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Invitrogen
Cathelicidin Polyclonal Antibody
Product Details
PA5-20513
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-20513 can be used with blocking peptide PEP-0633.
The immunogen is located within amino acids 50 - 100 of Cathelicidin.
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; hCAP-18; hCAP18
Gene Aliases: CAMP; CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
UniProt ID: (Human) P49913
Entrez Gene ID: (Human) 820
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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