blot to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels
Mon May 01 00:00:00 EDT 2017
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Aging cell
Bodea LG,Evans HT,Van der Jeugd A,Ittner LM,Delerue F,Kril J,Halliday G,Hodges J,Kiernan MC,Götz J
44758G was used in western blot to generate and characterize a new mouse model of Alzheimer's disease
Sat Apr 01 00:00:00 EDT 2017
Tau secretion is correlated to an increase of Golgi dynamics.
PloS one
Mohamed NV,Desjardins A,Leclerc N
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Mon Sep 18 00:00:00 EDT 2017
A validated antibody panel for the characterization of tau post-translational modifications.
Molecular neurodegeneration
Ercan E,Eid S,Weber C,Kowalski A,Bichmann M,Behrendt A,Matthes F,Krauss S,Reinhardt P,Fulle S,Ehrnhoefer DE
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Tue Nov 21 00:00:00 EST 2017
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Journal of Alzheimer's disease : JAD
Zimova I,Brezovakova V,Hromadka T,Weisova P,Cubinkova V,Valachova B,Filipcik P,Jadhav S,Smolek T,Novak M,Zilka N
44758G was used in western blot to describe the molecular and behavioral features of R3m/4 transgenic mice expressing human non-mutated truncated tau protein and assess these mice as a model for Alzheimer's disease
Tue Sep 06 00:00:00 EDT 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-758G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 EST 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-758G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 EST 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-758G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 EST 2016
Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.
Proteomics
Dammer EB,Lee AK,Duong DM,Gearing M,Lah JJ,Levey AI,Seyfried NT
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Thu Jan 01 00:00:00 EST 2015
Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.
Proteomics
Dammer EB,Lee AK,Duong DM,Gearing M,Lah JJ,Levey AI,Seyfried NT
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Thu Jan 01 00:00:00 EST 2015
Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation.
Scientific reports
Wang Y,Zhang Y,Hu W,Xie S,Gong CX,Iqbal K,Liu F
44-758G was used in western blot to characterize postmortem behavior and the rapid alteration of protein phosphorylation
Thu Oct 29 00:00:00 EDT 2015
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Tue Oct 13 00:00:00 EDT 2015
Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).
Age (Dordrecht, Netherlands)
Porquet D,Andrés-Benito P,Griñán-Ferré C,Camins A,Ferrer I,Canudas AM,Del Valle J,Pallàs M
44-758G was used in western blot to characterize cognitive and neuropathological Alzheimer's disease markers in a novel mouse model
Sun Feb 01 00:00:00 EST 2015
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
PloS one
Petry FR,Pelletier J,Bretteville A,Morin F,Calon F,Hébert SS,Whittington RA,Planel E
44-758G was used in western blot to study the specificity of a panel of commonly used anti-tau antibodies and issues likely to be encounted in Western blot experiments using material from murine Alzheimer's disease models
Mon Dec 22 00:00:00 EST 2014
MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Absalon S,Kochanek DM,Raghavan V,Krichevsky AM
Published figure using Phospho-Tau (Ser404) polyclonal antibody (Product # 44-758G) in Western Blot
Wed Sep 11 00:00:00 EDT 2013
Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau.
Biochimica et biophysica acta
Yamazaki A,Nishizawa Y,Matsuura I,Hayashi F,Usukura J,Bondarenko VA
44-758G was used in western blot to characterize tau in the rod outer segment of bovine retinal photoreceptors.
Tue Oct 01 00:00:00 EDT 2013
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.
Toxicological sciences : an official journal of the Society of Toxicology
Li G,Cai F,Yan W,Li C,Wang J
Fri Jun 01 00:00:00 EDT 2012
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
