Product References
Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages.
PloS one
Kitaura A,Nishinaka T,Hamasaki S,Hatipoglu OF,Wake H,Nishibori M,Mori S,Nakao S,Takahashi H
12-9041 was used in Flow cytometry/Cell sorting to indicate that the receptor for the AGE-initiated pathway partially impairs the immune response in diabetes patients.
Thu Jun 24 00:00:00 EDT 2021
Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages.
PloS one
Kitaura A,Nishinaka T,Hamasaki S,Hatipoglu OF,Wake H,Nishibori M,Mori S,Nakao S,Takahashi H
12-9041 was used in Flow cytometry/Cell sorting to indicate that the receptor for the AGE-initiated pathway partially impairs the immune response in diabetes patients.
Thu Jun 24 00:00:00 EDT 2021
Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression.
Cell death discovery
Xue Q,Liu X,Chen C,Zhang X,Xie P,Liu Y,Zhou S,Tang J
12-9041-80 was used in Flow Cytometry to shed a new light on how TLR4 regulating the activation of PARP-1 by LPS in macrophage.
Fri Jul 16 00:00:00 EDT 2021
Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression.
Cell death discovery
Xue Q,Liu X,Chen C,Zhang X,Xie P,Liu Y,Zhou S,Tang J
12-9041-80 was used in Flow Cytometry to shed a new light on how TLR4 regulating the activation of PARP-1 by LPS in macrophage.
Fri Jul 16 00:00:00 EDT 2021
Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice.
eLife
Gu H,Zeng X,Peng L,Xiang C,Zhou Y,Zhang X,Zhang J,Wang N,Guo G,Li Y,Liu K,Gu J,Zeng H,Zhuang Y,Li H,Zhang J,Zhang W,Zou Q,Shi Y
12-9041-80 was used in Flow Cytometry to reveal that a single intranasal immunization of inactivated whole cell of Acinetobacter baumannii induces rapid and efficient protection against certain Gram-negative bacterial pneumonia via training alveolar macrophage response.
Mon Sep 20 00:00:00 EDT 2021
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.
Immunobiology
Yau E,Chen Y,Song C,Webb J,Carillo M,Kawasawa YI,Tang Z,Takahashi Y,Umstead TM,Dovat S,Chroneos ZC
12-9041-80 was used in Flow Cytometry to suggest that the inflammatory differences seen in SP-R210L-deficient macrophages are a result of transcriptional differences that are mediated by epigenetic changes brought about by differential expression of the SP-R210 isoforms.
Mon Nov 01 00:00:00 EDT 2021
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
12-9041-80 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.
PLoS pathogens
Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P
Published figure using CD284 (TLR4) monoclonal antibody (Product # 12-9041-80) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice.
Frontiers in endocrinology
Petrovic I,Pejnovic N,Ljujic B,Pavlovic S,Miletic Kovacevic M,Jeftic I,Djukic A,Draginic N,Andjic M,Arsenijevic N,Lukic ML,Jovicic N
12-9041-80 was used in Flow Cytometry to suggest that increased expression of galectin 3 in the pancreatic β cells affects the metabolism of glucose and glycoregulation in mice on a high-fat diet, affecting both fasting glycemic values and glycemia after glucose loading.
Wed Feb 03 00:00:00 EST 2021
Interplay between RAGE and TLR4 Regulates HMGB1-Induced Inflammation by Promoting Cell Surface Expression of RAGE and TLR4.
Journal of immunology (Baltimore, Md. : 1950)
Zhong H,Li X,Zhou S,Jiang P,Liu X,Ouyang M,Nie Y,Chen X,Zhang L,Liu Y,Tao T,Tang J
12-9041-80 was used in Flow Cytometry to demonstrate that the interplay between RAGE and TLR4 are critical for HMGB1-induced inflammatory response.
Sat Aug 01 00:00:00 EDT 2020
Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis.
Scientific reports
Hamasaki S,Kobori T,Yamazaki Y,Kitaura A,Niwa A,Nishinaka T,Nishibori M,Mori S,Nakao S,Takahashi H
12-9041-80 was used in Flow Cytometry to indicate that CD204/scavenger receptors-1 class A stimulation plays a role in advanced glycation end-products uptake.
Thu Apr 12 00:00:00 EDT 2018
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain.
Frontiers in molecular neuroscience
Raj D,Yin Z,Breur M,Doorduin J,Holtman IR,Olah M,Mantingh-Otter IJ,Van Dam D,De Deyn PP,den Dunnen W,Eggen BJL,Amor S,Boddeke E
12-9041 was used in Flow cytometry/Cell sorting to indicate that microglia-induced neuroinflammation is predominant in the white matter of aging mice and humans as well as in EOAD brains.
Thu Oct 01 00:00:00 EDT 2020
Tissue damage negatively regulates LPS-induced macrophage necroptosis.
Cell death and differentiation
Li Z,Scott MJ,Fan EK,Li Y,Liu J,Xiao G,Li S,Billiar TR,Wilson MA,Jiang Y,Fan J
12-9041 was used in Flow cytometry/Cell sorting to investigate the mechanism and role of trauma/tissue damage in the regulation of LPS-induced MΦ necroptosis.
Thu Sep 01 00:00:00 EDT 2016
Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis.
Scientific reports
Ninkovic J,Anand V,Dutta R,Zhang L,Saluja A,Meng J,Koodie L,Banerjee S,Roy S
Published figure using CD284 (TLR4) monoclonal antibody (Product # 12-9041-80) in Flow Cytometry
Fri Feb 19 00:00:00 EST 2016
Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Zhan R,Han Q,Zhang C,Tian Z,Zhang J
12-9041 was used in Flow cytometry/Cell sorting to investigate the roles of TLR2 and TLR9 in regulating innate immunity against oral infection of Salmonella enterica serovar Typhimurium in mice.
Wed Apr 01 00:00:00 EDT 2015
Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-κB.
PloS one
Bhowmick R,Pore D,Chakrabarti MK
12-9041 was used in Flow cytometry/Cell sorting to investigate whether OmpA can modulate B cell functions.
Wed Jun 10 00:00:00 EDT 2015
A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance.
Cell death & disease
Liu C,Zhang C,Mitchel RE,Cui J,Lin J,Yang Y,Liu X,Cai J
Thu May 30 00:00:00 EDT 2013
Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A.
PloS one
Casella CR,Mitchell TC
Published figure using CD284 (TLR4) monoclonal antibody (Product # 12-9041-80) in Flow Cytometry
Mon Nov 11 00:00:00 EST 2013
Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease.
Investigative ophthalmology & visual science
Lee HS,Hattori T,Park EY,Stevenson W,Chauhan SK,Dana R
12-9041 was used in Flow cytometry/Cell sorting to study how DED increases the corneal expression of TLR4 and that TLR4 participates in the inflammatory response to ocular surface desiccating stress.
Fri Aug 17 00:00:00 EDT 2012
Comparison of blood monocytes and adipose tissue macrophages in a mouse model diet-induced weight gain.
Comparative medicine
McFarlin BK,Carpenter KC,Strohacker K,Breslin WL
12-9041 was used in Flow cytometry/Cell sorting to compare blood monocytes and adipose tissue macrophages in diet-induced weight gain in mice.
Sat Dec 01 00:00:00 EST 2012
Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice.
Biology of sex differences
Roberts BJ,Dragon JA,Moussawi M,Huber SA
12-9041 was used in Flow cytometry/Cell sorting to determine which TLRs show differential expression in CVB3 infected mice corresponding to male susceptibility and female resistance in Coxsackievirus B3.
Sat Dec 15 00:00:00 EST 2012
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
European journal of microbiology & immunology
Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D
12-9041 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.
Fri Jun 01 00:00:00 EDT 2012
The tumor suppressor ARF regulates innate immune responses in mice.
Journal of immunology (Baltimore, Md. : 1950)
Través PG,López-Fontal R,Luque A,Hortelano S
12-9041 was used in Flow cytometry/Cell sorting to investigate the role of the tumour suppressor alternative reading frame (ARF) in the regulation of innate immunity in mice.
Thu Dec 15 00:00:00 EST 2011
Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Miranda-Hernandez S,Gerlach N,Fletcher JM,Biros E,Mack M,Körner H,Baxter AG
12-9041 was used in Flow cytometry/Cell sorting to examine the effects of targeted deletions of specific TLRs on the induction of toxin-induced autoimmune encephalomyelitis.
Fri Jul 15 00:00:00 EDT 2011
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Immunity
Suzuki K,Maruya M,Kawamoto S,Sitnik K,Kitamura H,Agace WW,Fagarasan S
12-9041 was used in Flow cytometry/Cell sorting to investigate whether follicular dendritic cells within the germinal centers directly contribute to the IgA production in Peyer's patches, showing that sensing of environmental stimuli promotes IgA production.
Fri Jul 23 00:00:00 EDT 2010
TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation.
American journal of respiratory and critical care medicine
Garantziotis S,Li Z,Potts EN,Lindsey JY,Stober VP,Polosukhin VV,Blackwell TS,Schwartz DA,Foster WM,Hollingsworth JW
12-9041 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether hyaluronan acts as an endogenous toll-like receptor 4 ligand for the development of airway hyperresponsiveness following ozone-induced environmental airway injury.
Thu Apr 01 00:00:00 EDT 2010
Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Potts EN,Piantadosi CA,Foster WM,Hollingsworth JW
12-9041 was used in Flow cytometry/Cell sorting to provide evidence that ozone primes macrophage responsiveness to low-dose LPS, in part due to hyaluronan-induced TLR4 peripheralisation in lung macrophages.
Wed Dec 01 00:00:00 EST 2010
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.
The Journal of clinical investigation
Wang L,Harrington L,Trebicka E,Shi HN,Kagan JC,Hong CC,Lin HY,Babitt JL,Cherayil BJ
12-9041 was used in Flow cytometry/Cell sorting to show that manipulation of iron homeostasis could represent a new therapeutic approach to controlling inflammation.
Sun Nov 01 00:00:00 EDT 2009
Yersinia pestis and host macrophages: immunodeficiency of mouse macrophages induced by YscW.
Immunology
Bi Y,Du Z,Han Y,Guo Z,Tan Y,Zhu Z,Yang R
Published figure using CD284 (TLR4) monoclonal antibody (Product # 12-9041-80) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2009
Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.
Atherosclerosis
Dasu MR,Riosvelasco AC,Jialal I
12-9041 was used in Flow cytometry/Cell sorting to investigate the novel pathway by which candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.
Thu Jan 01 00:00:00 EST 2009
Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice.
Endocrinology
Dasu MR,Park S,Devaraj S,Jialal I
Published figure using CD284 (TLR4) monoclonal antibody (Product # 12-9041-80) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2009
Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Sherry CL,O'Connor JC,Kramer JM,Freund GG
12-9041-80 was used in Flow Cytometry to ndicate that augmented TNF-alpha production induced by LPS in macrophages during diabetes is due to hyperglycemia and increased LPS-dependent activation of p38 kinase.
Mon Jan 15 00:00:00 EST 2007
Gangliosides trigger inflammatory responses via TLR4 in brain glia.
The American journal of pathology
Jou I,Lee JH,Park SY,Yoon HJ,Joe EH,Park EJ
12-9041 was used in Flow cytometry/Cell sorting to suggest that TLR4 may provide an explanation for the pathological ability of gangliosides to cause inflammatory conditions in the brain.
Mon May 01 00:00:00 EDT 2006
Intraperitoneal injection of lipopolysaccharide induces dynamic migration of Gr-1high polymorphonuclear neutrophils in the murine abdominal cavity.
Clinical and diagnostic laboratory immunology
Miyazaki S,Ishikawa F,Fujikawa T,Nagata S,Yamaguchi K
12-9041 was used in Flow cytometry/Cell sorting to suggest that LPS induced polymorphonuclear neutrophil death and if expressing Gr-1 undergo apoptosis 180 min postinjection of LPS.
Sat May 01 00:00:00 EDT 2004
