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Cathelicidin Antibody (PA5-76029) in IHC (P)
Product Details
PA5-76029
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
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Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; Cathelin-like protein; cathelin-related antimicrobial peptide; CLP; hCAP-18; hCAP18
Gene Aliases: CAMP; CAP-18; CAP18; Cnlp; CRAMP; FALL-39; FALL39; HSD26; LL37; MCLP
UniProt ID: (Human) P49913, (Mouse) P51437
Entrez Gene ID: (Human) 820, (Mouse) 12796
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